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The map label for this gene is capD [H]

Identifier: 78222551

GI number: 78222551

Start: 1496100

End: 1498040

Strand: Direct

Name: capD [H]

Synonym: Gmet_1338

Alternate gene names: 78222551

Gene position: 1496100-1498040 (Clockwise)

Preceding gene: 304570570

Following gene: 78222552

Centisome position: 37.43

GC content: 57.91

Gene sequence:

>1941_bases
ATGCTCAAACCATTCACCTTCATGCTCTCCCAACGTCGCCTGATGGTCTTCGCCCTCGATACGGCGTCCATCGCTGCGTC
GTTCCTCCTCGCCTTCCTCCTCCGCTTCGACTTCACCTTTCCGCCGTTGTACCACGAAATTATCAAGGACGGCCTGCTGG
TTGTCCTGCTTGTAAAGCCTCTGGTTTTCCTTTTTTCGGGCATGTACCGCAGTATCTGGAAATACGCTTCATTACAGGAC
GGCATCGAAATTTTCAAGGTAGTAACCCTTTCCACGCTCATCACCTCCTTTGTCCTTTTTTTCCTGCATGATACCAGTGC
CATGCCCCGTTCCATCTATGTGCTCGACTGGGTTCTGCTCTTTGCCATGGTATCGACGTCACGGCTTCTGTGGCGGGTCT
ACCGTGAGACCTACATCATCCCCCGCTACCATACCGGCAAGCGGACGCTGATCGTCGGAGCCGGCGAGGCGGGCAACCTG
CTATTGAAGGAAATAAGAAAGCAGAAAAATCCAGCAAACCAGGTCATCGGATTCCTCGACGACGACCCGGCAAAGCAGGG
GATGCGCCTGGGAGGGATTCCGGTTATGGGTGATCTCGGCCGCCTTCGGGCCGCCATCCGGAAGCACCGGATTGAAGAGG
TCATTATCGCCATCGCGACTGCCCAGGGTGCTCTAACGCGCCAGGTTGTCTCCTGCTGCAAGGAGACCAAGGTCAGGTTC
AAGACCCTGCCGGGGATCAAGGATATCATCGATGGCACGGTCTCCATCTCCCAGATCAAGGATGTGGAGATCGAGGACAT
TCTCGGCCGTGAGCCGGTGAAGCTGGACCTGGAAACCATCCGGGGATACCTGACCAACAAGCGCGTACTGGTGACCGGCG
CGGCGGGGAGCATCGGCAGCGAAATCTGCCGCCAGGTGGCAGCGTTCTCCCCCTACAAGCTGCTCCTCTTCGAGAGCGCG
GAAACCCCCCTCTACCAGATCGAAAAAGAGCTTACGGCCAGCCACCCTGATCTCCGGATCATTCCGGTCATCGGCGACGT
GCGGGACCAGGCCAGGGTCGAGATGGTTTTTGACGAGTTCCAGCCCGAGGTGGTCTTTCACGCGGCAGCCTACAAGCATG
TGCCGATGATGGAGTATAACCCGGTGGAAGCGGTTACCAACAATATCGGCGGTACTCGAACGCTGGCGAATGCAGCCCAT
CGGTTCGGGGTTAAGAATTTCGTCATGATCTCCACCGACAAGGCGGTGAACCCGACCAACATCATGGGGGCTTCGAAGCG
GGTTGCGGAGATGTATGTCCAGGGCCTGGCGAGGAAGAGCCGGACAAATTTTACCACTGTCCGTTTTGGTAACGTGCTGG
GGAGCAACGGGAGCGTGATCCCGCTCTTCAAGGAGCAGATCAAGGCGGGAGGGCCGGTTACGGTCACCGACCCCAAGGTG
ATCCGCTACTTCATGACCATCCCCGAGGCGTGCCAGCTGGTGCTCCAGGCAGGGTGCATCGGCAACGGCGGCGAGATCTT
CGTACTCGACATGGGGGAGCCGGTCCGCATCCTTGACCTGGCGGAAGAGCTGATCAGGCTTTCGGGGTTTGTTCCCCATG
AGGAGATTGATATCGTTTTCACGGGATTGCGGCCCGGCGAGAAGCTTTTTGAGGAACTGCTCATCGACGGCGAGGGGATC
AAGCCGACACGGCACGGGAAGATCAAGGTTCTTGCGGCTATGGATTCCGATTTCGATGCCGTTGAAAGGAATCTGGGCGT
TCTCTTTGCCATGGCCGGGAACGCCGACATCGCGGGTATCGTGAAGCAGCTTCGGGTGCTTATCCCGGAATTCTCGCCCC
AGTATTCTTTCAACGGTCCGGCCCCCATTGCGTTCCAGCGGGTCCGTCCCGATCTTTTCCCGCCCCCGTCTTCGAAGGTG
GTCAAGTTGCAGAAGTCGTGA

Upstream 100 bases:

>100_bases
TGAAAATAATGATTTTGACTGCAATCAAGGTGTTACGCCGCGATGGTGTGACCCACTAAGTTTATACAAATACAAGCAAG
TGAAGGGACCGCCGTCAACC

Downstream 100 bases:

>100_bases
AGATAACGCAACCTGGAGGGGGGCAATTCAGGGTACGCGTTGATTGACCATCATTTCAACTCCTGCTATCATGTCTTACT
AAATCTTACCTGAGGGTAAC

Product: polysaccharide biosynthesis protein CapD

Products: UDPglucoseal [C]

Alternate protein names: NA

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MLKPFTFMLSQRRLMVFALDTASIAASFLLAFLLRFDFTFPPLYHEIIKDGLLVVLLVKPLVFLFSGMYRSIWKYASLQD
GIEIFKVVTLSTLITSFVLFFLHDTSAMPRSIYVLDWVLLFAMVSTSRLLWRVYRETYIIPRYHTGKRTLIVGAGEAGNL
LLKEIRKQKNPANQVIGFLDDDPAKQGMRLGGIPVMGDLGRLRAAIRKHRIEEVIIAIATAQGALTRQVVSCCKETKVRF
KTLPGIKDIIDGTVSISQIKDVEIEDILGREPVKLDLETIRGYLTNKRVLVTGAAGSIGSEICRQVAAFSPYKLLLFESA
ETPLYQIEKELTASHPDLRIIPVIGDVRDQARVEMVFDEFQPEVVFHAAAYKHVPMMEYNPVEAVTNNIGGTRTLANAAH
RFGVKNFVMISTDKAVNPTNIMGASKRVAEMYVQGLARKSRTNFTTVRFGNVLGSNGSVIPLFKEQIKAGGPVTVTDPKV
IRYFMTIPEACQLVLQAGCIGNGGEIFVLDMGEPVRILDLAEELIRLSGFVPHEEIDIVFTGLRPGEKLFEELLIDGEGI
KPTRHGKIKVLAAMDSDFDAVERNLGVLFAMAGNADIAGIVKQLRVLIPEFSPQYSFNGPAPIAFQRVRPDLFPPPSSKV
VKLQKS

Sequences:

>Translated_646_residues
MLKPFTFMLSQRRLMVFALDTASIAASFLLAFLLRFDFTFPPLYHEIIKDGLLVVLLVKPLVFLFSGMYRSIWKYASLQD
GIEIFKVVTLSTLITSFVLFFLHDTSAMPRSIYVLDWVLLFAMVSTSRLLWRVYRETYIIPRYHTGKRTLIVGAGEAGNL
LLKEIRKQKNPANQVIGFLDDDPAKQGMRLGGIPVMGDLGRLRAAIRKHRIEEVIIAIATAQGALTRQVVSCCKETKVRF
KTLPGIKDIIDGTVSISQIKDVEIEDILGREPVKLDLETIRGYLTNKRVLVTGAAGSIGSEICRQVAAFSPYKLLLFESA
ETPLYQIEKELTASHPDLRIIPVIGDVRDQARVEMVFDEFQPEVVFHAAAYKHVPMMEYNPVEAVTNNIGGTRTLANAAH
RFGVKNFVMISTDKAVNPTNIMGASKRVAEMYVQGLARKSRTNFTTVRFGNVLGSNGSVIPLFKEQIKAGGPVTVTDPKV
IRYFMTIPEACQLVLQAGCIGNGGEIFVLDMGEPVRILDLAEELIRLSGFVPHEEIDIVFTGLRPGEKLFEELLIDGEGI
KPTRHGKIKVLAAMDSDFDAVERNLGVLFAMAGNADIAGIVKQLRVLIPEFSPQYSFNGPAPIAFQRVRPDLFPPPSSKV
VKLQKS
>Mature_646_residues
MLKPFTFMLSQRRLMVFALDTASIAASFLLAFLLRFDFTFPPLYHEIIKDGLLVVLLVKPLVFLFSGMYRSIWKYASLQD
GIEIFKVVTLSTLITSFVLFFLHDTSAMPRSIYVLDWVLLFAMVSTSRLLWRVYRETYIIPRYHTGKRTLIVGAGEAGNL
LLKEIRKQKNPANQVIGFLDDDPAKQGMRLGGIPVMGDLGRLRAAIRKHRIEEVIIAIATAQGALTRQVVSCCKETKVRF
KTLPGIKDIIDGTVSISQIKDVEIEDILGREPVKLDLETIRGYLTNKRVLVTGAAGSIGSEICRQVAAFSPYKLLLFESA
ETPLYQIEKELTASHPDLRIIPVIGDVRDQARVEMVFDEFQPEVVFHAAAYKHVPMMEYNPVEAVTNNIGGTRTLANAAH
RFGVKNFVMISTDKAVNPTNIMGASKRVAEMYVQGLARKSRTNFTTVRFGNVLGSNGSVIPLFKEQIKAGGPVTVTDPKV
IRYFMTIPEACQLVLQAGCIGNGGEIFVLDMGEPVRILDLAEELIRLSGFVPHEEIDIVFTGLRPGEKLFEELLIDGEGI
KPTRHGKIKVLAAMDSDFDAVERNLGVLFAMAGNADIAGIVKQLRVLIPEFSPQYSFNGPAPIAFQRVRPDLFPPPSSKV
VKLQKS

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=260, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 5.1.3.2 [C]

Molecular weight: Translated: 71804; Mature: 71804

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPFTFMLSQRRLMVFALDTASIAASFLLAFLLRFDFTFPPLYHEIIKDGLLVVLLVKP
CCCCHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHH
LVFLFSGMYRSIWKYASLQDGIEIFKVVTLSTLITSFVLFFLHDTSAMPRSIYVLDWVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FAMVSTSRLLWRVYRETYIIPRYHTGKRTLIVGAGEAGNLLLKEIRKQKNPANQVIGFLD
HHHHHHHHHHHHHHHHHEEECCEECCCEEEEEECCCCCHHHHHHHHHCCCCHHHEEECCC
DDPAKQGMRLGGIPVMGDLGRLRAAIRKHRIEEVIIAIATAQGALTRQVVSCCKETKVRF
CCHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHH
KTLPGIKDIIDGTVSISQIKDVEIEDILGREPVKLDLETIRGYLTNKRVLVTGAAGSIGS
HCCCCHHHHHCCCEEHHHHCCCCHHHHCCCCCCEEEHHHHHHHHCCCEEEEEECCCCHHH
EICRQVAAFSPYKLLLFESAETPLYQIEKELTASHPDLRIIPVIGDVRDQARVEMVFDEF
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHC
QPEVVFHAAAYKHVPMMEYNPVEAVTNNIGGTRTLANAAHRFGVKNFVMISTDKAVNPTN
CCCEEEEHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHH
IMGASKRVAEMYVQGLARKSRTNFTTVRFGNVLGSNGSVIPLFKEQIKAGGPVTVTDPKV
HCCHHHHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCEEHHHHHHHCCCCCEEECCHHH
IRYFMTIPEACQLVLQAGCIGNGGEIFVLDMGEPVRILDLAEELIRLSGFVPHEEIDIVF
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEE
TGLRPGEKLFEELLIDGEGIKPTRHGKIKVLAAMDSDFDAVERNLGVLFAMAGNADIAGI
ECCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEECCCCHHHHH
VKQLRVLIPEFSPQYSFNGPAPIAFQRVRPDLFPPPSSKVVKLQKS
HHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MLKPFTFMLSQRRLMVFALDTASIAASFLLAFLLRFDFTFPPLYHEIIKDGLLVVLLVKP
CCCCHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHH
LVFLFSGMYRSIWKYASLQDGIEIFKVVTLSTLITSFVLFFLHDTSAMPRSIYVLDWVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FAMVSTSRLLWRVYRETYIIPRYHTGKRTLIVGAGEAGNLLLKEIRKQKNPANQVIGFLD
HHHHHHHHHHHHHHHHHEEECCEECCCEEEEEECCCCCHHHHHHHHHCCCCHHHEEECCC
DDPAKQGMRLGGIPVMGDLGRLRAAIRKHRIEEVIIAIATAQGALTRQVVSCCKETKVRF
CCHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHH
KTLPGIKDIIDGTVSISQIKDVEIEDILGREPVKLDLETIRGYLTNKRVLVTGAAGSIGS
HCCCCHHHHHCCCEEHHHHCCCCHHHHCCCCCCEEEHHHHHHHHCCCEEEEEECCCCHHH
EICRQVAAFSPYKLLLFESAETPLYQIEKELTASHPDLRIIPVIGDVRDQARVEMVFDEF
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHC
QPEVVFHAAAYKHVPMMEYNPVEAVTNNIGGTRTLANAAHRFGVKNFVMISTDKAVNPTN
CCCEEEEHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHH
IMGASKRVAEMYVQGLARKSRTNFTTVRFGNVLGSNGSVIPLFKEQIKAGGPVTVTDPKV
HCCHHHHHHHHHHHHHHHHCCCCEEEEEECCEECCCCCEEHHHHHHHCCCCCEEECCHHH
IRYFMTIPEACQLVLQAGCIGNGGEIFVLDMGEPVRILDLAEELIRLSGFVPHEEIDIVF
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEEEE
TGLRPGEKLFEELLIDGEGIKPTRHGKIKVLAAMDSDFDAVERNLGVLFAMAGNADIAGI
ECCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCEEEEECCCCHHHHH
VKQLRVLIPEFSPQYSFNGPAPIAFQRVRPDLFPPPSSKVVKLQKS
HHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 57600 [C]

Specific activity: 233.3

Km value (mM): 0.256 {UDPgalactose}} 0.225 {UDPgalactose}} 0.2 {UDPgalactose}} 0.18 {UDPgalactose}} 0.16 {UDPgalactose}} 0.14 {UDPgalactose}} 0.048 {UDPgalactose}} 0.026 {UDPgalactose}} [C]

Substrates: UDPglucose [C]

Specific reaction: UDPglucose <==> UDPglucoseal [C]

General reaction: Epimerization (specificity for carbon forming a hexosulose) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]