Click here to switch to the map view.

The map label for this gene is yhfN [H]

Identifier: 78355117

GI number: 78355117

Start: 60822

End: 62105

Strand: Direct

Name: yhfN [H]

Synonym: Dde_0070

Alternate gene names: 78355117

Gene position: 60822-62105 (Clockwise)

Preceding gene: 78355115

Following gene: 78355119

Centisome position: 1.63

GC content: 59.89

Gene sequence:

>1284_bases
ATGAACACGTATTGTATCATCATACTGGCGGCGGTGACGGGCAGTTGGCTGTTGCAGACCGCAGCGGCGGTGCTGGGGCT
GGGGAGGACAGGAACTCCGCTGCCTGCGGGTACAGGGCTGGATATGGAACCGGCGCGGCGCGAACGTATGCAGCGGTATG
TGGCTTCCGGAATGCGTCTGAACATCGCCGAGGACACGGCAGGTACGGCGGTGTTTCTGGTGTTCTGGCTTTGCGGGGGC
TTTGGGGTCGCGGATGCGCTGTCGAGGTCTGCCGGTGCGTTGCTTGGCGGCTTTGCAGGGGGTGGTCCGGCGGTAACCGG
AATCATGACCGGTCTGGTTTTCTTCGGCCTGCTGGGAGTGCTTTCGTCGCTGGCAGGTCTGCCTTTTTCTTTGTGGCGGA
CTTTTGTGCACGAAGAACGCTTCGGCTTCAACAGAACAACTCCGCTGACGTTTGTTGCGGACAGGCTGAAAGCCGGATTG
CTGGTTGCCGTTATGGGCGGTCCGCTGGCGGCCGGTGTGTTGTGGCTGCTGGCCCTGTACGGTCCGGAAGCGTGGCTGCC
CGTATGGCTGCTGGTCAGTGTGTTTTCGTTGCTGGTGTCTTTTCTGGCTCCGCGGTATCTGCTGCCGCTGTTTAATACCT
TTACTCCGCTGCCGCAGGGCGCATTGCGCAGTGCCATAGACAGATATGTGACAGGACAGGGGTATACGCTGTCGGGACTT
TTTGTTGTGGACGGGTCGCGGCGCAGCGCCAAGGTCAATGCTTATTTTACGGGTCTGGGCAGGCAGCGCCGCATAGCGCT
GTTTGATACGCTGCTGGAAAAACTGGATGACGATGAAGTTGTGGCGGTTGTGGCGCACGAGGTGGGGCACTGCACACTGG
GCCACATACCGGTGATGCTGGGGCTGAGCGTGGCACGCACCGGACTGATGCTCTGGCTGCTTTCTTTTTTTCTGACGGAG
CCGCAGCTTTTTGCGGCATTCGGTGTGCAGCAGGTGTCATACCATGCCGGTCTGGTCTTTTTTTCGCTGCTGTTCACTCC
GGTGTCTTTGTTTACCGGTGTGGGCTTCCATGCTTTGCTGCGGCGCAATGAATACGCCGCGGATGCCTTTGCAGCGCGCA
CCACAGGGCGTCCGGATGTGTTGTCTTCCGCGCTGCGTAAACTGGCATCCGAAAATATGACTAATCTGAACCCGCATCCG
TTGCAGGTTGCTCTGCACTACACACACCCGCCGCTGGTGCAGCGGCTGCAAGCTCTCGGCGCGTTGCCGGTACGGCGCGG
CTGA

Upstream 100 bases:

>100_bases
GAGGGTGCAGGGAGATCATCTCCCTGCCCGCCGGAGGCTTTTCTTTCGCGGGCGCTCATCTGTCAGAACGTAAAGCTGCT
GCGGCAGCGGGAATTCCACC

Downstream 100 bases:

>100_bases
CGCCGCAGACTGCTGCCGGCTGCGGTGCCCGCGACCGGCCGGTACGGTCAGCTGCGTGCCGAAACATCGTCGGGGCGTGA
GCTGTGCGGCACTCCTGTTC

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNTYCIIILAAVTGSWLLQTAAAVLGLGRTGTPLPAGTGLDMEPARRERMQRYVASGMRLNIAEDTAGTAVFLVFWLCGG
FGVADALSRSAGALLGGFAGGGPAVTGIMTGLVFFGLLGVLSSLAGLPFSLWRTFVHEERFGFNRTTPLTFVADRLKAGL
LVAVMGGPLAAGVLWLLALYGPEAWLPVWLLVSVFSLLVSFLAPRYLLPLFNTFTPLPQGALRSAIDRYVTGQGYTLSGL
FVVDGSRRSAKVNAYFTGLGRQRRIALFDTLLEKLDDDEVVAVVAHEVGHCTLGHIPVMLGLSVARTGLMLWLLSFFLTE
PQLFAAFGVQQVSYHAGLVFFSLLFTPVSLFTGVGFHALLRRNEYAADAFAARTTGRPDVLSSALRKLASENMTNLNPHP
LQVALHYTHPPLVQRLQALGALPVRRG

Sequences:

>Translated_427_residues
MNTYCIIILAAVTGSWLLQTAAAVLGLGRTGTPLPAGTGLDMEPARRERMQRYVASGMRLNIAEDTAGTAVFLVFWLCGG
FGVADALSRSAGALLGGFAGGGPAVTGIMTGLVFFGLLGVLSSLAGLPFSLWRTFVHEERFGFNRTTPLTFVADRLKAGL
LVAVMGGPLAAGVLWLLALYGPEAWLPVWLLVSVFSLLVSFLAPRYLLPLFNTFTPLPQGALRSAIDRYVTGQGYTLSGL
FVVDGSRRSAKVNAYFTGLGRQRRIALFDTLLEKLDDDEVVAVVAHEVGHCTLGHIPVMLGLSVARTGLMLWLLSFFLTE
PQLFAAFGVQQVSYHAGLVFFSLLFTPVSLFTGVGFHALLRRNEYAADAFAARTTGRPDVLSSALRKLASENMTNLNPHP
LQVALHYTHPPLVQRLQALGALPVRRG
>Mature_427_residues
MNTYCIIILAAVTGSWLLQTAAAVLGLGRTGTPLPAGTGLDMEPARRERMQRYVASGMRLNIAEDTAGTAVFLVFWLCGG
FGVADALSRSAGALLGGFAGGGPAVTGIMTGLVFFGLLGVLSSLAGLPFSLWRTFVHEERFGFNRTTPLTFVADRLKAGL
LVAVMGGPLAAGVLWLLALYGPEAWLPVWLLVSVFSLLVSFLAPRYLLPLFNTFTPLPQGALRSAIDRYVTGQGYTLSGL
FVVDGSRRSAKVNAYFTGLGRQRRIALFDTLLEKLDDDEVVAVVAHEVGHCTLGHIPVMLGLSVARTGLMLWLLSFFLTE
PQLFAAFGVQQVSYHAGLVFFSLLFTPVSLFTGVGFHALLRRNEYAADAFAARTTGRPDVLSSALRKLASENMTNLNPHP
LQVALHYTHPPLVQRLQALGALPVRRG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=434, Percent_Identity=32.258064516129, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505484, Length=342, Percent_Identity=30.1169590643275, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322577, Length=316, Percent_Identity=32.2784810126582, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19922414, Length=330, Percent_Identity=34.2424242424242, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI78707252, Length=339, Percent_Identity=27.7286135693215, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI78707254, Length=339, Percent_Identity=27.7286135693215, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24654305, Length=259, Percent_Identity=27.4131274131274, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 45892; Mature: 45892

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYCIIILAAVTGSWLLQTAAAVLGLGRTGTPLPAGTGLDMEPARRERMQRYVASGMRL
CCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
NIAEDTAGTAVFLVFWLCGGFGVADALSRSAGALLGGFAGGGPAVTGIMTGLVFFGLLGV
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LSSLAGLPFSLWRTFVHEERFGFNRTTPLTFVADRLKAGLLVAVMGGPLAAGVLWLLALY
HHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
GPEAWLPVWLLVSVFSLLVSFLAPRYLLPLFNTFTPLPQGALRSAIDRYVTGQGYTLSGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEE
FVVDGSRRSAKVNAYFTGLGRQRRIALFDTLLEKLDDDEVVAVVAHEVGHCTLGHIPVML
EEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHH
GLSVARTGLMLWLLSFFLTEPQLFAAFGVQQVSYHAGLVFFSLLFTPVSLFTGVGFHALL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RRNEYAADAFAARTTGRPDVLSSALRKLASENMTNLNPHPLQVALHYTHPPLVQRLQALG
HCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHC
ALPVRRG
CCCCCCC
>Mature Secondary Structure
MNTYCIIILAAVTGSWLLQTAAAVLGLGRTGTPLPAGTGLDMEPARRERMQRYVASGMRL
CCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
NIAEDTAGTAVFLVFWLCGGFGVADALSRSAGALLGGFAGGGPAVTGIMTGLVFFGLLGV
EECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LSSLAGLPFSLWRTFVHEERFGFNRTTPLTFVADRLKAGLLVAVMGGPLAAGVLWLLALY
HHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
GPEAWLPVWLLVSVFSLLVSFLAPRYLLPLFNTFTPLPQGALRSAIDRYVTGQGYTLSGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEE
FVVDGSRRSAKVNAYFTGLGRQRRIALFDTLLEKLDDDEVVAVVAHEVGHCTLGHIPVML
EEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHH
GLSVARTGLMLWLLSFFLTEPQLFAAFGVQQVSYHAGLVFFSLLFTPVSLFTGVGFHALL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RRNEYAADAFAARTTGRPDVLSSALRKLASENMTNLNPHPLQVALHYTHPPLVQRLQALG
HCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHC
ALPVRRG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]