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The map label for this gene is pyrG

Identifier: 78222490

GI number: 78222490

Start: 1437106

End: 1438722

Strand: Direct

Name: pyrG

Synonym: Gmet_1276

Alternate gene names: 78222490

Gene position: 1437106-1438722 (Clockwise)

Preceding gene: 78222489

Following gene: 78222491

Centisome position: 35.95

GC content: 59.25

Gene sequence:

>1617_bases
ATGAAAACCAAGTTTATCTTTGTGACCGGTGGAGTTGTTTCCTCCATAGGCAAGGGGCTTGCCTCGGCATCCCTCGGGGC
TCTCCTGGAGGCCAGGGGCCTGCGGGTTTCCATGCAGAAGCTCGACCCCTACATTAACGTCGATCCCGGTACCATGTCCC
CCTTCCAGCATGGTGAGGTTTTCGTTACCGATGATGGCGCCGAAACCGACCTGGACCTTGGCCACTACGAGCGCTATACG
TCGGCACGGCTTTCCAAACGGAGCAACTTCACCACGGGCCAGGTCTACTTTTCGGTCATCGAGAAGGAGCGTCGCGGCGA
TTACCTGGGAGGGACCGTCCAGGTAATTCCCCACATCACCGATGAGATCAAACATAAGATTCTCGAGAATGCCAAGGGTG
CCGATGTGGCTATCGTTGAGGTCGGGGGCACCGTGGGGGACATCGAGTCGCTGCCGTTCCTCGAGGCGATCCGCCAGTTC
AAGGCCGACCGTGGCGCAGGCAACGTTCTCTATCTCCACGTGACGCTCGTTCCCTACATCAAGACCGCCGGCGAGTTGAA
AACCAAGCCGACCCAACACTCGGTCAAGGAGTTGAGGGAAATTGGCATCCAGCCCGATATTCTCATTTGCCGCTGCGAGA
AGGATCTGCCCCACGACATGAAGGCGAAGATCGCCCTCTTCTGTAACGTGGAGGAAAAGGGGGTCATCACCTCCGCAGAC
GCCGAGCACATCTACGCAGTCCCCCTCGCGCTCCACAAACAGGGGCTCGACGACCAGGTGGTGGACAAGCTCAACATCTG
GACCAAGGCCCCGGACCTGGCCCCTTGGGAAAGCGTAGTGGAGAAGCTCCGCAACCCGCTCAAGGGCGAGGTTCACATTG
CCATCGTCGGTAAGTACGTGAACCTCACCGAATCGTACAAATCCCTTGCCGAGGCCCTAACCCACGGCGGGATCGCCAAT
GACTGCCGCGTTTACCTCCGCTACCTCGATTCCGAGAAGCTGGAGAGCGAAGGCCTCGGCGGTCTTCTGGACGACGTCGA
TGCCATTCTCGTGCCAGGCGGGTTCGGAGAACGGGGGACCGAAGGAAAGATCAAGGCCATCGAGTACGCCCGGACCCGGA
AAGTTCCGTTTTTCGGCATCTGTCTCGGCATGCAAATGGCTGTTGTCGAGTATGCCCGCAACGTCTGTGGCCTTGACAAC
GCCTTCTCCAGCGAATTCCGACCCGACTGCGCGAATCCGGTCATTCATCTTATGGAGGAGCAGAAGGGGGTGGAGCGCAA
GGGAGGAACCATGCGGCTTGGGGCCTATCCCTGTTCACTCTCGAAGGGGACCTTCGCCCACCGGGCCTATGGCTCCCTTG
ACGTCTCCGAGCGGCACCGCCACCGCTACGAATTCAACAACGCCTTCCGGGAGATTCTGGTTTCCAAAGGGCTCGTCATC
TCCGGCATCTACAAGGAGGGTGACCTCGTCGAGATCGTCGAGGTGGCGGATCACCCCTGGTTCCTTGGCTGCCAGTTCCA
TCCGGAGTTCAAGTCCAAGCCCCTCAATCCCCATCCGCTCTTCAGGACGTTCATTGCCGCTGCCCTGGAACACCGGGGCA
AGAGATCACAGGCTTAG

Upstream 100 bases:

>100_bases
CGAGATTCCAAATCTGAAGGTTCGCGGGCACGAGGGGACGGTTAAAGCAGGCAATCCCCTTTCTGATGTCCCTTACCATT
GGCTTGTTTTAGGAGCATTC

Downstream 100 bases:

>100_bases
TTCATCTGTCTAGGTACCGAGGTTCCCATGACCCGAGAAATCGCCATTGGCAACGTGAAGATGGGGGGCAGCCGTCCCCT
GGTGCTCATCGCCGGTCCCT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MKTKFIFVTGGVVSSIGKGLASASLGALLEARGLRVSMQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYT
SARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQF
KADRGAGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILICRCEKDLPHDMKAKIALFCNVEEKGVITSAD
AEHIYAVPLALHKQGLDDQVVDKLNIWTKAPDLAPWESVVEKLRNPLKGEVHIAIVGKYVNLTESYKSLAEALTHGGIAN
DCRVYLRYLDSEKLESEGLGGLLDDVDAILVPGGFGERGTEGKIKAIEYARTRKVPFFGICLGMQMAVVEYARNVCGLDN
AFSSEFRPDCANPVIHLMEEQKGVERKGGTMRLGAYPCSLSKGTFAHRAYGSLDVSERHRHRYEFNNAFREILVSKGLVI
SGIYKEGDLVEIVEVADHPWFLGCQFHPEFKSKPLNPHPLFRTFIAAALEHRGKRSQA

Sequences:

>Translated_538_residues
MKTKFIFVTGGVVSSIGKGLASASLGALLEARGLRVSMQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYT
SARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQF
KADRGAGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILICRCEKDLPHDMKAKIALFCNVEEKGVITSAD
AEHIYAVPLALHKQGLDDQVVDKLNIWTKAPDLAPWESVVEKLRNPLKGEVHIAIVGKYVNLTESYKSLAEALTHGGIAN
DCRVYLRYLDSEKLESEGLGGLLDDVDAILVPGGFGERGTEGKIKAIEYARTRKVPFFGICLGMQMAVVEYARNVCGLDN
AFSSEFRPDCANPVIHLMEEQKGVERKGGTMRLGAYPCSLSKGTFAHRAYGSLDVSERHRHRYEFNNAFREILVSKGLVI
SGIYKEGDLVEIVEVADHPWFLGCQFHPEFKSKPLNPHPLFRTFIAAALEHRGKRSQA
>Mature_538_residues
MKTKFIFVTGGVVSSIGKGLASASLGALLEARGLRVSMQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYT
SARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQF
KADRGAGNVLYLHVTLVPYIKTAGELKTKPTQHSVKELREIGIQPDILICRCEKDLPHDMKAKIALFCNVEEKGVITSAD
AEHIYAVPLALHKQGLDDQVVDKLNIWTKAPDLAPWESVVEKLRNPLKGEVHIAIVGKYVNLTESYKSLAEALTHGGIAN
DCRVYLRYLDSEKLESEGLGGLLDDVDAILVPGGFGERGTEGKIKAIEYARTRKVPFFGICLGMQMAVVEYARNVCGLDN
AFSSEFRPDCANPVIHLMEEQKGVERKGGTMRLGAYPCSLSKGTFAHRAYGSLDVSERHRHRYEFNNAFREILVSKGLVI
SGIYKEGDLVEIVEVADHPWFLGCQFHPEFKSKPLNPHPLFRTFIAAALEHRGKRSQA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=45.8181818181818, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=44, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=44, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=44, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1789142, Length=547, Percent_Identity=54.8446069469835, Blast_Score=604, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI25148299, Length=603, Percent_Identity=39.469320066335, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6322563, Length=565, Percent_Identity=43.0088495575221, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319432, Length=559, Percent_Identity=41.8604651162791, Blast_Score=429, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=44.1016333938294, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=42.741935483871, Blast_Score=381, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_GEOMG (Q39W62)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384237.1
- HSSP:   P17812
- ProteinModelPortal:   Q39W62
- SMR:   Q39W62
- STRING:   Q39W62
- GeneID:   3739137
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1276
- NMPDR:   fig|269799.3.peg.19
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   Q39W62
- ProtClustDB:   PRK05380
- BioCyc:   GMET269799:GMET_1276-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59478; Mature: 59478

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 507-507 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKFIFVTGGVVSSIGKGLASASLGALLEARGLRVSMQKLDPYINVDPGTMSPFQHGEV
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERYTSARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHH
DEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQFKADRGAGNVLYLHVTLVPYI
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEHHH
KTAGELKTKPTQHSVKELREIGIQPDILICRCEKDLPHDMKAKIALFCNVEEKGVITSAD
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEECC
AEHIYAVPLALHKQGLDDQVVDKLNIWTKAPDLAPWESVVEKLRNPLKGEVHIAIVGKYV
CCEEEEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEHH
NLTESYKSLAEALTHGGIANDCRVYLRYLDSEKLESEGLGGLLDDVDAILVPGGFGERGT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCCC
EGKIKAIEYARTRKVPFFGICLGMQMAVVEYARNVCGLDNAFSSEFRPDCANPVIHLMEE
CCCEEEEEHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHH
QKGVERKGGTMRLGAYPCSLSKGTFAHRAYGSLDVSERHRHRYEFNNAFREILVSKGLVI
HCCHHHCCCEEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
SGIYKEGDLVEIVEVADHPWFLGCQFHPEFKSKPLNPHPLFRTFIAAALEHRGKRSQA
EEECCCCCEEEEEECCCCCEEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTKFIFVTGGVVSSIGKGLASASLGALLEARGLRVSMQKLDPYINVDPGTMSPFQHGEV
CCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERYTSARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHH
DEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQFKADRGAGNVLYLHVTLVPYI
HHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEHHH
KTAGELKTKPTQHSVKELREIGIQPDILICRCEKDLPHDMKAKIALFCNVEEKGVITSAD
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCEEECC
AEHIYAVPLALHKQGLDDQVVDKLNIWTKAPDLAPWESVVEKLRNPLKGEVHIAIVGKYV
CCEEEEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEHH
NLTESYKSLAEALTHGGIANDCRVYLRYLDSEKLESEGLGGLLDDVDAILVPGGFGERGT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCCC
EGKIKAIEYARTRKVPFFGICLGMQMAVVEYARNVCGLDNAFSSEFRPDCANPVIHLMEE
CCCEEEEEHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHH
QKGVERKGGTMRLGAYPCSLSKGTFAHRAYGSLDVSERHRHRYEFNNAFREILVSKGLVI
HCCHHHCCCEEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
SGIYKEGDLVEIVEVADHPWFLGCQFHPEFKSKPLNPHPLFRTFIAAALEHRGKRSQA
EEECCCCCEEEEEECCCCCEEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA