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The map label for this gene is proY [H]

Identifier: 78065791

GI number: 78065791

Start: 1265455

End: 1266822

Strand: Reverse

Name: proY [H]

Synonym: Bcep18194_A4320

Alternate gene names: 78065791

Gene position: 1266822-1265455 (Counterclockwise)

Preceding gene: 78065792

Following gene: 78065789

Centisome position: 34.29

GC content: 66.45

Gene sequence:

>1368_bases
ATGAAAAACTTGCAGCGCCACCTGAGTGCGCGGCACATCCGCTTTCTCGCGCTGGGTTCGGCGATCGGCACGGGCCTGTT
CTACGGTTCGGCGTCCGCGATCCAGCTCGCGGGCCCGGCCGTGATCCTGGCGTACATCCTCGGCGGCGCGGCCGTCTACA
TGGTGATGCGCGCGCTCGGCGAGATGGCCGTGCGCGACCCGGTCGCCGGCTCGTTCGGCCACTACGCGACCGAGAACCTC
GGCCCGTTCGCCGGGTTCGTCACCGGCTGGACCTACACGCTCGAAATGGTGATCGTCGCGATCGCCGACATCACCGCGTT
CGGCATCTACATGGGCTTCTGGTTTCCGGATGTCCCGCAATGGATCTGGGTGCTCGGCGTCGTCGCGATCATCTGCGGGC
TGAACCTGTGCCATGTGAAGGTGTTCGGCGAGCTCGAATTCTGGCTGTCGATCATCAAGGTCGGCGCGATCGTCGCGATG
ATCGGCGGCGGCGTCGCGATCCTGCTGACCGGCATGCACTTCGGCCACTCGGCCGACGTGCCGACGTTCGCGAACCTGTG
GAACCACGGCGGCTTCCTGCCGAACGGCGTCGGCGGGCTGATCGCGTCGCTGTCGGTCGTGATCTTCGCGTACGGCGGGA
TCGAGGTGATCGGCATGAGCGCCGGCGAGGCGAAGGATCCGGAACGCGTGATTCCGCGCGCGATCAACGCGGTGCCCGCA
CGCATCCTGCTGTTCTACGTGCTGACGATGGTCGTATTGATGTCGATCAGCCCGTGGACGGGTGTCGGCAACGAAGGCAG
CCCGTTCGTGCAGATCTTCTCGGCGCTCGGCGTGAAGTCGGCCGCGACGATCCTCAACCTGGTGGTGATCAGCGCGGCGA
TCTCCGCGATCAACAGCGACATCTTCGGCGCGGGCCGGATGATGTTCGGGATGGCGCGCCAGGGCCAGGCGCCGCGCGTG
CTGATGACGACGTCGCGGCACGGTGTGCCGTGGGTCACGGTGGTCGTGATGGCAGCCGCGCTGCTCGTCGGCGTGCTGCT
CAACTACCTGATGCCGAAGGACGTGTTCCTGATGGTCGCGGCGATCGCGACGTTCGCCACCGTGTGGGTGTGGCTGATGA
TCCTGCTGTCGCAGGTCGCGATGCGCCGCCGGCTGTCGAGCACCGAAGTCGCGGCGCTGAAGTTCAAGGTGCCGTTGTGG
CCGGTCGCGCCGGCACTGACGATCGCGTTCATGGGCTTCGTGATCGTGATGCTCGGCTGGTTCGAGGACACGCGCGTCGC
GCTGTATGTCGGCGCGGCCTGGCTCGCGCTGCTCGCGCTCGTGTTCTACGCACGGATCCGCCCGAAATTCGCACCTGCGT
CACGTTGA

Upstream 100 bases:

>100_bases
GCTTGTTATCATTCGTTCACATTTAAGTTGTCTATACAACTTGAACCAATCGGACCGGCCCCGCTCGCCCGGTCCGTCGC
ATAACGATATCGGAGACACG

Downstream 100 bases:

>100_bases
CGCACGACTGACCCGCATACGCGGCGCGCCGGCTCCGGCGCCCGCTTCTCTCCCGGCTCCGCGCGGCATCCCGCGCGCCA
ATAGCCGGAGATTCATCCCC

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVRDPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLTGMHFGHSADVPTFANLWNHGGFLPNGVGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGNEGSPFVQIFSALGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LMTTSRHGVPWVTVVVMAAALLVGVLLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSSTEVAALKFKVPLW
PVAPALTIAFMGFVIVMLGWFEDTRVALYVGAAWLALLALVFYARIRPKFAPASR

Sequences:

>Translated_455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVRDPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLTGMHFGHSADVPTFANLWNHGGFLPNGVGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGNEGSPFVQIFSALGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LMTTSRHGVPWVTVVVMAAALLVGVLLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSSTEVAALKFKVPLW
PVAPALTIAFMGFVIVMLGWFEDTRVALYVGAAWLALLALVFYARIRPKFAPASR
>Mature_455_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALGEMAVRDPVAGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQWIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAM
IGGGVAILLTGMHFGHSADVPTFANLWNHGGFLPNGVGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
RILLFYVLTMVVLMSISPWTGVGNEGSPFVQIFSALGVKSAATILNLVVISAAISAINSDIFGAGRMMFGMARQGQAPRV
LMTTSRHGVPWVTVVVMAAALLVGVLLNYLMPKDVFLMVAAIATFATVWVWLMILLSQVAMRRRLSSTEVAALKFKVPLW
PVAPALTIAFMGFVIVMLGWFEDTRVALYVGAAWLALLALVFYARIRPKFAPASR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=356, Percent_Identity=26.4044943820225, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI110347453, Length=337, Percent_Identity=26.4094955489614, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1786602, Length=438, Percent_Identity=61.1872146118721, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=43.3333333333333, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=439, Percent_Identity=43.2801822323462, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1790653, Length=442, Percent_Identity=40.4977375565611, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=42.4593967517401, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=38.0597014925373, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87081708, Length=437, Percent_Identity=35.2402745995423, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1789017, Length=413, Percent_Identity=35.3510895883777, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788480, Length=432, Percent_Identity=34.7222222222222, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87081869, Length=194, Percent_Identity=26.2886597938144, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082023, Length=415, Percent_Identity=23.1325301204819, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=350, Percent_Identity=26, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532491, Length=368, Percent_Identity=26.3586956521739, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=418, Percent_Identity=25.1196172248804, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324061, Length=464, Percent_Identity=31.8965517241379, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=31.1512415349887, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=34.020618556701, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=407, Percent_Identity=31.4496314496315, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=355, Percent_Identity=31.830985915493, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=411, Percent_Identity=29.4403892944039, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324059, Length=445, Percent_Identity=28.7640449438202, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=27.3399014778325, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=398, Percent_Identity=25.3768844221106, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=26.7002518891688, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=416, Percent_Identity=25.7211538461538, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=396, Percent_Identity=27.020202020202, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=393, Percent_Identity=27.2264631043257, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=27.1144278606965, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=25.7611241217799, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=364, Percent_Identity=29.1208791208791, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324981, Length=415, Percent_Identity=27.4698795180723, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=23.1683168316832, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667468, Length=336, Percent_Identity=25.8928571428571, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666159, Length=406, Percent_Identity=24.1379310344828, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221512776, Length=406, Percent_Identity=24.1379310344828, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077963, Length=344, Percent_Identity=23.2558139534884, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48711; Mature: 48711

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVRDPVAGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQ
HHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
WIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAMIGGGVAILLTGMHFGHSADV
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
PTFANLWNHGGFLPNGVGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RILLFYVLTMVVLMSISPWTGVGNEGSPFVQIFSALGVKSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMFGMARQGQAPRVLMTTSRHGVPWVTVVVMAAALLVGVLLNYLMPKDVFLMVA
HHHCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQVAMRRRLSSTEVAALKFKVPLWPVAPALTIAFMGFVIVMLGW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
FEDTRVALYVGAAWLALLALVFYARIRPKFAPASR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIQLAGPAVILAYILGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVRDPVAGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPDVPQ
HHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
WIWVLGVVAIICGLNLCHVKVFGELEFWLSIIKVGAIVAMIGGGVAILLTGMHFGHSADV
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
PTFANLWNHGGFLPNGVGGLIASLSVVIFAYGGIEVIGMSAGEAKDPERVIPRAINAVPA
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RILLFYVLTMVVLMSISPWTGVGNEGSPFVQIFSALGVKSAATILNLVVISAAISAINSD
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IFGAGRMMFGMARQGQAPRVLMTTSRHGVPWVTVVVMAAALLVGVLLNYLMPKDVFLMVA
HHHCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIATFATVWVWLMILLSQVAMRRRLSSTEVAALKFKVPLWPVAPALTIAFMGFVIVMLGW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
FEDTRVALYVGAAWLALLALVFYARIRPKFAPASR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]