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The map label for this gene is slyD [H]

Identifier: 78357710

GI number: 78357710

Start: 2680386

End: 2680808

Strand: Direct

Name: slyD [H]

Synonym: Dde_2668

Alternate gene names: 78357710

Gene position: 2680386-2680808 (Clockwise)

Preceding gene: 78357709

Following gene: 78357713

Centisome position: 71.86

GC content: 57.45

Gene sequence:

>423_bases
ATGGCAATCAAAAACGGCGACACCGTGCGTGTCCACTATACAGGAACTCTTGATGACGGCACGGTGTTCGACTCATCCCG
CGACCGTGAACCGCTGGAATTCACCATGGGCGAAGGTATGCTCATTCCCGGTTTTGAAGCGGCTCTGATGGGTCTTGCCG
CTGGCGATACCACCAAGACCACCATCCAGCCCGAAGACGCCTACGGCGAGCCCAATGACGAACTCATTCTGGCCGTTGCG
CGTGAGCAGGTGCCCGACCACATCACCCCCGAAGTGGGTCTGATGCTGCAGGTGCAGACTGAAGAAGGCATGATGGATGT
GACCATCACCGACGTAACCGACGAACAGGTCGTGCTGGACGCCAACCACCCGCTGGCCGGCGAATCCCTGACCTTCGAAA
TAGAAGTGATGGAAGTTCTCTAA

Upstream 100 bases:

>100_bases
AGACACGCACAGAAGCATAAGAAACGTTTTGACTTTCATGGCTGAACAAGCCAAGGTGACGATGTTTCTTTATGCCAAAA
ACCATGCAAGGAGTTTTTAC

Downstream 100 bases:

>100_bases
GCCTCAGTGCCGCCCGTGCGGCTTTGACAGGGCGCCGCGGTGTATACCGCGGCGCCCTTTTTTTTTGCAGCACGGAAAAA
AGGCCGGAGAGGCGAACCTC

Product: peptidyl-prolyl cis-trans isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIKNGDTVRVHYTGTLDDGTVFDSSRDREPLEFTMGEGMLIPGFEAALMGLAAGDTTKTTIQPEDAYGEPNDELILAVA
REQVPDHITPEVGLMLQVQTEEGMMDVTITDVTDEQVVLDANHPLAGESLTFEIEVMEVL

Sequences:

>Translated_140_residues
MAIKNGDTVRVHYTGTLDDGTVFDSSRDREPLEFTMGEGMLIPGFEAALMGLAAGDTTKTTIQPEDAYGEPNDELILAVA
REQVPDHITPEVGLMLQVQTEEGMMDVTITDVTDEQVVLDANHPLAGESLTFEIEVMEVL
>Mature_139_residues
AIKNGDTVRVHYTGTLDDGTVFDSSRDREPLEFTMGEGMLIPGFEAALMGLAAGDTTKTTIQPEDAYGEPNDELILAVAR
EQVPDHITPEVGLMLQVQTEEGMMDVTITDVTDEQVVLDANHPLAGESLTFEIEVMEVL

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=67, Percent_Identity=47.7611940298507, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI4503725, Length=67, Percent_Identity=47.7611940298507, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI206725530, Length=68, Percent_Identity=42.6470588235294, Blast_Score=63, Evalue=8e-11,
Organism=Homo sapiens, GI17149844, Length=68, Percent_Identity=42.6470588235294, Blast_Score=63, Evalue=8e-11,
Organism=Homo sapiens, GI17149842, Length=68, Percent_Identity=42.6470588235294, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI1786211, Length=140, Percent_Identity=35.7142857142857, Blast_Score=95, Evalue=2e-21,
Organism=Escherichia coli, GI1789748, Length=139, Percent_Identity=33.8129496402878, Blast_Score=80, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=68, Percent_Identity=47.0588235294118, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24655568, Length=68, Percent_Identity=52.9411764705882, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363946, Length=69, Percent_Identity=46.3768115942029, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17352457, Length=69, Percent_Identity=46.3768115942029, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356629, Length=63, Percent_Identity=47.6190476190476, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15225; Mature: 15094

Theoretical pI: Translated: 3.69; Mature: 3.69

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKNGDTVRVHYTGTLDDGTVFDSSRDREPLEFTMGEGMLIPGFEAALMGLAAGDTTKT
CCCCCCCEEEEEEEEECCCCEEECCCCCCCCEEEECCCCEECCCHHHHEEEEECCCCCCE
TIQPEDAYGEPNDELILAVAREQVPDHITPEVGLMLQVQTEEGMMDVTITDVTDEQVVLD
EECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEEE
ANHPLAGESLTFEIEVMEVL
CCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure 
AIKNGDTVRVHYTGTLDDGTVFDSSRDREPLEFTMGEGMLIPGFEAALMGLAAGDTTKT
CCCCCCEEEEEEEEECCCCEEECCCCCCCCEEEECCCCEECCCHHHHEEEEECCCCCCE
TIQPEDAYGEPNDELILAVAREQVPDHITPEVGLMLQVQTEEGMMDVTITDVTDEQVVLD
EECCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEEE
ANHPLAGESLTFEIEVMEVL
CCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]