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The map label for this gene is hslU [H]

Identifier: 78484749

GI number: 78484749

Start: 454836

End: 456158

Strand: Reverse

Name: hslU [H]

Synonym: Tcr_0404

Alternate gene names: 78484749

Gene position: 456158-454836 (Counterclockwise)

Preceding gene: 78484752

Following gene: 78484748

Centisome position: 18.79

GC content: 47.62

Gene sequence:

>1323_bases
ATGATGACACCCAAGGAAATTGTTCACGAATTGGATAGCTATATCGTTGGTCAGGCAGAAGCGAAAAAATCCGTTGCCAT
TGCTTTACGTAACCGCTGGCGCAGAATGCAGCTGCCTGAAGAGCTCCGTCAGGAAGTCACGCCGAAAAATATTCTGATGA
TTGGGCCGACAGGGGTTGGGAAAACCGAAATTGCGCGCCGTTTGGCCAAACTAGCCAATGCCCCTTTCATTAAAGTCGAA
GCGACCAAGTACACAGAGGTGGGCTACGTCGGTCGAGAAGTGGACTCGATTATTAAAGATTTAGTGGAAAACGCCATCAA
AATGCAACGCGAACAAGCGATGAAAGGCGTCAAAAACAAAGCGCAAGATCTTGCGGAAGAGAAAATTCTCGATATTTTAT
TACCGCCCGCTCGCGGCCGTGAAGAAGACAGCTATGAACACATGTCTGAAACGCGTCAAAAATTCCGTAAACGCCTGCGT
GAAGGGGAATTAGACGACAAAGAAATCGAAATTGACTTGAACGCGGCACCGCCCCATGTGGAAATCATGGGCGCGCCAGG
CATGGAAGAAATGACCAACCAGCTGCAAGACATGTTTCAAGGCTTGAGCCAAGGAAAGAAGAACAAACGTAAACTGCCGA
TCAAGCAAGCGATGAAGTTACTCACCGAAGAGGAAGCGCAACGCATCATTGATCAGGAAGACTTGAAAACCAAAGCGATT
GAAAATGTTGAGCAGAACGGAATCGTCTTCATTGATGAAATCGACAAAGTGGCCAAACGTCAGGAAGGTGCTGGCGGCGG
CGACGTCTCTCGTGAAGGGGTTCAACGTGACCTGCTGCCATTGATTGAAGGGTCGACCGTGTCCACTAAATATGGCATGA
TCAAAACCGATCACATTCTGTTTGTGGCCTCCGGCGCATTCCATTTAGCCAAACCATCGGACTTGATTCCTGAGTTACAA
GGGCGTTTACCGATTCGCGTGGAGCTGAAGTCTTTAAAAGTGGAAGACTTTATCCGCATCTTGACCGAACCCAAGGCGGC
GTTAATTACGCAAGCGATTGAGTTGTTGAAAACCGAAGGCGTCAAGATTGAATTTACTGGCGAAGGCATCAAACGATTGG
CAGAAATTGCTTATCACGTGAATGAAACCACCGAAAACATCGGTGCAAGACGCTTGCACACGGTCATGGAACATTTGCTG
GAAGAAGTGTCTTTCAATGCTCCGGATTTCGGTCAAGAAACCGTCATCATCGATGAAGCATTTGTGAATGATCGCTTGGG
CGAACTGTCGCAAGACCAAGATCTCTCACAATACATTTTGTAA

Upstream 100 bases:

>100_bases
GTGTTTTGCTGTGCCTTATATCATTCATTACAGTAATTCCTTTATAATAAACGAATTACACGAAAATCAAAAACTCAGAA
TTGAAGGAAACCCGCTCAAA

Downstream 100 bases:

>100_bases
TGCATTGACACACCCAATAACGTACAGAGGCATTTATGGCATCAACTCCACAACCCACTGACATCAAGCTCAAGCAAGCC
TCACGTCAGTTGGTGGTGAC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MMTPKEIVHELDSYIVGQAEAKKSVAIALRNRWRRMQLPEELRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVE
ATKYTEVGYVGREVDSIIKDLVENAIKMQREQAMKGVKNKAQDLAEEKILDILLPPARGREEDSYEHMSETRQKFRKRLR
EGELDDKEIEIDLNAAPPHVEIMGAPGMEEMTNQLQDMFQGLSQGKKNKRKLPIKQAMKLLTEEEAQRIIDQEDLKTKAI
ENVEQNGIVFIDEIDKVAKRQEGAGGGDVSREGVQRDLLPLIEGSTVSTKYGMIKTDHILFVASGAFHLAKPSDLIPELQ
GRLPIRVELKSLKVEDFIRILTEPKAALITQAIELLKTEGVKIEFTGEGIKRLAEIAYHVNETTENIGARRLHTVMEHLL
EEVSFNAPDFGQETVIIDEAFVNDRLGELSQDQDLSQYIL

Sequences:

>Translated_440_residues
MMTPKEIVHELDSYIVGQAEAKKSVAIALRNRWRRMQLPEELRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVE
ATKYTEVGYVGREVDSIIKDLVENAIKMQREQAMKGVKNKAQDLAEEKILDILLPPARGREEDSYEHMSETRQKFRKRLR
EGELDDKEIEIDLNAAPPHVEIMGAPGMEEMTNQLQDMFQGLSQGKKNKRKLPIKQAMKLLTEEEAQRIIDQEDLKTKAI
ENVEQNGIVFIDEIDKVAKRQEGAGGGDVSREGVQRDLLPLIEGSTVSTKYGMIKTDHILFVASGAFHLAKPSDLIPELQ
GRLPIRVELKSLKVEDFIRILTEPKAALITQAIELLKTEGVKIEFTGEGIKRLAEIAYHVNETTENIGARRLHTVMEHLL
EEVSFNAPDFGQETVIIDEAFVNDRLGELSQDQDLSQYIL
>Mature_440_residues
MMTPKEIVHELDSYIVGQAEAKKSVAIALRNRWRRMQLPEELRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVE
ATKYTEVGYVGREVDSIIKDLVENAIKMQREQAMKGVKNKAQDLAEEKILDILLPPARGREEDSYEHMSETRQKFRKRLR
EGELDDKEIEIDLNAAPPHVEIMGAPGMEEMTNQLQDMFQGLSQGKKNKRKLPIKQAMKLLTEEEAQRIIDQEDLKTKAI
ENVEQNGIVFIDEIDKVAKRQEGAGGGDVSREGVQRDLLPLIEGSTVSTKYGMIKTDHILFVASGAFHLAKPSDLIPELQ
GRLPIRVELKSLKVEDFIRILTEPKAALITQAIELLKTEGVKIEFTGEGIKRLAEIAYHVNETTENIGARRLHTVMEHLL
EEVSFNAPDFGQETVIIDEAFVNDRLGELSQDQDLSQYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=442, Percent_Identity=68.0995475113122, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=44.2307692307692, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=39.0243902439024, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648291, Length=266, Percent_Identity=30.4511278195489, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648289, Length=266, Percent_Identity=30.4511278195489, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 49675; Mature: 49675

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTPKEIVHELDSYIVGQAEAKKSVAIALRNRWRRMQLPEELRQEVTPKNILMIGPTGVG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCC
KTEIARRLAKLANAPFIKVEATKYTEVGYVGREVDSIIKDLVENAIKMQREQAMKGVKNK
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDLAEEKILDILLPPARGREEDSYEHMSETRQKFRKRLREGELDDKEIEIDLNAAPPHV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCE
EIMGAPGMEEMTNQLQDMFQGLSQGKKNKRKLPIKQAMKLLTEEEAQRIIDQEDLKTKAI
EEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHH
ENVEQNGIVFIDEIDKVAKRQEGAGGGDVSREGVQRDLLPLIEGSTVSTKYGMIKTDHIL
HHHCCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCEE
FVASGAFHLAKPSDLIPELQGRLPIRVELKSLKVEDFIRILTEPKAALITQAIELLKTEG
EEECCCEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
VKIEFTGEGIKRLAEIAYHVNETTENIGARRLHTVMEHLLEEVSFNAPDFGQETVIIDEA
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHH
FVNDRLGELSQDQDLSQYIL
HHHHHHHCCCCCCCHHHHCC
>Mature Secondary Structure
MMTPKEIVHELDSYIVGQAEAKKSVAIALRNRWRRMQLPEELRQEVTPKNILMIGPTGVG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCC
KTEIARRLAKLANAPFIKVEATKYTEVGYVGREVDSIIKDLVENAIKMQREQAMKGVKNK
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQDLAEEKILDILLPPARGREEDSYEHMSETRQKFRKRLREGELDDKEIEIDLNAAPPHV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCE
EIMGAPGMEEMTNQLQDMFQGLSQGKKNKRKLPIKQAMKLLTEEEAQRIIDQEDLKTKAI
EEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHH
ENVEQNGIVFIDEIDKVAKRQEGAGGGDVSREGVQRDLLPLIEGSTVSTKYGMIKTDHIL
HHHCCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCEE
FVASGAFHLAKPSDLIPELQGRLPIRVELKSLKVEDFIRILTEPKAALITQAIELLKTEG
EEECCCEECCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
VKIEFTGEGIKRLAEIAYHVNETTENIGARRLHTVMEHLLEEVSFNAPDFGQETVIIDEA
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHH
FVNDRLGELSQDQDLSQYIL
HHHHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA