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The map label for this gene is rnr [H]

Identifier: 78222598

GI number: 78222598

Start: 1550693

End: 1552972

Strand: Direct

Name: rnr [H]

Synonym: Gmet_1386

Alternate gene names: 78222598

Gene position: 1550693-1552972 (Clockwise)

Preceding gene: 78222597

Following gene: 78222599

Centisome position: 38.79

GC content: 64.78

Gene sequence:

>2280_bases
ATGAAACGGAATCGGGAAACGGTGCAGGCGGTGATCCGCGAGCGGGGCGGTTCTGCCCCTTTCCGGGAGCTGATGCTGGC
TTTCGGGGTGACCAAGGGGGAGCGGCAGAGTTTCAAGGGGTTCGTGGACAAACTCGTCACTGACGGCCATCTCGTGCGAC
TCAGGGGAAACCGCTATGCCCTGGCCGATGGGGAGAATCTCGTGACCGGGCGGCTCACGTGCCACCCGGACGGCTACGGT
TTCGTCATTCCCGAAGGGGGAGGGGACGACGTCTATATCCCGGCCCGGGCCCTTGCCGGGAGCATGCACGGTGACACGGT
GGAGGTGCGGGTCGAGACCTTCAAGGCCGGCGGCAAGAAGGAGGGGCGGATCGTGCGGACCGTGACGCGGGGGCAAACCC
GTGTCGTGGGGCGGTTCGAGCAACTCAAGGGATTCGGGGTCGTGGTTCCCGATGAAACCCGCATCAGCCAGCAGATTGTC
ATCTCTCAGCAGGGAATCGGTCGGGCCAAGGGGGGACAGACGGTCGTGGCCGAGATCACCGCCTACCCCACGGAGAAGCG
CAGGCCCGAGGGGCGCATCGTGGAGGTGCTGGGGTGGCCCGACGACCCTGAAGTGGAAGTCCGGACCATTATCGCCAAGC
ACGGGCTCCCCTTCGAGTTCCCCGCCGAGGTGCTGGACGAGGCCCGGGCCGTTCCTCAGGCCATCGGGGAGAAGGATCTG
CAGGGGCGTACCGATCTGCGGGAGATCGTGACCGTCACCATCGACGGCGAGACGGCCCGGGACTTCGACGATGCCGTGGC
GGTCCGGAAGGAGCGGGGGGGGAACATCCGCCTCTGGGTCTCCATCGCCGATGTCTCCCATTACGTGAAGCCCGACGCGC
CCCTGGACCGGGAGGCGTACCTGCGGGGGACCTCGGTCTACTTTCCCGACCGCTGTATCCCCATGCTCCCCGAGGAGCTT
TCCAACGGCATCTGCTCCCTGAACCCCCGGGTGGAGCGGCTCACCATGACGGCGGAGATGCTCTTCACCCGCAGCGGCAC
CATGAAAGAGGCCACTTTCTACCCGAGCGTAATCAAAAGCGACGCCCGGCTCACCTACACCATTGTAAAAAAGATTCTCG
TGGACGGCGATGCCGAGGCCATGGCGGCTCACCAGGAGCTGGTCCCTCACCTGGAAGTCATGCGGGAGTTGGCCCAGAGC
CTCACGGAGAAGCGGCGTAAGCGGGGGAGCATCGACTTTGATCTCCCCGAGCCCCAGATTATCCTCGATCTCCAGGGGGA
GACCGTCGACATCATCCAGGCCGAGCGGAACCTGGCCCACCGGATCATCGAGGAGTTCATGCTGGCCGCCAACGAGGCGG
TTGCATCCCACATCGAGGCAAAGGGAATCCCCTCCCTCTACCGGGTCCACGAGCCCCCTGACCCGGCAAAGCTCATCGAC
TTCCAGGAGTTTATCTTCAATTTCGGCTTCCACTTCCGGATGGAGGGGGACCGGGTGGAGCCGGCGGAGATCCAGCGGCT
TCTGGTGGAGACCGAGGGGACGCCGGAGGAGCGGATGATCAACCAGGTGCTCCTGCGGTGCATGAAGCAGGCCCGCTACA
GTCACGAGAACCTGGGGCATTTCGGGCTTGCGGCCCGCTGTTACACCCACTTCACGTCCCCCATCCGCCGCTACCCTGAC
CTGGTCGTCCACCGCATCCTCAAGGCGCTCCTGGCCGGGAAGATTACCGACAAGGAGATCGCACGGCTGGAGACAACCCT
CCCCGAAACGGCGGAGCAGACCAGCCGGCGGGAGCGGGTCGCCATGGAGGCGGAGCGGGAGATCGTGGCCCTCAAAAAGG
CCCAGTTCATGCTCCAGAAGATCGGGGAGGACTTCGACGGCTACATCACCGGGGTCACGTCCTTCGGCCTTTTTGTGGAG
CTGACGGAGATATTCGTGGAGGGGATGGTCCACATCTCCACCATGGGTGACGACTACTACCGCTATGTGGAGAAACAGCA
TTCCCTGGTGGGTGAGCGGACGAAGGAGACCTACCGGATCGGCGACAAGGTGCGGGTGACCGTGGCGGCGGTGAGCATCG
AGAAGAAGCAGGTCGAGTTCGTGCTGGCCGGGCTTCATGAGCGGCGGCCCGGTGCCTCGTCGCCGCCGGGGTCGGAGGAG
TACCCGCGGATTGCCGTCACGGGGAAGCGCCCCCGGGTTCTTGAAGAGCGACGACGCCAGTCGAAGGGAGATAAGAAGGG
AAGCGGCAAGGGGAAGGGGCCACGCGGGAGGCGCCGGTAA

Upstream 100 bases:

>100_bases
TGCCCGCCACCGGACAGTAGTGAGTGCATATACGCATTGACTCCTGTGGCGCCCCTGTGCATAGTAGCCCCGTGCAACGG
GTAACGGGAGAGGATTGATT

Downstream 100 bases:

>100_bases
ACCCGGATATTCCATCAGACGGTGCGAAGCGCCTGCACGAGCCCTGCCGGACGCTTTCCGGCATCTTGCCGCCCGTTATC
CTCACCAATAGCCCTGCTAT

Product: 3'-5' exoribonuclease, VacB and RNase II:ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MKRNRETVQAVIRERGGSAPFRELMLAFGVTKGERQSFKGFVDKLVTDGHLVRLRGNRYALADGENLVTGRLTCHPDGYG
FVIPEGGGDDVYIPARALAGSMHGDTVEVRVETFKAGGKKEGRIVRTVTRGQTRVVGRFEQLKGFGVVVPDETRISQQIV
ISQQGIGRAKGGQTVVAEITAYPTEKRRPEGRIVEVLGWPDDPEVEVRTIIAKHGLPFEFPAEVLDEARAVPQAIGEKDL
QGRTDLREIVTVTIDGETARDFDDAVAVRKERGGNIRLWVSIADVSHYVKPDAPLDREAYLRGTSVYFPDRCIPMLPEEL
SNGICSLNPRVERLTMTAEMLFTRSGTMKEATFYPSVIKSDARLTYTIVKKILVDGDAEAMAAHQELVPHLEVMRELAQS
LTEKRRKRGSIDFDLPEPQIILDLQGETVDIIQAERNLAHRIIEEFMLAANEAVASHIEAKGIPSLYRVHEPPDPAKLID
FQEFIFNFGFHFRMEGDRVEPAEIQRLLVETEGTPEERMINQVLLRCMKQARYSHENLGHFGLAARCYTHFTSPIRRYPD
LVVHRILKALLAGKITDKEIARLETTLPETAEQTSRRERVAMEAEREIVALKKAQFMLQKIGEDFDGYITGVTSFGLFVE
LTEIFVEGMVHISTMGDDYYRYVEKQHSLVGERTKETYRIGDKVRVTVAAVSIEKKQVEFVLAGLHERRPGASSPPGSEE
YPRIAVTGKRPRVLEERRRQSKGDKKGSGKGKGPRGRRR

Sequences:

>Translated_759_residues
MKRNRETVQAVIRERGGSAPFRELMLAFGVTKGERQSFKGFVDKLVTDGHLVRLRGNRYALADGENLVTGRLTCHPDGYG
FVIPEGGGDDVYIPARALAGSMHGDTVEVRVETFKAGGKKEGRIVRTVTRGQTRVVGRFEQLKGFGVVVPDETRISQQIV
ISQQGIGRAKGGQTVVAEITAYPTEKRRPEGRIVEVLGWPDDPEVEVRTIIAKHGLPFEFPAEVLDEARAVPQAIGEKDL
QGRTDLREIVTVTIDGETARDFDDAVAVRKERGGNIRLWVSIADVSHYVKPDAPLDREAYLRGTSVYFPDRCIPMLPEEL
SNGICSLNPRVERLTMTAEMLFTRSGTMKEATFYPSVIKSDARLTYTIVKKILVDGDAEAMAAHQELVPHLEVMRELAQS
LTEKRRKRGSIDFDLPEPQIILDLQGETVDIIQAERNLAHRIIEEFMLAANEAVASHIEAKGIPSLYRVHEPPDPAKLID
FQEFIFNFGFHFRMEGDRVEPAEIQRLLVETEGTPEERMINQVLLRCMKQARYSHENLGHFGLAARCYTHFTSPIRRYPD
LVVHRILKALLAGKITDKEIARLETTLPETAEQTSRRERVAMEAEREIVALKKAQFMLQKIGEDFDGYITGVTSFGLFVE
LTEIFVEGMVHISTMGDDYYRYVEKQHSLVGERTKETYRIGDKVRVTVAAVSIEKKQVEFVLAGLHERRPGASSPPGSEE
YPRIAVTGKRPRVLEERRRQSKGDKKGSGKGKGPRGRRR
>Mature_759_residues
MKRNRETVQAVIRERGGSAPFRELMLAFGVTKGERQSFKGFVDKLVTDGHLVRLRGNRYALADGENLVTGRLTCHPDGYG
FVIPEGGGDDVYIPARALAGSMHGDTVEVRVETFKAGGKKEGRIVRTVTRGQTRVVGRFEQLKGFGVVVPDETRISQQIV
ISQQGIGRAKGGQTVVAEITAYPTEKRRPEGRIVEVLGWPDDPEVEVRTIIAKHGLPFEFPAEVLDEARAVPQAIGEKDL
QGRTDLREIVTVTIDGETARDFDDAVAVRKERGGNIRLWVSIADVSHYVKPDAPLDREAYLRGTSVYFPDRCIPMLPEEL
SNGICSLNPRVERLTMTAEMLFTRSGTMKEATFYPSVIKSDARLTYTIVKKILVDGDAEAMAAHQELVPHLEVMRELAQS
LTEKRRKRGSIDFDLPEPQIILDLQGETVDIIQAERNLAHRIIEEFMLAANEAVASHIEAKGIPSLYRVHEPPDPAKLID
FQEFIFNFGFHFRMEGDRVEPAEIQRLLVETEGTPEERMINQVLLRCMKQARYSHENLGHFGLAARCYTHFTSPIRRYPD
LVVHRILKALLAGKITDKEIARLETTLPETAEQTSRRERVAMEAEREIVALKKAQFMLQKIGEDFDGYITGVTSFGLFVE
LTEIFVEGMVHISTMGDDYYRYVEKQHSLVGERTKETYRIGDKVRVTVAAVSIEKKQVEFVLAGLHERRPGASSPPGSEE
YPRIAVTGKRPRVLEERRRQSKGDKKGSGKGKGPRGRRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=557, Percent_Identity=29.443447037702, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI190014623, Length=557, Percent_Identity=29.443447037702, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI134288890, Length=497, Percent_Identity=28.3702213279678, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI19115966, Length=584, Percent_Identity=26.541095890411, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI219521928, Length=586, Percent_Identity=26.6211604095563, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI156105693, Length=133, Percent_Identity=36.0902255639098, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI156105695, Length=133, Percent_Identity=36.0902255639098, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI87082383, Length=672, Percent_Identity=42.1130952380952, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1787542, Length=636, Percent_Identity=26.4150943396226, Blast_Score=184, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=498, Percent_Identity=29.9196787148594, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17553506, Length=531, Percent_Identity=28.6252354048964, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324552, Length=570, Percent_Identity=28.9473684210526, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6320499, Length=496, Percent_Identity=25, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24649634, Length=630, Percent_Identity=29.5238095238095, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI19922976, Length=412, Percent_Identity=31.3106796116505, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24654597, Length=412, Percent_Identity=31.3106796116505, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24654592, Length=412, Percent_Identity=31.3106796116505, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85306; Mature: 85306

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNRETVQAVIRERGGSAPFRELMLAFGVTKGERQSFKGFVDKLVTDGHLVRLRGNRYA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCEEE
LADGENLVTGRLTCHPDGYGFVIPEGGGDDVYIPARALAGSMHGDTVEVRVETFKAGGKK
EECCCCEEEEEEEECCCCEEEEEECCCCCCEEEEHHHHCCCCCCCEEEEEEEEECCCCCC
EGRIVRTVTRGQTRVVGRFEQLKGFGVVVPDETRISQQIVISQQGIGRAKGGQTVVAEIT
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCHHCCHHHEEECCCCCCCCCCCEEEEEEE
AYPTEKRRPEGRIVEVLGWPDDPEVEVRTIIAKHGLPFEFPAEVLDEARAVPQAIGEKDL
ECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
QGRTDLREIVTVTIDGETARDFDDAVAVRKERGGNIRLWVSIADVSHYVKPDAPLDREAY
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECHHHHCCCCCCCCHHHH
LRGTSVYFPDRCIPMLPEELSNGICSLNPRVERLTMTAEMLFTRSGTMKEATFYPSVIKS
CCCCCEECCCCCCCCCCHHHCCCEECCCCCHHHHHHHHHHHHHCCCCCCHHHHCHHHHCC
DARLTYTIVKKILVDGDAEAMAAHQELVPHLEVMRELAQSLTEKRRKRGSIDFDLPEPQI
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
ILDLQGETVDIIQAERNLAHRIIEEFMLAANEAVASHIEAKGIPSLYRVHEPPDPAKLID
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHH
FQEFIFNFGFHFRMEGDRVEPAEIQRLLVETEGTPEERMINQVLLRCMKQARYSHENLGH
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
FGLAARCYTHFTSPIRRYPDLVVHRILKALLAGKITDKEIARLETTLPETAEQTSRRERV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
AMEAEREIVALKKAQFMLQKIGEDFDGYITGVTSFGLFVELTEIFVEGMVHISTMGDDYY
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEEEECCHHHH
RYVEKQHSLVGERTKETYRIGDKVRVTVAAVSIEKKQVEFVLAGLHERRPGASSPPGSEE
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCC
YPRIAVTGKRPRVLEERRRQSKGDKKGSGKGKGPRGRRR
CCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRNRETVQAVIRERGGSAPFRELMLAFGVTKGERQSFKGFVDKLVTDGHLVRLRGNRYA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCEEE
LADGENLVTGRLTCHPDGYGFVIPEGGGDDVYIPARALAGSMHGDTVEVRVETFKAGGKK
EECCCCEEEEEEEECCCCEEEEEECCCCCCEEEEHHHHCCCCCCCEEEEEEEEECCCCCC
EGRIVRTVTRGQTRVVGRFEQLKGFGVVVPDETRISQQIVISQQGIGRAKGGQTVVAEIT
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCHHCCHHHEEECCCCCCCCCCCEEEEEEE
AYPTEKRRPEGRIVEVLGWPDDPEVEVRTIIAKHGLPFEFPAEVLDEARAVPQAIGEKDL
ECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
QGRTDLREIVTVTIDGETARDFDDAVAVRKERGGNIRLWVSIADVSHYVKPDAPLDREAY
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECHHHHCCCCCCCCHHHH
LRGTSVYFPDRCIPMLPEELSNGICSLNPRVERLTMTAEMLFTRSGTMKEATFYPSVIKS
CCCCCEECCCCCCCCCCHHHCCCEECCCCCHHHHHHHHHHHHHCCCCCCHHHHCHHHHCC
DARLTYTIVKKILVDGDAEAMAAHQELVPHLEVMRELAQSLTEKRRKRGSIDFDLPEPQI
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
ILDLQGETVDIIQAERNLAHRIIEEFMLAANEAVASHIEAKGIPSLYRVHEPPDPAKLID
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHH
FQEFIFNFGFHFRMEGDRVEPAEIQRLLVETEGTPEERMINQVLLRCMKQARYSHENLGH
HHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
FGLAARCYTHFTSPIRRYPDLVVHRILKALLAGKITDKEIARLETTLPETAEQTSRRERV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
AMEAEREIVALKKAQFMLQKIGEDFDGYITGVTSFGLFVELTEIFVEGMVHISTMGDDYY
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHEEEECCHHHH
RYVEKQHSLVGERTKETYRIGDKVRVTVAAVSIEKKQVEFVLAGLHERRPGASSPPGSEE
HHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCC
YPRIAVTGKRPRVLEERRRQSKGDKKGSGKGKGPRGRRR
CCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]