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The map label for this gene is folP [H]

Identifier: 78188398

GI number: 78188398

Start: 493489

End: 494364

Strand: Reverse

Name: folP [H]

Synonym: Cag_0420

Alternate gene names: 78188398

Gene position: 494364-493489 (Counterclockwise)

Preceding gene: 78188399

Following gene: 78188397

Centisome position: 19.22

GC content: 51.71

Gene sequence:

>876_bases
ATGGTAATGGGCATTCTTAACACAACGCCCGATTCGTTTTACGATGGCGGGAATTTTGTGCAATCGGGGAAGGCTATAGA
TGTGGAGTGCGCGCTTGAACGAGCACTTTGCATGGTGCGCGAGGGTGCGGCAATTATTGATGTTGGTGGCGAGTCGTCGC
GACCGGGTGCGGTAAAAATTAGTGCTGAAGAGGAAATTAAGCGCACGGTACCGCTGATTGCAAAGCTTCGTCAAGCAAGC
GATGTGCTCATTTCCATTGATACTTACAAAGCGGAGGTGGCAAAGGCGGCATTGCAAGCAGGCGCAAATATTGTGAATGA
TATTTCGGGCTTTACTTTTGATGCGGCGCTGCCTGAGGTGTGCCGTCGCTACAATGCGGGTGTGGTGCTTATGCAGACTC
CCGTAACGCCGCAGGAGATGCAGTGGAGCTTGCTCACCCCAAACAGCAATGGTAATGTGGTGGCGCAAGTGCGGCAGTCG
CTCGAAAAATCGCTTGCGGTTGCAAAGCGGCATGGTATTACTAACATTATGCTTGATCCCGGTTTTGGTTTTGGTAAAAG
TGTGGAGGAAAATTACCGCTTGCTTGCCCATCTCAGTTTGTTGCAAAACCTTGGCTATCCGTTGTTGGTAGGTTTGTCGC
GCAAGTCGTTTCTTGGGCGGCTCAAGGTTAATGGTGAAATGTTAATTTTTCCTGCTAAGGAGCGCTTCGTTGCAACCATT
GCGGCTCAAGCGCTGGCGTTGCAGCAGGGGGCGCGGATTATACGAGCGCACGATGTTGCGGAGGCTGTGCAGTGCTTGCA
AATTGTGGAGGCAACGCAAGCTGCGGGAGCTGTTGATTATCCCCACGATTCTGGATTCCCGCATTCACGGGAATGA

Upstream 100 bases:

>100_bases
TCAAACGGTCTCCATGACAATTCATTCCAGCCATCCCCAAAGCAACAACAATTACCTCCTCCGTTGCACCGATAAGCAGC
TTGACTTACGGTGTGGTGCG

Downstream 100 bases:

>100_bases
CGGCAAAAATGACTTTTAGAGAACTTCCTAAACGCAGTGGTGGCGAAGCAAGCATTACCGAGAGATAACCATGTACCTTG
CTAAAATTGAGCTGTTGGGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MVMGILNTTPDSFYDGGNFVQSGKAIDVECALERALCMVREGAAIIDVGGESSRPGAVKISAEEEIKRTVPLIAKLRQAS
DVLISIDTYKAEVAKAALQAGANIVNDISGFTFDAALPEVCRRYNAGVVLMQTPVTPQEMQWSLLTPNSNGNVVAQVRQS
LEKSLAVAKRHGITNIMLDPGFGFGKSVEENYRLLAHLSLLQNLGYPLLVGLSRKSFLGRLKVNGEMLIFPAKERFVATI
AAQALALQQGARIIRAHDVAEAVQCLQIVEATQAAGAVDYPHDSGFPHSRE

Sequences:

>Translated_291_residues
MVMGILNTTPDSFYDGGNFVQSGKAIDVECALERALCMVREGAAIIDVGGESSRPGAVKISAEEEIKRTVPLIAKLRQAS
DVLISIDTYKAEVAKAALQAGANIVNDISGFTFDAALPEVCRRYNAGVVLMQTPVTPQEMQWSLLTPNSNGNVVAQVRQS
LEKSLAVAKRHGITNIMLDPGFGFGKSVEENYRLLAHLSLLQNLGYPLLVGLSRKSFLGRLKVNGEMLIFPAKERFVATI
AAQALALQQGARIIRAHDVAEAVQCLQIVEATQAAGAVDYPHDSGFPHSRE
>Mature_291_residues
MVMGILNTTPDSFYDGGNFVQSGKAIDVECALERALCMVREGAAIIDVGGESSRPGAVKISAEEEIKRTVPLIAKLRQAS
DVLISIDTYKAEVAKAALQAGANIVNDISGFTFDAALPEVCRRYNAGVVLMQTPVTPQEMQWSLLTPNSNGNVVAQVRQS
LEKSLAVAKRHGITNIMLDPGFGFGKSVEENYRLLAHLSLLQNLGYPLLVGLSRKSFLGRLKVNGEMLIFPAKERFVATI
AAQALALQQGARIIRAHDVAEAVQCLQIVEATQAAGAVDYPHDSGFPHSRE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=42.3913043478261, Blast_Score=197, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=29.6296296296296, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31317; Mature: 31317

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMGILNTTPDSFYDGGNFVQSGKAIDVECALERALCMVREGAAIIDVGGESSRPGAVKI
CEEEEECCCCCCCCCCCCEECCCCEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEE
SAEEEIKRTVPLIAKLRQASDVLISIDTYKAEVAKAALQAGANIVNDISGFTFDAALPEV
CCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHCCCCEEHHHHHHH
CRRYNAGVVLMQTPVTPQEMQWSLLTPNSNGNVVAQVRQSLEKSLAVAKRHGITNIMLDP
HHHHCCCEEEEECCCCHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECC
GFGFGKSVEENYRLLAHLSLLQNLGYPLLVGLSRKSFLGRLKVNGEMLIFPAKERFVATI
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHEEEEECCCEEEEECHHHHHHHH
AAQALALQQGARIIRAHDVAEAVQCLQIVEATQAAGAVDYPHDSGFPHSRE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVMGILNTTPDSFYDGGNFVQSGKAIDVECALERALCMVREGAAIIDVGGESSRPGAVKI
CEEEEECCCCCCCCCCCCEECCCCEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEE
SAEEEIKRTVPLIAKLRQASDVLISIDTYKAEVAKAALQAGANIVNDISGFTFDAALPEV
CCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCHHHHHCCCCEEHHHHHHH
CRRYNAGVVLMQTPVTPQEMQWSLLTPNSNGNVVAQVRQSLEKSLAVAKRHGITNIMLDP
HHHHCCCEEEEECCCCHHHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECC
GFGFGKSVEENYRLLAHLSLLQNLGYPLLVGLSRKSFLGRLKVNGEMLIFPAKERFVATI
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHEEEEECCCEEEEECHHHHHHHH
AAQALALQQGARIIRAHDVAEAVQCLQIVEATQAAGAVDYPHDSGFPHSRE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]