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The map label for this gene is clpP

Identifier: 78188367

GI number: 78188367

Start: 452131

End: 452808

Strand: Reverse

Name: clpP

Synonym: Cag_0389

Alternate gene names: 78188367

Gene position: 452808-452131 (Counterclockwise)

Preceding gene: 78188369

Following gene: 78188366

Centisome position: 17.6

GC content: 46.17

Gene sequence:

>678_bases
ATGGCAAATATCAATTTTGGGTTTGAGCACCATGCCAAAAAGCTCTATTCGGGAGCTATTGAGCAAGGCATTAGCAATTC
ACTTGTGCCTATGGTTATTGAAACCTCAGGACGTGGCGAGCGAGCATTCGATATTTTTTCACGCTTGTTGCGCGAGCGCA
TCATCTTTCTTGGCACGGGCATTGATGAGCATGTTGCGGGCTTAATTATGGCTCAGCTCATTTTTTTGGAGTCAGAAGAT
CCTGAGCGCGACATCTACATTTATATTAATTCACCGGGTGGTAGTGTATCGGCAGGATTGGGTATTTATGATACCATGCA
ATACATTCGCCCCGAAATTTCTACCGTTTGTGTTGGTATGGCGGCAAGTATGGGGGCGTTTTTGCTTGCAAGCGGTAACA
AAGGCAAACGAGCATCGCTGCCCCACTCACGCATTATGATTCACCAGCCATCGGGTGGAGCACAAGGGCAGGAGACTGAT
ATTGTTATTCAAGCGCGTGAAATTGAAAAAATTCGTCGTTTGCTTGAAGAGTTGCTAGCTAAGCACACAGGGCAGCCGGT
AGAAAAAGTTCGTGAAGATTCTGAGCGCGACCGCTGGATGAATCCGCAAGAGGCGCTTGAGTATGGCTTAATTGATGCCA
TTTTTGAAAAACGTCCTACGCCAGAGAAAAAAGATTAA

Upstream 100 bases:

>100_bases
TTCTTATCCACAACGCAAGTTTGCGGAGGTATAGGGCGTATAAGATACCACAACTGTTTTTCTTTCTATAAAAGTTAAGA
GCATTAAGGAGTTGTCCATT

Downstream 100 bases:

>100_bases
TTACCGCAACGAGAAGGGAGTGAAAGCATAATGAGCAGCGAGAACGCTTGGGTAAATTTGGAGAAAACCTACAATCCGCA
TGATGTTGAAGAGCGGTGGC

Product: peptidase S14, ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MANINFGFEHHAKKLYSGAIEQGISNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTGIDEHVAGLIMAQLIFLESED
PERDIYIYINSPGGSVSAGLGIYDTMQYIRPEISTVCVGMAASMGAFLLASGNKGKRASLPHSRIMIHQPSGGAQGQETD
IVIQAREIEKIRRLLEELLAKHTGQPVEKVREDSERDRWMNPQEALEYGLIDAIFEKRPTPEKKD

Sequences:

>Translated_225_residues
MANINFGFEHHAKKLYSGAIEQGISNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTGIDEHVAGLIMAQLIFLESED
PERDIYIYINSPGGSVSAGLGIYDTMQYIRPEISTVCVGMAASMGAFLLASGNKGKRASLPHSRIMIHQPSGGAQGQETD
IVIQAREIEKIRRLLEELLAKHTGQPVEKVREDSERDRWMNPQEALEYGLIDAIFEKRPTPEKKD
>Mature_224_residues
ANINFGFEHHAKKLYSGAIEQGISNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTGIDEHVAGLIMAQLIFLESEDP
ERDIYIYINSPGGSVSAGLGIYDTMQYIRPEISTVCVGMAASMGAFLLASGNKGKRASLPHSRIMIHQPSGGAQGQETDI
VIQAREIEKIRRLLEELLAKHTGQPVEKVREDSERDRWMNPQEALEYGLIDAIFEKRPTPEKKD

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=58.3333333333333, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=61.4583333333333, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=216, Evalue=7e-57,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=56.4766839378238, Blast_Score=230, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CHLCH (Q3ATL3)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378705.1
- ProteinModelPortal:   Q3ATL3
- SMR:   Q3ATL3
- STRING:   Q3ATL3
- MEROPS:   S14.001
- GeneID:   3747557
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0389
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   CLSK637818
- BioCyc:   CCHL340177:CAG_0389-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 25070; Mature: 24939

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 123-123 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINFGFEHHAKKLYSGAIEQGISNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIMAQLIFLESEDPERDIYIYINSPGGSVSAGLGIYDTMQYIRPEISTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AASMGAFLLASGNKGKRASLPHSRIMIHQPSGGAQGQETDIVIQAREIEKIRRLLEELLA
HHHHCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
KHTGQPVEKVREDSERDRWMNPQEALEYGLIDAIFEKRPTPEKKD
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ANINFGFEHHAKKLYSGAIEQGISNSLVPMVIETSGRGERAFDIFSRLLRERIIFLGTG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIMAQLIFLESEDPERDIYIYINSPGGSVSAGLGIYDTMQYIRPEISTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AASMGAFLLASGNKGKRASLPHSRIMIHQPSGGAQGQETDIVIQAREIEKIRRLLEELLA
HHHHCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
KHTGQPVEKVREDSERDRWMNPQEALEYGLIDAIFEKRPTPEKKD
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA