Definition Prochlorococcus marinus str. MIT 9312, complete genome.
Accession NC_007577
Length 1,709,204

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The map label for this gene is gyrA [H]

Identifier: 78778390

GI number: 78778390

Start: 5916

End: 8357

Strand: Reverse

Name: gyrA [H]

Synonym: PMT9312_0005

Alternate gene names: 78778390

Gene position: 8357-5916 (Counterclockwise)

Preceding gene: 78778391

Following gene: NA

Centisome position: 0.49

GC content: 26.62

Gene sequence:

>2442_bases
ATGGATAAGAAAAAATTCACTTCTATCTCTCTCCAAGAAGAAATGCAACGTTCTTATTTGGAGTATGCAATGAGTGTAAT
AGTTGGTCGTGCTTTACCCGATGCAAGAGACGGTCTTAAGCCTGTACAAAGAAGAATACTTTTTGCAATGTATGAATTAG
GTTTAACACCAGATAAGCCATTTAGAAAGTGTGCCAGAGTTGTTGGAGATGTACTTGGAAAATATCATCCTCATGGAGAT
CAGGCAGTATATGATGCATTAGTCAGGCTAGTTCAAAATTTTTCAACTAAATATCCTACTCTAGACGGCCATGGGAATTT
TGGATCTGTAGATAATGATCCGCCAGCAGCAATGAGATACACAGAGACCAGATTAGCACCGATATCACATAAAGGATTTC
TTGAAGAGATAGATTCAGAAACAGTAAATTTCTCAAATAACTTTGACGGTTCACAAAAAGAACCAGATGTTCTTCCAGCC
CAACTTCCATTTTTATTATTGAACGGATCATCAGGTATTGCAGTTGGAATGGCAACAAACATTCCCCCCCACAATCTAGG
GGAAATAGTAGATGGTTTAATTGCTCTAATCAACAATAAAGAGGTAAGTAATAAAAAACTTTCTAATATAATTAAAGGAC
CTGATTTTCCTACAGGGGGAGAGTTAATTTATAGTCGTGCAATAGAAGAACTTTACGCCACAGGAAAAGGTTCAATCACA
ATAAGAGGTGTCATAAATTCAGAAGCAATAAATTTAGGCAAAGGTAAACATAAAAGAAATGCATTAATCATTACTGAACT
TCCTTTTCAAATCAGTAAGGCAGGATGGATTGAAAAACTAGCAGAACTTGTTAATTCAAGCAAAATTAATGGGATCTCTG
ATATTAGGGACGAAAGTGATAGAGATGGAATGAGAATTGTAATAGAGTTAAAAAAAGATTCTAATGCTGAACTTGTAATT
TCTAATTTATATAAAAAAACTACTCTCCAAACCAACTTTGGTGCCATTTTTTTAGCATTAATAAAGGGCAAACCTGTCCA
ACTAAACTTAAAACAATATCTAAACTATTTTCTTGAATTTAGAGAAGAAACAATTAGAAAAAGAACTAATTATTTTCTGA
AAAACACTCTTGAAAAACTAGAAATATTAGAAGGTTTATCTAAAGCAACAAAAAACATCAAAAAAATTATCGAGATTATT
GAAGATTCAGAAAATTCTGCTGAAGCCAAATCAAAATTAATTGATATTTTCTACTTAAGTGCAAAACAGGCAAATTCAGT
TTTGGATATGCCTCTAAAAAAATTAACAAATCTGGAAAAAAATCAAATTGATGAGGATATAAGAAAATTACAAGAAAAAA
AAGATTATTTTCAAAATTTATTAAATGAAAGAAAATTATTACTTGAATTACTAGTAGATGAATTATTAATATTAAAGAAA
AAATATAATGTTAAAAGAAAAACAAAACTACTTAAAAATATTGATCAAAATGAAGAATTAGAAACAATTAATAATCAGAT
ATTAGAAGACTTTATCAATAAAAAAACTAAATTATTTATAGACAACAGATTATATTTAAGAAAGATGATTTTAAATAATT
ATAAAAAATCGTTTGAAGATGTAAATAAAATTATAGATAATAAAAACATTCAAAAATTCATATGTAATATCGATAAAAAT
GTAAAAATAATTGGGATCACATATACAGGAAAAGTTTTTCATATTAATTGGGAGTCAAATATTAATAATGACTATAAATT
AGATAAAAAAATCATTGGGAATATTGATCAAAATAAAATAATAAATTTTCATTCAATAAAAAAGGGAATTAAAAATTATT
TATGTATCTTAAATTCAGATGGAAGATTTAAAAAAGTTTTGTTTGATGAAGATATGATTAAAAGTAATAGATGTTTCTCA
ATAACAAAATTAAAAAATAATATTAAAACAATTGATTCATTTATTTTTAGTGAAGAAAAAAATTTAATAATATTAACCTC
AATAGGAAGAATGTTTAAATTTAATTTATCAAACAAATTTTTAACCCCGACTACTAAACAATCGCAAGGATTAATGCTTA
CAAAACTTTTACCAACTGAAAAAATTGTATCTTGTTGTTCATATCAAAATGGAGAAAATATTTACTTAGTTTCTAGAAAA
GGGAAAATCTTTTGTATAAATAGTAATGAAATTTATTATGCCAATGAATACAGTTTAGGATATTTAAATGAAATTACTCA
ACTTAAAAACGATTACTTCCTAAAAATTTTGCCGAGTAACCATTACCTTGATATTGAAACTAATAAAAATAAATCTGCTA
GGTTAAATTTTGATAAATTGAATTTTAAATCTAAGAAAACAAATTTTTTAATTGACTTTTTAAAATTAGACGATGAGGAA
TATATTGAAAATTGTTTTCAACTCGAAAACTTTCTTGACTAA

Upstream 100 bases:

>100_bases
CAAAAATAAATACATCTTCTTAATTTCCAATACTGGTAAATATTTGTTTACCTATTAGTCTTAATTTAATAAATCAATAA
ATATTTAATTTTACGCTCTG

Downstream 100 bases:

>100_bases
GATTTATATTCATTTTCAACCCAATTTAAATATTCTTGATTTACTTTTCCTGTTACATAAATACCAGTAAAGCAACTCAT
CTCTAAATCTTCAATAGGAG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MDKKKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSTKYPTLDGHGNFGSVDNDPPAAMRYTETRLAPISHKGFLEEIDSETVNFSNNFDGSQKEPDVLPA
QLPFLLLNGSSGIAVGMATNIPPHNLGEIVDGLIALINNKEVSNKKLSNIIKGPDFPTGGELIYSRAIEELYATGKGSIT
IRGVINSEAINLGKGKHKRNALIITELPFQISKAGWIEKLAELVNSSKINGISDIRDESDRDGMRIVIELKKDSNAELVI
SNLYKKTTLQTNFGAIFLALIKGKPVQLNLKQYLNYFLEFREETIRKRTNYFLKNTLEKLEILEGLSKATKNIKKIIEII
EDSENSAEAKSKLIDIFYLSAKQANSVLDMPLKKLTNLEKNQIDEDIRKLQEKKDYFQNLLNERKLLLELLVDELLILKK
KYNVKRKTKLLKNIDQNEELETINNQILEDFINKKTKLFIDNRLYLRKMILNNYKKSFEDVNKIIDNKNIQKFICNIDKN
VKIIGITYTGKVFHINWESNINNDYKLDKKIIGNIDQNKIINFHSIKKGIKNYLCILNSDGRFKKVLFDEDMIKSNRCFS
ITKLKNNIKTIDSFIFSEEKNLIILTSIGRMFKFNLSNKFLTPTTKQSQGLMLTKLLPTEKIVSCCSYQNGENIYLVSRK
GKIFCINSNEIYYANEYSLGYLNEITQLKNDYFLKILPSNHYLDIETNKNKSARLNFDKLNFKSKKTNFLIDFLKLDDEE
YIENCFQLENFLD

Sequences:

>Translated_813_residues
MDKKKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSTKYPTLDGHGNFGSVDNDPPAAMRYTETRLAPISHKGFLEEIDSETVNFSNNFDGSQKEPDVLPA
QLPFLLLNGSSGIAVGMATNIPPHNLGEIVDGLIALINNKEVSNKKLSNIIKGPDFPTGGELIYSRAIEELYATGKGSIT
IRGVINSEAINLGKGKHKRNALIITELPFQISKAGWIEKLAELVNSSKINGISDIRDESDRDGMRIVIELKKDSNAELVI
SNLYKKTTLQTNFGAIFLALIKGKPVQLNLKQYLNYFLEFREETIRKRTNYFLKNTLEKLEILEGLSKATKNIKKIIEII
EDSENSAEAKSKLIDIFYLSAKQANSVLDMPLKKLTNLEKNQIDEDIRKLQEKKDYFQNLLNERKLLLELLVDELLILKK
KYNVKRKTKLLKNIDQNEELETINNQILEDFINKKTKLFIDNRLYLRKMILNNYKKSFEDVNKIIDNKNIQKFICNIDKN
VKIIGITYTGKVFHINWESNINNDYKLDKKIIGNIDQNKIINFHSIKKGIKNYLCILNSDGRFKKVLFDEDMIKSNRCFS
ITKLKNNIKTIDSFIFSEEKNLIILTSIGRMFKFNLSNKFLTPTTKQSQGLMLTKLLPTEKIVSCCSYQNGENIYLVSRK
GKIFCINSNEIYYANEYSLGYLNEITQLKNDYFLKILPSNHYLDIETNKNKSARLNFDKLNFKSKKTNFLIDFLKLDDEE
YIENCFQLENFLD
>Mature_813_residues
MDKKKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSTKYPTLDGHGNFGSVDNDPPAAMRYTETRLAPISHKGFLEEIDSETVNFSNNFDGSQKEPDVLPA
QLPFLLLNGSSGIAVGMATNIPPHNLGEIVDGLIALINNKEVSNKKLSNIIKGPDFPTGGELIYSRAIEELYATGKGSIT
IRGVINSEAINLGKGKHKRNALIITELPFQISKAGWIEKLAELVNSSKINGISDIRDESDRDGMRIVIELKKDSNAELVI
SNLYKKTTLQTNFGAIFLALIKGKPVQLNLKQYLNYFLEFREETIRKRTNYFLKNTLEKLEILEGLSKATKNIKKIIEII
EDSENSAEAKSKLIDIFYLSAKQANSVLDMPLKKLTNLEKNQIDEDIRKLQEKKDYFQNLLNERKLLLELLVDELLILKK
KYNVKRKTKLLKNIDQNEELETINNQILEDFINKKTKLFIDNRLYLRKMILNNYKKSFEDVNKIIDNKNIQKFICNIDKN
VKIIGITYTGKVFHINWESNINNDYKLDKKIIGNIDQNKIINFHSIKKGIKNYLCILNSDGRFKKVLFDEDMIKSNRCFS
ITKLKNNIKTIDSFIFSEEKNLIILTSIGRMFKFNLSNKFLTPTTKQSQGLMLTKLLPTEKIVSCCSYQNGENIYLVSRK
GKIFCINSNEIYYANEYSLGYLNEITQLKNDYFLKILPSNHYLDIETNKNKSARLNFDKLNFKSKKTNFLIDFLKLDDEE
YIENCFQLENFLD

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=352, Percent_Identity=27.5568181818182, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=27.4143302180685, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788562, Length=773, Percent_Identity=35.7050452781371, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1789396, Length=691, Percent_Identity=34.7322720694645, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=320, Percent_Identity=27.8125, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=33.1428571428571, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=171, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=383, Percent_Identity=26.6318537859008, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=320, Percent_Identity=26.5625, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93473; Mature: 93473

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMYELGLTPDKP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
FRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSTKYPTLDGHGNFGSVDNDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
TETRLAPISHKGFLEEIDSETVNFSNNFDGSQKEPDVLPAQLPFLLLNGSSGIAVGMATN
HHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLGEIVDGLIALINNKEVSNKKLSNIIKGPDFPTGGELIYSRAIEELYATGKGSIT
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
IRGVINSEAINLGKGKHKRNALIITELPFQISKAGWIEKLAELVNSSKINGISDIRDESD
EEEEECCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
RDGMRIVIELKKDSNAELVISNLYKKTTLQTNFGAIFLALIKGKPVQLNLKQYLNYFLEF
CCCCEEEEEEECCCCCCEEHHHHHHHHHCCCCHHHHEEHHHCCCCEEEEHHHHHHHHHHH
REETIRKRTNYFLKNTLEKLEILEGLSKATKNIKKIIEIIEDSENSAEAKSKLIDIFYLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEE
AKQANSVLDMPLKKLTNLEKNQIDEDIRKLQEKKDYFQNLLNERKLLLELLVDELLILKK
CHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNVKRKTKLLKNIDQNEELETINNQILEDFINKKTKLFIDNRLYLRKMILNNYKKSFED
HCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
VNKIIDNKNIQKFICNIDKNVKIIGITYTGKVFHINWESNINNDYKLDKKIIGNIDQNKI
HHHHHCCCCHHHHHHCCCCCEEEEEEEEECEEEEEEECCCCCCCCEECHHHHCCCCCCCE
INFHSIKKGIKNYLCILNSDGRFKKVLFDEDMIKSNRCFSITKLKNNIKTIDSFIFSEEK
EEHHHHHHHHHHEEEEECCCCCEEEEEECHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCC
NLIILTSIGRMFKFNLSNKFLTPTTKQSQGLMLTKLLPTEKIVSCCSYQNGENIYLVSRK
CEEEEEECCCEEEEECCCCEECCCCCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEECC
GKIFCINSNEIYYANEYSLGYLNEITQLKNDYFLKILPSNHYLDIETNKNKSARLNFDKL
CEEEEEECCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCEEECHHHC
NFKSKKTNFLIDFLKLDDEEYIENCFQLENFLD
CCCCCCCHHEEEHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKKKFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMYELGLTPDKP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
FRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSTKYPTLDGHGNFGSVDNDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE
TETRLAPISHKGFLEEIDSETVNFSNNFDGSQKEPDVLPAQLPFLLLNGSSGIAVGMATN
HHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLGEIVDGLIALINNKEVSNKKLSNIIKGPDFPTGGELIYSRAIEELYATGKGSIT
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
IRGVINSEAINLGKGKHKRNALIITELPFQISKAGWIEKLAELVNSSKINGISDIRDESD
EEEEECCCCEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCC
RDGMRIVIELKKDSNAELVISNLYKKTTLQTNFGAIFLALIKGKPVQLNLKQYLNYFLEF
CCCCEEEEEEECCCCCCEEHHHHHHHHHCCCCHHHHEEHHHCCCCEEEEHHHHHHHHHHH
REETIRKRTNYFLKNTLEKLEILEGLSKATKNIKKIIEIIEDSENSAEAKSKLIDIFYLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEE
AKQANSVLDMPLKKLTNLEKNQIDEDIRKLQEKKDYFQNLLNERKLLLELLVDELLILKK
CHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNVKRKTKLLKNIDQNEELETINNQILEDFINKKTKLFIDNRLYLRKMILNNYKKSFED
HCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHH
VNKIIDNKNIQKFICNIDKNVKIIGITYTGKVFHINWESNINNDYKLDKKIIGNIDQNKI
HHHHHCCCCHHHHHHCCCCCEEEEEEEEECEEEEEEECCCCCCCCEECHHHHCCCCCCCE
INFHSIKKGIKNYLCILNSDGRFKKVLFDEDMIKSNRCFSITKLKNNIKTIDSFIFSEEK
EEHHHHHHHHHHEEEEECCCCCEEEEEECHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCC
NLIILTSIGRMFKFNLSNKFLTPTTKQSQGLMLTKLLPTEKIVSCCSYQNGENIYLVSRK
CEEEEEECCCEEEEECCCCEECCCCCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEECC
GKIFCINSNEIYYANEYSLGYLNEITQLKNDYFLKILPSNHYLDIETNKNKSARLNFDKL
CEEEEEECCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCEEECHHHC
NFKSKKTNFLIDFLKLDDEEYIENCFQLENFLD
CCCCCCCHHEEEHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]