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The map label for this gene is hisM [H]

Identifier: 78067202

GI number: 78067202

Start: 2838365

End: 2839078

Strand: Direct

Name: hisM [H]

Synonym: Bcep18194_A5733

Alternate gene names: 78067202

Gene position: 2838365-2839078 (Clockwise)

Preceding gene: 78067201

Following gene: 78067203

Centisome position: 76.83

GC content: 63.73

Gene sequence:

>714_bases
ATGATCGAACTCATCCAAGAATACTGGCGCAACTATCTCTACACCGACGGCTATCGCATTACCGGTGTGGCGATCACGTT
GTGGCTGCTGGTCGTGTCGATCGGCCTCGGCTTCTGCCTGTCGATACCGCTCGCGGTCGCGCGCGTGTCGAAGAAGAAGT
GGCTGTCGGGCGCCGTATGGCTCTACACGTACGTATTCCGCGGCACGCCGCTCTACGTGCAGCTGCTGCTCTGCTACACG
GGCCTCTACAGCCTGCAGGCCGTGCGCGGCACGCCGATGCTCGACGCGTTCTTCCGCGACGGGATGCACTGCACGCTGCT
CGCGTTCACGCTGAACACCTGCGCGTACACCACCGAGATCTTCGCGGGCGCGATCAAGGCGACGTCCTACGGCGAAATCG
AAGCCGCGCGTGCGTACGGGATGTCGACGTTCACGATGTATCGCCGCGTGATCCTGCCGTCAGCGCTGCGCCGCGCGCTG
CCGCTGTACAGCAACGAAGTGATCCTGATGCTGCACGCGACCACCGTCGCCTTCACCGCGACCGTGCCGGACATCCTGAA
GATCGCCCGCGACGTCAACTCGGCGACCTACATGTCGTTCCATGCGTTCGGCATCGCCGCCCTGCTCTATCTCGTGATCT
CGTTCACGCTCGTCTGGCTGTTCCGCCAGGCCGAGCGCCGCTGGCTCGCGTATCTGCGCCCGCAAGGCAAGTAA

Upstream 100 bases:

>100_bases
TGATCGCGGGTGCCGTCTACCTCGCGATCACGACGATCTCGAACTTCGTGCTGATGTGGCTCGAAAAGCGCTACTCGACC
GGCGTCCGCAAGGCTGACCT

Downstream 100 bases:

>100_bases
GTTTTCGCAGGACTATTGATGAATTCCCAGACTCAGAAGCTTTTCGTCGACGATCTGCACAAGCGGTACGGCGACAACGA
GGTGCTCAAGGGCGTGTCGC

Product: ABC amino acid transporter, inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSIPLAVARVSKKKWLSGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMHCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRQAERRWLAYLRPQGK

Sequences:

>Translated_237_residues
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSIPLAVARVSKKKWLSGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMHCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRQAERRWLAYLRPQGK
>Mature_237_residues
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSIPLAVARVSKKKWLSGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMHCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRQAERRWLAYLRPQGK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=66.1016949152542, Blast_Score=333, Evalue=5e-93,
Organism=Escherichia coli, GI1787086, Length=217, Percent_Identity=33.6405529953917, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788226, Length=226, Percent_Identity=30.5309734513274, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787030, Length=210, Percent_Identity=29.5238095238095, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788646, Length=218, Percent_Identity=28.4403669724771, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786873, Length=224, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994930, Length=167, Percent_Identity=29.3413173652695, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787087, Length=124, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26888; Mature: 26888

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSIPLAVARVSKKKWLSGAVW
CHHHHHHHHHHCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPMLDAFFRDGMHCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRQAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSIPLAVARVSKKKWLSGAVW
CHHHHHHHHHHCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPMLDAFFRDGMHCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRQAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]