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The map label for this gene is panF

Identifier: 78358361

GI number: 78358361

Start: 3307561

End: 3309045

Strand: Reverse

Name: panF

Synonym: Dde_3321

Alternate gene names: 78358361

Gene position: 3309045-3307561 (Counterclockwise)

Preceding gene: 78358362

Following gene: 78358359

Centisome position: 88.71

GC content: 60.0

Gene sequence:

>1485_bases
ATGAGCGCTCCGCTGATGACTGCCATTCCTGTTGTGCTGTACCTTGCCTTTTCGTTCGCGGTGGCGTTGTGGGCGCGGCG
CAAGGCTGATTCGCAGGCCACATCACAGGGTGTTCTTGAGGAATATTATATCGGCGGACGCACCATGGGCGGCTTTGTGC
TGGCCATGACCATCATCGCCAGCTACACCAGCGCCAGCAGCTTTGTGGGCGGGCCGGGAGTTGCCTACCGGCTGGGGCTC
AGCTGGGTGCTGCTGGCCATGATTCAGGTGCCCACAACCTTTCTGACACTGGGTGTGCTGGGCAAGCGCTTTGCCATTGT
GGCGCGCAGAACCGGTTCCGTGACACTGACGGATTATCTGCGGGCACGATATGCCAGCAATACAGTGGTCAATCTGTGTT
CGCTGGCGCTGCTTGTTTTTTTCATGGCAGCCATGCTGGCTCAGTTCATCGGCGGGGCGCGGCTGTTTCAGGCTGTTACG
GGGTATCCGTATGTGGTCGGGCTGGCGCTGTTCGGCATAACGGTGGTGCTGTACACTTCGGTGGGTGGTTTTCGTGCCGT
GGTAGTTACTGATGCCGTGCAGGGTATAGTAATGGTGATTGCCGTGGTTGTGGTGCTGCTGGCCGTGGTGGACGCAGGCG
GAGGCATGGCTCAGTGCGTGGCCACGCTCAAGGCTATCGATCCCGGTCTGATTACCCCTTCGGGGCCTGATAATGCGGTG
CCCAAACCGTTTATTCTTTCTTTCTGGGTTCTTGTCGGCCTTGGTGTTATCGGCCTGCCGCAGACGGCGCAGCGTTGCAT
GGGATACAAGGACGCGCGCGCCATGCACAACGCCATGGTCATCGGGACGCTGCTCATCGGCTTCATGATTCTGTGCGCCC
ATCTGGCAGGCACGCTGGGACGCGCCGTGCGGCCGGACCTGCCTGCGGGTGACCTTGCCATTCCCACGCTTATTGTCGAC
CTGCTGCCGCCTTTCTGGGCAGGGGTGTTTATTGCCGGACCGCTGGCCGCCATCATGTCCACGGTGGATTCCATGCTGCT
GCTGGCTTCCGCCGCCATCGTCAAGGATTTGTATGTGCACTACCGGCTGCAGGGCGATGCTTCAAGGCTGAAACCGGTCA
CGATGAAAAAAATGAGTCTTGCCAGCACCGGTGTCATCGGTGTGCTGGTTTTTCTGGCGGCCGTGGAACCGCCCGACCTG
CTGGTCTGGATCAACCTGTTCGCATTCGGCGGGCTGGAGGCCGTTTTCCTGTGGCCCATTGTGCTGGGGCTATACTGGAA
AAAAGCCAACGCCGCCGGAGCCGTGGCTTCCATTGTAACCGGTGTGTCCGTTTTTATCAGTCTTACGCTGCTCAAACCGG
ACATGGGCGGTATTCATGCCATTGTTCCCACCACACTGGCGGCGCTGGCGGCATTCATAGCAGGGGCCTGTTGCGGGCGT
GCTCCCGACAGCCGGGTGGTTTCCGTGTTCTGGGACGAGCGCTGA

Upstream 100 bases:

>100_bases
GTCAGGACAGCACCGCACAGGCTGCCGGAACTGCCGGGGACACGGCGTATGGTGCCGGCGGCGGGGCGGGTGCTGTTGCA
GACAAGGACGGTGGACAGCA

Downstream 100 bases:

>100_bases
CCGGCCACACGCGGCAGAAAAGCGTAAAGTAAAGCCCCCGCAGCACACGACAAGTGTGGCGCGGGGGCTTTTTGCGTATC
AAAACAGACTGGCGGTTTGT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSAPLMTAIPVVLYLAFSFAVALWARRKADSQATSQGVLEEYYIGGRTMGGFVLAMTIIASYTSASSFVGGPGVAYRLGL
SWVLLAMIQVPTTFLTLGVLGKRFAIVARRTGSVTLTDYLRARYASNTVVNLCSLALLVFFMAAMLAQFIGGARLFQAVT
GYPYVVGLALFGITVVLYTSVGGFRAVVVTDAVQGIVMVIAVVVVLLAVVDAGGGMAQCVATLKAIDPGLITPSGPDNAV
PKPFILSFWVLVGLGVIGLPQTAQRCMGYKDARAMHNAMVIGTLLIGFMILCAHLAGTLGRAVRPDLPAGDLAIPTLIVD
LLPPFWAGVFIAGPLAAIMSTVDSMLLLASAAIVKDLYVHYRLQGDASRLKPVTMKKMSLASTGVIGVLVFLAAVEPPDL
LVWINLFAFGGLEAVFLWPIVLGLYWKKANAAGAVASIVTGVSVFISLTLLKPDMGGIHAIVPTTLAALAAFIAGACCGR
APDSRVVSVFWDER

Sequences:

>Translated_494_residues
MSAPLMTAIPVVLYLAFSFAVALWARRKADSQATSQGVLEEYYIGGRTMGGFVLAMTIIASYTSASSFVGGPGVAYRLGL
SWVLLAMIQVPTTFLTLGVLGKRFAIVARRTGSVTLTDYLRARYASNTVVNLCSLALLVFFMAAMLAQFIGGARLFQAVT
GYPYVVGLALFGITVVLYTSVGGFRAVVVTDAVQGIVMVIAVVVVLLAVVDAGGGMAQCVATLKAIDPGLITPSGPDNAV
PKPFILSFWVLVGLGVIGLPQTAQRCMGYKDARAMHNAMVIGTLLIGFMILCAHLAGTLGRAVRPDLPAGDLAIPTLIVD
LLPPFWAGVFIAGPLAAIMSTVDSMLLLASAAIVKDLYVHYRLQGDASRLKPVTMKKMSLASTGVIGVLVFLAAVEPPDL
LVWINLFAFGGLEAVFLWPIVLGLYWKKANAAGAVASIVTGVSVFISLTLLKPDMGGIHAIVPTTLAALAAFIAGACCGR
APDSRVVSVFWDER
>Mature_493_residues
SAPLMTAIPVVLYLAFSFAVALWARRKADSQATSQGVLEEYYIGGRTMGGFVLAMTIIASYTSASSFVGGPGVAYRLGLS
WVLLAMIQVPTTFLTLGVLGKRFAIVARRTGSVTLTDYLRARYASNTVVNLCSLALLVFFMAAMLAQFIGGARLFQAVTG
YPYVVGLALFGITVVLYTSVGGFRAVVVTDAVQGIVMVIAVVVVLLAVVDAGGGMAQCVATLKAIDPGLITPSGPDNAVP
KPFILSFWVLVGLGVIGLPQTAQRCMGYKDARAMHNAMVIGTLLIGFMILCAHLAGTLGRAVRPDLPAGDLAIPTLIVDL
LPPFWAGVFIAGPLAAIMSTVDSMLLLASAAIVKDLYVHYRLQGDASRLKPVTMKKMSLASTGVIGVLVFLAAVEPPDLL
VWINLFAFGGLEAVFLWPIVLGLYWKKANAAGAVASIVTGVSVFISLTLLKPDMGGIHAIVPTTLAALAAFIAGACCGRA
PDSRVVSVFWDER

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=482, Percent_Identity=28.2157676348548, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI14140236, Length=403, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4507035, Length=395, Percent_Identity=28.1012658227848, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI157671931, Length=363, Percent_Identity=24.7933884297521, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI17941285, Length=476, Percent_Identity=23.5294117647059, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507033, Length=411, Percent_Identity=25.0608272506083, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI167466278, Length=368, Percent_Identity=25.2717391304348, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507031, Length=489, Percent_Identity=24.1308793456033, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI256985183, Length=425, Percent_Identity=24, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI109659836, Length=505, Percent_Identity=23.1683168316832, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI206597483, Length=403, Percent_Identity=22.8287841191067, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI87082237, Length=481, Percent_Identity=51.7671517671518, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1787251, Length=472, Percent_Identity=25.2118644067797, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790113, Length=469, Percent_Identity=24.3070362473348, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790503, Length=480, Percent_Identity=21.25, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573698, Length=361, Percent_Identity=22.7146814404432, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51867; Mature: 51735

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCEEEEEECCC
>Mature Secondary Structure 
SAPLMTAIPVVLYLAFSFAVALWARRKADSQATSQGVLEEYYIGGRTMGGFVLAMTIIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH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CCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]