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The map label for this gene is moaA [H]

Identifier: 78355756

GI number: 78355756

Start: 726158

End: 727219

Strand: Direct

Name: moaA [H]

Synonym: Dde_0709

Alternate gene names: 78355756

Gene position: 726158-727219 (Clockwise)

Preceding gene: 78355755

Following gene: 78355760

Centisome position: 19.47

GC content: 58.66

Gene sequence:

>1062_bases
ATGAGCACCTTGCATCACGCTTTTTCCGGCAATGTGCCGCAGGCTGCCGGACCGGCAGCGGCGGAACGGTTTTCCGACGA
ATACGGCAGGCAGGTGAGCTATCTGCGTCTTTCTGTCACAGACAGGTGTAATCTGCGCTGCATGTATTGCTGGACCTGTG
ACGGTCTTTCCTTCATTCCCCACGACAGCATACTTAAATATGAAGAAATGCTTCAGCTGGTGGACGCGGCCGTGGGCATG
GGCGTGGAAAAGGTGCGCCTGACAGGCGGCGAACCGTTTGTCCGCAAGGATTTTCTGTTTCTTGTGGAATCGCTGGTCAG
GCGGCATCCTTCGCTGGATGTGCGCATAACCACAAATGCCACGCTGCTGGCGGGCAAAGTGGCTGCTCTGCGTGATCTGG
GTGTGCGGTATGTGAATATTTCGCTGGATACGTTCGAGCGCGAACGGTTCCGCCGTGTGGCGGGGCGCGATATGCTGCGC
CATGTGCGTCGGGCGCTGGATGAAGTGCTGGAACACGGCATAGGGCTGAAGCTTAACGCAGTGGCCCTGCGCGGCTTCAA
TGACGACGAACTGCCTGTTTTTCTTAATTTTGCGCGGCGTAATGCCGTGGACGTGCGGTTTATCGAGTTTATGCCCATGG
GCGGCTGCACACGCTGGTCGCAGGAAAATTTCTGGCCTGCATCCGATATTCTGGAGACAGCCCGCAGACACGCGGATCTG
ACGCCGGTGGAAGGACGCAGCAGACGCAGCGGGCCTGCCCGTTTGTACAGCATCGAAGGCGGCAAAGGGCGTTTCGGCCT
TATCACGCCGCTTTCAGACCACTTCTGCAACTCGTGCAACAGACTGCGCATAACACCTGACGGCAGGCTGCGCACCTGTC
TTTTTTCCGACAAGGAATACCGTCTGCGGCCGCTTATCCGCCATCCCCGTCTGGGAATGTCCGCCGTGATGAAGGTCATG
CGGCTGGCCGCGCAACGCAAACCGCTGGGCTACAGGATGCTGGAACAGCTGCATGCCGACGGTTCCGTGGCGGAAAAGCG
CATGTCCGCCATTGGCGGTTGA

Upstream 100 bases:

>100_bases
ATCGCGTCGCATACTCGCGGGAGGAATCCCTGCCCTTTTTCAATGTGAATTATCCGGCGGATCTGGAAATGGCCCGCCGC
GTCATACGGGCACTGACAAC

Downstream 100 bases:

>100_bases
TGCAGCAGCACCGGATTCAGCCGTCTGCGGTGTGCCTGTATCAGCAGGCGGAAGCCGCCGCGTGTTCCAGTGCTTCGGGC
AGGCAGTCAAACGTGCGGGC

Product: GTP cyclohydrolase subunit MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSTLHHAFSGNVPQAAGPAAAERFSDEYGRQVSYLRLSVTDRCNLRCMYCWTCDGLSFIPHDSILKYEEMLQLVDAAVGM
GVEKVRLTGGEPFVRKDFLFLVESLVRRHPSLDVRITTNATLLAGKVAALRDLGVRYVNISLDTFERERFRRVAGRDMLR
HVRRALDEVLEHGIGLKLNAVALRGFNDDELPVFLNFARRNAVDVRFIEFMPMGGCTRWSQENFWPASDILETARRHADL
TPVEGRSRRSGPARLYSIEGGKGRFGLITPLSDHFCNSCNRLRITPDGRLRTCLFSDKEYRLRPLIRHPRLGMSAVMKVM
RLAAQRKPLGYRMLEQLHADGSVAEKRMSAIGG

Sequences:

>Translated_353_residues
MSTLHHAFSGNVPQAAGPAAAERFSDEYGRQVSYLRLSVTDRCNLRCMYCWTCDGLSFIPHDSILKYEEMLQLVDAAVGM
GVEKVRLTGGEPFVRKDFLFLVESLVRRHPSLDVRITTNATLLAGKVAALRDLGVRYVNISLDTFERERFRRVAGRDMLR
HVRRALDEVLEHGIGLKLNAVALRGFNDDELPVFLNFARRNAVDVRFIEFMPMGGCTRWSQENFWPASDILETARRHADL
TPVEGRSRRSGPARLYSIEGGKGRFGLITPLSDHFCNSCNRLRITPDGRLRTCLFSDKEYRLRPLIRHPRLGMSAVMKVM
RLAAQRKPLGYRMLEQLHADGSVAEKRMSAIGG
>Mature_352_residues
STLHHAFSGNVPQAAGPAAAERFSDEYGRQVSYLRLSVTDRCNLRCMYCWTCDGLSFIPHDSILKYEEMLQLVDAAVGMG
VEKVRLTGGEPFVRKDFLFLVESLVRRHPSLDVRITTNATLLAGKVAALRDLGVRYVNISLDTFERERFRRVAGRDMLRH
VRRALDEVLEHGIGLKLNAVALRGFNDDELPVFLNFARRNAVDVRFIEFMPMGGCTRWSQENFWPASDILETARRHADLT
PVEGRSRRSGPARLYSIEGGKGRFGLITPLSDHFCNSCNRLRITPDGRLRTCLFSDKEYRLRPLIRHPRLGMSAVMKVMR
LAAQRKPLGYRMLEQLHADGSVAEKRMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=308, Percent_Identity=37.6623376623377, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI22027536, Length=318, Percent_Identity=37.4213836477987, Blast_Score=205, Evalue=7e-53,
Organism=Escherichia coli, GI1786999, Length=336, Percent_Identity=30.6547619047619, Blast_Score=174, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI32566331, Length=284, Percent_Identity=39.7887323943662, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566329, Length=284, Percent_Identity=39.7887323943662, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17561210, Length=284, Percent_Identity=38.3802816901408, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574490, Length=324, Percent_Identity=37.962962962963, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI28574488, Length=309, Percent_Identity=38.8349514563107, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39982; Mature: 39851

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLHHAFSGNVPQAAGPAAAERFSDEYGRQVSYLRLSVTDRCNLRCMYCWTCDGLSFIP
CCCCCCHHCCCCCCCCCCHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEEEECCCCCCCC
HDSILKYEEMLQLVDAAVGMGVEKVRLTGGEPFVRKDFLFLVESLVRRHPSLDVRITTNA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
TLLAGKVAALRDLGVRYVNISLDTFERERFRRVAGRDMLRHVRRALDEVLEHGIGLKLNA
EEHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VALRGFNDDELPVFLNFARRNAVDVRFIEFMPMGGCTRWSQENFWPASDILETARRHADL
EEEECCCCCCCCEEEEEHHCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCC
TPVEGRSRRSGPARLYSIEGGKGRFGLITPLSDHFCNSCNRLRITPDGRLRTCLFSDKEY
CCCCCCCCCCCCCEEEEECCCCCCEEEECCCHHHHHCCCCEEEECCCCCEEEEEECCCCH
RLRPLIRHPRLGMSAVMKVMRLAAQRKPLGYRMLEQLHADGSVAEKRMSAIGG
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
STLHHAFSGNVPQAAGPAAAERFSDEYGRQVSYLRLSVTDRCNLRCMYCWTCDGLSFIP
CCCCCHHCCCCCCCCCCHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEEEECCCCCCCC
HDSILKYEEMLQLVDAAVGMGVEKVRLTGGEPFVRKDFLFLVESLVRRHPSLDVRITTNA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
TLLAGKVAALRDLGVRYVNISLDTFERERFRRVAGRDMLRHVRRALDEVLEHGIGLKLNA
EEHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VALRGFNDDELPVFLNFARRNAVDVRFIEFMPMGGCTRWSQENFWPASDILETARRHADL
EEEECCCCCCCCEEEEEHHCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCC
TPVEGRSRRSGPARLYSIEGGKGRFGLITPLSDHFCNSCNRLRITPDGRLRTCLFSDKEY
CCCCCCCCCCCCCEEEEECCCCCCEEEECCCHHHHHCCCCEEEECCCCCEEEEEECCCCH
RLRPLIRHPRLGMSAVMKVMRLAAQRKPLGYRMLEQLHADGSVAEKRMSAIGG
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA