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The map label for this gene is adh1 [H]

Identifier: 78358307

GI number: 78358307

Start: 3262827

End: 3263936

Strand: Reverse

Name: adh1 [H]

Synonym: Dde_3267

Alternate gene names: 78358307

Gene position: 3263936-3262827 (Counterclockwise)

Preceding gene: 78358308

Following gene: 78358306

Centisome position: 87.5

GC content: 56.4

Gene sequence:

>1110_bases
GTGACACAGTTCTACGGAAAAACAAAAATCTGCTATGGCGAAGATGCCCTTGAGACCCTTGAGCGCCTTCCCATCAAGCA
GGCGTTCATCGTCACCGATCCGTTCATGGTGAAGACCGGTTTCATCGACAGGCTCATAAGTCATCTTGATCTGGGCGGCA
TCCGTCACCGCGTGTTTGACGGTGTGGAGCCGGATCCTTCGCTGGAAACAGTCACCAAAGGTACCCACCTGTACATGCAG
GATCATGCCGAAGCTGTCATAGCGCTCGGCGGCGGTTCTGCCATCGACGCGGCCAAGGCCATAGCCTTTTTTGCCAGCAA
GGTTGATACCTCGCGGCCGCGGCCCATTCTGGTGGCCATTCCCACCACCAGCGGCACCGGGTCTGAAGTCACGGCCATAT
CGGTTGTGACGGACAAGGTGAACGAGGTGAAGATTCCGCTCAATGACGAACAGCTCATTCCCGATCTGGCCATCCTTGAT
GCGCGGTTCACCCGTACGCTGCCCCCCTCGGTGACTTCCGTCACCGGTATGGATGTGCTGACGCATGCCATTGAAGCATA
TACCTCGCGCAAGGCAAACGCGTTTACGTCCATCTACGCGGAATATGCCATCAGGTATGTTTTCGAATATCTGCCCCGCG
CGTACCGCTGCAGCGACGATATGGAAGCCCGTGAGAAAATGCTGCTTGCCTCCTGCATGGCAGGTATGGCCTTCAACAAC
AGCGGGCTGGGCATCACCCACAGCATAGCGCACAGCCTCGGCGGTATTTTTCATGTGCCGCACGGACTTGCCAATGCCGT
GGTGCTGCCTTTCGTCATTCAGTTCAACAGCTTTGACGCTGCGGTGCAGTACCGCGAAATCGCACAGATGCTGTCTCTGC
CTGCCGGTTCGGTGGGCGAGGGCACCCAGAGCCTTATCAAGGCCGTGCGCGAACTGAACGAATCCATGGGAATACCCAAC
AGAATAGGTGCTCTTAAAATAGAAGAGAGTGCTTACCGCCAGCATGCCGATGTCATCGCCAGAAACGTGCTGGACGATAT
ATGCACCGCAGGCAATCCGAGAATGCCTTCGCGGGCCGATATCAGAATGCTGCTGGAACAGGCATGGTAG

Upstream 100 bases:

>100_bases
GCGCGGACAGCCGCAGACGGCACAGCCGCAGACGGCACGGCCGCAGTATGCCGCCGCAACATAACCAAATGCTCAACAAT
CGTATATTAAGGGGGCAAGG

Downstream 100 bases:

>100_bases
ACGCGGTGCCGTAAAGGTACCGCGGGCACAGATATACGCGCGTGTAGCTGTGTGACGACCGGAATCACGCAGACCATGAA
AAGGGGAAGACGATGACTGG

Product: alcetaldehyde dehydrogenase or NADPH-dependent butanol dehydrogenase

Products: NA

Alternate protein names: BDH [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTQFYGKTKICYGEDALETLERLPIKQAFIVTDPFMVKTGFIDRLISHLDLGGIRHRVFDGVEPDPSLETVTKGTHLYMQ
DHAEAVIALGGGSAIDAAKAIAFFASKVDTSRPRPILVAIPTTSGTGSEVTAISVVTDKVNEVKIPLNDEQLIPDLAILD
ARFTRTLPPSVTSVTGMDVLTHAIEAYTSRKANAFTSIYAEYAIRYVFEYLPRAYRCSDDMEAREKMLLASCMAGMAFNN
SGLGITHSIAHSLGGIFHVPHGLANAVVLPFVIQFNSFDAAVQYREIAQMLSLPAGSVGEGTQSLIKAVRELNESMGIPN
RIGALKIEESAYRQHADVIARNVLDDICTAGNPRMPSRADIRMLLEQAW

Sequences:

>Translated_369_residues
MTQFYGKTKICYGEDALETLERLPIKQAFIVTDPFMVKTGFIDRLISHLDLGGIRHRVFDGVEPDPSLETVTKGTHLYMQ
DHAEAVIALGGGSAIDAAKAIAFFASKVDTSRPRPILVAIPTTSGTGSEVTAISVVTDKVNEVKIPLNDEQLIPDLAILD
ARFTRTLPPSVTSVTGMDVLTHAIEAYTSRKANAFTSIYAEYAIRYVFEYLPRAYRCSDDMEAREKMLLASCMAGMAFNN
SGLGITHSIAHSLGGIFHVPHGLANAVVLPFVIQFNSFDAAVQYREIAQMLSLPAGSVGEGTQSLIKAVRELNESMGIPN
RIGALKIEESAYRQHADVIARNVLDDICTAGNPRMPSRADIRMLLEQAW
>Mature_368_residues
TQFYGKTKICYGEDALETLERLPIKQAFIVTDPFMVKTGFIDRLISHLDLGGIRHRVFDGVEPDPSLETVTKGTHLYMQD
HAEAVIALGGGSAIDAAKAIAFFASKVDTSRPRPILVAIPTTSGTGSEVTAISVVTDKVNEVKIPLNDEQLIPDLAILDA
RFTRTLPPSVTSVTGMDVLTHAIEAYTSRKANAFTSIYAEYAIRYVFEYLPRAYRCSDDMEAREKMLLASCMAGMAFNNS
GLGITHSIAHSLGGIFHVPHGLANAVVLPFVIQFNSFDAAVQYREIAQMLSLPAGSVGEGTQSLIKAVRELNESMGIPNR
IGALKIEESAYRQHADVIARNVLDDICTAGNPRMPSRADIRMLLEQAW

Specific function: This enzyme has activity using butanol and ethanol as substrates [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=320, Percent_Identity=29.0625, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI87082107, Length=347, Percent_Identity=38.6167146974063, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1787493, Length=379, Percent_Identity=36.6754617414248, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI48994951, Length=359, Percent_Identity=36.4902506963788, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789163, Length=384, Percent_Identity=34.1145833333333, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789386, Length=345, Percent_Identity=26.0869565217391, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537053, Length=402, Percent_Identity=25.3731343283582, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321181, Length=385, Percent_Identity=34.025974025974, Blast_Score=215, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24657991, Length=361, Percent_Identity=26.5927977839335, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: NA

Molecular weight: Translated: 40262; Mature: 40131

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFYGKTKICYGEDALETLERLPIKQAFIVTDPFMVKTGFIDRLISHLDLGGIRHRVFD
CCCCCCCCEEEECCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHC
GVEPDPSLETVTKGTHLYMQDHAEAVIALGGGSAIDAAKAIAFFASKVDTSRPRPILVAI
CCCCCCCHHHHHCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE
PTTSGTGSEVTAISVVTDKVNEVKIPLNDEQLIPDLAILDARFTRTLPPSVTSVTGMDVL
ECCCCCCCCEEEEEEEECCCCEEECCCCCHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHH
THAIEAYTSRKANAFTSIYAEYAIRYVFEYLPRAYRCSDDMEAREKMLLASCMAGMAFNN
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
SGLGITHSIAHSLGGIFHVPHGLANAVVLPFVIQFNSFDAAVQYREIAQMLSLPAGSVGE
CCCCHHHHHHHHHCCEEECCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCCCCCC
GTQSLIKAVRELNESMGIPNRIGALKIEESAYRQHADVIARNVLDDICTAGNPRMPSRAD
CHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IRMLLEQAW
HHHHHHHCC
>Mature Secondary Structure 
TQFYGKTKICYGEDALETLERLPIKQAFIVTDPFMVKTGFIDRLISHLDLGGIRHRVFD
CCCCCCCEEEECCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHC
GVEPDPSLETVTKGTHLYMQDHAEAVIALGGGSAIDAAKAIAFFASKVDTSRPRPILVAI
CCCCCCCHHHHHCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE
PTTSGTGSEVTAISVVTDKVNEVKIPLNDEQLIPDLAILDARFTRTLPPSVTSVTGMDVL
ECCCCCCCCEEEEEEEECCCCEEECCCCCHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHH
THAIEAYTSRKANAFTSIYAEYAIRYVFEYLPRAYRCSDDMEAREKMLLASCMAGMAFNN
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
SGLGITHSIAHSLGGIFHVPHGLANAVVLPFVIQFNSFDAAVQYREIAQMLSLPAGSVGE
CCCCHHHHHHHHHCCEEECCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCCCCCC
GTQSLIKAVRELNESMGIPNRIGALKIEESAYRQHADVIARNVLDDICTAGNPRMPSRAD
CHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IRMLLEQAW
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2673928 [H]