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The map label for this gene is guaA

Identifier: 78778422

GI number: 78778422

Start: 34810

End: 36396

Strand: Direct

Name: guaA

Synonym: PMT9312_0037

Alternate gene names: 78778422

Gene position: 34810-36396 (Clockwise)

Preceding gene: 78778421

Following gene: 78778424

Centisome position: 2.04

GC content: 33.27

Gene sequence:

>1587_bases
ATGAGTCAAACATCTTTAAAAAAAGAACGCGATCCTTCAATACTAATTTTAGATTTCGGATCTCAATATTCTGAATTGAT
TGCAAGAAGAATTAGAGAAACTAATGTTTTTTCTCTTGTAGTAAGTAACTGTATTTCAATTGAAGAAATTAATGATATTA
ATCCTAAAGGGATAATTTTGAGTGGCGGTCCAAATTCTGTATATGAAAAAAATGCTCCAAAATGTGATGAAAAAATTTTT
AATTTAGGAATTCCTATTCTTGGCATATGCTATGGAATGCAATTAATGGTCAAAGAACTTGGTGGATCTGTAACTTCAGC
AACCAAAAAAGCAGAATATGGTAGAGCACCAATAAATATAGATCAAGAATCTGAACTCCTTTCTGATGTAGAAGATAAAT
CCATAATGTGGATGAGTCATGGCGATTCAATTAATTGTTTGCCTGATGGATTTAATAAAATTGCTCATACCGAGAACACA
CTCCATGCAGCAATTTCAAATGATAGAAAGAAATTATTTGGCGTACAATTTCATCCTGAAGTAATTCATTCAGAGTTTGG
GATAACGGTAATTAAAAATTTTGTTTATGGCATTTCTAGTTGTGTGGCTGATTGGACAACCGAAACCTATATAGAGGAAA
CTATTCCTAGGATAAGAGATCAAGTTGGCAATAAAAAAGTTTTGCTTGCTTTGTCAGGAGGAGTTGATTCGTCAACTCTT
GCGTTTCTTCTCAATAAAGCAATTGGAAATCAGCTTACATGCATGTTTATAGACCAAGGTTTTATGAGAAAAGGTGAACC
TGAATTTTTAATGAATTTTTTTGATAAGAAATTTCATATAAAGGTTGAATATATTAATGCAAGGGAAAGGTTTATTTCCA
AATTAAAAGGGATTACTGATCCAGAACAAAAAAGGAAAATTATTGGTGAAGAATTTATTAGAGTATTTGAAGAAGAAAGT
AATAGATTGGGCCCTTTTCAGTATTTAGCCCAAGGTACTCTTTATCCTGATGTTATTGAAAGTGCTGGTACTAATATTGA
TCCAAAGACTGGGGAAAGAATAGCTGTAAAAATTAAGAGTCATCATAATGTGGGGGGATTACCAAAAGATTTACAATTTA
AATTAGTTGAGCCATTAAGAAAACTTTTTAAGGATGAAGTCCGCAAATTGGGAGCTGCCTTAGGTTTGCCGGATGAAATT
ATAAAAAGGCATCCATTCCCGGGACCAGGTTTAGCGATAAGAATTTTGGGAGAAGTTAATAATGAAAAACTTGACTGTTT
AAGAGATGCAGATTGGATAGTGCGAGACGAAATTAAAAAAGCAGGTCTTTACAATGATATTTGGCAAGCTTTCGCAGTAT
TGCTACCAGTTAAAACTGTAGGAGTTATGGGTGATAAAAGGACTTATGCATGGCCAATAGTTTTACGTTGTGTATCTAGT
GAAGATGGTATGACAGCAGACTGGTCAAAAATTCCTTTTCCGATTTTAGAGAGAATTTCTAATAGAATCGTAAATGAAGT
AGTTTCAGTTAATAGAGTGGTTTATGATATTACAAGCAAACCTCCAGGAACTATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GTGGGCTGGAACTTACGGTAATAAGTATATTTCTGATTTTCAATGAGATTAATTTTTGATTGATTATGCTTTTGTAAATA
AATTGAGCTAACTTTTATAC

Downstream 100 bases:

>100_bases
CGGAAAATTGCCATATTTTATCAACAATGGAATTTTTGGGTTTTACGTGGGTTTTACGTGGAAATTTCACTTTCATAAAT
CCCTTGATACCAATGTGTTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNCISIEEINDINPKGIILSGGPNSVYEKNAPKCDEKIF
NLGIPILGICYGMQLMVKELGGSVTSATKKAEYGRAPINIDQESELLSDVEDKSIMWMSHGDSINCLPDGFNKIAHTENT
LHAAISNDRKKLFGVQFHPEVIHSEFGITVIKNFVYGISSCVADWTTETYIEETIPRIRDQVGNKKVLLALSGGVDSSTL
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFISKLKGITDPEQKRKIIGEEFIRVFEEES
NRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKLGAALGLPDEI
IKRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSS
EDGMTADWSKIPFPILERISNRIVNEVVSVNRVVYDITSKPPGTIEWE

Sequences:

>Translated_528_residues
MSQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNCISIEEINDINPKGIILSGGPNSVYEKNAPKCDEKIF
NLGIPILGICYGMQLMVKELGGSVTSATKKAEYGRAPINIDQESELLSDVEDKSIMWMSHGDSINCLPDGFNKIAHTENT
LHAAISNDRKKLFGVQFHPEVIHSEFGITVIKNFVYGISSCVADWTTETYIEETIPRIRDQVGNKKVLLALSGGVDSSTL
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFISKLKGITDPEQKRKIIGEEFIRVFEEES
NRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKLGAALGLPDEI
IKRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSS
EDGMTADWSKIPFPILERISNRIVNEVVSVNRVVYDITSKPPGTIEWE
>Mature_527_residues
SQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNCISIEEINDINPKGIILSGGPNSVYEKNAPKCDEKIFN
LGIPILGICYGMQLMVKELGGSVTSATKKAEYGRAPINIDQESELLSDVEDKSIMWMSHGDSINCLPDGFNKIAHTENTL
HAAISNDRKKLFGVQFHPEVIHSEFGITVIKNFVYGISSCVADWTTETYIEETIPRIRDQVGNKKVLLALSGGVDSSTLA
FLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFISKLKGITDPEQKRKIIGEEFIRVFEEESN
RLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKLGAALGLPDEII
KRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSSE
DGMTADWSKIPFPILERISNRIVNEVVSVNRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=554, Percent_Identity=38.8086642599278, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=49.9043977055449, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=36.8695652173913, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=36.8695652173913, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=575, Percent_Identity=36.8695652173913, Blast_Score=299, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=49.2337164750958, Blast_Score=499, Evalue=1e-142,
Organism=Drosophila melanogaster, GI281365319, Length=557, Percent_Identity=36.8043087971275, Blast_Score=288, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59363; Mature: 59232

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNCISIEEINDINPKGIIL
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEE
SGGPNSVYEKNAPKCDEKIFNLGIPILGICYGMQLMVKELGGSVTSATKKAEYGRAPINI
ECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DQESELLSDVEDKSIMWMSHGDSINCLPDGFNKIAHTENTLHAAISNDRKKLFGVQFHPE
CCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCHHHCCCEECHH
VIHSEFGITVIKNFVYGISSCVADWTTETYIEETIPRIRDQVGNKKVLLALSGGVDSSTL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFISKLKGITD
HHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHCCCEEEEEEEEECHHHHHHHHHCCCCC
PEQKRKIIGEEFIRVFEEESNRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
HHNVGGLPKDLQFKLVEPLRKLFKDEVRKLGAALGLPDEIIKRHPFPGPGLAIRILGEVN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECCC
NEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSS
CCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHEEECC
EDGMTADWSKIPFPILERISNRIVNEVVSVNRVVYDITSKPPGTIEWE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SQTSLKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNCISIEEINDINPKGIIL
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEE
SGGPNSVYEKNAPKCDEKIFNLGIPILGICYGMQLMVKELGGSVTSATKKAEYGRAPINI
ECCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DQESELLSDVEDKSIMWMSHGDSINCLPDGFNKIAHTENTLHAAISNDRKKLFGVQFHPE
CCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCHHHCCCEECHH
VIHSEFGITVIKNFVYGISSCVADWTTETYIEETIPRIRDQVGNKKVLLALSGGVDSSTL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHH
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFISKLKGITD
HHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHCCCEEEEEEEEECHHHHHHHHHCCCCC
PEQKRKIIGEEFIRVFEEESNRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCCEEEEEEEC
HHNVGGLPKDLQFKLVEPLRKLFKDEVRKLGAALGLPDEIIKRHPFPGPGLAIRILGEVN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEEECCC
NEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSS
CCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHEEECC
EDGMTADWSKIPFPILERISNRIVNEVVSVNRVVYDITSKPPGTIEWE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA