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The map label for this gene is gpsA

Identifier: 78358218

GI number: 78358218

Start: 3164666

End: 3165658

Strand: Reverse

Name: gpsA

Synonym: Dde_3178

Alternate gene names: 78358218

Gene position: 3165658-3164666 (Counterclockwise)

Preceding gene: 78358226

Following gene: 78358213

Centisome position: 84.86

GC content: 61.93

Gene sequence:

>993_bases
ATGAAAATAGCCGTAGCCGGAGGCGGAAGCTGGGGGAGCGCTCTTGCCCATCTGCTGGCCGCCAATGCCTGTGACGTGAC
GCTGCTGGTGCGCGATGCCGTACAGGCCCGCCGTATCAATGCCGACCATGTGAATCCCGATTATCTGCCGGATGTGGTGC
TGCACAGTTCTGTGCGGGCCACTGTGGATGATGCTGAAGCGCTGGATGGTGCCGGTCTGCTGCTGATGGCCGTGCCGTGC
CAGCATTTTCGCAAGGTGCTGCAAAGATTGCGGCCGCTGCTGCCGCCGGAGCCGGTTGTGGTGTGCGCCAACAAGGGCAT
AGAGGTGGAAAATCTGTGCACGGTTTCAGAGGTTGTGGCGCAGGAACTGGAAGGCACCGGTCACACCTTTGCCATGCTTT
CCGGACCGTCTTTTGCCGTCGAAGTCATGCGCGATATGCCCACCGCGGTGGTGCTGGGCTGCAGGGATGCCGCCACAGGA
CGCCGGCTGCGTCATATTTTTTCGTACGGGCTGTTCCGCACGTATTCCAGCACGGACGTACGCGGAGTGGAGCTGGGCGG
GGCGGTTAAAAACGTCATCGCCATTGCGGCCGGTCTGGCAGACGGGCTGGGGTTCGGCCATAATGCCCGTGCGGCGCTCA
TCACCCGCGGGCTGGCAGAAATGAGCCGTCTGGGTGTGGCCATGGGCGCGCGGGCTTCCACGTTTATGGGGTTGTCCGGC
ATGGGCGATCTGGTGCTGACCTGCACCGGAGACCTTTCCCGTAACAGGCAGGTGGGGTTGAAGCTTGCGCAGGGCATGAC
TCTGGAAGAGGTGACCAGAAGCATGCGCATGGTGGCGGAAGGCGTGAAGACCACCGAGGCCGTGCACACTCTGGCGGCGC
GGCTGCAGGTTGATCTGCCCATTACTTCGGCCATGTATGATGTGCTGCACAGCGGTAAAAATCCGCGTGATGCCGTGCGC
GAACTGATGAGCAGGGAGCTCAAGGAAGAGTAG

Upstream 100 bases:

>100_bases
GTTGCAACCATGCAGCCGCACTTGAGCCCGGACGCTGTTTGCAGTATGTGCCGTGTGCGTGGCATCGCCGCTGCATAACT
CTGCAAAAACGGGGAGACCC

Downstream 100 bases:

>100_bases
GGCGCCGGATACGGATTGCTGCCGTGCTGCATTGCCCGCCGCGGGTTACAGCGCGCGGCTGAGCGCCATGATAACCACGC
CGCTGAGCATGGCTGCCAGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MKIAVAGGGSWGSALAHLLAANACDVTLLVRDAVQARRINADHVNPDYLPDVVLHSSVRATVDDAEALDGAGLLLMAVPC
QHFRKVLQRLRPLLPPEPVVVCANKGIEVENLCTVSEVVAQELEGTGHTFAMLSGPSFAVEVMRDMPTAVVLGCRDAATG
RRLRHIFSYGLFRTYSSTDVRGVELGGAVKNVIAIAAGLADGLGFGHNARAALITRGLAEMSRLGVAMGARASTFMGLSG
MGDLVLTCTGDLSRNRQVGLKLAQGMTLEEVTRSMRMVAEGVKTTEAVHTLAARLQVDLPITSAMYDVLHSGKNPRDAVR
ELMSRELKEE

Sequences:

>Translated_330_residues
MKIAVAGGGSWGSALAHLLAANACDVTLLVRDAVQARRINADHVNPDYLPDVVLHSSVRATVDDAEALDGAGLLLMAVPC
QHFRKVLQRLRPLLPPEPVVVCANKGIEVENLCTVSEVVAQELEGTGHTFAMLSGPSFAVEVMRDMPTAVVLGCRDAATG
RRLRHIFSYGLFRTYSSTDVRGVELGGAVKNVIAIAAGLADGLGFGHNARAALITRGLAEMSRLGVAMGARASTFMGLSG
MGDLVLTCTGDLSRNRQVGLKLAQGMTLEEVTRSMRMVAEGVKTTEAVHTLAARLQVDLPITSAMYDVLHSGKNPRDAVR
ELMSRELKEE
>Mature_330_residues
MKIAVAGGGSWGSALAHLLAANACDVTLLVRDAVQARRINADHVNPDYLPDVVLHSSVRATVDDAEALDGAGLLLMAVPC
QHFRKVLQRLRPLLPPEPVVVCANKGIEVENLCTVSEVVAQELEGTGHTFAMLSGPSFAVEVMRDMPTAVVLGCRDAATG
RRLRHIFSYGLFRTYSSTDVRGVELGGAVKNVIAIAAGLADGLGFGHNARAALITRGLAEMSRLGVAMGARASTFMGLSG
MGDLVLTCTGDLSRNRQVGLKLAQGMTLEEVTRSMRMVAEGVKTTEAVHTLAARLQVDLPITSAMYDVLHSGKNPRDAVR
ELMSRELKEE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=335, Percent_Identity=31.6417910447761, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI24307999, Length=346, Percent_Identity=29.1907514450867, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1790037, Length=329, Percent_Identity=44.9848024316109, Blast_Score=264, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI32564399, Length=342, Percent_Identity=30.4093567251462, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32564403, Length=351, Percent_Identity=29.6296296296296, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193210136, Length=351, Percent_Identity=29.6296296296296, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17507425, Length=348, Percent_Identity=29.8850574712644, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193210134, Length=339, Percent_Identity=27.7286135693215, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324513, Length=344, Percent_Identity=26.7441860465116, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320181, Length=357, Percent_Identity=26.3305322128852, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17136200, Length=341, Percent_Identity=30.2052785923754, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17136204, Length=341, Percent_Identity=30.2052785923754, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17136202, Length=341, Percent_Identity=30.2052785923754, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI22026922, Length=345, Percent_Identity=25.5072463768116, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45551945, Length=348, Percent_Identity=26.1494252873563, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281362270, Length=291, Percent_Identity=27.8350515463918, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648969, Length=337, Percent_Identity=25.8160237388724, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_DESDG (Q30WH4)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389667.1
- HSSP:   Q8N1B0
- ProteinModelPortal:   Q30WH4
- SMR:   Q30WH4
- STRING:   Q30WH4
- GeneID:   3758153
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_3178
- NMPDR:   fig|207559.3.peg.2834
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   DDES207559:DDE_3178-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 35108; Mature: 35108

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 190-190 BINDING 105-105 BINDING 105-105 BINDING 139-139 BINDING 254-254 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVAGGGSWGSALAHLLAANACDVTLLVRDAVQARRINADHVNPDYLPDVVLHSSVRA
CEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
TVDDAEALDGAGLLLMAVPCQHFRKVLQRLRPLLPPEPVVVCANKGIEVENLCTVSEVVA
CCCHHHHCCCCCHHEEHHCHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHH
QELEGTGHTFAMLSGPSFAVEVMRDMPTAVVLGCRDAATGRRLRHIFSYGLFRTYSSTDV
HHHCCCCCEEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
RGVELGGAVKNVIAIAAGLADGLGFGHNARAALITRGLAEMSRLGVAMGARASTFMGLSG
CEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
MGDLVLTCTGDLSRNRQVGLKLAQGMTLEEVTRSMRMVAEGVKTTEAVHTLAARLQVDLP
CCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
ITSAMYDVLHSGKNPRDAVRELMSRELKEE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAVAGGGSWGSALAHLLAANACDVTLLVRDAVQARRINADHVNPDYLPDVVLHSSVRA
CEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
TVDDAEALDGAGLLLMAVPCQHFRKVLQRLRPLLPPEPVVVCANKGIEVENLCTVSEVVA
CCCHHHHCCCCCHHEEHHCHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHH
QELEGTGHTFAMLSGPSFAVEVMRDMPTAVVLGCRDAATGRRLRHIFSYGLFRTYSSTDV
HHHCCCCCEEEEECCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
RGVELGGAVKNVIAIAAGLADGLGFGHNARAALITRGLAEMSRLGVAMGARASTFMGLSG
CEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
MGDLVLTCTGDLSRNRQVGLKLAQGMTLEEVTRSMRMVAEGVKTTEAVHTLAARLQVDLP
CCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
ITSAMYDVLHSGKNPRDAVRELMSRELKEE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA