Click here to switch to the map view.

The map label for this gene is degS [H]

Identifier: 78355793

GI number: 78355793

Start: 773612

End: 774775

Strand: Direct

Name: degS [H]

Synonym: Dde_0746

Alternate gene names: 78355793

Gene position: 773612-774775 (Clockwise)

Preceding gene: 78355792

Following gene: 78355794

Centisome position: 20.74

GC content: 59.88

Gene sequence:

>1164_bases
GTGACTTCCCGCGTGGAGGCCACCCGCGCCATGGAGGCCGTGCGCAAGACGCTGGAAGAACGCGTCAAGGAACGCACGGC
AGCCTTGGGCAGAGTGAACGACCGTCTGGAACGTGAGATAGCTGAGCGCAAACTGCACGAAGAGCTTATCGTGCAGCACC
GCAATCATCTTGAGGCATTGATGAACGCGCTTGCCGACAGCGCGCTGCTGATGGATACGGGCGGCAGGATAATAACGCTC
AACATCACCGCCGCACAGCGGCTGGGGCTGCCCGAAAGGGGGTCCGGCGGGCAGGTGTTTTTTGACCTGCTGCAGGGGAC
TACCGATACACTGGTGTGGCGCGATGCGCTGCACGAAGTGCTGGAAACCTTTCTGCCTGCACGTTTCGAGGTGCAGGCTT
TCGGGCTGGAACTGGATGTGACCTATTATCCGGTTTTCGGGTATGCCGACTGGGTTACCGGGGTGGCCGTGTACATGATG
GACGTTACCGAGCAGAAACAGATTTCGCGGCGTCTCAGACGGCTTTCCGCACAGGTGCTTTCCGCGCAGGAGGAAGAACG
CAAGCGCATAGGCCGTGAACTGCATGATTCCATGGCGCAGACGCTTTCGGGCATCAAGTTCATGCTGGAAGGCGAACGCA
GCAGGCTGGAACAGTCCGGCACGGGCTGGCCCACGGAACGCATATCGAAAACCATCGAATATGTGCAGCATGCCATTGTG
GAGACGCGGCGCATAGTCATGGACCTGCGCCCCACGGTGCTGGACGACCTGGGACTCATCGCCGCGCTGCGCTGGCTGCA
GCAGGAAATGAGCCAGATCCATTCTCTTACCATCACAAGCCATCTTTCTCTGCCGGAAAATGCGCTGTCGGATGTGCAGA
AATCGGTGTTGTTCCGCGTGGCGCAGGAGGCGCTGAACAACGTCATACGGCACAGCGGTTCTGATTCGGCCCGGATCAGC
CTTGAGCAGGTGGGGGAAGAATGCGTGATGACCGTCACCGATAACGGCAGCGGTTTTGACCGGCTGGACAACACCCGCAA
CGGCATAGGGCTGGACAGCATGCGCGAACGGCTGGAGCTTATATGCGGCCGGCTGGATATTGTGACGGAGAAAGGCATAG
GCACGGTTGTGCGCGCCGTGGTGCCGCTGGATTCTCCGTGCTGA

Upstream 100 bases:

>100_bases
GGGGACTTGGTAGGGGAACAACAACCATTGGTGGAAACCATGACATTTTTATTGTCCCAAACCGTCCCAAAAAGGTGACA
TTTTCATTGGCTGTTTACAC

Downstream 100 bases:

>100_bases
CCGCGCTGTGCATTTGACCGCGCGGCTGCGCAGGGCTATGTTCAACATCCATTTCAGGCAGCCCTGCTGCCGGCCGGAGG
TTACGTGCGGGACGATCCAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MTSRVEATRAMEAVRKTLEERVKERTAALGRVNDRLEREIAERKLHEELIVQHRNHLEALMNALADSALLMDTGGRIITL
NITAAQRLGLPERGSGGQVFFDLLQGTTDTLVWRDALHEVLETFLPARFEVQAFGLELDVTYYPVFGYADWVTGVAVYMM
DVTEQKQISRRLRRLSAQVLSAQEEERKRIGRELHDSMAQTLSGIKFMLEGERSRLEQSGTGWPTERISKTIEYVQHAIV
ETRRIVMDLRPTVLDDLGLIAALRWLQQEMSQIHSLTITSHLSLPENALSDVQKSVLFRVAQEALNNVIRHSGSDSARIS
LEQVGEECVMTVTDNGSGFDRLDNTRNGIGLDSMRERLELICGRLDIVTEKGIGTVVRAVVPLDSPC

Sequences:

>Translated_387_residues
MTSRVEATRAMEAVRKTLEERVKERTAALGRVNDRLEREIAERKLHEELIVQHRNHLEALMNALADSALLMDTGGRIITL
NITAAQRLGLPERGSGGQVFFDLLQGTTDTLVWRDALHEVLETFLPARFEVQAFGLELDVTYYPVFGYADWVTGVAVYMM
DVTEQKQISRRLRRLSAQVLSAQEEERKRIGRELHDSMAQTLSGIKFMLEGERSRLEQSGTGWPTERISKTIEYVQHAIV
ETRRIVMDLRPTVLDDLGLIAALRWLQQEMSQIHSLTITSHLSLPENALSDVQKSVLFRVAQEALNNVIRHSGSDSARIS
LEQVGEECVMTVTDNGSGFDRLDNTRNGIGLDSMRERLELICGRLDIVTEKGIGTVVRAVVPLDSPC
>Mature_386_residues
TSRVEATRAMEAVRKTLEERVKERTAALGRVNDRLEREIAERKLHEELIVQHRNHLEALMNALADSALLMDTGGRIITLN
ITAAQRLGLPERGSGGQVFFDLLQGTTDTLVWRDALHEVLETFLPARFEVQAFGLELDVTYYPVFGYADWVTGVAVYMMD
VTEQKQISRRLRRLSAQVLSAQEEERKRIGRELHDSMAQTLSGIKFMLEGERSRLEQSGTGWPTERISKTIEYVQHAIVE
TRRIVMDLRPTVLDDLGLIAALRWLQQEMSQIHSLTITSHLSLPENALSDVQKSVLFRVAQEALNNVIRHSGSDSARISL
EQVGEECVMTVTDNGSGFDRLDNTRNGIGLDSMRERLELICGRLDIVTEKGIGTVVRAVVPLDSPC

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=222, Percent_Identity=32.4324324324324, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1787474, Length=202, Percent_Identity=29.2079207920792, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788812, Length=195, Percent_Identity=29.2307692307692, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43560; Mature: 43429

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRVEATRAMEAVRKTLEERVKERTAALGRVNDRLEREIAERKLHEELIVQHRNHLEAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNALADSALLMDTGGRIITLNITAAQRLGLPERGSGGQVFFDLLQGTTDTLVWRDALHEV
HHHHHCCCEEEECCCEEEEEEEHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
LETFLPARFEVQAFGLELDVTYYPVFGYADWVTGVAVYMMDVTEQKQISRRLRRLSAQVL
HHHHCCCCEEEEEECEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAQEEERKRIGRELHDSMAQTLSGIKFMLEGERSRLEQSGTGWPTERISKTIEYVQHAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ETRRIVMDLRPTVLDDLGLIAALRWLQQEMSQIHSLTITSHLSLPENALSDVQKSVLFRV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AQEALNNVIRHSGSDSARISLEQVGEECVMTVTDNGSGFDRLDNTRNGIGLDSMRERLEL
HHHHHHHHHHCCCCCHHEEEHHHCCHHHEEEEECCCCCCHHCCCCCCCCCHHHHHHHHHH
ICGRLDIVTEKGIGTVVRAVVPLDSPC
HHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TSRVEATRAMEAVRKTLEERVKERTAALGRVNDRLEREIAERKLHEELIVQHRNHLEAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNALADSALLMDTGGRIITLNITAAQRLGLPERGSGGQVFFDLLQGTTDTLVWRDALHEV
HHHHHCCCEEEECCCEEEEEEEHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
LETFLPARFEVQAFGLELDVTYYPVFGYADWVTGVAVYMMDVTEQKQISRRLRRLSAQVL
HHHHCCCCEEEEEECEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAQEEERKRIGRELHDSMAQTLSGIKFMLEGERSRLEQSGTGWPTERISKTIEYVQHAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ETRRIVMDLRPTVLDDLGLIAALRWLQQEMSQIHSLTITSHLSLPENALSDVQKSVLFRV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AQEALNNVIRHSGSDSARISLEQVGEECVMTVTDNGSGFDRLDNTRNGIGLDSMRERLEL
HHHHHHHHHHCCCCCHHEEEHHHCCHHHEEEEECCCCCCHHCCCCCCCCCHHHHHHHHHH
ICGRLDIVTEKGIGTVVRAVVPLDSPC
HHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]