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The map label for this gene is hemN [H]

Identifier: 78188266

GI number: 78188266

Start: 311173

End: 312600

Strand: Reverse

Name: hemN [H]

Synonym: Cag_0285

Alternate gene names: 78188266

Gene position: 312600-311173 (Counterclockwise)

Preceding gene: 78188270

Following gene: 78188265

Centisome position: 12.15

GC content: 44.82

Gene sequence:

>1428_bases
ATGGCAACCAATTTGGCAGAAAAGTACAGCAATCCTGGACCCCGTTACACCAGTTATCCCACCATTCCATCATGGAGCAC
CGATGGTGTAACGCAGCAGCAGTGGCGTGAAGCTATGGTAAAAGGCTTTAACGACAGCAACGAAACCACTGGCGTTAGTA
TGTACATTCATATTCCTTATTGTGAAAACTACTGCTATTTTTGTGGTTGCAATGCGCACCGCACGCAAGATCACTCCTTT
GAAAAACCCTACCTTGATGCCCTTTTAAAAGAGTGGCAAATGTACCTTGATGTGTTCCCTGGTACTCTGAACGTTAAAGA
GCTGCACATTGGTGGCGGCACTCCAACCTTTTTAAGTCCCGAAAATCTCACACGACTTGTTGATGGACTCTTTAAGCATG
TGAACCGCATGGATAACCACATGTTTAGCTTTGAAACCAATCCCAAGTCAACCACCAAAGAGCATCTTGAAGCGCTCTAC
AATGTTGGCTTCCGCCGTATGAGCTTTGGTATTCAAGATTTTGACCCCATTGTTCAAAAAGAAATTAATCGTCTGCAATC
ATTTGAGTTAGTAAAAGAGAAAATTGATTTGGCACGCCAAATTGGCTTTACCTCCATTAACTTCGACCTTGTATATGGTC
TCCCAAAACAGACGATGGCAACCATTACCGATACTATACAGAAAGTAATGGAGCTTCGTCCTGACCGCTTAGCATTTTAT
GCGTATGGGCACAATCCACACATGTACGAAGGGCAGAAAAAGTTTAATGAGGCTGACTTGCCCGTAGGCGATGCAAAGCA
AGAGTTGTACGAAAAAGGCAGCGCCATGCTTGAATCCATTGGTTACCACGAAATTGGCATGGATCACTTTGCCATTGAGG
GCGACCCACTCTACATTGCTGCACAGAATGGCACCTTGCACCGTAACTTTATGGGTTACACCGAAAACACCACACAAATG
ATGTTGGCGCTTGGCTCATCCTCCATTAGCGATACATGGTACGCTTTTGCGCAAAATGAGCGCACCGATGGCGAGTACAT
TAAAGCCGTTAATGAAGATCGCTTCCCACTGCATCGTGGTCATTTATTGACAGATGAGGATTTAGTGCTTCGCCGCCACA
TTCTTAACCTTATGTGTAAGCAAACGACCTCATGGGAAGATCCAAAACTTTACACCGATGAGCTTGATGTTGCGTTAGTA
CGCCTTGAGGATATGCAAAATGATGGCATGGTAATTCTTGGCGAGAAGAGTGTTACGGTTACAGAAGTAGGCATTCCATT
CCTTCGCAACATTTGCATGGCATTTGATGCACGCCTTTGGAGTTCCGACAGCCTTTCAAAAGCCTACAACGTATCGCGCG
ATATTCAAAAAACATACATTGAAAAAGCACGTCTTGCAAAGCTACAACGCGAGCAAGCTGGTGCATAA

Upstream 100 bases:

>100_bases
GTAACAAATAAATAGAGCTGCCCATGATTTTGAAGGCATTTATTGTATCTTCACCACATTTAAATTTAACAAAATTTATC
CTTGTAGGGGAAGAGAAACA

Downstream 100 bases:

>100_bases
TGGTGATTGAGAGCAGTCAGCCTTTGCTCTAAATATTACACAAACAAGTAAGGGCGACCGCAATAGTCGCCCTTTTTTTA
TGGCAAAAATAGCACTATGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MATNLAEKYSNPGPRYTSYPTIPSWSTDGVTQQQWREAMVKGFNDSNETTGVSMYIHIPYCENYCYFCGCNAHRTQDHSF
EKPYLDALLKEWQMYLDVFPGTLNVKELHIGGGTPTFLSPENLTRLVDGLFKHVNRMDNHMFSFETNPKSTTKEHLEALY
NVGFRRMSFGIQDFDPIVQKEINRLQSFELVKEKIDLARQIGFTSINFDLVYGLPKQTMATITDTIQKVMELRPDRLAFY
AYGHNPHMYEGQKKFNEADLPVGDAKQELYEKGSAMLESIGYHEIGMDHFAIEGDPLYIAAQNGTLHRNFMGYTENTTQM
MLALGSSSISDTWYAFAQNERTDGEYIKAVNEDRFPLHRGHLLTDEDLVLRRHILNLMCKQTTSWEDPKLYTDELDVALV
RLEDMQNDGMVILGEKSVTVTEVGIPFLRNICMAFDARLWSSDSLSKAYNVSRDIQKTYIEKARLAKLQREQAGA

Sequences:

>Translated_475_residues
MATNLAEKYSNPGPRYTSYPTIPSWSTDGVTQQQWREAMVKGFNDSNETTGVSMYIHIPYCENYCYFCGCNAHRTQDHSF
EKPYLDALLKEWQMYLDVFPGTLNVKELHIGGGTPTFLSPENLTRLVDGLFKHVNRMDNHMFSFETNPKSTTKEHLEALY
NVGFRRMSFGIQDFDPIVQKEINRLQSFELVKEKIDLARQIGFTSINFDLVYGLPKQTMATITDTIQKVMELRPDRLAFY
AYGHNPHMYEGQKKFNEADLPVGDAKQELYEKGSAMLESIGYHEIGMDHFAIEGDPLYIAAQNGTLHRNFMGYTENTTQM
MLALGSSSISDTWYAFAQNERTDGEYIKAVNEDRFPLHRGHLLTDEDLVLRRHILNLMCKQTTSWEDPKLYTDELDVALV
RLEDMQNDGMVILGEKSVTVTEVGIPFLRNICMAFDARLWSSDSLSKAYNVSRDIQKTYIEKARLAKLQREQAGA
>Mature_474_residues
ATNLAEKYSNPGPRYTSYPTIPSWSTDGVTQQQWREAMVKGFNDSNETTGVSMYIHIPYCENYCYFCGCNAHRTQDHSFE
KPYLDALLKEWQMYLDVFPGTLNVKELHIGGGTPTFLSPENLTRLVDGLFKHVNRMDNHMFSFETNPKSTTKEHLEALYN
VGFRRMSFGIQDFDPIVQKEINRLQSFELVKEKIDLARQIGFTSINFDLVYGLPKQTMATITDTIQKVMELRPDRLAFYA
YGHNPHMYEGQKKFNEADLPVGDAKQELYEKGSAMLESIGYHEIGMDHFAIEGDPLYIAAQNGTLHRNFMGYTENTTQMM
LALGSSSISDTWYAFAQNERTDGEYIKAVNEDRFPLHRGHLLTDEDLVLRRHILNLMCKQTTSWEDPKLYTDELDVALVR
LEDMQNDGMVILGEKSVTVTEVGIPFLRNICMAFDARLWSSDSLSKAYNVSRDIQKTYIEKARLAKLQREQAGA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=263, Percent_Identity=25.8555133079848, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI87082341, Length=440, Percent_Identity=38.1818181818182, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=28.3950617283951, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54501; Mature: 54370

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNLAEKYSNPGPRYTSYPTIPSWSTDGVTQQQWREAMVKGFNDSNETTGVSMYIHIPY
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
CENYCYFCGCNAHRTQDHSFEKPYLDALLKEWQMYLDVFPGTLNVKELHIGGGTPTFLSP
ECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
ENLTRLVDGLFKHVNRMDNHMFSFETNPKSTTKEHLEALYNVGFRRMSFGIQDFDPIVQK
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCCHHHHH
EINRLQSFELVKEKIDLARQIGFTSINFDLVYGLPKQTMATITDTIQKVMELRPDRLAFY
HHHHHHHHHHHHHHHHHHHHCCCEEECEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEE
AYGHNPHMYEGQKKFNEADLPVGDAKQELYEKGSAMLESIGYHEIGMDHFAIEGDPLYIA
EECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEECCCEEEEE
AQNGTLHRNFMGYTENTTQMMLALGSSSISDTWYAFAQNERTDGEYIKAVNEDRFPLHRG
ECCCCEECCCCCCCCCHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHCCCCCCCCCCC
HLLTDEDLVLRRHILNLMCKQTTSWEDPKLYTDELDVALVRLEDMQNDGMVILGEKSVTV
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHEEEEEEECCCCCCEEEEECCCEEE
TEVGIPFLRNICMAFDARLWSSDSLSKAYNVSRDIQKTYIEKARLAKLQREQAGA
EECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATNLAEKYSNPGPRYTSYPTIPSWSTDGVTQQQWREAMVKGFNDSNETTGVSMYIHIPY
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEE
CENYCYFCGCNAHRTQDHSFEKPYLDALLKEWQMYLDVFPGTLNVKELHIGGGTPTFLSP
ECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
ENLTRLVDGLFKHVNRMDNHMFSFETNPKSTTKEHLEALYNVGFRRMSFGIQDFDPIVQK
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCCHHHHH
EINRLQSFELVKEKIDLARQIGFTSINFDLVYGLPKQTMATITDTIQKVMELRPDRLAFY
HHHHHHHHHHHHHHHHHHHHCCCEEECEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEE
AYGHNPHMYEGQKKFNEADLPVGDAKQELYEKGSAMLESIGYHEIGMDHFAIEGDPLYIA
EECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCCCEEECCCEEEEE
AQNGTLHRNFMGYTENTTQMMLALGSSSISDTWYAFAQNERTDGEYIKAVNEDRFPLHRG
ECCCCEECCCCCCCCCHHHHHHHHCCCCCCCHHHEEECCCCCCCHHHHHCCCCCCCCCCC
HLLTDEDLVLRRHILNLMCKQTTSWEDPKLYTDELDVALVRLEDMQNDGMVILGEKSVTV
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHEEEEEEECCCCCCEEEEECCCEEE
TEVGIPFLRNICMAFDARLWSSDSLSKAYNVSRDIQKTYIEKARLAKLQREQAGA
EECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]