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The map label for this gene is hldE [H]

Identifier: 78358644

GI number: 78358644

Start: 3566327

End: 3566833

Strand: Reverse

Name: hldE [H]

Synonym: Dde_3605

Alternate gene names: 78358644

Gene position: 3566833-3566327 (Counterclockwise)

Preceding gene: 78358645

Following gene: 78358641

Centisome position: 95.62

GC content: 61.74

Gene sequence:

>507_bases
ATGAATGCAGAGCAGGCGGCGTCTTGTCTGGCGCACCCTAAAGTGGTCACCTCCGAAGAACTGCAGCGGCGGCTTGCCGG
GCGCCGCGGTGAAAAGGTGGTCTTTACCAACGGCTGTTACGACATCCTGCACCCCGGCCATGTGGACCTGCTGGCGCGCG
CCCGTGCACAGGGTGACCTGCTGGTGCTGGGACTGAACAGCGACGCTTCCGTGCGCCGTCAGGGCAAGGGCGCGGACAGG
CCGGTAAACACGTTTGCCGTGCGCGCTTTTGTGCTGGCCCATCTGGAAAGTGTGGATTACGTCGTCATGTTCGAGGAGGA
CACCCCCTATAACCTTATCAGTGCCGTGCGGCCGCAGGTGCTGGTGAAAGGCGGTGACTGGACGCCGGACAGAATCGTGG
GGCGTGATATAGTGGAGGCTGACGGCGGCAGGGTGCTTTCGTTGCCGCTGCTGGAGGGATATTCCACAACGGCGCTTATC
AGCAGGATACGTACTGCTTTGCGGTAA

Upstream 100 bases:

>100_bases
GCATCCTTGAGGATGAGGAAGCCCGGCTGGAATTCGGCTTTGACTGGACCGAGCTGGTGCTTTTCGGCGATAATGAACGT
CTTCAGGTGGTTAACCCGTA

Downstream 100 bases:

>100_bases
CGGTCTGCTGTCTTGATTTTTTTGCGGCGGCGTCGGCAAGGCGCCGCCTTTTTTACGGCATTGCCGTGGCAGCCGGAAAA
AAAGCGCAGTAATGCTCACA

Product: bifunctional ADP-heptose synthase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MNAEQAASCLAHPKVVTSEELQRRLAGRRGEKVVFTNGCYDILHPGHVDLLARARAQGDLLVLGLNSDASVRRQGKGADR
PVNTFAVRAFVLAHLESVDYVVMFEEDTPYNLISAVRPQVLVKGGDWTPDRIVGRDIVEADGGRVLSLPLLEGYSTTALI
SRIRTALR

Sequences:

>Translated_168_residues
MNAEQAASCLAHPKVVTSEELQRRLAGRRGEKVVFTNGCYDILHPGHVDLLARARAQGDLLVLGLNSDASVRRQGKGADR
PVNTFAVRAFVLAHLESVDYVVMFEEDTPYNLISAVRPQVLVKGGDWTPDRIVGRDIVEADGGRVLSLPLLEGYSTTALI
SRIRTALR
>Mature_168_residues
MNAEQAASCLAHPKVVTSEELQRRLAGRRGEKVVFTNGCYDILHPGHVDLLARARAQGDLLVLGLNSDASVRRQGKGADR
PVNTFAVRAFVLAHLESVDYVVMFEEDTPYNLISAVRPQVLVKGGDWTPDRIVGRDIVEADGGRVLSLPLLEGYSTTALI
SRIRTALR

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=152, Percent_Identity=53.2894736842105, Blast_Score=150, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 18375; Mature: 18375

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAEQAASCLAHPKVVTSEELQRRLAGRRGEKVVFTNGCYDILHPGHVDLLARARAQGDL
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHCCCCHHHHHHHHCCCCCE
LVLGLNSDASVRRQGKGADRPVNTFAVRAFVLAHLESVDYVVMFEEDTPYNLISAVRPQV
EEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCEE
LVKGGDWTPDRIVGRDIVEADGGRVLSLPLLEGYSTTALISRIRTALR
EEECCCCCCHHHHCCHHEECCCCEEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNAEQAASCLAHPKVVTSEELQRRLAGRRGEKVVFTNGCYDILHPGHVDLLARARAQGDL
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHCCCCHHHHHHHHCCCCCE
LVLGLNSDASVRRQGKGADRPVNTFAVRAFVLAHLESVDYVVMFEEDTPYNLISAVRPQV
EEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCEE
LVKGGDWTPDRIVGRDIVEADGGRVLSLPLLEGYSTTALISRIRTALR
EEECCCCCCHHHHCCHHEECCCCEEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA