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The map label for this gene is gap [H]

Identifier: 78222426

GI number: 78222426

Start: 1358065

End: 1359510

Strand: Direct

Name: gap [H]

Synonym: Gmet_1211

Alternate gene names: 78222426

Gene position: 1358065-1359510 (Clockwise)

Preceding gene: 78222425

Following gene: 78222427

Centisome position: 33.97

GC content: 63.0

Gene sequence:

>1446_bases
ATGAACAATCAGATGCAGGTGACCTACCTCAAGGAGTGGCAACACCTGGAGGAGTGTGCCGAATGCATGCTCCCCCTGAT
CGGCAAGCTTTACCGCGAGCATAACGTCGTGACCACGGTCTACGGCCGTACGCTCGTCAACAGTACCACCATCGACATTC
TCAAATCCCATCGGTTTGCCCGGCTGATCCTCGATGACGAACTCTCCGTGCTCGACACCTTTCCCATTGTGGAGGCAATG
ACGCGGCTCGACCTGGCCCCGGCCCGGGTCGACATCGGCAAGCTGACCGTCCGCTACAAGGCCGAGGGGAGCGGGATCGG
CGTGGATGATTTCGCGCGCCGGGAGCTGGCCTCCGTCAACACCGGCCGCAGCCCCATCCTGAGCGAGCCCCGCGACGTCG
TCCTCTACGGTTTCGGCCGCATCGGCCGCCTCCTTGCCCGAATCCTCGTGGAGAAGGCGGGAAGCGGCGAGAAGCTCCGG
ATCAGGGCCGCCGTGGTCCGCAAGGGGGGCGCCGACGACCTGGCCAAGCGGGCGAGTCTCCTGCGCCGCGACTCGGTCCA
CGGCCATTTCAACGGCATCATCACCTTTGACGAGCAGGAAAACGCCATCATCGCCAACGGCAACATGATCCGCATCATCT
ACGCCGACGCGCCCGAGAACGTGGACTACACCCAGTACGGCATCAAGAACGCCATCCTCATCGACAACACCGGCAAGTGG
CGCGACCGCGACGGCCTCGGCCGGCACCTGAAGGCCAAGGGAATTGACAAGGTCATTCTCACCGCCCCGGGCAAAGGGGA
CATCCCCAACATCGTGGCCGGTATCAACAACGAGCTGATCACCCCGGACGAGCATATCTTCTCCGCCGCCAGCTGTACCA
CCAATGCCATCGTCCCGGTGCTCAAGGCGGTCAATGACCGGTTCGGCATCGTGAGCGGCCACGTGGAGACCTGCCACTCC
TACACCAACGACCAGAACCTCATCGACAACTATCACAAGGCGTCCCGCCGGGGCCGGAGCGCCCCCCTCAACATGGTCAT
CACCGAGACCGGCGCCGCCAAGGCCGTGGCCAAGGCGCTTCCGGAGCTGACCGGGAAGCTGACCGGCAACGCCATCCGGG
TGCCGACCCCCAACGTCTCCCTGGCCATCCTCAATCTGGAACTGGGGCAGGAGGCAAGCGTTGCGGAGATCAACGGCTAC
CTGCGTCAAATCTCCCTTGATTCAGCGCTCCAGAACCAGATCGACTACACCAACTCGTCCGAGGTCGTTTCCAGCGATTT
TGTCGGCTCGCGCCACGCCGGCGTGGTCGATTCCCTGGCCACCATCTCCCAGGGTAAGCGCTGCGTCCTCTATGTCTGGT
ACGATAACGAATTCGGCTACAGCTGCCAGGTGGTACGCATGGTCCAGAAAATGGCCGGGGTGGAACTGCCGTCCGTGCCG
AACTGA

Upstream 100 bases:

>100_bases
ATCTGTTGTTTACTGTGCCTGAATTTTGTAATACTAGGAGCGCCCTGCACGGGTTGTTCGGCAATCCGCTGCAGGAAACC
AACGGAGAAGGAGTTGTTGC

Downstream 100 bases:

>100_bases
ACAAGCGACGGCCACATCCTGGTTTGCAACAGAAAGGGCATCCCGCGGGGTGCCCTTTCTGTTGTCCAGAGTCTGGTTTC
CCGGTCTTATGGTATATGAT

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNNQMQVTYLKEWQHLEECAECMLPLIGKLYREHNVVTTVYGRTLVNSTTIDILKSHRFARLILDDELSVLDTFPIVEAM
TRLDLAPARVDIGKLTVRYKAEGSGIGVDDFARRELASVNTGRSPILSEPRDVVLYGFGRIGRLLARILVEKAGSGEKLR
IRAAVVRKGGADDLAKRASLLRRDSVHGHFNGIITFDEQENAIIANGNMIRIIYADAPENVDYTQYGIKNAILIDNTGKW
RDRDGLGRHLKAKGIDKVILTAPGKGDIPNIVAGINNELITPDEHIFSAASCTTNAIVPVLKAVNDRFGIVSGHVETCHS
YTNDQNLIDNYHKASRRGRSAPLNMVITETGAAKAVAKALPELTGKLTGNAIRVPTPNVSLAILNLELGQEASVAEINGY
LRQISLDSALQNQIDYTNSSEVVSSDFVGSRHAGVVDSLATISQGKRCVLYVWYDNEFGYSCQVVRMVQKMAGVELPSVP
N

Sequences:

>Translated_481_residues
MNNQMQVTYLKEWQHLEECAECMLPLIGKLYREHNVVTTVYGRTLVNSTTIDILKSHRFARLILDDELSVLDTFPIVEAM
TRLDLAPARVDIGKLTVRYKAEGSGIGVDDFARRELASVNTGRSPILSEPRDVVLYGFGRIGRLLARILVEKAGSGEKLR
IRAAVVRKGGADDLAKRASLLRRDSVHGHFNGIITFDEQENAIIANGNMIRIIYADAPENVDYTQYGIKNAILIDNTGKW
RDRDGLGRHLKAKGIDKVILTAPGKGDIPNIVAGINNELITPDEHIFSAASCTTNAIVPVLKAVNDRFGIVSGHVETCHS
YTNDQNLIDNYHKASRRGRSAPLNMVITETGAAKAVAKALPELTGKLTGNAIRVPTPNVSLAILNLELGQEASVAEINGY
LRQISLDSALQNQIDYTNSSEVVSSDFVGSRHAGVVDSLATISQGKRCVLYVWYDNEFGYSCQVVRMVQKMAGVELPSVP
N
>Mature_481_residues
MNNQMQVTYLKEWQHLEECAECMLPLIGKLYREHNVVTTVYGRTLVNSTTIDILKSHRFARLILDDELSVLDTFPIVEAM
TRLDLAPARVDIGKLTVRYKAEGSGIGVDDFARRELASVNTGRSPILSEPRDVVLYGFGRIGRLLARILVEKAGSGEKLR
IRAAVVRKGGADDLAKRASLLRRDSVHGHFNGIITFDEQENAIIANGNMIRIIYADAPENVDYTQYGIKNAILIDNTGKW
RDRDGLGRHLKAKGIDKVILTAPGKGDIPNIVAGINNELITPDEHIFSAASCTTNAIVPVLKAVNDRFGIVSGHVETCHS
YTNDQNLIDNYHKASRRGRSAPLNMVITETGAAKAVAKALPELTGKLTGNAIRVPTPNVSLAILNLELGQEASVAEINGY
LRQISLDSALQNQIDYTNSSEVVSSDFVGSRHAGVVDSLATISQGKRCVLYVWYDNEFGYSCQVVRMVQKMAGVELPSVP
N

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=341, Percent_Identity=37.8299120234604, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI7657116, Length=338, Percent_Identity=36.3905325443787, Blast_Score=189, Evalue=6e-48,
Organism=Escherichia coli, GI1788079, Length=342, Percent_Identity=36.2573099415205, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1789295, Length=346, Percent_Identity=31.5028901734104, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534679, Length=347, Percent_Identity=36.0230547550432, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17534677, Length=347, Percent_Identity=36.0230547550432, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32566163, Length=353, Percent_Identity=36.5439093484419, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17568413, Length=343, Percent_Identity=37.0262390670554, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322409, Length=342, Percent_Identity=38.3040935672515, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322468, Length=342, Percent_Identity=38.8888888888889, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321631, Length=342, Percent_Identity=39.1812865497076, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI85725000, Length=337, Percent_Identity=38.5756676557863, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI22023983, Length=337, Percent_Identity=38.5756676557863, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=38.2789317507418, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=38.2789317507418, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19922412, Length=335, Percent_Identity=38.2089552238806, Blast_Score=191, Evalue=8e-49,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 52734; Mature: 52734

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQMQVTYLKEWQHLEECAECMLPLIGKLYREHNVVTTVYGRTLVNSTTIDILKSHRFA
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHCCHHHHHHHCCCEE
RLILDDELSVLDTFPIVEAMTRLDLAPARVDIGKLTVRYKAEGSGIGVDDFARRELASVN
EEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHCC
TGRSPILSEPRDVVLYGFGRIGRLLARILVEKAGSGEKLRIRAAVVRKGGADDLAKRASL
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHH
LRRDSVHGHFNGIITFDEQENAIIANGNMIRIIYADAPENVDYTQYGIKNAILIDNTGKW
HHHCCCCEEECEEEEEECCCCEEEECCCEEEEEECCCCCCCCHHHHCCCCEEEEECCCCC
RDRDGLGRHLKAKGIDKVILTAPGKGDIPNIVAGINNELITPDEHIFSAASCTTNAIVPV
CCCCCCCCCCHHCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHH
LKAVNDRFGIVSGHVETCHSYTNDQNLIDNYHKASRRGRSAPLNMVITETGAAKAVAKAL
HHHHCCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHH
PELTGKLTGNAIRVPTPNVSLAILNLELGQEASVAEINGYLRQISLDSALQNQIDYTNSS
HHHHHCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EVVSSDFVGSRHAGVVDSLATISQGKRCVLYVWYDNEFGYSCQVVRMVQKMAGVELPSVP
HHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
N
C
>Mature Secondary Structure
MNNQMQVTYLKEWQHLEECAECMLPLIGKLYREHNVVTTVYGRTLVNSTTIDILKSHRFA
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHCCHHHHHHHCCCEE
RLILDDELSVLDTFPIVEAMTRLDLAPARVDIGKLTVRYKAEGSGIGVDDFARRELASVN
EEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHCC
TGRSPILSEPRDVVLYGFGRIGRLLARILVEKAGSGEKLRIRAAVVRKGGADDLAKRASL
CCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHH
LRRDSVHGHFNGIITFDEQENAIIANGNMIRIIYADAPENVDYTQYGIKNAILIDNTGKW
HHHCCCCEEECEEEEEECCCCEEEECCCEEEEEECCCCCCCCHHHHCCCCEEEEECCCCC
RDRDGLGRHLKAKGIDKVILTAPGKGDIPNIVAGINNELITPDEHIFSAASCTTNAIVPV
CCCCCCCCCCHHCCCCEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHH
LKAVNDRFGIVSGHVETCHSYTNDQNLIDNYHKASRRGRSAPLNMVITETGAAKAVAKAL
HHHHCCCCCEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHH
PELTGKLTGNAIRVPTPNVSLAILNLELGQEASVAEINGYLRQISLDSALQNQIDYTNSS
HHHHHCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EVVSSDFVGSRHAGVVDSLATISQGKRCVLYVWYDNEFGYSCQVVRMVQKMAGVELPSVP
HHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]