Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 78188442

GI number: 78188442

Start: 545212

End: 546069

Strand: Reverse

Name: uppS [H]

Synonym: Cag_0464

Alternate gene names: 78188442

Gene position: 546069-545212 (Counterclockwise)

Preceding gene: 78188445

Following gene: 78188441

Centisome position: 21.23

GC content: 46.27

Gene sequence:

>858_bases
ATGGCACTCAAAAAAGTTACCAACGTTACCACATCGCTCCCATCCCGCTGGTTCTCTTCTGATACCAACCGTACCGATAA
AGAGCAGCAAGCAGCATTGCAAAAAGCTGGGCAATTACCGCAGCACATTGCTATTATTATGGATGGAAATGGACGTTGGG
CAAAAATGAAGGGCAAAAGCCGTATGGAAGGGCATATTGCTGGAGTGTCGTCCGTTCGTGATATTGTTGAAGCGTGCCAT
CAACTTGGCATTGGTTACTTAACGCTTTTTACCTTTTCAACCGAAAATTGGAAGCGACCTGAACAAGAAATTTCAGCCTT
AATGCAATTGCTCATTCGCGTTATTGGACGTGAAAGCCGTAAACTGCACGAAAACAACATTCGTCTGCAAGTAATTGGCG
AAATGCACCGCTTACCCCAAAAAGTTGAGCGTGTATTGCGCGATTGTATGGAACTAACAAAAGAAAATAATGGCTTAATG
CTCAACCTTGCTTTAAGCTATAGTGGGCAGTGGGATATGCTGCAAGCGTGCCGTGCCATAGCGGCTGACGTACAAGCAGG
CACCTTGCAACTCGAAGCAATTGATGAGGCGTGCATGGCATCGTACCTATCAACGGCAGAAATGCCCGATCCTGAATTAC
TTATTCGCACCAGTGGTGAATTTCGGCTGAGTAACTTTTTGCTGTGGCAAAGCGCCTATTCGGAGATTTACTATACCTCA
ATATATTGGCCTGATTTTCGCCGTGAGCAACTTTACGAAGCACTGTACGATTTTCAGCAGCGTGAACGCCGTTTTGGGCA
AACCAGCGAGCAAGTGCAAACGCGAATGCCTGCAAGCGCTCAAACGCAACACCATTAA

Upstream 100 bases:

>100_bases
GGAATAACTACCTATAATTCAATTCAGGCTTTTTTCATCCTTAAAAAGCTTGTGTAGCGGCAGCAAGATTTGCCACACCA
CAACGCCTTACTCATGAGTT

Downstream 100 bases:

>100_bases
AACAATGTACCCCTCTCTAAAGGCACACCAAGCTTTAGAGATTCCATAACAGTTTATATGACTTTATTTTAAGCATAGAT
CTTTTAATGAAACATTCTTA

Product: di-trans-poly-cis-decaprenylcistransferase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MALKKVTNVTTSLPSRWFSSDTNRTDKEQQAALQKAGQLPQHIAIIMDGNGRWAKMKGKSRMEGHIAGVSSVRDIVEACH
QLGIGYLTLFTFSTENWKRPEQEISALMQLLIRVIGRESRKLHENNIRLQVIGEMHRLPQKVERVLRDCMELTKENNGLM
LNLALSYSGQWDMLQACRAIAADVQAGTLQLEAIDEACMASYLSTAEMPDPELLIRTSGEFRLSNFLLWQSAYSEIYYTS
IYWPDFRREQLYEALYDFQQRERRFGQTSEQVQTRMPASAQTQHH

Sequences:

>Translated_285_residues
MALKKVTNVTTSLPSRWFSSDTNRTDKEQQAALQKAGQLPQHIAIIMDGNGRWAKMKGKSRMEGHIAGVSSVRDIVEACH
QLGIGYLTLFTFSTENWKRPEQEISALMQLLIRVIGRESRKLHENNIRLQVIGEMHRLPQKVERVLRDCMELTKENNGLM
LNLALSYSGQWDMLQACRAIAADVQAGTLQLEAIDEACMASYLSTAEMPDPELLIRTSGEFRLSNFLLWQSAYSEIYYTS
IYWPDFRREQLYEALYDFQQRERRFGQTSEQVQTRMPASAQTQHH
>Mature_284_residues
ALKKVTNVTTSLPSRWFSSDTNRTDKEQQAALQKAGQLPQHIAIIMDGNGRWAKMKGKSRMEGHIAGVSSVRDIVEACHQ
LGIGYLTLFTFSTENWKRPEQEISALMQLLIRVIGRESRKLHENNIRLQVIGEMHRLPQKVERVLRDCMELTKENNGLML
NLALSYSGQWDMLQACRAIAADVQAGTLQLEAIDEACMASYLSTAEMPDPELLIRTSGEFRLSNFLLWQSAYSEIYYTSI
YWPDFRREQLYEALYDFQQRERRFGQTSEQVQTRMPASAQTQHH

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=232, Percent_Identity=37.0689655172414, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI45580742, Length=232, Percent_Identity=37.0689655172414, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=47.4358974358974, Blast_Score=233, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=32.3144104803493, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=35.9090909090909, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=27.0742358078603, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=34.2222222222222, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 32779; Mature: 32648

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKKVTNVTTSLPSRWFSSDTNRTDKEQQAALQKAGQLPQHIAIIMDGNGRWAKMKGKS
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCC
RMEGHIAGVSSVRDIVEACHQLGIGYLTLFTFSTENWKRPEQEISALMQLLIRVIGRESR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHH
KLHENNIRLQVIGEMHRLPQKVERVLRDCMELTKENNGLMLNLALSYSGQWDMLQACRAI
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH
AADVQAGTLQLEAIDEACMASYLSTAEMPDPELLIRTSGEFRLSNFLLWQSAYSEIYYTS
HHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHEEEEE
IYWPDFRREQLYEALYDFQQRERRFGQTSEQVQTRMPASAQTQHH
EECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ALKKVTNVTTSLPSRWFSSDTNRTDKEQQAALQKAGQLPQHIAIIMDGNGRWAKMKGKS
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCC
RMEGHIAGVSSVRDIVEACHQLGIGYLTLFTFSTENWKRPEQEISALMQLLIRVIGRESR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHH
KLHENNIRLQVIGEMHRLPQKVERVLRDCMELTKENNGLMLNLALSYSGQWDMLQACRAI
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHH
AADVQAGTLQLEAIDEACMASYLSTAEMPDPELLIRTSGEFRLSNFLLWQSAYSEIYYTS
HHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHEEEEE
IYWPDFRREQLYEALYDFQQRERRFGQTSEQVQTRMPASAQTQHH
EECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]