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The map label for this gene is ybhO [H]

Identifier: 78067519

GI number: 78067519

Start: 3191045

End: 3192319

Strand: Reverse

Name: ybhO [H]

Synonym: Bcep18194_A6050

Alternate gene names: 78067519

Gene position: 3192319-3191045 (Counterclockwise)

Preceding gene: 78067520

Following gene: 78067518

Centisome position: 86.42

GC content: 67.06

Gene sequence:

>1275_bases
ATGACGGCGGAAGCCCGCAAGCGCTTCGCGCAATTGCGGCAGATGTTCCTGCAGGAACGCGGTTCCGCGTCGCGGCTCGC
CTTCACGTCGGGCAATACCGTGCGGCTGTGCGAAGGCGGCGGCGCGTTCTTCCGGGCATTGATCGAGCGGATTGATGCCG
CCCGCGAGCAGGTGATGCTCGAAACCTACATCTTCTGCGACGACGCGGCCGGCCGGCCGGTGTCGGACGCGCTGATCCGC
GCGGCGCAGCGCGGCGTGCGCGTGCGCGTGATCACCGACGGCATCGGCACCGCACGCCTGCCGCTGTTCGACACGTGGGT
CGCGGCCGGCGTCGAGCACTGCATCTACAACCGTTTCCTGTTCGGCCGCTTCGGCTTCTCGCGCACGCATCGCAAGCTTG
CGGTGATCGATCACGCGGTCGCATTCTGCGGCGGCATCAACATCATCGACGACTATGCGCAGAACGGCACGACGCTGCCG
TTTCCACGCTGGGATTTCGCGGTCGAGATGGCGGGGCCCGCGGTGTCCGACGTGCGCGCCGCGTTCGAACTGCAGTGGCA
CCGGATCATGTTCGGCCACAAGCCGTATGCGCAATACGCGGCCGGGCTGCATGGCGGCGAAGCATTCCCCGACATGTTCC
GGCGCTGGATGCGCAGCCATCGGTGGATCAAGGCCGGCGCGCTGCGGGTCGTGACGGAGCCGAGCGTCGCGTTCGTCGCG
CGCGACAATGTCGTGAATCGCCGCGCGATCGAGAAGGCGTATCTCGCGGCGATCGGCCAGGCGCGCCAGCGGATCCTGCT
CGCTAATCCGTACTTCATGCCGGGCCGCAAGCTGCGCCGCGCGCTGACGGGCGCCGCGCGACGCGGCGTCGACGTGCGGA
TCCTGATCGGCCGCAAGGAGTTCGCGGCACTCGATACGGCCGTGCCGTTCCTCTATCACGCGCTGCTGCGCGCAGGCGTG
CGCGTGGCCGAATACGACAAGACGATGCTGCACGGCAAGGTGGCCGTGATCGACGACAATTGGGCGACGGTCGGTTCGTC
GAACCTGGACGCGCTGAGCCTGATGCTGAACAATGAAGCGAATGTCGTGCTGGTGCGCTACGATGCTGTCACGAACGAAC
TGCGCGACGCGATCGCGGCCGCATTCGCCGACGGCCGGGAAATCGACCCCGCCCGATTCGCCGCGCGCCCGCGTATCGAG
CGCATGCTGAACTGGCTTGCCTATACGGCGTATCGTCTCGTGATGAAGGCGCTGACGGTCGGTGGTTACGACTGA

Upstream 100 bases:

>100_bases
GCGAGGCGGCCGCGCGCTGCTTCTCGCCGTCGAACGCCGAAGCGATCCTGCAACTGCCCGCCCGCGTGGCACTCTCGCGC
GCGCCGCACGGCTCGTCCGC

Downstream 100 bases:

>100_bases
CGAAGACTAAGCGTTCGCTTCAAAAAATCTGTCCGCACGTTCGTGCGGAAAAGCCGCTCCGGTCCCGCCGGAATCGCGCA
AAATAGCGGCTCGGTTAGAC

Product: phospholipase D/transphosphatidylase

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTAEARKRFAQLRQMFLQERGSASRLAFTSGNTVRLCEGGGAFFRALIERIDAAREQVMLETYIFCDDAAGRPVSDALIR
AAQRGVRVRVITDGIGTARLPLFDTWVAAGVEHCIYNRFLFGRFGFSRTHRKLAVIDHAVAFCGGINIIDDYAQNGTTLP
FPRWDFAVEMAGPAVSDVRAAFELQWHRIMFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVRILIGRKEFAALDTAVPFLYHALLRAGV
RVAEYDKTMLHGKVAVIDDNWATVGSSNLDALSLMLNNEANVVLVRYDAVTNELRDAIAAAFADGREIDPARFAARPRIE
RMLNWLAYTAYRLVMKALTVGGYD

Sequences:

>Translated_424_residues
MTAEARKRFAQLRQMFLQERGSASRLAFTSGNTVRLCEGGGAFFRALIERIDAAREQVMLETYIFCDDAAGRPVSDALIR
AAQRGVRVRVITDGIGTARLPLFDTWVAAGVEHCIYNRFLFGRFGFSRTHRKLAVIDHAVAFCGGINIIDDYAQNGTTLP
FPRWDFAVEMAGPAVSDVRAAFELQWHRIMFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVRILIGRKEFAALDTAVPFLYHALLRAGV
RVAEYDKTMLHGKVAVIDDNWATVGSSNLDALSLMLNNEANVVLVRYDAVTNELRDAIAAAFADGREIDPARFAARPRIE
RMLNWLAYTAYRLVMKALTVGGYD
>Mature_423_residues
TAEARKRFAQLRQMFLQERGSASRLAFTSGNTVRLCEGGGAFFRALIERIDAAREQVMLETYIFCDDAAGRPVSDALIRA
AQRGVRVRVITDGIGTARLPLFDTWVAAGVEHCIYNRFLFGRFGFSRTHRKLAVIDHAVAFCGGINIIDDYAQNGTTLPF
PRWDFAVEMAGPAVSDVRAAFELQWHRIMFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVAR
DNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVRILIGRKEFAALDTAVPFLYHALLRAGVR
VAEYDKTMLHGKVAVIDDNWATVGSSNLDALSLMLNNEANVVLVRYDAVTNELRDAIAAAFADGREIDPARFAARPRIER
MLNWLAYTAYRLVMKALTVGGYD

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=381, Percent_Identity=38.0577427821522, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787502, Length=351, Percent_Identity=26.2108262108262, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 47417; Mature: 47286

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEARKRFAQLRQMFLQERGSASRLAFTSGNTVRLCEGGGAFFRALIERIDAAREQVML
CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
ETYIFCDDAAGRPVSDALIRAAQRGVRVRVITDGIGTARLPLFDTWVAAGVEHCIYNRFL
HHEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
FGRFGFSRTHRKLAVIDHAVAFCGGINIIDDYAQNGTTLPFPRWDFAVEMAGPAVSDVRA
HHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHH
AFELQWHRIMFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
HHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVRILIGRKE
CCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCHH
FAALDTAVPFLYHALLRAGVRVAEYDKTMLHGKVAVIDDNWATVGSSNLDALSLMLNNEA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEEECCCC
NVVLVRYDAVTNELRDAIAAAFADGREIDPARFAARPRIERMLNWLAYTAYRLVMKALTV
CEEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GGYD
CCCC
>Mature Secondary Structure 
TAEARKRFAQLRQMFLQERGSASRLAFTSGNTVRLCEGGGAFFRALIERIDAAREQVML
CHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
ETYIFCDDAAGRPVSDALIRAAQRGVRVRVITDGIGTARLPLFDTWVAAGVEHCIYNRFL
HHEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
FGRFGFSRTHRKLAVIDHAVAFCGGINIIDDYAQNGTTLPFPRWDFAVEMAGPAVSDVRA
HHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHH
AFELQWHRIMFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
HHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVRILIGRKE
CCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCHH
FAALDTAVPFLYHALLRAGVRVAEYDKTMLHGKVAVIDDNWATVGSSNLDALSLMLNNEA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEEECCCC
NVVLVRYDAVTNELRDAIAAAFADGREIDPARFAARPRIERMLNWLAYTAYRLVMKALTV
CEEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GGYD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]