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The map label for this gene is nrdZ [H]

Identifier: 78222511

GI number: 78222511

Start: 1458039

End: 1460267

Strand: Reverse

Name: nrdZ [H]

Synonym: Gmet_1297

Alternate gene names: 78222511

Gene position: 1460267-1458039 (Counterclockwise)

Preceding gene: 78222519

Following gene: 78222509

Centisome position: 36.53

GC content: 63.57

Gene sequence:

>2229_bases
ATGGCAGAAACGAAGACGACAGTGGATATCCCCGGCCTTTCGAAGAACGCCCGCACCGTGCTCGAGAAGCGATACCTCAA
GCGAGACACTGACGGGAGAGTCCTCGAAACTCCCGCCGACATGTTCCGGCGCGTGGCCGAGGCCATTGCCGTTGCTGACC
GTAATTTCGACAAGAAGGCCGACACCAAGGCCCTGGCCCAGAAGTTCTACGACCTGATGACCTCCTTCGAGTTCCTCCCC
AACTCCCCCACCCTCATGAACGCGGGGCGCGAGCTGGGCCAGCTCTCCGCCTGCTTCGTCCTCCCTGTGGGGGACTCCAT
GGAGGAGATCTTCGACGCGGTCAAGTACACGGCCCTCATCCACAAGTCCGGCGGCGGCACCGGCTTTTCCTTCTCGCGGC
TGCGTCCGGCCAACGACGTGGTCCGTTCCACCTCGGGCATCTCCAGCGGCCCCATCTCGTTCATGCGGGTCTTCGACGCC
GCCACCGAAACCATCAAGCAGGGGGGAACCCGGCGCGGCGCCAACATGGGGATCCTCCGCGTGGATCATCCGGATATCAT
GGACTTCATCATGTGCAAGGATGACCAGAAGCACCTCAACAACTTCAACATCTCCGTGGGGCTCACCGAGGCCTTCATGG
AGGCGGTGGAGAGGGACGCCGATTACGATCTGCGCAACCCCCGTGACGGGAAGCCCTGCGGGACCCTCAACGCCCGCAAG
GTCTTCAGCCGCATCGTGAAGCAGGCCTGGAAAAACGGCGAGCCGGGAATCATCTTCCTGGACCGCCTCAACAAGGACAA
CCCGACTCCCCACATCGGCGAGATCGAGTCCACCAACCCCTGCGGCGAGCAGCCGCTCCTCCCCTACGAGTCATGCAACC
TGGGCTCCATCAACCTGGGGAAGATGGTGAATAACGGCGACGTGGACTGGAAGCGCCTGCGGGAGGTCATCCGCCTGGGA
GTCCACTTCCTGGACAACGTCATCGAGGTGAACAACTACCCCCTCCCCCAGATCAACGACATGACCCGCTCCAACCGCAA
GATCGGCCTCGGCGTCATGGGGTGGGCAGACATGCTGATCCTCCTGGGGATCCCCTACAGCTCCCCGGAGGCCATCAGCC
TCGGCGAGAAGGTGATGCGTTTCATTAACGACGAGGGGCACGCCTATTCCCGCGAACTGGCCGCCGTGCGGGGAGCGTTC
CCGAACTTCGTGGGTTCCACCTTTGACCGGCCGGGAGAAGGCCCCATCCGCAACGCCACGGTGACCACCATCGCCCCCAC
CGGCACCATCTCCATCATTGCCAACGCATCCAGCGGTGTGGAACCCCTCTTCGCAGTCTCCTTCGTGCGCCAGGTCCTCG
ACAAGAACATCCTCGTGGAGGTAAACCCCATTTTCGAGGAGATTGCCCGGGATCAGGGCTTCTATTCCGAGGAGCTCATG
CAGAAGATCGCCCAGCACGGCACCGTCCACGACCTGGCCGAGATTCCCGAGGATATCCGCAAGGTCTTCGTGACCGCCCA
CGACATCACCCCGGAAGACCACATCGAGATGCAGGCCGCCTTCCAGAAATACACCGACAACGCCGTCTCCAAGACGGTCA
ACTTCCCCAACGCCGCCACCATCGAAGAGGTGGAGAAAGTCTACCGCCTGGCCTACAAACTGGAGTGCAAGGGGGTCACC
ATCTACCGCGACGGCTCCCGGGACGAGCAGGTCCTCTCCACAGGCGCCAAGGAGGAAAAGGAGAAAGTTGTCCAGACGGA
GGAGAAACGGGCCGTGAAGCGGGACCGTCCCAAGGCCCTCAAGGGATGGACCTACCAGATGCAGACCGGCTGCGGCCCAC
TCTATGTCACCGTCAACGAGGACAAGGCCGGGCTTTTCGAGCTCTTCACCACCATGGGGAAGGCGGGCGGGTGCGCCTCC
TCCCAGTGCGAGGCCATCGGCCGCATGGTGTCCCTCGCCTGGCGCAGCGGCGTCCAGGCCCGGCAGGTGATCAAGCAGCT
TCTCGGCATCTCCTGCCACCTCCCCGCGGGCTTCGGCGACAACAAGGTTCTTTCCTGCGCCGACGCCGTGGCCAGGGCGA
TCCAGGCCCACATGCAGGCTGCCGGCTACGATGTGGGGCTCGAAACCGCGGCTCCTGAACGGGGCGCCTGCCCCGAGTGC
GGCGGCATCGTGGAGCACGAAGGCGGCTGCGCCGTCTGCCGGGTCTGCGGCTATTCCGAATGCGCCTGA

Upstream 100 bases:

>100_bases
CCATACATATTGTGGATATTCTTTTGCGGCACCACAACATATATGGCAAACAGCCTTTATACTGCATTATTCACCAAACA
CTGCGCAAGGAGAGGAAATT

Downstream 100 bases:

>100_bases
CCGGCAACAACTGACCATGAACGACGAAAGGCCCGCATCTTGCGGGCCTTTCTCATTGACAAAACGTTCAGTATGTTCCT
GCCACCGTGCCGTCAGGGAC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MAETKTTVDIPGLSKNARTVLEKRYLKRDTDGRVLETPADMFRRVAEAIAVADRNFDKKADTKALAQKFYDLMTSFEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFSRLRPANDVVRSTSGISSGPISFMRVFDA
ATETIKQGGTRRGANMGILRVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLRNPRDGKPCGTLNARK
VFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVNNGDVDWKRLREVIRLG
VHFLDNVIEVNNYPLPQINDMTRSNRKIGLGVMGWADMLILLGIPYSSPEAISLGEKVMRFINDEGHAYSRELAAVRGAF
PNFVGSTFDRPGEGPIRNATVTTIAPTGTISIIANASSGVEPLFAVSFVRQVLDKNILVEVNPIFEEIARDQGFYSEELM
QKIAQHGTVHDLAEIPEDIRKVFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNAATIEEVEKVYRLAYKLECKGVT
IYRDGSRDEQVLSTGAKEEKEKVVQTEEKRAVKRDRPKALKGWTYQMQTGCGPLYVTVNEDKAGLFELFTTMGKAGGCAS
SQCEAIGRMVSLAWRSGVQARQVIKQLLGISCHLPAGFGDNKVLSCADAVARAIQAHMQAAGYDVGLETAAPERGACPEC
GGIVEHEGGCAVCRVCGYSECA

Sequences:

>Translated_742_residues
MAETKTTVDIPGLSKNARTVLEKRYLKRDTDGRVLETPADMFRRVAEAIAVADRNFDKKADTKALAQKFYDLMTSFEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFSRLRPANDVVRSTSGISSGPISFMRVFDA
ATETIKQGGTRRGANMGILRVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLRNPRDGKPCGTLNARK
VFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVNNGDVDWKRLREVIRLG
VHFLDNVIEVNNYPLPQINDMTRSNRKIGLGVMGWADMLILLGIPYSSPEAISLGEKVMRFINDEGHAYSRELAAVRGAF
PNFVGSTFDRPGEGPIRNATVTTIAPTGTISIIANASSGVEPLFAVSFVRQVLDKNILVEVNPIFEEIARDQGFYSEELM
QKIAQHGTVHDLAEIPEDIRKVFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNAATIEEVEKVYRLAYKLECKGVT
IYRDGSRDEQVLSTGAKEEKEKVVQTEEKRAVKRDRPKALKGWTYQMQTGCGPLYVTVNEDKAGLFELFTTMGKAGGCAS
SQCEAIGRMVSLAWRSGVQARQVIKQLLGISCHLPAGFGDNKVLSCADAVARAIQAHMQAAGYDVGLETAAPERGACPEC
GGIVEHEGGCAVCRVCGYSECA
>Mature_741_residues
AETKTTVDIPGLSKNARTVLEKRYLKRDTDGRVLETPADMFRRVAEAIAVADRNFDKKADTKALAQKFYDLMTSFEFLPN
SPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFSRLRPANDVVRSTSGISSGPISFMRVFDAA
TETIKQGGTRRGANMGILRVDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLRNPRDGKPCGTLNARKV
FSRIVKQAWKNGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVNNGDVDWKRLREVIRLGV
HFLDNVIEVNNYPLPQINDMTRSNRKIGLGVMGWADMLILLGIPYSSPEAISLGEKVMRFINDEGHAYSRELAAVRGAFP
NFVGSTFDRPGEGPIRNATVTTIAPTGTISIIANASSGVEPLFAVSFVRQVLDKNILVEVNPIFEEIARDQGFYSEELMQ
KIAQHGTVHDLAEIPEDIRKVFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNAATIEEVEKVYRLAYKLECKGVTI
YRDGSRDEQVLSTGAKEEKEKVVQTEEKRAVKRDRPKALKGWTYQMQTGCGPLYVTVNEDKAGLFELFTTMGKAGGCASS
QCEAIGRMVSLAWRSGVQARQVIKQLLGISCHLPAGFGDNKVLSCADAVARAIQAHMQAAGYDVGLETAAPERGACPECG
GIVEHEGGCAVCRVCGYSECA

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=579, Percent_Identity=27.4611398963731, Blast_Score=214, Evalue=3e-55,
Organism=Escherichia coli, GI1789030, Length=629, Percent_Identity=26.3910969793323, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555242, Length=576, Percent_Identity=27.9513888888889, Blast_Score=220, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322123, Length=669, Percent_Identity=26.457399103139, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320914, Length=599, Percent_Identity=27.212020033389, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17352481, Length=587, Percent_Identity=25.8943781942078, Blast_Score=201, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 81522; Mature: 81391

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETKTTVDIPGLSKNARTVLEKRYLKRDTDGRVLETPADMFRRVAEAIAVADRNFDKKA
CCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCHH
DTKALAQKFYDLMTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALI
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHE
HKSGGGTGFSFSRLRPANDVVRSTSGISSGPISFMRVFDAATETIKQGGTRRGANMGILR
EECCCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
VDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLRNPRDGKPCGTLNARK
ECCCHHHHHHHCCCCHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
VFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLG
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
KMVNNGDVDWKRLREVIRLGVHFLDNVIEVNNYPLPQINDMTRSNRKIGLGVMGWADMLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEHHHHHHHHH
LLGIPYSSPEAISLGEKVMRFINDEGHAYSRELAAVRGAFPNFVGSTFDRPGEGPIRNAT
HHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCE
VTTIAPTGTISIIANASSGVEPLFAVSFVRQVLDKNILVEVNPIFEEIARDQGFYSEELM
EEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCHHHHH
QKIAQHGTVHDLAEIPEDIRKVFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNAAT
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IEEVEKVYRLAYKLECKGVTIYRDGSRDEQVLSTGAKEEKEKVVQTEEKRAVKRDRPKAL
HHHHHHHHHHHHEEEECCEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
KGWTYQMQTGCGPLYVTVNEDKAGLFELFTTMGKAGGCASSQCEAIGRMVSLAWRSGVQA
CCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHH
RQVIKQLLGISCHLPAGFGDNKVLSCADAVARAIQAHMQAAGYDVGLETAAPERGACPEC
HHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GGIVEHEGGCAVCRVCGYSECA
CCCEECCCCCCEEEECCCCCCC
>Mature Secondary Structure 
AETKTTVDIPGLSKNARTVLEKRYLKRDTDGRVLETPADMFRRVAEAIAVADRNFDKKA
CCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCHH
DTKALAQKFYDLMTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALI
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHE
HKSGGGTGFSFSRLRPANDVVRSTSGISSGPISFMRVFDAATETIKQGGTRRGANMGILR
EECCCCCCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
VDHPDIMDFIMCKDDQKHLNNFNISVGLTEAFMEAVERDADYDLRNPRDGKPCGTLNARK
ECCCHHHHHHHCCCCHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
VFSRIVKQAWKNGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLG
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
KMVNNGDVDWKRLREVIRLGVHFLDNVIEVNNYPLPQINDMTRSNRKIGLGVMGWADMLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEEHHHHHHHHH
LLGIPYSSPEAISLGEKVMRFINDEGHAYSRELAAVRGAFPNFVGSTFDRPGEGPIRNAT
HHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCE
VTTIAPTGTISIIANASSGVEPLFAVSFVRQVLDKNILVEVNPIFEEIARDQGFYSEELM
EEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCHHHHH
QKIAQHGTVHDLAEIPEDIRKVFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNAAT
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IEEVEKVYRLAYKLECKGVTIYRDGSRDEQVLSTGAKEEKEKVVQTEEKRAVKRDRPKAL
HHHHHHHHHHHHEEEECCEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
KGWTYQMQTGCGPLYVTVNEDKAGLFELFTTMGKAGGCASSQCEAIGRMVSLAWRSGVQA
CCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHH
RQVIKQLLGISCHLPAGFGDNKVLSCADAVARAIQAHMQAAGYDVGLETAAPERGACPEC
HHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GGIVEHEGGCAVCRVCGYSECA
CCCEECCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]