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The map label for this gene is gyaR [H]

Identifier: 78065688

GI number: 78065688

Start: 1150851

End: 1151840

Strand: Direct

Name: gyaR [H]

Synonym: Bcep18194_A4216

Alternate gene names: 78065688

Gene position: 1150851-1151840 (Clockwise)

Preceding gene: 78065687

Following gene: 78065689

Centisome position: 31.15

GC content: 68.38

Gene sequence:

>990_bases
ATGCAGAAGATCCTGGTCGCGCGTCCGATCTTTCCGGACGTGATCGAGCGGCTCAAGCAGTATTTCGATGTCGACTGGCA
CAACGGCGACGCACTCGCTCCCGACGCGCTCGCCGCGCGTCTGGCCGACAAGGACGGCGCGCTGACGGCAGGGGACCTGG
TCGGCGCGGCCGAGCTCGCGGCGGCGCCGCGCCTGCGCGTCGTGGCGAACATGGCGGTCGGCTACAACAATTTCGACATG
GCCGCGTTCAACGCGGCGAACGTGCTCGGCACCAACACGCCCGACGTACTGAACGAGTCGACTGCCGATTTCGGCTGGGC
GCTGATGATGGCCGCAGCACGCCGGATCGCCGAATCCGAGCACTGGCTGCGGGCCGGCCACTGGCAAAAGTGGGCGTACG
ACGGTTTCCTCGGCAGCGACATTTACGGCTCGACGCTCGGCGTCATCGGGATGGGGCGCATCGGCCAGGCGCTCGCGCGT
CGCGCGCGCGGCTTCGGGATGCAGGTGATCTATCACAACCGGTCGCGCGTCGCGCCCGAGATCGAGGCCGAGCTGAATGC
CGAATACGTGTCGAAGGATGCGCTGCTTGCGCGTGCCGATCACGTCGTGCTCGTGCTGCCGTACACGAAGGAGAACCATC
ACACGATCGGCGCGGCCGAGCTCGCGAAGATGAAGCCCACCGCGACGCTCACCAACATCGCACGTGGCGGGATCGTCGAC
GACGCGGCGCTGGCCGTCGCGCTGCGCGACGGGACGATCGCCGCGGCCGGCCTCGACGTGTACGAAGGCGAGCCGACCGT
CCATCCGGCGCTGCTCGAAGTGCCGAACGTCGTGCTGACGCCGCATATCGCGAGCGCGACCGAGAAAACGCGCCGCGCGA
TGGCGAACCTCGCCGCCGACAATCTGATTGCCGCGCTGGGCGAAGGGCCGCGCGCCGGGCAGCCGCCGAATCCGATCAAC
CCTGACGTGATCGGGAAGCCGCGCGCATGA

Upstream 100 bases:

>100_bases
GATCTTCTTCACGGCGTAAGCTGACGATTTTCAACCTAGAGCGGGCGGTCCCGGCGGCGCATGGCGTGCTGCGATCCGTC
CGCGGCATGCGGAGATGGCG

Downstream 100 bases:

>100_bases
CAATGACGTTGTTGCTTGCGGCGGTCGTCGTGCTGGCCGTCGCGCTTGCGGTGGCGATCGTCGCGCTCGTGCGTGGCGGT
GGCCGCCACGACGATGCGGC

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLKQYFDVDWHNGDALAPDALAARLADKDGALTAGDLVGAAELAAAPRLRVVANMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAVALRDGTIAAAGLDVYEGEPTVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLKQYFDVDWHNGDALAPDALAARLADKDGALTAGDLVGAAELAAAPRLRVVANMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAVALRDGTIAAAGLDVYEGEPTVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA
>Mature_329_residues
MQKILVARPIFPDVIERLKQYFDVDWHNGDALAPDALAARLADKDGALTAGDLVGAAELAAAPRLRVVANMAVGYNNFDM
AAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELNAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAVALRDGTIAAAGLDVYEGEPTVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=39.5256916996047, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=28.7671232876712, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=35.2, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=35.2, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=35.2, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=7e-28,
Organism=Escherichia coli, GI87082289, Length=326, Percent_Identity=42.3312883435583, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=29.3650793650794, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789279, Length=314, Percent_Identity=28.0254777070064, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081824, Length=212, Percent_Identity=29.2452830188679, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=31.4754098360656, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=28.515625, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.1463414634146, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=28.4403669724771, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=274, Percent_Identity=30.2919708029197, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6321253, Length=283, Percent_Identity=23.321554770318, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=31.9444444444444, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=38.0503144654088, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=38.0503144654088, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=38.0503144654088, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=38.0503144654088, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=38.0503144654088, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=39.922480620155, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI28571528, Length=310, Percent_Identity=36.7741935483871, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=34.7826086956522, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19921140, Length=330, Percent_Identity=30, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24646446, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646448, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646452, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646450, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35056; Mature: 35056

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWHNGDALAPDALAARLADKDGALTAGDLVGAAELA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHH
AAPRLRVVANMAVGYNNFDMAAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
CCCCCEEEEHHHCCCCCCCHHHCCCCHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHCCCCCHHEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELNAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHCCHHHHHHHHHHEECCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCC
DAALAVALRDGTIAAAGLDVYEGEPTVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
CCEEEEEEECCEEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWHNGDALAPDALAARLADKDGALTAGDLVGAAELA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHH
AAPRLRVVANMAVGYNNFDMAAFNAANVLGTNTPDVLNESTADFGWALMMAAARRIAESE
CCCCCEEEEHHHCCCCCCCHHHCCCCHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
HWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHCCCCCHHEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELNAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHCCHHHHHHHHHHEECCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCC
DAALAVALRDGTIAAAGLDVYEGEPTVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
CCEEEEEEECCEEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA