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The map label for this gene is glyA

Identifier: 78778645

GI number: 78778645

Start: 248411

End: 249682

Strand: Reverse

Name: glyA

Synonym: PMT9312_0260

Alternate gene names: 78778645

Gene position: 249682-248411 (Counterclockwise)

Preceding gene: 78778648

Following gene: 78778644

Centisome position: 14.61

GC content: 35.93

Gene sequence:

>1272_bases
ATGAATATTCTTCAAAATCTTAAAAAAAGTGATCCAGTAATATCCAATTTCATTAACTCCGAAAAAAATAGACAGGAAAC
TCACCTTGAGTTAATAGCAAGTGAGAATTTTGCATCGATTGCTGTCATGCAGGCTCAAGGATCGGTCCTTACTAATAAAT
ACGCGGAAGGATTACCTCAAAAGAGATATTACGGTGGATGCGAATTTGTTGATGAAATCGAAGAATTAGCTATTCAGAGA
GCAAAAAAATTATTTAATGCAAATTGGGCTAATGTTCAACCTCATAGTGGAGCACAGGCAAATGCTGCTGTTTTCTTAAG
CCTTCTTCAACCTGGCGATACAATCATGGGAATGGATTTATCTCATGGTGGACACCTTACTCATGGATCTCCAGTCAATA
TGAGTGGCAAGTGGTTTAATGCAGTTCACTATGGTGTAAATAAAGAAACTAGTGAGTTAAATTTTGATGAAATAAGAGAG
ATCGCACTAGAAACAAAACCAAAATTAATCATATGCGGATATTCTGCTTATCCAAGAACAATTGATTTTGAATCATTTAG
AAATATTGCAGATGAAGTTGGTGCATTCTTAATGGCTGATATTGCACACATCGCGGGGCTCGTAGCAAGTAAACTTCATC
CAAATCCTCTACCTTATTGTGATGTAGTTACTACAACTACTCATAAGACATTGAGAGGGCCTAGAGGAGGACTTATCTTA
TGTAAAGATGGAGAATTTGGAAAGAAATTTGATAAATCTGTTTTCCCTGGAACTCAGGGTGGCCCCCTAGAACATATTAT
TGCCGCTAAAGCAGTTGCATTTGGAGAAGCCTTACAACCAGATTTCGTTAATTATTCCCAACAAGTTATAAAAAATGCGA
AAGTGTTGGCTTCCACTTTAATAAGTAGAGGTATTGATATTGTTAGTGGAGGGACTGATAATCATATTGTTTTACTAGAT
TTAAGAAGTATAAATATGACTGGAAAAATTGCTGATTTGCTAGTAAGCGCAGTGAATATCACAGCTAATAAAAATACTGT
TCCATTTGATCCTGAATCGCCTTTTGTTACCAGTGGGCTAAGGCTGGGTACTGCTGCTTTAACTACCAGAGGCTTTAATG
AAACTGCTTTTGCTGAAGTTGGAGAAATTATTGCTGATAGATTACTTAATCCAAATGATTCAGTGATTGAAAGTCAATGT
AAGGACAAAGTATTAGCTTTATGTAATCGTTTTCCTCTTTATGAAGGCAAACTTGAAGCATCAATTAAATGA

Upstream 100 bases:

>100_bases
GGAGTTCGAATCTCTCCAGGCGCGTTTAAAAATATGAAATATCCTTTTTATATTTTTCCAAAAATTTCGTTTATATTATG
AGTATTACTTATCAAGTTCA

Downstream 100 bases:

>100_bases
CTTCTAATTCCAAAGGAGTTGAAATTCTTTCTATTGGAACAGAGCTACTTTTAGGAAATATTGTAAATACAAATGCTAAA
TGGATTTCTGAGCAGTTGTC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNILQNLKKSDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLQPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPLPYCDVVTTTTHKTLRGPRGGLIL
CKDGEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLISRGIDIVSGGTDNHIVLLD
LRSINMTGKIADLLVSAVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNETAFAEVGEIIADRLLNPNDSVIESQC
KDKVLALCNRFPLYEGKLEASIK

Sequences:

>Translated_423_residues
MNILQNLKKSDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLQPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPLPYCDVVTTTTHKTLRGPRGGLIL
CKDGEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLISRGIDIVSGGTDNHIVLLD
LRSINMTGKIADLLVSAVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNETAFAEVGEIIADRLLNPNDSVIESQC
KDKVLALCNRFPLYEGKLEASIK
>Mature_423_residues
MNILQNLKKSDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQKRYYGGCEFVDEIEELAIQR
AKKLFNANWANVQPHSGAQANAAVFLSLLQPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIRE
IALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPLPYCDVVTTTTHKTLRGPRGGLIL
CKDGEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLISRGIDIVSGGTDNHIVLLD
LRSINMTGKIADLLVSAVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNETAFAEVGEIIADRLLNPNDSVIESQC
KDKVLALCNRFPLYEGKLEASIK

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=403, Percent_Identity=48.1389578163772, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI261862350, Length=403, Percent_Identity=48.1389578163772, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI261862348, Length=403, Percent_Identity=48.1389578163772, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI19923315, Length=403, Percent_Identity=48.1389578163772, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI261862346, Length=403, Percent_Identity=47.8908188585608, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI22547186, Length=405, Percent_Identity=47.1604938271605, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI22547189, Length=391, Percent_Identity=45.5242966751918, Blast_Score=305, Evalue=4e-83,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=56.9343065693431, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=46.2871287128713, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=46.2871287128713, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=429, Percent_Identity=42.1911421911422, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=405, Percent_Identity=42.2222222222222, Blast_Score=319, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=47.2222222222222, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=47.2222222222222, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46016; Mature: 46016

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILQNLKKSDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQ
CCHHHHHHHCCCHHHHHHCCCCCCHHHHHHEEECCCCCEEEEEECCCCHHHHHHHHCCCC
KRYYGGCEFVDEIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLQPGDTIMGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALETKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC
IDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPLPYCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCEEE
CKDGEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTL
ECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ISRGIDIVSGGTDNHIVLLDLRSINMTGKIADLLVSAVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNETAFAEVGEIIADRLLNPNDSVIESQCKDKVLALCNRFPLYEGKLEA
HHCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SIK
CCC
>Mature Secondary Structure
MNILQNLKKSDPVISNFINSEKNRQETHLELIASENFASIAVMQAQGSVLTNKYAEGLPQ
CCHHHHHHHCCCHHHHHHCCCCCCHHHHHHEEECCCCCEEEEEECCCCHHHHHHHHCCCC
KRYYGGCEFVDEIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLQPGDTIMGMDL
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
SHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALETKPKLIICGYSAYPRT
CCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCC
IDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPLPYCDVVTTTTHKTLRGPRGGLIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHCCCCCCEEE
CKDGEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTL
ECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ISRGIDIVSGGTDNHIVLLDLRSINMTGKIADLLVSAVNITANKNTVPFDPESPFVTSGL
HHCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCHHCCC
RLGTAALTTRGFNETAFAEVGEIIADRLLNPNDSVIESQCKDKVLALCNRFPLYEGKLEA
HHCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA