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The map label for this gene is metC [H]

Identifier: 78066547

GI number: 78066547

Start: 2116388

End: 2117569

Strand: Reverse

Name: metC [H]

Synonym: Bcep18194_A5078

Alternate gene names: 78066547

Gene position: 2117569-2116388 (Counterclockwise)

Preceding gene: 78066548

Following gene: 78066544

Centisome position: 57.32

GC content: 67.26

Gene sequence:

>1182_bases
ATGACTGCATCCACTCCCAAGCGCGCGCTGCAAACCCGCATCGTTCAACCCGACGACGTGATCCCGGAAGGCTTCCGTTC
GTTCGTGCCGCCGGTCGCGCGCGCGTCGACGGTCGTGTTCCCCGATCTCGCGACGATGCGTGCGCTCGTCTGGCACAACG
ACAACCAGTGGCGCTACGGCCTGCATGCGACGCCGACGTCGCTCGCGCTTGCGCAGCGGCTCGCCGAGATCGAGGGCGGC
ACGCATGCGCTGCTGCAGCCGTCGGGTCTCGCGGCCATCATGAACGTCTACTTCGGGATCGTGAAAGCCGGCGACGACGT
GCTGATTCCGCACAACGTGTACGGGCCGAACGCCGATTTCGGCAACTGGCTCGCGAAGGATTTCGGCATCACCGCGCGCT
TCTACGATCCGTTGATCGGCGCCGGCATTGCCGACCTGATCCAGCCGAACACGCGGCTGATCTGGATCGAAGCGCCGGGC
TCGGTGACGATGGAAGTGCCGGACGTGCAGGCGATCGCGGCGGCCGCGAAGGCGCGCGGCATCGTCACCGCCATCGACAA
CACGTTCTCGGCCGGGCTCGCGTTCAAGCCGTTCGAACACGGCGTCGACATCTCGGTGCAGGCGCTGACCAAGTACCAGT
CGGGCGGCAGCGACGTGCTGATGGGCGCGACGATCACCGCGAACGCGGAACTGCACGCGAAGCTGAAGCTCGCACGGATG
CGCTGCGGCGTCGGCGTGTCGGTCGACGATTGCTCGCTCGTGCTGCGCAGCCTGCCGAGCATGCAGGTGCGTTTCGACGC
GCACAGCAAGAGCGCGCTCGCGCTTGCGCAATGGCTGAAGGCGCGGCCGGAGATCGCGGCGGTCCTGCACCCGCAGATCG
CCGATTGCCCGGGGCACGCGTCGTTCATGCGTGATTTCACCGGCGCGGGCGGGCTGTTCTCGGTGGTGTTCGACGAGCGC
TACAGCGCGGAGCAGATCGACCGCTTCGTCGAGTCGCTCGAACTGTTCGCGATCGGCTGGAGCTGGGGCGGCGCGTGCAG
CCTCGCGATGCCTTACGACGTCGCGTCGATGCGTCCGGACTGGCCGCATCGCGGCACGCTGGTGCGTTTCTATGTCGGCC
TGGAAGACGAAGCCGACTTGCGCGCGGACATCGAGCGCGCGATGCAGGACGTACTCGGCTGA

Upstream 100 bases:

>100_bases
CGGTGCGCGCGGCGCGCATTGTACCGGGCCAATTGCGCCGATTTTGGCTAATCTAGCTGCATATTCCGCAACCGAACGGC
CTCGTGCCGGGCTTCCTGTC

Downstream 100 bases:

>100_bases
TCGCAGGCCGCGAAGGCTCCGCGGAAAAACAAAACGCCGGCGCGATGTTGCATCGCACCGGCGTTTTTCATTTCGGATTC
TGCAGGATCAGAACAGGCGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTASTPKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHNDNQWRYGLHATPTSLALAQRLAEIEGG
THALLQPSGLAAIMNVYFGIVKAGDDVLIPHNVYGPNADFGNWLAKDFGITARFYDPLIGAGIADLIQPNTRLIWIEAPG
SVTMEVPDVQAIAAAAKARGIVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
RCGVGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHASFMRDFTGAGGLFSVVFDER
YSAEQIDRFVESLELFAIGWSWGGACSLAMPYDVASMRPDWPHRGTLVRFYVGLEDEADLRADIERAMQDVLG

Sequences:

>Translated_393_residues
MTASTPKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHNDNQWRYGLHATPTSLALAQRLAEIEGG
THALLQPSGLAAIMNVYFGIVKAGDDVLIPHNVYGPNADFGNWLAKDFGITARFYDPLIGAGIADLIQPNTRLIWIEAPG
SVTMEVPDVQAIAAAAKARGIVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
RCGVGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHASFMRDFTGAGGLFSVVFDER
YSAEQIDRFVESLELFAIGWSWGGACSLAMPYDVASMRPDWPHRGTLVRFYVGLEDEADLRADIERAMQDVLG
>Mature_392_residues
TASTPKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHNDNQWRYGLHATPTSLALAQRLAEIEGGT
HALLQPSGLAAIMNVYFGIVKAGDDVLIPHNVYGPNADFGNWLAKDFGITARFYDPLIGAGIADLIQPNTRLIWIEAPGS
VTMEVPDVQAIAAAAKARGIVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARMR
CGVGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHASFMRDFTGAGGLFSVVFDERY
SAEQIDRFVESLELFAIGWSWGGACSLAMPYDVASMRPDWPHRGTLVRFYVGLEDEADLRADIERAMQDVLG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=30.7692307692308, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI299473759, Length=237, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI25453487, Length=324, Percent_Identity=26.8518518518519, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789383, Length=362, Percent_Identity=37.5690607734807, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1790375, Length=374, Percent_Identity=29.144385026738, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17560056, Length=362, Percent_Identity=30.939226519337, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17538055, Length=329, Percent_Identity=31.0030395136778, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71980708, Length=380, Percent_Identity=29.4736842105263, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321170, Length=325, Percent_Identity=36.9230769230769, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319307, Length=345, Percent_Identity=28.695652173913, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=25.3588516746411, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321904, Length=371, Percent_Identity=25.6064690026954, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321254, Length=264, Percent_Identity=28.7878787878788, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922554, Length=388, Percent_Identity=32.2164948453608, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42560; Mature: 42429

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASTPKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHNDNQWRYG
CCCCCHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCEEECCCHHHHEEHEEECCCCEEEE
LHATPTSLALAQRLAEIEGGTHALLQPSGLAAIMNVYFGIVKAGDDVLIPHNVYGPNADF
CCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCH
GNWLAKDFGITARFYDPLIGAGIADLIQPNTRLIWIEAPGSVTMEVPDVQAIAAAAKARG
HHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
IVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
EEEEECCCCCCCCEECCHHCCCCEEEEEHHHHCCCCCCEEEEEEEEECCEEHHHHHHHHH
RCGVGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHA
HCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
SFMRDFTGAGGLFSVVFDERYSAEQIDRFVESLELFAIGWSWGGACSLAMPYDVASMRPD
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHCCCC
WPHRGTLVRFYVGLEDEADLRADIERAMQDVLG
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TASTPKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHNDNQWRYG
CCCCHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCEEECCCHHHHEEHEEECCCCEEEE
LHATPTSLALAQRLAEIEGGTHALLQPSGLAAIMNVYFGIVKAGDDVLIPHNVYGPNADF
CCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCH
GNWLAKDFGITARFYDPLIGAGIADLIQPNTRLIWIEAPGSVTMEVPDVQAIAAAAKARG
HHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
IVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
EEEEECCCCCCCCEECCHHCCCCEEEEEHHHHCCCCCCEEEEEEEEECCEEHHHHHHHHH
RCGVGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHA
HCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
SFMRDFTGAGGLFSVVFDERYSAEQIDRFVESLELFAIGWSWGGACSLAMPYDVASMRPD
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHCCCC
WPHRGTLVRFYVGLEDEADLRADIERAMQDVLG
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]