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The map label for this gene is cls [H]

Identifier: 78355637

GI number: 78355637

Start: 612406

End: 613860

Strand: Direct

Name: cls [H]

Synonym: Dde_0590

Alternate gene names: 78355637

Gene position: 612406-613860 (Clockwise)

Preceding gene: 78355636

Following gene: 78355638

Centisome position: 16.42

GC content: 60.76

Gene sequence:

>1455_bases
ATGGATTTCACTCTTCTCAGCGGCCTGCTGGTGGTGATCAACCTGTGCGTGTCGTTCACCGCTGCGGGCCATGCCCTGCT
GAACAAGCGGGAGCCCAGAGCCTCTCTCGGGTGGGTGGCGGTGTGCCTTACCTTTCCTCTGGCGGGGCCGTTGCTCTATT
TCGTGTTCGGCATCAACCGTGTGCGCAGCAAGGCAGAACGGTTGAATGAAGAAAATTCGGCCAGAGGCACCGCCACAAAA
GGGCGGCTGCACGGCGGAACCCATCCCTTTCTGCCGCCCGGCTCCATGGACGATTATCTTATTGCGCCGGTCTACCGCAC
GCTGCAGCGTTCCGGTCTGGCTGTCACCGGAATGCCGCTGGTGGGCGGTAACGATGTGCGCATAATGCATAACGGCGAGC
AGGCCTACCCCCGCATGATCGAAGCGGTGGAATGTGCCGAAGACTCACTGTACCTTGCCACATATATTTTTGAAACCGGA
CCGGAAGGCCGGCGCTTTATCGAAGCTCTGAGCTCCGCTGCGGCACGGGGCGTTGATGTGCGTGTGCTGGTGGACGGCGT
GGGCGAGCTGTACGCCTTTCCCCGCGCGGGAACCCTGCTGCAGCGGCGGGGAGTGCGCGTGGCGCGTTTCCTTCCGCCTC
GTCTTTTTCCTCCCCAGCTTAGTGTCAATCTGCGCAACCACCGCAAGGTGCTGGTGGCCGACGGGCAGGTAGGCTTTACC
GGCGGCATGAATCTGGGTGACAGGCATATGGTGGACAATCCGGAAAACAGACGCCCCGTGGTGGACATTCATTTCGGATT
TTCCGGCCCTGTGGTGGCCCAGCTGCAGGAAGCTTTTCTGGATGACTGGGGGTTTGCCACGGGCGAATATACGCTGCCCC
GCCGCGTGACGGAAGAGCCGTGCGGCGATACGCTGTGCCGCGTGGTCAAAGGCGGTCCCGGGCAGGATATCGACCGTATT
TCGGCTTTGATGACGGGCGTCATCTCCAGTGCGTGCCGCTCGGTACGCATCATGACTCCGTATTTTCTGCCGTCCGGCGA
TCTGATAAGCGCCATGCAGGCAGCTGCCCTGCGCGGGGTGCGGGTGGATGTGGTGCTGCCCGGAAAAAATAATCTGCCGG
CAGTGCACTGGGCCACACGCAACATGCTGTGGCAGCTGCTGCGGTTCGGGGTGCATGTCTACTACCAGCCCGGCCCTTTT
GTACATTCCAAGATCATGCTCATCGACGGCAGTTACGCGCAGGTGGGGTCTGCCAATCTGGACCCCCGCAGCCTGCGGCT
TAATTTCGAGCTGAATGTGGAGATATTTGATACGTCCGTCGTGCGTCCGCTGGTAAGGCATTTCGACAACGTGCGGCGCA
ATGCGCGCAGCATAACCCTGAGCGAACTGGAAAACCGTTCCCTGCCGGTGCGTATGCGCGATGCCGCATTCTGGCTGTTC
ACCCCGTATTTGTAG

Upstream 100 bases:

>100_bases
TACCAGCCGCGTTCCTGCGGCTGCCCCGCAGCATGCCGTTGTCTGCCCGTTTGCAGCAGCATGCCGCGGCCGGAGTTGTA
ACTGAAAGCGGAGTCGCGAG

Downstream 100 bases:

>100_bases
TCGTGCTGTGAGTATGCTAAAAAATGAAGTGCTGCTATTTCTTCCGGTTGGCACAAAGGCGGCTGATAGCTGTTGACATG
TCGTGCCGGAGAGCTAGTAC

Product: cardiolipin synthetase 2

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MDFTLLSGLLVVINLCVSFTAAGHALLNKREPRASLGWVAVCLTFPLAGPLLYFVFGINRVRSKAERLNEENSARGTATK
GRLHGGTHPFLPPGSMDDYLIAPVYRTLQRSGLAVTGMPLVGGNDVRIMHNGEQAYPRMIEAVECAEDSLYLATYIFETG
PEGRRFIEALSSAAARGVDVRVLVDGVGELYAFPRAGTLLQRRGVRVARFLPPRLFPPQLSVNLRNHRKVLVADGQVGFT
GGMNLGDRHMVDNPENRRPVVDIHFGFSGPVVAQLQEAFLDDWGFATGEYTLPRRVTEEPCGDTLCRVVKGGPGQDIDRI
SALMTGVISSACRSVRIMTPYFLPSGDLISAMQAAALRGVRVDVVLPGKNNLPAVHWATRNMLWQLLRFGVHVYYQPGPF
VHSKIMLIDGSYAQVGSANLDPRSLRLNFELNVEIFDTSVVRPLVRHFDNVRRNARSITLSELENRSLPVRMRDAAFWLF
TPYL

Sequences:

>Translated_484_residues
MDFTLLSGLLVVINLCVSFTAAGHALLNKREPRASLGWVAVCLTFPLAGPLLYFVFGINRVRSKAERLNEENSARGTATK
GRLHGGTHPFLPPGSMDDYLIAPVYRTLQRSGLAVTGMPLVGGNDVRIMHNGEQAYPRMIEAVECAEDSLYLATYIFETG
PEGRRFIEALSSAAARGVDVRVLVDGVGELYAFPRAGTLLQRRGVRVARFLPPRLFPPQLSVNLRNHRKVLVADGQVGFT
GGMNLGDRHMVDNPENRRPVVDIHFGFSGPVVAQLQEAFLDDWGFATGEYTLPRRVTEEPCGDTLCRVVKGGPGQDIDRI
SALMTGVISSACRSVRIMTPYFLPSGDLISAMQAAALRGVRVDVVLPGKNNLPAVHWATRNMLWQLLRFGVHVYYQPGPF
VHSKIMLIDGSYAQVGSANLDPRSLRLNFELNVEIFDTSVVRPLVRHFDNVRRNARSITLSELENRSLPVRMRDAAFWLF
TPYL
>Mature_484_residues
MDFTLLSGLLVVINLCVSFTAAGHALLNKREPRASLGWVAVCLTFPLAGPLLYFVFGINRVRSKAERLNEENSARGTATK
GRLHGGTHPFLPPGSMDDYLIAPVYRTLQRSGLAVTGMPLVGGNDVRIMHNGEQAYPRMIEAVECAEDSLYLATYIFETG
PEGRRFIEALSSAAARGVDVRVLVDGVGELYAFPRAGTLLQRRGVRVARFLPPRLFPPQLSVNLRNHRKVLVADGQVGFT
GGMNLGDRHMVDNPENRRPVVDIHFGFSGPVVAQLQEAFLDDWGFATGEYTLPRRVTEEPCGDTLCRVVKGGPGQDIDRI
SALMTGVISSACRSVRIMTPYFLPSGDLISAMQAAALRGVRVDVVLPGKNNLPAVHWATRNMLWQLLRFGVHVYYQPGPF
VHSKIMLIDGSYAQVGSANLDPRSLRLNFELNVEIFDTSVVRPLVRHFDNVRRNARSITLSELENRSLPVRMRDAAFWLF
TPYL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=494, Percent_Identity=27.9352226720648, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1787007, Length=339, Percent_Identity=32.7433628318584, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 53554; Mature: 53554

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTLLSGLLVVINLCVSFTAAGHALLNKREPRASLGWVAVCLTFPLAGPLLYFVFGINR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSKAERLNEENSARGTATKGRLHGGTHPFLPPGSMDDYLIAPVYRTLQRSGLAVTGMPL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCEE
VGGNDVRIMHNGEQAYPRMIEAVECAEDSLYLATYIFETGPEGRRFIEALSSAAARGVDV
ECCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
RVLVDGVGELYAFPRAGTLLQRRGVRVARFLPPRLFPPQLSVNLRNHRKVLVADGQVGFT
EEEEECCHHHHCCCCCCHHHHHCCCEEEECCCCCCCCCCEEEEECCCCEEEEECCCEEEC
GGMNLGDRHMVDNPENRRPVVDIHFGFSGPVVAQLQEAFLDDWGFATGEYTLPRRVTEEP
CCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
CGDTLCRVVKGGPGQDIDRISALMTGVISSACRSVRIMTPYFLPSGDLISAMQAAALRGV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCEECCCCHHHHHHHHHHHCCC
RVDVVLPGKNNLPAVHWATRNMLWQLLRFGVHVYYQPGPFVHSKIMLIDGSYAQVGSANL
EEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEEECCCHHCCCCCC
DPRSLRLNFELNVEIFDTSVVRPLVRHFDNVRRNARSITLSELENRSLPVRMRDAAFWLF
CCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCEEEECCEEEEE
TPYL
ECCC
>Mature Secondary Structure
MDFTLLSGLLVVINLCVSFTAAGHALLNKREPRASLGWVAVCLTFPLAGPLLYFVFGINR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VRSKAERLNEENSARGTATKGRLHGGTHPFLPPGSMDDYLIAPVYRTLQRSGLAVTGMPL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCEE
VGGNDVRIMHNGEQAYPRMIEAVECAEDSLYLATYIFETGPEGRRFIEALSSAAARGVDV
ECCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
RVLVDGVGELYAFPRAGTLLQRRGVRVARFLPPRLFPPQLSVNLRNHRKVLVADGQVGFT
EEEEECCHHHHCCCCCCHHHHHCCCEEEECCCCCCCCCCEEEEECCCCEEEEECCCEEEC
GGMNLGDRHMVDNPENRRPVVDIHFGFSGPVVAQLQEAFLDDWGFATGEYTLPRRVTEEP
CCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
CGDTLCRVVKGGPGQDIDRISALMTGVISSACRSVRIMTPYFLPSGDLISAMQAAALRGV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCEECCCCHHHHHHHHHHHCCC
RVDVVLPGKNNLPAVHWATRNMLWQLLRFGVHVYYQPGPFVHSKIMLIDGSYAQVGSANL
EEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEEECCCHHCCCCCC
DPRSLRLNFELNVEIFDTSVVRPLVRHFDNVRRNARSITLSELENRSLPVRMRDAAFWLF
CCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCEEEECCEEEEE
TPYL
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA