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The map label for this gene is cysK [H]

Identifier: 78778512

GI number: 78778512

Start: 122326

End: 123294

Strand: Reverse

Name: cysK [H]

Synonym: PMT9312_0126

Alternate gene names: 78778512

Gene position: 123294-122326 (Counterclockwise)

Preceding gene: 78778515

Following gene: 78778511

Centisome position: 7.21

GC content: 36.12

Gene sequence:

>969_bases
ATGGAAATAGCAAATGATATCACTTCTCTAGTTGGAAATACTCCATTAGTTAAATTAAGTCGAATCAGAAATTACTTTAA
TTGTTATCCAGAAATAATAGCCAAACTCGAAAGTTTCAATCCATCAGCGTCTGTAAAAGATCGTATTGCTTATTCAATGT
TATGCAAAGCTGAAGAAGAAGGATTGATAACACCAGACAAAACAACATTGATTGAAGCAACAAGTGGAAATACTGGCATC
GCATTAGCAATGGTTGCTGCAGCTAAAGGCTATAAATTGATATTAACTATGCCTGATACGATGAGTATTGAAAGAAGGGC
AATGTTGCGAGCATATGGGGCTGAATTACAGCTAACGCCAGGTCAAGAAGGAATGAAAGGAGCCTTAGATTTAGCTAATG
AGTTGTCTTCTAGCATTGCAAATAGCTATCAATTTAATCAATTTGAAAACTTTGCTAATCCAGATATTCATGAAAGAACA
ACCGCTCAAGAAATATGGGCCCAATCCAATAACAATTTAGATGGACTAGTTACGGGAGTAGGCACAGGAGGCACAATTAC
TGGTTGCGCACGTTTTTTGAAAAAAGTTAATCCAAATTGCAAAATTTATGCTGTAGAGCCCAGAAAAAGTGCTGTCATTT
CCGGAGAAAAAGCAGGATCTCATTCGATTCAAGGAATAGGGGCAGGTTTCGTACCGAAAGTCCTGAATACTAAATTAATT
GATGAAATTATAAAAATTGATGACGACGAAGCATTTTATTATGGGCGTTTATTAGCTCGATTGGAAGGTCTTTTATCAGG
CATCAGCAGCGGAGCCGCTTTAGCAGCAACTATAAAAATTGGTGAAAGGAAAGAACTAATTAATAAAAGATTGATAGTAA
TTCTGCCAAGTTTTGGTGAAAGATATTTATCAACCGCAATGTTTGAATCCAATACCTCAATTCAAGCAAGAACAGATGGT
TATCTTTAA

Upstream 100 bases:

>100_bases
ATTTTTAATTAAATTCTTTTATGAAAATCATATAAAAGATCTTTAAATACAATTATTATGTAAAGAGGAGAGTTAATTTG
GCAATTTAAATAATCATTTC

Downstream 100 bases:

>100_bases
TTCCTAATTTATAAAAATGGAAAAAAATTTATATGAAGAATTAGGCCTCAAAAAAAATGCACCCAAAAGTGAAATTAAAT
CTTCATATCGTTCTTTAGTT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MEIANDITSLVGNTPLVKLSRIRNYFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEEGLITPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGQEGMKGALDLANELSSSIANSYQFNQFENFANPDIHERT
TAQEIWAQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPRKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELINKRLIVILPSFGERYLSTAMFESNTSIQARTDG
YL

Sequences:

>Translated_322_residues
MEIANDITSLVGNTPLVKLSRIRNYFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEEGLITPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGQEGMKGALDLANELSSSIANSYQFNQFENFANPDIHERT
TAQEIWAQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPRKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELINKRLIVILPSFGERYLSTAMFESNTSIQARTDG
YL
>Mature_322_residues
MEIANDITSLVGNTPLVKLSRIRNYFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEEGLITPDKTTLIEATSGNTGI
ALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTPGQEGMKGALDLANELSSSIANSYQFNQFENFANPDIHERT
TAQEIWAQSNNNLDGLVTGVGTGGTITGCARFLKKVNPNCKIYAVEPRKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELINKRLIVILPSFGERYLSTAMFESNTSIQARTDG
YL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=40.5144694533762, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=40.5144694533762, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=40.5144694533762, Blast_Score=225, Evalue=4e-59,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=51.8987341772152, Blast_Score=270, Evalue=9e-74,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=42.9530201342282, Blast_Score=220, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=50.1628664495114, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=48.8294314381271, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=47.0588235294118, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=47.8405315614618, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=44.8051948051948, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=45.7547169811321, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=327, Percent_Identity=35.1681957186544, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=34.8101265822785, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=37.5, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=25.609756097561, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=40.3174603174603, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6321449, Length=336, Percent_Identity=33.6309523809524, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=39.1975308641975, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=39.1975308641975, Blast_Score=189, Evalue=1e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34902; Mature: 34902

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIANDITSLVGNTPLVKLSRIRNYFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEE
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
GLITPDKTTLIEATSGNTGIALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTP
CCCCCCCCEEEEECCCCCCHHHHEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GQEGMKGALDLANELSSSIANSYQFNQFENFANPDIHERTTAQEIWAQSNNNLDGLVTGV
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTITGCARFLKKVNPNCKIYAVEPRKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELINKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHCCEEEEEECCCCH
RYLSTAMFESNTSIQARTDGYL
HHHHHHHHCCCCCEEECCCCCC
>Mature Secondary Structure
MEIANDITSLVGNTPLVKLSRIRNYFNCYPEIIAKLESFNPSASVKDRIAYSMLCKAEEE
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
GLITPDKTTLIEATSGNTGIALAMVAAAKGYKLILTMPDTMSIERRAMLRAYGAELQLTP
CCCCCCCCEEEEECCCCCCHHHHEEHHCCCCEEEEECCCCCCHHHHHHHHHHCCCEEECC
GQEGMKGALDLANELSSSIANSYQFNQFENFANPDIHERTTAQEIWAQSNNNLDGLVTGV
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
GTGGTITGCARFLKKVNPNCKIYAVEPRKSAVISGEKAGSHSIQGIGAGFVPKVLNTKLI
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
DEIIKIDDDEAFYYGRLLARLEGLLSGISSGAALAATIKIGERKELINKRLIVILPSFGE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHCCEEEEEECCCCH
RYLSTAMFESNTSIQARTDGYL
HHHHHHHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]