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The map label for this gene is phr [H]

Identifier: 78355226

GI number: 78355226

Start: 164786

End: 166249

Strand: Direct

Name: phr [H]

Synonym: Dde_0179

Alternate gene names: 78355226

Gene position: 164786-166249 (Clockwise)

Preceding gene: 78355225

Following gene: 78355227

Centisome position: 4.42

GC content: 62.7

Gene sequence:

>1464_bases
ATGCACTCTGGACGTCTGAGTTACAGCACGGTACCGCCGCAAGAAGCCCGCGGACATGCCGCGGGAGCGCCGGTTCTGTA
CTGGATGCACCGCGAGATGCGCGCCCGTGACAACTGGGCGCTGTTGCATGCGCAGCAGTGCGCCGCGGCCGGCGGAGCGC
CTCTGGCCGTGGTGTTCTGCCTTGTGCCGCAGTTTATCGATGCCGGACTGCGGCATTTCCATTTTATGCTGCAGGGGCTG
GAAGAAACTGCCCGTATTCTGGAAGAGCTGGGCATTCCGCTGTTTCTTCTGCGCGGTACGCCGCCGGAGGAGGTTGTCCG
CTTTGCACAGGCGCACGGCGCGTCACGCGTGGTGACCGATTTTGACACGCTGCGCATCAAGCGGCAGTGGATACGCAGCG
CGGTGGAAGCCGCCAGACAGCTGGACATAGCCGTGGATGTGGTGGACAGCCGCAATGTGGTGCCCTGCCTGCGTGCTTCT
GACAAACGTGAATACGCGGCCCGTACCATACGCCCTAAAATTCACCGCCTGCTTGATGAATACCTTGATCCGCTGCCTGC
CCTGCAGCCCGCAGCCGTGCCGTGGAAAGGCGCGTATCAGCGTCCGGACTGGCAGGCGGCGCTGGACAGTCTGCAGGCCG
ATGCATCAGTGCAGCCGGCGGGCTGGCTGCCCCCCGGAGAGAACGCGGCACTGGCCGAACTGACGGCGTTCATCAGGGTG
CGTATGCACCGTTATGCCGCCGAACGGAATAATCCGCTCATGCCGGTGCTTTCGCATCTGTCACCATATCTGCATTTCGG
CATGCTGTCGGCTCAGCGCGCGGTGCTGGAGGTTATGCAGGCACAGGGGACTGCTGCCGGAGGCACGTACGGCGAAGGGG
CCGCTGCCTTTGTGGAAGAACTTGTGGTGCGGCGTGAGCTGGCGGATAATTTCTGCTGGTATGAACCGTCCTACGACAGC
GTGGAGGCTTTTCCCGACTGGGCGCTGAAGACGCTGGACAGACACCGCGCAGACCGCCGCCCGTATCTGTACGATGAGCA
GCAGCTGGAAAAGGCCCGCACCCATGACCCGCTGTGGAATGCGGCGCAGCAGGAAATGGTGCTTACCGGCAAGATGCACG
GGTACATGCGCATGTACTGGGCCAAAAAAATTCTTGAATGGACCGAGTCGCCTGAAGAGGCGCTGCGCATTGTCATCCGC
CAGAACGACCGCTGGTCGCTGGACGGGCGTGACTCCAACGGATACGCAGGCGCGGCGTGGTCTGTGGGCGGGGTGCACGA
CAGGCCGTGGCGCGAACGCGAAGTGTTTGGCACCATCCGTTTCATGAGCTATAACGGAGCACGGTCCAAATTTGATGTGG
ACGGTTATGTGGCCGCTGTGGCGGCGCTTGAAAATCATCCTGTTCCGGCACCCGTCTCCCGCTGTGGCGGCCGGCGGAAA
CCGGCACAGGGCCTGCTGCTGTAG

Upstream 100 bases:

>100_bases
TTGAGGTGGAGGAATTTTACTGGCGCGTTAACCAGACCGTAAGCGTGCTGGAAGTGATGAAAGACCTGCGGACCTGTCAG
GATACCTTGCCGGAGGGATA

Downstream 100 bases:

>100_bases
TGCTTCGCAGGAGCGGCGGCAGGACTTACCCGTCATTGCACGGCGCGGACAATCATGTCCGGACCGTGTGTATCAAGGAG
TGCATCATGGCTGAACAGGT

Product: deoxyribodipyrimidine photo-lyase type II

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MHSGRLSYSTVPPQEARGHAAGAPVLYWMHREMRARDNWALLHAQQCAAAGGAPLAVVFCLVPQFIDAGLRHFHFMLQGL
EETARILEELGIPLFLLRGTPPEEVVRFAQAHGASRVVTDFDTLRIKRQWIRSAVEAARQLDIAVDVVDSRNVVPCLRAS
DKREYAARTIRPKIHRLLDEYLDPLPALQPAAVPWKGAYQRPDWQAALDSLQADASVQPAGWLPPGENAALAELTAFIRV
RMHRYAAERNNPLMPVLSHLSPYLHFGMLSAQRAVLEVMQAQGTAAGGTYGEGAAAFVEELVVRRELADNFCWYEPSYDS
VEAFPDWALKTLDRHRADRRPYLYDEQQLEKARTHDPLWNAAQQEMVLTGKMHGYMRMYWAKKILEWTESPEEALRIVIR
QNDRWSLDGRDSNGYAGAAWSVGGVHDRPWREREVFGTIRFMSYNGARSKFDVDGYVAAVAALENHPVPAPVSRCGGRRK
PAQGLLL

Sequences:

>Translated_487_residues
MHSGRLSYSTVPPQEARGHAAGAPVLYWMHREMRARDNWALLHAQQCAAAGGAPLAVVFCLVPQFIDAGLRHFHFMLQGL
EETARILEELGIPLFLLRGTPPEEVVRFAQAHGASRVVTDFDTLRIKRQWIRSAVEAARQLDIAVDVVDSRNVVPCLRAS
DKREYAARTIRPKIHRLLDEYLDPLPALQPAAVPWKGAYQRPDWQAALDSLQADASVQPAGWLPPGENAALAELTAFIRV
RMHRYAAERNNPLMPVLSHLSPYLHFGMLSAQRAVLEVMQAQGTAAGGTYGEGAAAFVEELVVRRELADNFCWYEPSYDS
VEAFPDWALKTLDRHRADRRPYLYDEQQLEKARTHDPLWNAAQQEMVLTGKMHGYMRMYWAKKILEWTESPEEALRIVIR
QNDRWSLDGRDSNGYAGAAWSVGGVHDRPWREREVFGTIRFMSYNGARSKFDVDGYVAAVAALENHPVPAPVSRCGGRRK
PAQGLLL
>Mature_487_residues
MHSGRLSYSTVPPQEARGHAAGAPVLYWMHREMRARDNWALLHAQQCAAAGGAPLAVVFCLVPQFIDAGLRHFHFMLQGL
EETARILEELGIPLFLLRGTPPEEVVRFAQAHGASRVVTDFDTLRIKRQWIRSAVEAARQLDIAVDVVDSRNVVPCLRAS
DKREYAARTIRPKIHRLLDEYLDPLPALQPAAVPWKGAYQRPDWQAALDSLQADASVQPAGWLPPGENAALAELTAFIRV
RMHRYAAERNNPLMPVLSHLSPYLHFGMLSAQRAVLEVMQAQGTAAGGTYGEGAAAFVEELVVRRELADNFCWYEPSYDS
VEAFPDWALKTLDRHRADRRPYLYDEQQLEKARTHDPLWNAAQQEMVLTGKMHGYMRMYWAKKILEWTESPEEALRIVIR
QNDRWSLDGRDSNGYAGAAWSVGGVHDRPWREREVFGTIRFMSYNGARSKFDVDGYVAAVAALENHPVPAPVSRCGGRRK
PAQGLLL

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=435, Percent_Identity=48.735632183908, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24586398, Length=435, Percent_Identity=48.735632183908, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24586404, Length=150, Percent_Identity=57.3333333333333, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54830; Mature: 54830

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01083 DNA_PHOTOLYASES_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSGRLSYSTVPPQEARGHAAGAPVLYWMHREMRARDNWALLHAQQCAAAGGAPLAVVFC
CCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCHHHHHHH
LVPQFIDAGLRHFHFMLQGLEETARILEELGIPLFLLRGTPPEEVVRFAQAHGASRVVTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHH
FDTLRIKRQWIRSAVEAARQLDIAVDVVDSRNVVPCLRASDKREYAARTIRPKIHRLLDE
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
YLDPLPALQPAAVPWKGAYQRPDWQAALDSLQADASVQPAGWLPPGENAALAELTAFIRV
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RMHRYAAERNNPLMPVLSHLSPYLHFGMLSAQRAVLEVMQAQGTAAGGTYGEGAAAFVEE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LVVRRELADNFCWYEPSYDSVEAFPDWALKTLDRHRADRRPYLYDEQQLEKARTHDPLWN
HHHHHHHHHCCEECCCCCCCHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHH
AAQQEMVLTGKMHGYMRMYWAKKILEWTESPEEALRIVIRQNDRWSLDGRDSNGYAGAAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCEE
SVGGVHDRPWREREVFGTIRFMSYNGARSKFDVDGYVAAVAALENHPVPAPVSRCGGRRK
CCCCCCCCCCHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCC
PAQGLLL
CCCCCCC
>Mature Secondary Structure
MHSGRLSYSTVPPQEARGHAAGAPVLYWMHREMRARDNWALLHAQQCAAAGGAPLAVVFC
CCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCHHHHHHH
LVPQFIDAGLRHFHFMLQGLEETARILEELGIPLFLLRGTPPEEVVRFAQAHGASRVVTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHH
FDTLRIKRQWIRSAVEAARQLDIAVDVVDSRNVVPCLRASDKREYAARTIRPKIHRLLDE
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
YLDPLPALQPAAVPWKGAYQRPDWQAALDSLQADASVQPAGWLPPGENAALAELTAFIRV
HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RMHRYAAERNNPLMPVLSHLSPYLHFGMLSAQRAVLEVMQAQGTAAGGTYGEGAAAFVEE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LVVRRELADNFCWYEPSYDSVEAFPDWALKTLDRHRADRRPYLYDEQQLEKARTHDPLWN
HHHHHHHHHCCEECCCCCCCHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHH
AAQQEMVLTGKMHGYMRMYWAKKILEWTESPEEALRIVIRQNDRWSLDGRDSNGYAGAAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCEE
SVGGVHDRPWREREVFGTIRFMSYNGARSKFDVDGYVAAVAALENHPVPAPVSRCGGRRK
CCCCCCCCCCHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCC
PAQGLLL
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7813451; 9371463 [H]