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The map label for this gene is nadC [H]

Identifier: 78778576

GI number: 78778576

Start: 180631

End: 181497

Strand: Reverse

Name: nadC [H]

Synonym: PMT9312_0190

Alternate gene names: 78778576

Gene position: 181497-180631 (Counterclockwise)

Preceding gene: 78778577

Following gene: 78778575

Centisome position: 10.62

GC content: 28.95

Gene sequence:

>867_bases
GTGGATTTAAATACTCCAATAATAAGTAAGATCATTGATAATTGGATCGATGAAGATATAGGTAGGGGAGATCTTACAAG
GCCTTCTATTACAGAAGAGAATGGTAATGCATATTGGATTGCAAAAGAAGGTGGTATATTTTGTGGTGTCGAAATCATAA
AAGAAATTTTTAAAAAAATTGATTTAAACATCAGTTCAAAATTTAATATCTCTGATGGAAATCAATTTTTTAAAGATCAA
AAACTCCTGGAAATATATGGACCTTCAAAAAGTTTGCTAGCCAGTGAAAGAATAGGCTTAAATATAGCAATGCATTTATC
TGGAATATCAACATATACAAAGAATCTTGTAAATAAGTTAGAAGGTACAAATATAAAATTAGCAGATACTAGGAAAACTA
CTCCTGGCTTAAGAATATTTGAAAAATATGCATTCAAATGTGGAGGTGGAGTGAATCATAGAATGGGATTATACGATGCA
GCTATGATAAAAGAAAATCACATTGCATGGACAGATAATCTTAATAATGCAGTAAAAAAAATTCGACTAAATTCGCCTTT
TACAACTCATATCATAATTGAAGCTGAGAATATCGAACAGGCAAAAGAAGCAGTATTAGCAGGAGCAGATAGTGTCTTAT
TGGATGAACTTAGCCCTGAAATAATCCAAAAAAACGTTCAAGAATTAAGAGATTTATCAATGAATAGCTTAAAAAAAGAA
GTCAATAAAAATTTGATAATAGAAGTTTCTGGAATTAACCCTAAAGAAATTAGTAAATATCTAATAAAAGGTATTGATTT
GATTTCAACAAGTTCTTCAATTACCAAAAGTAATTGGATTGATTTAAGTATGCGTTATATTAATTAA

Upstream 100 bases:

>100_bases
TTTTGTATTGGTAAATAAATTTGAGTTAAATTACATAGTGATATATAGTTGATTCTCTAACTTCAGTTTAATTTTTATTA
ATTAATTATTTTTTAGTTTA

Downstream 100 bases:

>100_bases
TTATATAGATAAATAATTGAATAATTAATGCTAATCATTTTTAAAGAATTAACAAAACAATTTGAACAATCTCTTTTAGA
TAGTCTTGAAAAAAATGATA

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTRPSITEENGNAYWIAKEGGIFCGVEIIKEIFKKIDLNISSKFNISDGNQFFKDQ
KLLEIYGPSKSLLASERIGLNIAMHLSGISTYTKNLVNKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRLNSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIQKNVQELRDLSMNSLKKE
VNKNLIIEVSGINPKEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN

Sequences:

>Translated_288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTRPSITEENGNAYWIAKEGGIFCGVEIIKEIFKKIDLNISSKFNISDGNQFFKDQ
KLLEIYGPSKSLLASERIGLNIAMHLSGISTYTKNLVNKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRLNSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIQKNVQELRDLSMNSLKKE
VNKNLIIEVSGINPKEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
>Mature_288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTRPSITEENGNAYWIAKEGGIFCGVEIIKEIFKKIDLNISSKFNISDGNQFFKDQ
KLLEIYGPSKSLLASERIGLNIAMHLSGISTYTKNLVNKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRLNSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIQKNVQELRDLSMNSLKKE
VNKNLIIEVSGINPKEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=281, Percent_Identity=27.7580071174377, Blast_Score=121, Evalue=6e-28,
Organism=Escherichia coli, GI1786299, Length=253, Percent_Identity=37.9446640316205, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=284, Percent_Identity=32.7464788732394, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32260; Mature: 32260

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNTPIISKIIDNWIDEDIGRGDLTRPSITEENGNAYWIAKEGGIFCGVEIIKEIFKKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEECHHHHHHHHHHH
DLNISSKFNISDGNQFFKDQKLLEIYGPSKSLLASERIGLNIAMHLSGISTYTKNLVNKL
CCCCCCEEECCCCHHHHHCCCEEEEECCCHHHHHHHCCCEEEEEEECHHHHHHHHHHHHH
EGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDAAMIKENHIAWTDNLNNAVKK
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHE
IRLNSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIQKNVQELRDLSMNSLKKE
EECCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VNKNLIIEVSGINPKEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MDLNTPIISKIIDNWIDEDIGRGDLTRPSITEENGNAYWIAKEGGIFCGVEIIKEIFKKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEECHHHHHHHHHHH
DLNISSKFNISDGNQFFKDQKLLEIYGPSKSLLASERIGLNIAMHLSGISTYTKNLVNKL
CCCCCCEEECCCCHHHHHCCCEEEEECCCHHHHHHHCCCEEEEEEECHHHHHHHHHHHHH
EGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDAAMIKENHIAWTDNLNNAVKK
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHE
IRLNSPFTTHIIIEAENIEQAKEAVLAGADSVLLDELSPEIIQKNVQELRDLSMNSLKKE
EECCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VNKNLIIEVSGINPKEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]