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The map label for this gene is phbA [H]

Identifier: 78066549

GI number: 78066549

Start: 2118244

End: 2119434

Strand: Reverse

Name: phbA [H]

Synonym: Bcep18194_A5080

Alternate gene names: 78066549

Gene position: 2119434-2118244 (Counterclockwise)

Preceding gene: 78066550

Following gene: 78066548

Centisome position: 57.37

GC content: 68.51

Gene sequence:

>1191_bases
ATGCAACGTGAAGTGGTGGTGGTGAGCGGCGTGCGTACCGCGATCGGCGATTTCGGCGGCAGCCTGAAGGACATTGCGCC
GACCGCGCTCGGCGCGCAGGTCGTGCGCGAAGTGCTGAAGCGCGCGCAGGTGTCGGGCGACGAGGTTGGCCACGTGGTGT
TCGGCAACGTCGTGCACACGGAGCCGAGGGACATGTATCTCGCGCGCGTCGCCGCGATCGACGGCGGCGTCGCGCAGCAC
GCGCCGGCGCTCACGGTGAACCGGCTGTGCGGCTCGGGCCTGCAGGCGATCGTGTCGGCCGCGCAGGGCGTGCTGCTCGG
CGATGCGGACATCGCGATCGCAGGCGGCGCGGAGAACATGAGCCGCGCGCCGTATTCGATCCCGGCCGCGCGCTTCGGGC
AGCGCATGGGCGACATGCGCGCAGTCGACATGATGGTCGGCGCGCTGAACGATCCGTTCCAGACGATCCACATGGGCGTG
ACGGCCGAGAACGTTGCGGCGAAGTACGGCATTTCACGCGACGCGCAGGATGCGCTCGCGCTCGAATCGCACCGCCGCGC
GTCGCATGCGGCGAAGGCCGGTTACTTCAAGGACCAGATCCTGCCGGTCGAGCTGATCGGCTCGAAGAAGGGCACGCCGG
TCGTGTTCGATCACGACGAGCACGTGCGCCACGATGCGAGCCTGGAGGATTTCTCGAAGCTGCGGCCCGTATTCGTGAAG
GAGAACGGCACGGTGACGGCCGGCAACGCGTCGGGCATCAACGATGCGGCGGCTGCCGTGCTGCTGATGGAGCGCAGCGT
TGCCGAGCAGCGCGGTGCGCAGCCGCTCGCGCGCCTCGTTGCGTATGCGCACGCGGGCGTCGATCCGGCCTACATGGGGA
TCGGCCCCGTGCCGGCGACGCAGAAAGTGCTCGCGCGTGCGGGGCTGACGGTGGCCGATCTCGACGTGATCGAGGCAAAC
GAGGCGTTCGCCGCGCAGGCATGCGCGGTGACGCAGGAACTGGGTCTCGACCCGGCAAAGGTGAATCCGAACGGGTCCGG
CATTTCGCTCGGCCACCCGATCGGCGCGACGGGCGCGCTGATCACTGTCAAGGCGCTGTACGAACTGCAGCGCGTCGGCG
GCCGATATGCGCTCGTCACGATGTGCATTGGCGGCGGGCAAGGCATCGCCGCGATTTTCGAGCGAATCTGA

Upstream 100 bases:

>100_bases
CGATGCGGTGGAGCGCCTGATGCAAGGCTGACGCGGCATGCGCACGCCGGCCACGGCACCGCACGAACGATTCATTCGAT
CAGAAGGATGAGGAGGCGAC

Downstream 100 bases:

>100_bases
AGCAAGGAGCAACACAAGGTGGGTCGATATTCGCAATGGCAACGGGCGCTCGTCGTCGCGGGCGCGCTGGCGGCGGGCAT
GACGATGCCGGGCGTAGTCG

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQREVVVVSGVRTAIGDFGGSLKDIAPTALGAQVVREVLKRAQVSGDEVGHVVFGNVVHTEPRDMYLARVAAIDGGVAQH
APALTVNRLCGSGLQAIVSAAQGVLLGDADIAIAGGAENMSRAPYSIPAARFGQRMGDMRAVDMMVGALNDPFQTIHMGV
TAENVAAKYGISRDAQDALALESHRRASHAAKAGYFKDQILPVELIGSKKGTPVVFDHDEHVRHDASLEDFSKLRPVFVK
ENGTVTAGNASGINDAAAAVLLMERSVAEQRGAQPLARLVAYAHAGVDPAYMGIGPVPATQKVLARAGLTVADLDVIEAN
EAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRVGGRYALVTMCIGGGQGIAAIFERI

Sequences:

>Translated_396_residues
MQREVVVVSGVRTAIGDFGGSLKDIAPTALGAQVVREVLKRAQVSGDEVGHVVFGNVVHTEPRDMYLARVAAIDGGVAQH
APALTVNRLCGSGLQAIVSAAQGVLLGDADIAIAGGAENMSRAPYSIPAARFGQRMGDMRAVDMMVGALNDPFQTIHMGV
TAENVAAKYGISRDAQDALALESHRRASHAAKAGYFKDQILPVELIGSKKGTPVVFDHDEHVRHDASLEDFSKLRPVFVK
ENGTVTAGNASGINDAAAAVLLMERSVAEQRGAQPLARLVAYAHAGVDPAYMGIGPVPATQKVLARAGLTVADLDVIEAN
EAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRVGGRYALVTMCIGGGQGIAAIFERI
>Mature_396_residues
MQREVVVVSGVRTAIGDFGGSLKDIAPTALGAQVVREVLKRAQVSGDEVGHVVFGNVVHTEPRDMYLARVAAIDGGVAQH
APALTVNRLCGSGLQAIVSAAQGVLLGDADIAIAGGAENMSRAPYSIPAARFGQRMGDMRAVDMMVGALNDPFQTIHMGV
TAENVAAKYGISRDAQDALALESHRRASHAAKAGYFKDQILPVELIGSKKGTPVVFDHDEHVRHDASLEDFSKLRPVFVK
ENGTVTAGNASGINDAAAAVLLMERSVAEQRGAQPLARLVAYAHAGVDPAYMGIGPVPATQKVLARAGLTVADLDVIEAN
EAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGALITVKALYELQRVGGRYALVTMCIGGGQGIAAIFERI

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=45.0381679389313, Blast_Score=341, Evalue=7e-94,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=44.5569620253165, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=42.6767676767677, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=39.6508728179551, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=35.3629976580796, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=33.3333333333333, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788554, Length=400, Percent_Identity=49, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=47.2081218274112, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.2970297029703, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=39.1521197007481, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=35.5231143552311, Blast_Score=216, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=45.5470737913486, Blast_Score=337, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=396, Percent_Identity=33.3333333333333, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=400, Percent_Identity=33.25, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.3943661971831, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=26.2626262626263, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=37.8109452736318, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6322031, Length=406, Percent_Identity=37.192118226601, Blast_Score=233, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=46.7005076142132, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=43.6868686868687, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=38.8324873096447, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=32.093023255814, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41121; Mature: 41121

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREVVVVSGVRTAIGDFGGSLKDIAPTALGAQVVREVLKRAQVSGDEVGHVVFGNVVHT
CCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEC
EPRDMYLARVAAIDGGVAQHAPALTVNRLCGSGLQAIVSAAQGVLLGDADIAIAGGAENM
CCHHHHHHHHHHHCCCHHHCCCCHHHHHHHCHHHHHHHHHHCCEEECCCCEEEECCCCCC
SRAPYSIPAARFGQRMGDMRAVDMMVGALNDPFQTIHMGVTAENVAAKYGISRDAQDALA
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHEEECCCHHHHHHHHCCCCCHHHHHH
LESHRRASHAAKAGYFKDQILPVELIGSKKGTPVVFDHDEHVRHDASLEDFSKLRPVFVK
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEECCCHHHCCCCCHHHHHHCCCEEEE
ENGTVTAGNASGINDAAAAVLLMERSVAEQRGAQPLARLVAYAHAGVDPAYMGIGPVPAT
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCCCCCHH
QKVLARAGLTVADLDVIEANEAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGAL
HHHHHHCCCEEEECEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCHHH
ITVKALYELQRVGGRYALVTMCIGGGQGIAAIFERI
HHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MQREVVVVSGVRTAIGDFGGSLKDIAPTALGAQVVREVLKRAQVSGDEVGHVVFGNVVHT
CCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEC
EPRDMYLARVAAIDGGVAQHAPALTVNRLCGSGLQAIVSAAQGVLLGDADIAIAGGAENM
CCHHHHHHHHHHHCCCHHHCCCCHHHHHHHCHHHHHHHHHHCCEEECCCCEEEECCCCCC
SRAPYSIPAARFGQRMGDMRAVDMMVGALNDPFQTIHMGVTAENVAAKYGISRDAQDALA
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHEEECCCHHHHHHHHCCCCCHHHHHH
LESHRRASHAAKAGYFKDQILPVELIGSKKGTPVVFDHDEHVRHDASLEDFSKLRPVFVK
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEECCCHHHCCCCCHHHHHHCCCEEEE
ENGTVTAGNASGINDAAAAVLLMERSVAEQRGAQPLARLVAYAHAGVDPAYMGIGPVPAT
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHCCCCCCCHH
QKVLARAGLTVADLDVIEANEAFAAQACAVTQELGLDPAKVNPNGSGISLGHPIGATGAL
HHHHHHCCCEEEECEEEECCHHHHHHHHHHHHHHCCCCCEECCCCCCEECCCCCCCCHHH
ITVKALYELQRVGGRYALVTMCIGGGQGIAAIFERI
HHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396692 [H]