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The map label for this gene is mtnU [H]

Identifier: 78224719

GI number: 78224719

Start: 3970401

End: 3971180

Strand: Direct

Name: mtnU [H]

Synonym: Gmet_3536

Alternate gene names: 78224719

Gene position: 3970401-3971180 (Clockwise)

Preceding gene: 78224713

Following gene: 78224720

Centisome position: 99.32

GC content: 65.51

Gene sequence:

>780_bases
ATGACGCGTACCGTGAAGGCAGGAGCCGTCCAGTTCACCATCAAGGTTGGCGATGTGGACGTCAACATGCGGTATGTGGA
GGGGGCGCTGCGCCGCCTCGCCGCCCAGGGGTGCGCCCTGGCGGTCCTCCCCGAGATGTGGGACACGGGCTATGCCTACC
GGGAGCTGAACGAGCTGGCAAAGCGGACCCCCGAGGTGGTGACGGAACTGGGACGGCTCTCCCGGGAGCTGGGGATGGTG
ATCGTCGGGAGCATGCCGGAGCCCCATGGGGAAAAGGTCTGCAATACCGCCTACGTCCTGGACCGGGGGGAGCTGGTCGG
CTCCTACCGGAAGATCCACCTCTTCTCCCTCATGGGGGAGGACCGCTCCTTGGACGGCGGCGACCGCTGGCTCGTGGTGG
ATACCAGCGTGGGACGGATCGGCGTCTTCATCTGCTACGACCTCCGGTTCCCGGAGCTGACCCGGCGGCTGGCGGTGGAG
GGGGCGGAGATTCTCGTGGTGCCAGCCGAATGGCCCAAGCCCCGGGACGAGCACTGGAAGGCGCTCCTGAAGGCGCGTGC
CATCGAGAACCAGCTCTTCGTGGTGGCGGCCAACTGCTGCGGAATCCAGGGAAAGCTGGACTTCTTCGGTTCAAGCCTCA
TCATCGGCCCCAAGGGGGAGCACCTGGCCGAGGGGGGGTATGAGCCGTGCGAGATCAGCGCCACCCTCGACTTTGGCGAA
ATGCAATCCTGGCGGCGGCAGATCCCCTGCTTCGAGGATCGAAAGCCCGAATATTACTAA

Upstream 100 bases:

>100_bases
ACGTGGAAGTCCAAACTTCTTTGGTTGAAAATGGCCCGGTATGCCGCTACACTAAACGGCGTTCCGCAGGCACCCCAAAA
GGACCCGGAGGGAGATCGGC

Downstream 100 bases:

>100_bases
GATTATTCTCTGCCGATTTCGGTCGGCTTCAGGAAAACGGTTGACGCGACGGCGGGCCGGGACTATTGTTCAGCGATCAC
GTAACCCATTAATTATTAAC

Product: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTRTVKAGAVQFTIKVGDVDVNMRYVEGALRRLAAQGCALAVLPEMWDTGYAYRELNELAKRTPEVVTELGRLSRELGMV
IVGSMPEPHGEKVCNTAYVLDRGELVGSYRKIHLFSLMGEDRSLDGGDRWLVVDTSVGRIGVFICYDLRFPELTRRLAVE
GAEILVVPAEWPKPRDEHWKALLKARAIENQLFVVAANCCGIQGKLDFFGSSLIIGPKGEHLAEGGYEPCEISATLDFGE
MQSWRRQIPCFEDRKPEYY

Sequences:

>Translated_259_residues
MTRTVKAGAVQFTIKVGDVDVNMRYVEGALRRLAAQGCALAVLPEMWDTGYAYRELNELAKRTPEVVTELGRLSRELGMV
IVGSMPEPHGEKVCNTAYVLDRGELVGSYRKIHLFSLMGEDRSLDGGDRWLVVDTSVGRIGVFICYDLRFPELTRRLAVE
GAEILVVPAEWPKPRDEHWKALLKARAIENQLFVVAANCCGIQGKLDFFGSSLIIGPKGEHLAEGGYEPCEISATLDFGE
MQSWRRQIPCFEDRKPEYY
>Mature_258_residues
TRTVKAGAVQFTIKVGDVDVNMRYVEGALRRLAAQGCALAVLPEMWDTGYAYRELNELAKRTPEVVTELGRLSRELGMVI
VGSMPEPHGEKVCNTAYVLDRGELVGSYRKIHLFSLMGEDRSLDGGDRWLVVDTSVGRIGVFICYDLRFPELTRRLAVEG
AEILVVPAEWPKPRDEHWKALLKARAIENQLFVVAANCCGIQGKLDFFGSSLIIGPKGEHLAEGGYEPCEISATLDFGEM
QSWRRQIPCFEDRKPEYY

Specific function: May be involved in a regulatory step in the methylthioribose (MTR) recycling pathway [H]

COG id: COG0388

COG function: function code R; Predicted amidohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 CN hydrolase domain [H]

Homologues:

Organism=Homo sapiens, GI9910460, Length=242, Percent_Identity=31.8181818181818, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI297632348, Length=272, Percent_Identity=33.4558823529412, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI297632350, Length=272, Percent_Identity=33.4558823529412, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI5031947, Length=272, Percent_Identity=33.4558823529412, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI297632346, Length=182, Percent_Identity=32.4175824175824, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786412, Length=238, Percent_Identity=31.0924369747899, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17556280, Length=260, Percent_Identity=30, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323383, Length=281, Percent_Identity=28.4697508896797, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322335, Length=306, Percent_Identity=24.1830065359477, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17933642, Length=273, Percent_Identity=32.6007326007326, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355835, Length=261, Percent_Identity=29.8850574712644, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21358471, Length=256, Percent_Identity=25.78125, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003010 [H]

Pfam domain/function: PF00795 CN_hydrolase [H]

EC number: 3.5.-.- [C]

Molecular weight: Translated: 29031; Mature: 28900

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50263 CN_HYDROLASE ; PS01227 UPF0012

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTVKAGAVQFTIKVGDVDVNMRYVEGALRRLAAQGCALAVLPEMWDTGYAYRELNELA
CCCEEECCEEEEEEEECCEEEEHHHHHHHHHHHHHCCCEEEECHHHHCCCHHHHHHHHHH
KRTPEVVTELGRLSRELGMVIVGSMPEPHGEKVCNTAYVLDRGELVGSYRKIHLFSLMGE
HCCHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHEEEEECHHHHCCHHEEEEEEEECC
DRSLDGGDRWLVVDTSVGRIGVFICYDLRFPELTRRLAVEGAEILVVPAEWPKPRDEHWK
CCCCCCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
ALLKARAIENQLFVVAANCCGIQGKLDFFGSSLIIGPKGEHLAEGGYEPCEISATLDFGE
HHHHHHHHCCEEEEEEECCCCCCCCHHHCCCEEEECCCCCHHHCCCCCCEEEEEEECHHH
MQSWRRQIPCFEDRKPEYY
HHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TRTVKAGAVQFTIKVGDVDVNMRYVEGALRRLAAQGCALAVLPEMWDTGYAYRELNELA
CCEEECCEEEEEEEECCEEEEHHHHHHHHHHHHHCCCEEEECHHHHCCCHHHHHHHHHH
KRTPEVVTELGRLSRELGMVIVGSMPEPHGEKVCNTAYVLDRGELVGSYRKIHLFSLMGE
HCCHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHEEEEECHHHHCCHHEEEEEEEECC
DRSLDGGDRWLVVDTSVGRIGVFICYDLRFPELTRRLAVEGAEILVVPAEWPKPRDEHWK
CCCCCCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
ALLKARAIENQLFVVAANCCGIQGKLDFFGSSLIIGPKGEHLAEGGYEPCEISATLDFGE
HHHHHHHHCCEEEEEEECCCCCCCCHHHCCCEEEECCCCCHHHCCCCCCEEEEEEECHHH
MQSWRRQIPCFEDRKPEYY
HHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 12022921 [H]