Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 78778672

GI number: 78778672

Start: 274961

End: 276397

Strand: Reverse

Name: phr [H]

Synonym: PMT9312_0287

Alternate gene names: 78778672

Gene position: 276397-274961 (Counterclockwise)

Preceding gene: 78778673

Following gene: 78778669

Centisome position: 16.17

GC content: 31.25

Gene sequence:

>1437_bases
ATGAATAATCCTAGAATACTATTTTGGCATAGAAAGGATTTAAGAATATTCGATAATCAAGCTTTAATCAAAGCATTTTC
ATTATCAAATGCTATTACTTCAACTTATATATTAGATAGAAATTACACACACGATTTTAGTGCAAATTCAAGAGCTTGGT
TTCTAGGAGATTCGCTTCAAGAATTAGGAAATAATTGGGAAAAAATGGGTAGTAGACTAGTTATAGAAGAAGGAGATCCT
GTATTAATAATCCCTCAATTAGCAAAGACAATAGATGCTAAATTTGTTATTTGGAATAAAACAATTGAACCTTATGAGAT
TAATCGAGATTTACAAATAAAAAAAAATTTAAAAGAAAAAAATATTCAAGTTATTGAATCTTGGGATCACTTATTAGTAG
AACCTTTAAAAATATTTTCAGGGAATAATAAACCTTATTCGGTTTATGGACCTTTTTATAAAAACCTTAAATCAAAAATG
AATTTATTAGGGTTATATGATCAAGATAAAGTTATTTTCCAGTTTAAAGATATAGATAATAAGCTAAAAGAAAATAAGTT
AATAAATTCATCTGATTCCACCCTAAAGAAATTTCTCAAAAATATCAAATTTTCTGGATCTAATATTTGTCCATGTAGAC
CAGGTGAGAACGGTGCAGAAATATTATTAGAAAAATTCATTAACGAAAAAAATATATATTCTTACAATTCCGCAAGAGAT
TTGCCTTCCCATAATGGGACATCTTTTTTAAGTGCATCGCTTAGATTCGGAACCATCAGCATTAGAAAAGTTTGGAATGC
CACATTAGATTTAAATTCGGATTTTGAAAGTCATGAAAATTCCCTATCAATTGAAACTTGGCAAAAAGAACTTGTTTGGC
GTGAATTTTATCAACATTGCTTATTCCATTTCCCAGAGCTAGAGAAAGGTCCATATAGAAAAAAATGGGGTCAATTTCCA
TGGCAAAACAATAATGAATGGTTTCAGCATTGGAGCAACGGCGAGACTGGTGTACCTATAGTTGATGCTGCAATGCGTCA
ACTAAACAGTACTGGCTGGATGCATAACAGATGTCGAATGATAGTCGCTTCATTTCTAGTAAAAGATCTTATATGCAGTT
GGCAAATGGGCGAGAAAAAATTTATGGAGACGTTGGTTGATGGAGACTTAGCCGCAAATAATGGGGGGTGGCAGTGGAGC
GCTAGTAGCGGTATGGATCCAAAACCACTAAGAATTTTTAATCCATATACTCAAGCAAAAAAATTTGATCCTATCTGCGA
ATATATAAAATCTTGGATTCCTGAATTGTCTAAAGTGTCAAATTCAGACCTATTAAATGGCGAGATATCTAATTTAGAAA
AAAATAATTATTCAACCCCTATTGTCGATCACAACATACAGCAAAGATTATTTAAATCACTTTATGCTGAAATTTGA

Upstream 100 bases:

>100_bases
ATCCCGACGAACTTGATAATCTTATTTCTAGTGGGGATGAAATTCTTGACGCAAAAACTGTGACAGCTTGGTTTAGAGCT
AAACAATTTTTAGATAAATT

Downstream 100 bases:

>100_bases
ATTTCCTCTATGCAATTCTTTAAAACTTTATTTAAATTTTCTGCGACATAAACTTGCTCTTCATAAGAAATTTCAGGAAA
CATTGGAAGACTGAGAACTT

Product: deoxyribodipyrimidine photo-lyase type I

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MNNPRILFWHRKDLRIFDNQALIKAFSLSNAITSTYILDRNYTHDFSANSRAWFLGDSLQELGNNWEKMGSRLVIEEGDP
VLIIPQLAKTIDAKFVIWNKTIEPYEINRDLQIKKNLKEKNIQVIESWDHLLVEPLKIFSGNNKPYSVYGPFYKNLKSKM
NLLGLYDQDKVIFQFKDIDNKLKENKLINSSDSTLKKFLKNIKFSGSNICPCRPGENGAEILLEKFINEKNIYSYNSARD
LPSHNGTSFLSASLRFGTISIRKVWNATLDLNSDFESHENSLSIETWQKELVWREFYQHCLFHFPELEKGPYRKKWGQFP
WQNNNEWFQHWSNGETGVPIVDAAMRQLNSTGWMHNRCRMIVASFLVKDLICSWQMGEKKFMETLVDGDLAANNGGWQWS
ASSGMDPKPLRIFNPYTQAKKFDPICEYIKSWIPELSKVSNSDLLNGEISNLEKNNYSTPIVDHNIQQRLFKSLYAEI

Sequences:

>Translated_478_residues
MNNPRILFWHRKDLRIFDNQALIKAFSLSNAITSTYILDRNYTHDFSANSRAWFLGDSLQELGNNWEKMGSRLVIEEGDP
VLIIPQLAKTIDAKFVIWNKTIEPYEINRDLQIKKNLKEKNIQVIESWDHLLVEPLKIFSGNNKPYSVYGPFYKNLKSKM
NLLGLYDQDKVIFQFKDIDNKLKENKLINSSDSTLKKFLKNIKFSGSNICPCRPGENGAEILLEKFINEKNIYSYNSARD
LPSHNGTSFLSASLRFGTISIRKVWNATLDLNSDFESHENSLSIETWQKELVWREFYQHCLFHFPELEKGPYRKKWGQFP
WQNNNEWFQHWSNGETGVPIVDAAMRQLNSTGWMHNRCRMIVASFLVKDLICSWQMGEKKFMETLVDGDLAANNGGWQWS
ASSGMDPKPLRIFNPYTQAKKFDPICEYIKSWIPELSKVSNSDLLNGEISNLEKNNYSTPIVDHNIQQRLFKSLYAEI
>Mature_478_residues
MNNPRILFWHRKDLRIFDNQALIKAFSLSNAITSTYILDRNYTHDFSANSRAWFLGDSLQELGNNWEKMGSRLVIEEGDP
VLIIPQLAKTIDAKFVIWNKTIEPYEINRDLQIKKNLKEKNIQVIESWDHLLVEPLKIFSGNNKPYSVYGPFYKNLKSKM
NLLGLYDQDKVIFQFKDIDNKLKENKLINSSDSTLKKFLKNIKFSGSNICPCRPGENGAEILLEKFINEKNIYSYNSARD
LPSHNGTSFLSASLRFGTISIRKVWNATLDLNSDFESHENSLSIETWQKELVWREFYQHCLFHFPELEKGPYRKKWGQFP
WQNNNEWFQHWSNGETGVPIVDAAMRQLNSTGWMHNRCRMIVASFLVKDLICSWQMGEKKFMETLVDGDLAANNGGWQWS
ASSGMDPKPLRIFNPYTQAKKFDPICEYIKSWIPELSKVSNSDLLNGEISNLEKNNYSTPIVDHNIQQRLFKSLYAEI

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=500, Percent_Identity=28, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI4758072, Length=493, Percent_Identity=28.1947261663286, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI188536103, Length=458, Percent_Identity=27.292576419214, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1786926, Length=472, Percent_Identity=36.4406779661017, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6324962, Length=494, Percent_Identity=30.1619433198381, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137248, Length=455, Percent_Identity=29.2307692307692, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24585455, Length=455, Percent_Identity=29.2307692307692, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24648152, Length=474, Percent_Identity=27.6371308016878, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55670; Mature: 55670

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPRILFWHRKDLRIFDNQALIKAFSLSNAITSTYILDRNYTHDFSANSRAWFLGDSLQ
CCCCCEEEEECCCCEEECCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEECHHHH
ELGNNWEKMGSRLVIEEGDPVLIIPQLAKTIDAKFVIWNKTIEPYEINRDLQIKKNLKEK
HHCCCHHHHCCEEEEECCCCEEEEHHHHHHHCCEEEEECCCCCCEECCCCCHHHHCCCCC
NIQVIESWDHLLVEPLKIFSGNNKPYSVYGPFYKNLKSKMNLLGLYDQDKVIFQFKDIDN
CHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHEEEECCCCEEEEEECHHH
KLKENKLINSSDSTLKKFLKNIKFSGSNICPCRPGENGAEILLEKFINEKNIYSYNSARD
HHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCC
LPSHNGTSFLSASLRFGTISIRKVWNATLDLNSDFESHENSLSIETWQKELVWREFYQHC
CCCCCCCHHEEEEEEECEEEEEEHHCCEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHH
LFHFPELEKGPYRKKWGQFPWQNNNEWFQHWSNGETGVPIVDAAMRQLNSTGWMHNRCRM
HHCCCCCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
IVASFLVKDLICSWQMGEKKFMETLVDGDLAANNGGWQWSASSGMDPKPLRIFNPYTQAK
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCEEECCCCCCCCCCEEEECCHHHHH
KFDPICEYIKSWIPELSKVSNSDLLNGEISNLEKNNYSTPIVDHNIQQRLFKSLYAEI
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNPRILFWHRKDLRIFDNQALIKAFSLSNAITSTYILDRNYTHDFSANSRAWFLGDSLQ
CCCCCEEEEECCCCEEECCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEEECHHHH
ELGNNWEKMGSRLVIEEGDPVLIIPQLAKTIDAKFVIWNKTIEPYEINRDLQIKKNLKEK
HHCCCHHHHCCEEEEECCCCEEEEHHHHHHHCCEEEEECCCCCCEECCCCCHHHHCCCCC
NIQVIESWDHLLVEPLKIFSGNNKPYSVYGPFYKNLKSKMNLLGLYDQDKVIFQFKDIDN
CHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHEEEECCCCEEEEEECHHH
KLKENKLINSSDSTLKKFLKNIKFSGSNICPCRPGENGAEILLEKFINEKNIYSYNSARD
HHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCCC
LPSHNGTSFLSASLRFGTISIRKVWNATLDLNSDFESHENSLSIETWQKELVWREFYQHC
CCCCCCCHHEEEEEEECEEEEEEHHCCEECCCCCHHHCCCCCCHHHHHHHHHHHHHHHHH
LFHFPELEKGPYRKKWGQFPWQNNNEWFQHWSNGETGVPIVDAAMRQLNSTGWMHNRCRM
HHCCCCCCCCCCHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
IVASFLVKDLICSWQMGEKKFMETLVDGDLAANNGGWQWSASSGMDPKPLRIFNPYTQAK
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCEEECCCCCCCCCCEEEECCHHHHH
KFDPICEYIKSWIPELSKVSNSDLLNGEISNLEKNNYSTPIVDHNIQQRLFKSLYAEI
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2837735; 2110564; 9360600 [H]