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The map label for this gene is aroE

Identifier: 78358603

GI number: 78358603

Start: 3522659

End: 3523498

Strand: Reverse

Name: aroE

Synonym: Dde_3564

Alternate gene names: 78358603

Gene position: 3523498-3522659 (Counterclockwise)

Preceding gene: 78358604

Following gene: 78358599

Centisome position: 94.46

GC content: 61.9

Gene sequence:

>840_bases
ATGACAATTCCGCGCATTCCACGGCAGCTTTACGGCATCATCGGATATCCTCTGGGCCACTCCATGAGCCCCTTGCTGCA
TAACTGGGGCTTTGAACTGCTGGGCGAGCAGGCCGCCTATATGGCTTTTCCCGTGGCGCCTGAAAAACTGGCGGAATTCA
TCTGCTGTGCACGTATGCTTCCTGTATCCGGGCTCAGTGTGACCATACCGCATAAGCAGGCGGTCATGCCGCTGCTGGAC
GCGGTGACCCCCCGTGCGCAGGCTGCCGGCGCGGTGAACACGCTTTTTTATGATGATGGAAAACTGACCGGCGATAATAC
GGATGTGTACGGCTTTCTGCATCCGCTGGATTCGTGCGGTACGGCGCATGCTGCCGCGCTGGTGCTGGGAGCCGGCGGGG
CGGCCAATGCCGTGCTGGCCGCACTGACTGCGCGGGGCATGTGCAATGTGACAGTGACCAACCGCAACGGCGACCGCGCC
CGTATTCTGGCAGAGCGTTTCGGGGTGCGCTGCGTGGCGTGGGAGGAACGCCATGCCGTGGATGCGGATCTTGTGGTAAA
CACCACACCGCTGGGCATGGCCGGAGACCGGCAGGCGCAGACGCCGCTTGATCCGGCATTTTTCAGCTCCCGGCCCGCGG
GGCTGGCCTATGATCTTATATACAATCCTGCACAGACATTTTTTCTGGCATCGGCACAGGCGGCAGGCTGGCGGGTGTTG
AACGGGCTGGACATGTTTGTCGCACAGGGGGCGGAACAATTCCGCATCTGGCGCGGTCGTGAGCTGCCCTTTGCGCAGGC
ACGCGCGCTTATCGCAGACGCGCTGGCTTCAGGCTGCTGA

Upstream 100 bases:

>100_bases
TATGCCGGAGGCTGCCCCATGTCACAGGGGCAGCCTTTTTTCGTTCAGCAACCGTCTACCGCACAGGCCCGGCCGCGCCG
GTCTGTTTTCAGGAACCGCT

Downstream 100 bases:

>100_bases
TTGTACCGGTTTCTGCCGCGTACGCGGAGCGCAACGGAGCGGTATGTGCGCCCCGCCGTCGCGTGGAGGCGGGGCGCACG
GGGCTTTACGGGTACTGTGT

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTIPRIPRQLYGIIGYPLGHSMSPLLHNWGFELLGEQAAYMAFPVAPEKLAEFICCARMLPVSGLSVTIPHKQAVMPLLD
AVTPRAQAAGAVNTLFYDDGKLTGDNTDVYGFLHPLDSCGTAHAAALVLGAGGAANAVLAALTARGMCNVTVTNRNGDRA
RILAERFGVRCVAWEERHAVDADLVVNTTPLGMAGDRQAQTPLDPAFFSSRPAGLAYDLIYNPAQTFFLASAQAAGWRVL
NGLDMFVAQGAEQFRIWRGRELPFAQARALIADALASGC

Sequences:

>Translated_279_residues
MTIPRIPRQLYGIIGYPLGHSMSPLLHNWGFELLGEQAAYMAFPVAPEKLAEFICCARMLPVSGLSVTIPHKQAVMPLLD
AVTPRAQAAGAVNTLFYDDGKLTGDNTDVYGFLHPLDSCGTAHAAALVLGAGGAANAVLAALTARGMCNVTVTNRNGDRA
RILAERFGVRCVAWEERHAVDADLVVNTTPLGMAGDRQAQTPLDPAFFSSRPAGLAYDLIYNPAQTFFLASAQAAGWRVL
NGLDMFVAQGAEQFRIWRGRELPFAQARALIADALASGC
>Mature_278_residues
TIPRIPRQLYGIIGYPLGHSMSPLLHNWGFELLGEQAAYMAFPVAPEKLAEFICCARMLPVSGLSVTIPHKQAVMPLLDA
VTPRAQAAGAVNTLFYDDGKLTGDNTDVYGFLHPLDSCGTAHAAALVLGAGGAANAVLAALTARGMCNVTVTNRNGDRAR
ILAERFGVRCVAWEERHAVDADLVVNTTPLGMAGDRQAQTPLDPAFFSSRPAGLAYDLIYNPAQTFFLASAQAAGWRVLN
GLDMFVAQGAEQFRIWRGRELPFAQARALIADALASGC

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=280, Percent_Identity=32.1428571428571, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789675, Length=264, Percent_Identity=35.2272727272727, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320332, Length=274, Percent_Identity=30.6569343065693, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_DESDG (Q30VD9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_390052.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q30VD9
- SMR:   Q30VD9
- STRING:   Q30VD9
- GeneID:   3758544
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_3564
- NMPDR:   fig|207559.3.peg.2396
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   EGRNTDA
- ProtClustDB:   CLSK704419
- BioCyc:   DDES207559:DDE_3564-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29800; Mature: 29668

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPRIPRQLYGIIGYPLGHSMSPLLHNWGFELLGEQAAYMAFPVAPEKLAEFICCARML
CCCCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCHHEEEECCCHHHHHHHHHHHHHC
PVSGLSVTIPHKQAVMPLLDAVTPRAQAAGAVNTLFYDDGKLTGDNTDVYGFLHPLDSCG
CCCCCEEECCCHHHHHHHHHHCCCCHHHCCCEEEEEEECCEECCCCCEEEEEECCCCCCC
TAHAAALVLGAGGAANAVLAALTARGMCNVTVTNRNGDRARILAERFGVRCVAWEERHAV
HHHHHHEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCC
DADLVVNTTPLGMAGDRQAQTPLDPAFFSSRPAGLAYDLIYNPAQTFFLASAQAAGWRVL
CCCEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCEEEHEEECCHHHHEEECCCCCCCHHH
NGLDMFVAQGAEQFRIWRGRELPFAQARALIADALASGC
HHHHHHHHCCHHHHEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIPRIPRQLYGIIGYPLGHSMSPLLHNWGFELLGEQAAYMAFPVAPEKLAEFICCARML
CCCCCCHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCHHEEEECCCHHHHHHHHHHHHHC
PVSGLSVTIPHKQAVMPLLDAVTPRAQAAGAVNTLFYDDGKLTGDNTDVYGFLHPLDSCG
CCCCCEEECCCHHHHHHHHHHCCCCHHHCCCEEEEEEECCEECCCCCEEEEEECCCCCCC
TAHAAALVLGAGGAANAVLAALTARGMCNVTVTNRNGDRARILAERFGVRCVAWEERHAV
HHHHHHEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCC
DADLVVNTTPLGMAGDRQAQTPLDPAFFSSRPAGLAYDLIYNPAQTFFLASAQAAGWRVL
CCCEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCEEEHEEECCHHHHEEECCCCCCCHHH
NGLDMFVAQGAEQFRIWRGRELPFAQARALIADALASGC
HHHHHHHHCCHHHHEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA