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The map label for this gene is proA

Identifier: 78778975

GI number: 78778975

Start: 552967

End: 554277

Strand: Direct

Name: proA

Synonym: PMT9312_0590

Alternate gene names: 78778975

Gene position: 552967-554277 (Clockwise)

Preceding gene: 78778974

Following gene: 78778976

Centisome position: 32.35

GC content: 33.26

Gene sequence:

>1311_bases
ATGGCCAATATCTTTGAAGTTCCTCAACCAGGTAATGATCTTTTAGAAAAAGCTGATCAAGTTCGTTTGGCATCAATAAA
AATAAGTCAGACTGAAAATCACAATAGAATTAAAGCTTTAAATTCTATGGCTGATTGTCTAGAAAAAAGTACTAAAGAAA
TTTTAGAGGCGAATAATGAGGACTATACAAGAGCCCAAAAGAAAGGAATTTCAAAGGCTTTACTCTCTAGATTAAAGTTA
TCAAAAGAAAAATTAAATTCAGGAATTGAAGGAGTAAGAAAAGTTGGAGACTTGGCTGATCCTGTCAATCAAGTTCAAAT
CAAAAGAGAGCTTGCTAAGGGATTGATTTTAGAAAGAAAGACTGTGCCTATAGGAGTCCTAGGGGTTATTTTTGAATCGA
GGCCAGATGCTGTTATGCAGATTAGTTCTCTAGCAATAAGATCAGGTAATGGCGTAATGCTAAAGGGCGGTAGTGAAGCC
AATTTAACAAATACTGCAATAGTCAAGGCTTTGAAAAAGGGTTTGTATGAATCAGGACTTGATAAAAATGCAATATGCTT
ACTTACAAGCAGAAAAGATAGTATGTCGATGTTAAATCTTGAGAAATATATTAATTTGATAATTCCTAGAGGAAGTAATG
AATTAGTTAAATTTATTCAGGAGAATACAAGAATTCCCGTGTTAGGTCATGCTGATGGAATTTGTCATTTATTTATAGAT
AATGAGGCAAATCTCGAGATGGCTTTATCAGTAGCTTTGGATAGCAAAATTCAATATCCTGCAGCATGTAATGCTATTGA
AACTTTATTAGTGCATAAAGATATTGCACAAGTTTTTCTAGAAAAGGCAATACCTTTGTTTAATTCTAATGACGTTAAAT
TAATTGGAGATAAACGAACAGTTGAGTTAGGGGTGAAGTATGAGGCTAGTGTAGAAGATTGGCAAACTGAATATTTAGAT
TTAATTTTATCGATAAAAATTGTTGACGATCTTGAGGAGGCAATTAATCATATTCAAAAATTTAGTTCAAAACATACAGA
TGGAATAATCACTGAAAATTCAACTTCTGCTAAAAAATTTATGAATGTAGTTGATAGTGCAGGTGTTTTTCATAATTGCT
CTACTAGATTTGCAGATGGGTTTAGATATGGATTCGGAGCCGAAATTGGGATATCTACTCAAACTCTTCCCCCAAGAGGA
CCTGTAGGTCTAGAGGGTTTGGTTACATATAAATATTTTCTAAATGGCGATGGGAATATCGTTGATGATTTTTCATCTGG
TAAGGCTATCTATACTCATAAGGATCTTTGA

Upstream 100 bases:

>100_bases
AAAAGTCAAGTTCAATTATTTTTTAGATATTAAGTCATAAAAAAAGTTAGTTCAAAGAATCCTTAATTTGAATTATTATT
AAATTAATTAAAATATATAT

Downstream 100 bases:

>100_bases
ATTTTTTGAAGATGGAAACATTTTTAAAAATTGAGAATATTAAACTTTGGGCTAGAGTGGGTGTTCTTGAGGAAGAAAGG
CAATTAGGACAATTATTTAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MANIFEVPQPGNDLLEKADQVRLASIKISQTENHNRIKALNSMADCLEKSTKEILEANNEDYTRAQKKGISKALLSRLKL
SKEKLNSGIEGVRKVGDLADPVNQVQIKRELAKGLILERKTVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEA
NLTNTAIVKALKKGLYESGLDKNAICLLTSRKDSMSMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
NEANLEMALSVALDSKIQYPAACNAIETLLVHKDIAQVFLEKAIPLFNSNDVKLIGDKRTVELGVKYEASVEDWQTEYLD
LILSIKIVDDLEEAINHIQKFSSKHTDGIITENSTSAKKFMNVVDSAGVFHNCSTRFADGFRYGFGAEIGISTQTLPPRG
PVGLEGLVTYKYFLNGDGNIVDDFSSGKAIYTHKDL

Sequences:

>Translated_436_residues
MANIFEVPQPGNDLLEKADQVRLASIKISQTENHNRIKALNSMADCLEKSTKEILEANNEDYTRAQKKGISKALLSRLKL
SKEKLNSGIEGVRKVGDLADPVNQVQIKRELAKGLILERKTVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEA
NLTNTAIVKALKKGLYESGLDKNAICLLTSRKDSMSMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
NEANLEMALSVALDSKIQYPAACNAIETLLVHKDIAQVFLEKAIPLFNSNDVKLIGDKRTVELGVKYEASVEDWQTEYLD
LILSIKIVDDLEEAINHIQKFSSKHTDGIITENSTSAKKFMNVVDSAGVFHNCSTRFADGFRYGFGAEIGISTQTLPPRG
PVGLEGLVTYKYFLNGDGNIVDDFSSGKAIYTHKDL
>Mature_435_residues
ANIFEVPQPGNDLLEKADQVRLASIKISQTENHNRIKALNSMADCLEKSTKEILEANNEDYTRAQKKGISKALLSRLKLS
KEKLNSGIEGVRKVGDLADPVNQVQIKRELAKGLILERKTVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEAN
LTNTAIVKALKKGLYESGLDKNAICLLTSRKDSMSMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFIDN
EANLEMALSVALDSKIQYPAACNAIETLLVHKDIAQVFLEKAIPLFNSNDVKLIGDKRTVELGVKYEASVEDWQTEYLDL
ILSIKIVDDLEEAINHIQKFSSKHTDGIITENSTSAKKFMNVVDSAGVFHNCSTRFADGFRYGFGAEIGISTQTLPPRGP
VGLEGLVTYKYFLNGDGNIVDDFSSGKAIYTHKDL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=435, Percent_Identity=42.2988505747126, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI62912457, Length=435, Percent_Identity=42.2988505747126, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1786438, Length=404, Percent_Identity=39.8514851485149, Blast_Score=301, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17569967, Length=430, Percent_Identity=42.5581395348837, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI17569969, Length=430, Percent_Identity=42.5581395348837, Blast_Score=348, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6324899, Length=442, Percent_Identity=41.8552036199095, Blast_Score=343, Evalue=4e-95,
Organism=Drosophila melanogaster, GI21357643, Length=423, Percent_Identity=43.4988179669031, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PROM9 (Q31BU4)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397087.1
- ProteinModelPortal:   Q31BU4
- SMR:   Q31BU4
- STRING:   Q31BU4
- GeneID:   3765390
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_0590
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   PMAR74546:PMT9312_0590-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 47951; Mature: 47819

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIFEVPQPGNDLLEKADQVRLASIKISQTENHNRIKALNSMADCLEKSTKEILEANNE
CCCCCCCCCCCHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
DYTRAQKKGISKALLSRLKLSKEKLNSGIEGVRKVGDLADPVNQVQIKRELAKGLILERK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECC
TVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEANLTNTAIVKALKKGLYESGL
CCCEEEEEHHCCCCCHHHHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DKNAICLLTSRKDSMSMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
CCCEEEEEECCCCHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCEEEECCCCEEEEEEC
NEANLEMALSVALDSKIQYPAACNAIETLLVHKDIAQVFLEKAIPLFNSNDVKLIGDKRT
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEE
VELGVKYEASVEDWQTEYLDLILSIKIVDDLEEAINHIQKFSSKHTDGIITENSTSAKKF
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHH
MNVVDSAGVFHNCSTRFADGFRYGFGAEIGISTQTLPPRGPVGLEGLVTYKYFLNGDGNI
HHHHHCCCCCCCCCHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCE
VDDFSSGKAIYTHKDL
EECCCCCCEEEEECCC
>Mature Secondary Structure 
ANIFEVPQPGNDLLEKADQVRLASIKISQTENHNRIKALNSMADCLEKSTKEILEANNE
CCCCCCCCCCHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
DYTRAQKKGISKALLSRLKLSKEKLNSGIEGVRKVGDLADPVNQVQIKRELAKGLILERK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECC
TVPIGVLGVIFESRPDAVMQISSLAIRSGNGVMLKGGSEANLTNTAIVKALKKGLYESGL
CCCEEEEEHHCCCCCHHHHHHHHHEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DKNAICLLTSRKDSMSMLNLEKYINLIIPRGSNELVKFIQENTRIPVLGHADGICHLFID
CCCEEEEEECCCCHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCCEEEECCCCEEEEEEC
NEANLEMALSVALDSKIQYPAACNAIETLLVHKDIAQVFLEKAIPLFNSNDVKLIGDKRT
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEE
VELGVKYEASVEDWQTEYLDLILSIKIVDDLEEAINHIQKFSSKHTDGIITENSTSAKKF
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHH
MNVVDSAGVFHNCSTRFADGFRYGFGAEIGISTQTLPPRGPVGLEGLVTYKYFLNGDGNI
HHHHHCCCCCCCCCHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCE
VDDFSSGKAIYTHKDL
EECCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA