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The map label for this gene is icd [H]

Identifier: 78358515

GI number: 78358515

Start: 3437477

End: 3438625

Strand: Reverse

Name: icd [H]

Synonym: Dde_3476

Alternate gene names: 78358515

Gene position: 3438625-3437477 (Counterclockwise)

Preceding gene: 78358517

Following gene: 78358513

Centisome position: 92.18

GC content: 60.31

Gene sequence:

>1149_bases
ATGCGCAAGACTGTGTATTTCATCGAAGGTGACGGCATCGGACCGGAGGTCTGGAACGCCGCCCGTCCTGTCATCGACAA
GGCCGTGGAACTGGCATACGGCAACGGGCGTTCTCTGGAATGGAAGGAACTGCTTGCCGGCGAAAAAGCCTATGCCGAAA
CAGGCACCTATCTGCCTCAGGAAACGCTCGACACGCTGGCCGGTGCCGAACTGGCCATCAAGGGGCCGCTGGGCACCCCC
GTGGGCAAGGGGTTCCGCAGTCTCAACGTGACCATGCGCCAGACTCTCGACCTGTATGCCTGCATCCGGCCCATACGGTA
TTTCGAAGGCATCGAATCACCGGTGAAGCATCCGGAGCGGGTCAATATGGTTGTCTTCCGCGAAAACACCGAAGACGTGT
ACGCCGGTATAGAATACAAGGCTGACACCGACGAAGCCAGAAAGCTGATTGCCTTTCTGCGCGACGAACTGGGCGCCAAT
GTGGACGAGCGCTGCGCCGTGGGCATAAAGCCCATGAGTGAAAAAGGCTCCAAGCGTCTGGTGCGCCGCGCCATGGACTT
TGCTCTGGCGCAGGGGCTGCCCAGCGTCACGCTGGTGCACAAAGGCAATATCATGAAATTTACCGAAGGCGGATTCCGCC
AGTGGGGCTACGAACTGGCGCATGACGAATACGCCGGACGCGCGGTGACCGAAGCACAGGCAGCCGCCGGCGAAACCGGT
CTGGTGGTCAAGGACCGTATAGCCGACGCCATGTTCCAGGAAGTGCTCATCCGTCCGGAACAGTACAGCGTGGTTGCCAC
CAGCAACCTGAACGGCGATTATATTTCGGATGCGCTTGCTGCGCAGGTGGGCGGTCTGGGACTGGCTCCGGGCGTGAACA
TGTCCGATACGCTGGCCTTCTTTGAAGCCACCCACGGCACGGCACCCACCATTGCCGGAAAAGATATGGCCAACCCGGGC
AGTCTTATTCTGTGCGGGGGCATGCTGCTGGAACATCTTGGCTGGCATGAGGCTGCAACCCGTATCCATACCGCCATGAA
CACCGTCATAGGCAACCGCACGGTCACCGTGGATCTGGCCAGCCAGATGCAGGGTGCCTCCACTGTGGGCTGCCGGCAGT
TCGGCGAATTGCTGGGCGCGGCATTGTAG

Upstream 100 bases:

>100_bases
TCACACCATCAATACGTGATTTTGGACAGGTCGTGACCTGCTTACCGCCGCTCTTCTCTCGCAGAAGGGCGGCGGAAATT
TTACGGGAGGAACGCTCTTT

Downstream 100 bases:

>100_bases
CCGCGGTCACATCATGCATCCAGACGTCCCGGTTATGCCGGGACGTTTTTTTTTGCGCTCCGGACTGCCGGTTGAGCCGG
TGCGGGCTGTGGCGTGCAAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MRKTVYFIEGDGIGPEVWNAARPVIDKAVELAYGNGRSLEWKELLAGEKAYAETGTYLPQETLDTLAGAELAIKGPLGTP
VGKGFRSLNVTMRQTLDLYACIRPIRYFEGIESPVKHPERVNMVVFRENTEDVYAGIEYKADTDEARKLIAFLRDELGAN
VDERCAVGIKPMSEKGSKRLVRRAMDFALAQGLPSVTLVHKGNIMKFTEGGFRQWGYELAHDEYAGRAVTEAQAAAGETG
LVVKDRIADAMFQEVLIRPEQYSVVATSNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFFEATHGTAPTIAGKDMANPG
SLILCGGMLLEHLGWHEAATRIHTAMNTVIGNRTVTVDLASQMQGASTVGCRQFGELLGAAL

Sequences:

>Translated_382_residues
MRKTVYFIEGDGIGPEVWNAARPVIDKAVELAYGNGRSLEWKELLAGEKAYAETGTYLPQETLDTLAGAELAIKGPLGTP
VGKGFRSLNVTMRQTLDLYACIRPIRYFEGIESPVKHPERVNMVVFRENTEDVYAGIEYKADTDEARKLIAFLRDELGAN
VDERCAVGIKPMSEKGSKRLVRRAMDFALAQGLPSVTLVHKGNIMKFTEGGFRQWGYELAHDEYAGRAVTEAQAAAGETG
LVVKDRIADAMFQEVLIRPEQYSVVATSNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFFEATHGTAPTIAGKDMANPG
SLILCGGMLLEHLGWHEAATRIHTAMNTVIGNRTVTVDLASQMQGASTVGCRQFGELLGAAL
>Mature_382_residues
MRKTVYFIEGDGIGPEVWNAARPVIDKAVELAYGNGRSLEWKELLAGEKAYAETGTYLPQETLDTLAGAELAIKGPLGTP
VGKGFRSLNVTMRQTLDLYACIRPIRYFEGIESPVKHPERVNMVVFRENTEDVYAGIEYKADTDEARKLIAFLRDELGAN
VDERCAVGIKPMSEKGSKRLVRRAMDFALAQGLPSVTLVHKGNIMKFTEGGFRQWGYELAHDEYAGRAVTEAQAAAGETG
LVVKDRIADAMFQEVLIRPEQYSVVATSNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFFEATHGTAPTIAGKDMANPG
SLILCGGMLLEHLGWHEAATRIHTAMNTVIGNRTVTVDLASQMQGASTVGCRQFGELLGAAL

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=376, Percent_Identity=33.2446808510638, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI28178838, Length=357, Percent_Identity=28.8515406162465, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4758582, Length=365, Percent_Identity=28.7671232876712, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI28178816, Length=383, Percent_Identity=28.7206266318538, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI28178821, Length=346, Percent_Identity=28.0346820809249, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI28178819, Length=179, Percent_Identity=31.2849162011173, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1787381, Length=384, Percent_Identity=54.1666666666667, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI1788101, Length=372, Percent_Identity=29.3010752688172, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87081683, Length=392, Percent_Identity=25.5102040816327, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=358, Percent_Identity=32.122905027933, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=371, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=380, Percent_Identity=27.8947368421053, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=335, Percent_Identity=26.2686567164179, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324709, Length=360, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322097, Length=354, Percent_Identity=33.0508474576271, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324291, Length=351, Percent_Identity=29.9145299145299, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24643270, Length=381, Percent_Identity=32.5459317585302, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643268, Length=381, Percent_Identity=32.5459317585302, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24661184, Length=377, Percent_Identity=30.2387267904509, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI161078637, Length=270, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078635, Length=270, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078633, Length=270, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24650122, Length=270, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078639, Length=270, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281362242, Length=369, Percent_Identity=27.9132791327913, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648872, Length=369, Percent_Identity=27.9132791327913, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI20130355, Length=345, Percent_Identity=22.8985507246377, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 41274; Mature: 41274

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTVYFIEGDGIGPEVWNAARPVIDKAVELAYGNGRSLEWKELLAGEKAYAETGTYLPQ
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHCCCCCCH
ETLDTLAGAELAIKGPLGTPVGKGFRSLNVTMRQTLDLYACIRPIRYFEGIESPVKHPER
HHHHHHCCCCEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
VNMVVFRENTEDVYAGIEYKADTDEARKLIAFLRDELGANVDERCAVGIKPMSEKGSKRL
EEEEEEECCCCHHHCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHEECCCCCCCHHHHHH
VRRAMDFALAQGLPSVTLVHKGNIMKFTEGGFRQWGYELAHDEYAGRAVTEAQAAAGETG
HHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHCHHHHHHHHCCCHHHHHHHHCCCCC
LVVKDRIADAMFQEVLIRPEQYSVVATSNLNGDYISDALAAQVGGLGLAPGVNMSDTLAF
CEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FEATHGTAPTIAGKDMANPGSLILCGGMLLEHLGWHEAATRIHTAMNTVIGNRTVTVDLA
HHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEH
SQMQGASTVGCRQFGELLGAAL
HHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKTVYFIEGDGIGPEVWNAARPVIDKAVELAYGNGRSLEWKELLAGEKAYAETGTYLPQ
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHCCCCCCH
ETLDTLAGAELAIKGPLGTPVGKGFRSLNVTMRQTLDLYACIRPIRYFEGIESPVKHPER
HHHHHHCCCCEEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCC
VNMVVFRENTEDVYAGIEYKADTDEARKLIAFLRDELGANVDERCAVGIKPMSEKGSKRL
EEEEEEECCCCHHHCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHEECCCCCCCHHHHHH
VRRAMDFALAQGLPSVTLVHKGNIMKFTEGGFRQWGYELAHDEYAGRAVTEAQAAAGETG
HHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHCHHHHHHHHCCCHHHHHHHHCCCCC
LVVKDRIADAMFQEVLIRPEQYSVVATSNLNGDYISDALAAQVGGLGLAPGVNMSDTLAF
CEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FEATHGTAPTIAGKDMANPGSLILCGGMLLEHLGWHEAATRIHTAMNTVIGNRTVTVDLA
HHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEH
SQMQGASTVGCRQFGELLGAAL
HHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]