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The map label for this gene is capA [H]

Identifier: 78224712

GI number: 78224712

Start: 3962463

End: 3963512

Strand: Direct

Name: capA [H]

Synonym: Gmet_3529

Alternate gene names: 78224712

Gene position: 3962463-3963512 (Clockwise)

Preceding gene: 78224703

Following gene: 78224713

Centisome position: 99.13

GC content: 66.38

Gene sequence:

>1050_bases
ATGCGCCAGGTCCGGCTTATGCTTGCCGCCATCGTCACCCTCCTTGCCGTCCCGGCCCTGGGCGCCGACGGAATCGTCAT
CACCTGCGTCGGCGACATCATGCTCGCCGGCAGCGCCACACCGACCCTCTCCCGGTCGGGATACGACTACCCCTTCGCGA
AGACGGCCCAGGAACTTCGGCGGGGCGATATTGCCATGGGGAACCTGGAGGCCCCCCTTACGGAGCGCGGAACCGAGTAC
CGGGACAAAACGTACCGTTTCCGGACAAACCCCATCGCTGCAGCAGCCTTGAAGCGGGCCGGCTTCTCGGTCCTCACCCT
GGCCAACAACCACATGATGGATTACGGAAATGAGGGACTCCAGGACACCCTGGCGACCCTCTCCCGCCACGGCATTGCCC
ACACGGGCGCCGGCGCGTCACTGGCCGAGGCCCGCCGGGAGGCGGTGGTCTCGGTGCGGGGGAAGCGGATCGCCTTCCTC
GCTTATTCCCTCACCTTTCCGTCGGAGTTCTATGCTGGCCCGAACCGGCCAGGCACCGCCCCCGGCTACGCCCCCCATGT
ACGGGAGGATATCAGGCGGGCGAAGGCGGAGGCCGACTACGTGGTGGTCTCGTTCCACTGGGGGGCGGAACGGGCAGAGT
TTCCGAAGCAGTACCAGACGGAGACTGCCCGATTGGCCATTGATGCCGGCGCCGACGCCATCATCGGCCACCACCCCCAC
GTGCTCCAGGGGATCGAATTCTACCGGGGAAAGCCGATTCTCTACAGCCTCGGCAACTTCGCCTTCGGCAGCCGGAGCAC
CGCCGCCGATCGGAGCGTCATGGCACGGCTGACCCTCTCCGACGAAGAAACCTCCGTGGAACTGGTACCCCTGAACGTTC
TGCACCGGGAGACCCGCTACCAGCCCGGCATCCTTGCGGGGCGCAAGGGAGCGGAGGTTATCGAGCGGCTGAACCGGCTG
TCGCAACCGTTCGGCACGGTGATTTCGGGTTCTGCGGGGCGCTTCAGGGCAAGAACATCCGGAGCCGACCAGCGCATCGC
CACCCGCTGA

Upstream 100 bases:

>100_bases
GGGTCAAGCATGGATAAGTCCTTTACTTTTCAGGCATTAAAGCTATAGTTCTTAGCATCCGTATCCCCAAGAGTCAACCG
TTTTCCCCCTCGGAGTCCCC

Downstream 100 bases:

>100_bases
CGGGTTGGAAAGGAGGCGCGTCATGCGCCTGTTCGTGGCAATCGATCTTCCCGACGAGGTCAAACGGTCAGTGGCTGATA
TCTGCCGGGGAGTCCCCGGA

Product: capsule biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MRQVRLMLAAIVTLLAVPALGADGIVITCVGDIMLAGSATPTLSRSGYDYPFAKTAQELRRGDIAMGNLEAPLTERGTEY
RDKTYRFRTNPIAAAALKRAGFSVLTLANNHMMDYGNEGLQDTLATLSRHGIAHTGAGASLAEARREAVVSVRGKRIAFL
AYSLTFPSEFYAGPNRPGTAPGYAPHVREDIRRAKAEADYVVVSFHWGAERAEFPKQYQTETARLAIDAGADAIIGHHPH
VLQGIEFYRGKPILYSLGNFAFGSRSTAADRSVMARLTLSDEETSVELVPLNVLHRETRYQPGILAGRKGAEVIERLNRL
SQPFGTVISGSAGRFRARTSGADQRIATR

Sequences:

>Translated_349_residues
MRQVRLMLAAIVTLLAVPALGADGIVITCVGDIMLAGSATPTLSRSGYDYPFAKTAQELRRGDIAMGNLEAPLTERGTEY
RDKTYRFRTNPIAAAALKRAGFSVLTLANNHMMDYGNEGLQDTLATLSRHGIAHTGAGASLAEARREAVVSVRGKRIAFL
AYSLTFPSEFYAGPNRPGTAPGYAPHVREDIRRAKAEADYVVVSFHWGAERAEFPKQYQTETARLAIDAGADAIIGHHPH
VLQGIEFYRGKPILYSLGNFAFGSRSTAADRSVMARLTLSDEETSVELVPLNVLHRETRYQPGILAGRKGAEVIERLNRL
SQPFGTVISGSAGRFRARTSGADQRIATR
>Mature_349_residues
MRQVRLMLAAIVTLLAVPALGADGIVITCVGDIMLAGSATPTLSRSGYDYPFAKTAQELRRGDIAMGNLEAPLTERGTEY
RDKTYRFRTNPIAAAALKRAGFSVLTLANNHMMDYGNEGLQDTLATLSRHGIAHTGAGASLAEARREAVVSVRGKRIAFL
AYSLTFPSEFYAGPNRPGTAPGYAPHVREDIRRAKAEADYVVVSFHWGAERAEFPKQYQTETARLAIDAGADAIIGHHPH
VLQGIEFYRGKPILYSLGNFAFGSRSTAADRSVMARLTLSDEETSVELVPLNVLHRETRYQPGILAGRKGAEVIERLNRL
SQPFGTVISGSAGRFRARTSGADQRIATR

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 37919; Mature: 37919

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQVRLMLAAIVTLLAVPALGADGIVITCVGDIMLAGSATPTLSRSGYDYPFAKTAQELR
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHH
RGDIAMGNLEAPLTERGTEYRDKTYRFRTNPIAAAALKRAGFSVLTLANNHMMDYGNEGL
HCCEEECCCCCCHHHCCCCHHCCCEEEECCCHHHHHHHHCCCEEEEEECCCCCCCCCCCH
QDTLATLSRHGIAHTGAGASLAEARREAVVSVRGKRIAFLAYSLTFPSEFYAGPNRPGTA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHCCCCCCCCCC
PGYAPHVREDIRRAKAEADYVVVSFHWGAERAEFPKQYQTETARLAIDAGADAIIGHHPH
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHCCCHHEEEEECCCCEEECCCCH
VLQGIEFYRGKPILYSLGNFAFGSRSTAADRSVMARLTLSDEETSVELVPLNVLHRETRY
HHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHEEEEEECCCCCEEEEEEHHHHHHHHCC
QPGILAGRKGAEVIERLNRLSQPFGTVISGSAGRFRARTSGADQRIATR
CCCCEECCCHHHHHHHHHHHCCCCCHHCCCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MRQVRLMLAAIVTLLAVPALGADGIVITCVGDIMLAGSATPTLSRSGYDYPFAKTAQELR
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHH
RGDIAMGNLEAPLTERGTEYRDKTYRFRTNPIAAAALKRAGFSVLTLANNHMMDYGNEGL
HCCEEECCCCCCHHHCCCCHHCCCEEEECCCHHHHHHHHCCCEEEEEECCCCCCCCCCCH
QDTLATLSRHGIAHTGAGASLAEARREAVVSVRGKRIAFLAYSLTFPSEFYAGPNRPGTA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHCCCCCCCCCC
PGYAPHVREDIRRAKAEADYVVVSFHWGAERAEFPKQYQTETARLAIDAGADAIIGHHPH
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHCCCHHEEEEECCCCEEECCCCH
VLQGIEFYRGKPILYSLGNFAFGSRSTAADRSVMARLTLSDEETSVELVPLNVLHRETRY
HHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHEEEEEECCCCCEEEEEEHHHHHHHHCC
QPGILAGRKGAEVIERLNRLSQPFGTVISGSAGRFRARTSGADQRIATR
CCCCEECCCHHHHHHHHHHHCCCCCHHCCCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]