Click here to switch to the map view.

The map label for this gene is tyrP [H]

Identifier: 78358338

GI number: 78358338

Start: 3286607

End: 3287773

Strand: Reverse

Name: tyrP [H]

Synonym: Dde_3298

Alternate gene names: 78358338

Gene position: 3287773-3286607 (Counterclockwise)

Preceding gene: 78358344

Following gene: 78358337

Centisome position: 88.14

GC content: 60.41

Gene sequence:

>1167_bases
ATGTTGGATTCCAGACATTCCGGCGCGGCCTGTATTGTGGCGGGCACCGCCATAGGGGCGGGCATGCTGGGGCTGCCCAT
GGTTATCGGTCCCATGGGCTTTCTGCCGGGAACATTGCTTATGGCCGTGGTATGGGCCATGGCGCTTTTTTCCGCGCTGC
TTCTGCTTGAAGTGAATCTGAAAATAGGCGCCGGAAAAAATTTCAATAATATGGCCCGCGAAGTGCTGGGCCGCGGCGGG
CAGATAGTGGCCACGGGCAGCATGGCTTTTTTGCTGTATGCGCTGCTGGTAGCCTATCTGACCGGTGTGGGCGGTCTTGT
GGCACGTACCGGCGGCGCGCTGGGCATGGCCGTCACTCCGCAGGCCGGCAGTCTGCTTTTTGCAGTGGCCGGCGGTGTGG
TGGTGCTTATCGGCACGGCGCTTGTGGTCAGAGTCAATAAAGCGCTTTTCTACGGTATGCTTGTGGCCATGGTTGTGGCT
TTTGCCAGCCTTGTGCCGGGGGTGGATGTGGCGAACCTGACCACGGCGGCCCCCCGCGAAAAGCTGGTACTGGCCTGCCT
GCCCGTGCTGTTTACGTCTTTCGGGTTTCATACGGGCATACCGAGCATCGTCCGTTTTTTGCGCAGCGATGCCCGCAGCC
TGCGAAGAGTCATTCTGGTGGGTACGGCGTTGCCCGTCATTTGTTACTTTCTGTGGCTTATGGTGTCGCTGGGAGGTATG
CCCGCTGCGGACATCAGCCGTATGGGCGGTAATGTGGACACGCTTGTTTCCGCCCTTGCCGGCAGTTCGGCATGGCTCGG
ATCGGTACTGTCCGCTTTTGCCGCTCTGGCGCTGATCACATCGTTTCTCGGGGTGGCACTGGCACTGTTTGACCTTCTGG
CCGAAACATTCCGGCTTAGCGATTCTGTGCTGCACCGGACGGTTACGGCTGTGCTGGTGTTTGCCCCGCCGGTGACTGCC
GCGCTATTGTCGCCGGGCAGATTCATTCAGGCACTGGCCCATGCGGGCGCCGCGTTGACCATCCTTGCGGTGTTTCTGCC
CTGTGCCATGGCATGGAAGCTGCGGCGCGACAATGTGCAGGCGTCCTATCAGGTGGCGGGCGGTACCGCCGCGCTTGTGG
TGACCTCTGCTTTCGGTTTGCTGGTGGTTTCGGCAAGCTATCTGTAA

Upstream 100 bases:

>100_bases
CCGTATCTGCTTTTATCCGGGGCACAAGCGGGCAGCGTGGGTGCCACGCCGCCTGCCTGCCTCCGTGCGGCCATGCCGCA
TGAAACAAGGGGTGTGATCA

Downstream 100 bases:

>100_bases
GTTTCCTGCTATGCCGGTCCAAGGCTCCGCACGATGTGCGGAGCCTTTTGTTTTGCACAGTGAGCCCTACCGGCTGAATT
TTTCACGCGCGTTGACGTTG

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MLDSRHSGAACIVAGTAIGAGMLGLPMVIGPMGFLPGTLLMAVVWAMALFSALLLLEVNLKIGAGKNFNNMAREVLGRGG
QIVATGSMAFLLYALLVAYLTGVGGLVARTGGALGMAVTPQAGSLLFAVAGGVVVLIGTALVVRVNKALFYGMLVAMVVA
FASLVPGVDVANLTTAAPREKLVLACLPVLFTSFGFHTGIPSIVRFLRSDARSLRRVILVGTALPVICYFLWLMVSLGGM
PAADISRMGGNVDTLVSALAGSSAWLGSVLSAFAALALITSFLGVALALFDLLAETFRLSDSVLHRTVTAVLVFAPPVTA
ALLSPGRFIQALAHAGAALTILAVFLPCAMAWKLRRDNVQASYQVAGGTAALVVTSAFGLLVVSASYL

Sequences:

>Translated_388_residues
MLDSRHSGAACIVAGTAIGAGMLGLPMVIGPMGFLPGTLLMAVVWAMALFSALLLLEVNLKIGAGKNFNNMAREVLGRGG
QIVATGSMAFLLYALLVAYLTGVGGLVARTGGALGMAVTPQAGSLLFAVAGGVVVLIGTALVVRVNKALFYGMLVAMVVA
FASLVPGVDVANLTTAAPREKLVLACLPVLFTSFGFHTGIPSIVRFLRSDARSLRRVILVGTALPVICYFLWLMVSLGGM
PAADISRMGGNVDTLVSALAGSSAWLGSVLSAFAALALITSFLGVALALFDLLAETFRLSDSVLHRTVTAVLVFAPPVTA
ALLSPGRFIQALAHAGAALTILAVFLPCAMAWKLRRDNVQASYQVAGGTAALVVTSAFGLLVVSASYL
>Mature_388_residues
MLDSRHSGAACIVAGTAIGAGMLGLPMVIGPMGFLPGTLLMAVVWAMALFSALLLLEVNLKIGAGKNFNNMAREVLGRGG
QIVATGSMAFLLYALLVAYLTGVGGLVARTGGALGMAVTPQAGSLLFAVAGGVVVLIGTALVVRVNKALFYGMLVAMVVA
FASLVPGVDVANLTTAAPREKLVLACLPVLFTSFGFHTGIPSIVRFLRSDARSLRRVILVGTALPVICYFLWLMVSLGGM
PAADISRMGGNVDTLVSALAGSSAWLGSVLSAFAALALITSFLGVALALFDLLAETFRLSDSVLHRTVTAVLVFAPPVTA
ALLSPGRFIQALAHAGAALTILAVFLPCAMAWKLRRDNVQASYQVAGGTAALVVTSAFGLLVVSASYL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=395, Percent_Identity=39.4936708860759, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1789552, Length=368, Percent_Identity=32.3369565217391, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1790145, Length=396, Percent_Identity=30.8080808080808, Blast_Score=178, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 39793; Mature: 39793

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSRHSGAACIVAGTAIGAGMLGLPMVIGPMGFLPGTLLMAVVWAMALFSALLLLEVNL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
KIGAGKNFNNMAREVLGRGGQIVATGSMAFLLYALLVAYLTGVGGLVARTGGALGMAVTP
EECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECC
QAGSLLFAVAGGVVVLIGTALVVRVNKALFYGMLVAMVVAFASLVPGVDVANLTTAAPRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHH
KLVLACLPVLFTSFGFHTGIPSIVRFLRSDARSLRRVILVGTALPVICYFLWLMVSLGGM
HHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAADISRMGGNVDTLVSALAGSSAWLGSVLSAFAALALITSFLGVALALFDLLAETFRLS
CHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSVLHRTVTAVLVFAPPVTAALLSPGRFIQALAHAGAALTILAVFLPCAMAWKLRRDNVQ
HHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
ASYQVAGGTAALVVTSAFGLLVVSASYL
EEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDSRHSGAACIVAGTAIGAGMLGLPMVIGPMGFLPGTLLMAVVWAMALFSALLLLEVNL
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
KIGAGKNFNNMAREVLGRGGQIVATGSMAFLLYALLVAYLTGVGGLVARTGGALGMAVTP
EECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECC
QAGSLLFAVAGGVVVLIGTALVVRVNKALFYGMLVAMVVAFASLVPGVDVANLTTAAPRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHH
KLVLACLPVLFTSFGFHTGIPSIVRFLRSDARSLRRVILVGTALPVICYFLWLMVSLGGM
HHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAADISRMGGNVDTLVSALAGSSAWLGSVLSAFAALALITSFLGVALALFDLLAETFRLS
CHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSVLHRTVTAVLVFAPPVTAALLSPGRFIQALAHAGAALTILAVFLPCAMAWKLRRDNVQ
HHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
ASYQVAGGTAALVVTSAFGLLVVSASYL
EEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]