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The map label for this gene is bioF [H]

Identifier: 78357704

GI number: 78357704

Start: 2674865

End: 2676022

Strand: Direct

Name: bioF [H]

Synonym: Dde_2662

Alternate gene names: 78357704

Gene position: 2674865-2676022 (Clockwise)

Preceding gene: 78357703

Following gene: 78357705

Centisome position: 71.71

GC content: 63.04

Gene sequence:

>1158_bases
ATGGCTTACGCGGCATTGAACGCGCGGTTGCGGGCACTGACGGCCGCAGGACTGTACCGCAGACGCATCTGTCAGGAATC
CCGTCAGGGAAAATGGGTGACAGTGGACGGCAGGCAACTGTTGAATTTTGCCTCAAACGACTATCTGGGACTGGCAGCGG
ATACGGACTGGCAGGCTCAGGTGGCCCGCTGCTTTGCACAGCATCCCCCGTCCGCCTCTGCCTCGGCTCTGGCGGGGGGG
CACTCGCGCACCATCAGGGCCGCCGAAGAATCACTTGCCGAATATTTCGGCTATGCGGAATGCGTGCTGCTGCCCAGCGG
TTATCAGGCCAATCTGGCCCTGCTGCAGGCGCTGGCCTTTTGCGGCGATACAGTGCTGTACGACAAACGCATCCATGCCA
GCACTGCAGCAGCCGTACGCGCCGGTGCCGCAACGCCCTGCGGTTTCCGCCACAACGATACACGGCATCTTACCCGCAGG
CTGGAAAAAACGGACAAGCCGGACAGTACGGGCACAAAAGTTATTCTGGTGGAATCGCTGTACAGTATGGACGGCGACAG
TCCGGACTTTGCCGCACTGCGCCGGATCAAGGAACGGCATAACGCCATACTGGTGGCAGACGAGGCGCACGCCTTCGGCG
TGCTGGGCACAGAAGGCAGAGGGCTGGCAACCGGCAGTGCCGACATGGCTGTGGGCACGCTGGGAAAAGCGCTGGGACTG
TTCGGTGCATTCATTCTGCTGCCGCGCGGCGGAACAGAATTGCTGTGCAATCTGGCGTCGCCCTTCATTCACTCCACGGC
ACTGCCCGACGCGCACGCCGCATGCGCGGCCATGCTGCCCCGGCGCATTGCACGCATGGAGGAACAACGCGACCGTGTGG
CCCGGCTGAGCCGTCTCATGCGGACGGAACTGCAGGAGCTGGGGCTGCCTGTGCACGGCACAGCGCACATCATCACGCTG
GAAACAGGCGACGAAGCACTGACAAGCCGGACAGCTGCCGCGCTGCGGCAGCACGGTATTCTGGCACTGGCGGCACGGCA
CCCCACCGTGCCCGCACGAAGAGCCGTCATACGTCTGGGCATGACGGCTCTGCATTCGGCCCGCGACGTAGAGGTATGCG
TGCGGAGCCTTACGACGATCCTGCGAGGTATTGTATGA

Upstream 100 bases:

>100_bases
GTGCCCGCACCGTGCAGGGAATACTGCTTACCGGCACCCTGCCCTATGACGGCAGATTTTCAGCTGACCGGCTGCAGAAG
CGTTACAGGGAGCTTTTCGC

Downstream 100 bases:

>100_bases
ATCATCGTGAACCGATGCCCCTGCACCTGTTTGTCACAGGAACGGACACCGGTGCGGGAAAAACCGTGGTCAGCCTGCTG
CTGCTTAAAGTTCTGCACGG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MAYAALNARLRALTAAGLYRRRICQESRQGKWVTVDGRQLLNFASNDYLGLAADTDWQAQVARCFAQHPPSASASALAGG
HSRTIRAAEESLAEYFGYAECVLLPSGYQANLALLQALAFCGDTVLYDKRIHASTAAAVRAGAATPCGFRHNDTRHLTRR
LEKTDKPDSTGTKVILVESLYSMDGDSPDFAALRRIKERHNAILVADEAHAFGVLGTEGRGLATGSADMAVGTLGKALGL
FGAFILLPRGGTELLCNLASPFIHSTALPDAHAACAAMLPRRIARMEEQRDRVARLSRLMRTELQELGLPVHGTAHIITL
ETGDEALTSRTAAALRQHGILALAARHPTVPARRAVIRLGMTALHSARDVEVCVRSLTTILRGIV

Sequences:

>Translated_385_residues
MAYAALNARLRALTAAGLYRRRICQESRQGKWVTVDGRQLLNFASNDYLGLAADTDWQAQVARCFAQHPPSASASALAGG
HSRTIRAAEESLAEYFGYAECVLLPSGYQANLALLQALAFCGDTVLYDKRIHASTAAAVRAGAATPCGFRHNDTRHLTRR
LEKTDKPDSTGTKVILVESLYSMDGDSPDFAALRRIKERHNAILVADEAHAFGVLGTEGRGLATGSADMAVGTLGKALGL
FGAFILLPRGGTELLCNLASPFIHSTALPDAHAACAAMLPRRIARMEEQRDRVARLSRLMRTELQELGLPVHGTAHIITL
ETGDEALTSRTAAALRQHGILALAARHPTVPARRAVIRLGMTALHSARDVEVCVRSLTTILRGIV
>Mature_384_residues
AYAALNARLRALTAAGLYRRRICQESRQGKWVTVDGRQLLNFASNDYLGLAADTDWQAQVARCFAQHPPSASASALAGGH
SRTIRAAEESLAEYFGYAECVLLPSGYQANLALLQALAFCGDTVLYDKRIHASTAAAVRAGAATPCGFRHNDTRHLTRRL
EKTDKPDSTGTKVILVESLYSMDGDSPDFAALRRIKERHNAILVADEAHAFGVLGTEGRGLATGSADMAVGTLGKALGLF
GAFILLPRGGTELLCNLASPFIHSTALPDAHAACAAMLPRRIARMEEQRDRVARLSRLMRTELQELGLPVHGTAHIITLE
TGDEALTSRTAAALRQHGILALAARHPTVPARRAVIRLGMTALHSARDVEVCVRSLTTILRGIV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=29.0155440414508, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI284448556, Length=412, Percent_Identity=27.1844660194175, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=30.7042253521127, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=30.7042253521127, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=30.7042253521127, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI4502025, Length=366, Percent_Identity=28.4153005464481, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI40316939, Length=366, Percent_Identity=28.4153005464481, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=23.3870967741935, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI119220554, Length=367, Percent_Identity=22.8882833787466, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=33.5227272727273, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790046, Length=388, Percent_Identity=27.8350515463918, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994529, Length=388, Percent_Identity=25.2577319587629, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=23.8605898123324, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560914, Length=298, Percent_Identity=26.1744966442953, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560912, Length=298, Percent_Identity=26.1744966442953, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982617, Length=292, Percent_Identity=25.6849315068493, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982625, Length=292, Percent_Identity=25.6849315068493, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320438, Length=371, Percent_Identity=24.7978436657682, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320267, Length=374, Percent_Identity=24.5989304812834, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323954, Length=297, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=26.5463917525773, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17137420, Length=388, Percent_Identity=28.8659793814433, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17136286, Length=383, Percent_Identity=26.8929503916449, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24653280, Length=215, Percent_Identity=26.5116279069767, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653276, Length=215, Percent_Identity=26.5116279069767, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653278, Length=215, Percent_Identity=26.5116279069767, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 41388; Mature: 41257

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYAALNARLRALTAAGLYRRRICQESRQGKWVTVDGRQLLNFASNDYLGLAADTDWQAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCCEEEECCCCHHHH
VARCFAQHPPSASASALAGGHSRTIRAAEESLAEYFGYAECVLLPSGYQANLALLQALAF
HHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
CGDTVLYDKRIHASTAAAVRAGAATPCGFRHNDTRHLTRRLEKTDKPDSTGTKVILVESL
HCCHHEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEHH
YSMDGDSPDFAALRRIKERHNAILVADEAHAFGVLGTEGRGLATGSADMAVGTLGKALGL
HHCCCCCCHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCEECCCCHHHHHHHHHHHHH
FGAFILLPRGGTELLCNLASPFIHSTALPDAHAACAAMLPRRIARMEEQRDRVARLSRLM
HHHHHEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTELQELGLPVHGTAHIITLETGDEALTSRTAAALRQHGILALAARHPTVPARRAVIRLG
HHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
MTALHSARDVEVCVRSLTTILRGIV
HHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AYAALNARLRALTAAGLYRRRICQESRQGKWVTVDGRQLLNFASNDYLGLAADTDWQAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCCEEEECCCCHHHH
VARCFAQHPPSASASALAGGHSRTIRAAEESLAEYFGYAECVLLPSGYQANLALLQALAF
HHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
CGDTVLYDKRIHASTAAAVRAGAATPCGFRHNDTRHLTRRLEKTDKPDSTGTKVILVESL
HCCHHEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEHH
YSMDGDSPDFAALRRIKERHNAILVADEAHAFGVLGTEGRGLATGSADMAVGTLGKALGL
HHCCCCCCHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCEECCCCHHHHHHHHHHHHH
FGAFILLPRGGTELLCNLASPFIHSTALPDAHAACAAMLPRRIARMEEQRDRVARLSRLM
HHHHHEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTELQELGLPVHGTAHIITLETGDEALTSRTAAALRQHGILALAARHPTVPARRAVIRLG
HHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
MTALHSARDVEVCVRSLTTILRGIV
HHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA