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The map label for this gene is ytpA [H]

Identifier: 78065643

GI number: 78065643

Start: 1107002

End: 1107922

Strand: Reverse

Name: ytpA [H]

Synonym: Bcep18194_A4171

Alternate gene names: 78065643

Gene position: 1107922-1107002 (Counterclockwise)

Preceding gene: 78065650

Following gene: 78065641

Centisome position: 29.99

GC content: 71.66

Gene sequence:

>921_bases
ATGACCGCCACCACTACGCCGGCCGCCGCACCCGCCACCGCCGGACCGGCACCTTCGTCGTCGCCCGCGCCGACCATGGG
CCGGCTCCGTACCGTGGACGGGCTCGAACTGGCGTCGTACCGGTGGCCCGCCGGAGGCGGCACCGCGCCACCGCGCGCGA
CGATCGCGCTCGTGCACGGCCTCGCCGAACACGCGGGCCGCTATGCCGCACTCGCCGGCCGGTTGAATGCGGCCGGCATC
GACGTGCTCGCGATCGACCTGCGCGGCCATGGCCAGTCACCCGGCAAGCGCGCCTGGGTCGAGCGTTTCGACGGCTACCT
GAACGATGCGGATGCGCTGGTCGCGGAAGCCGCACGCGGCAATTCGCCGCTGTTCCTGATGGGGCACAGCATGGGTGGCG
CGGTCGCGGCGCTGTACGCAATCGAGCGCGCGCCGACACGTGGCCACGCATTGACGGGCCTCGTGCTGTCGAGCCCGGCG
CTCGCGCCGGGGCGCGACGTGCCGCGCTGGATGCTCGCGGTGAGCCGCGTCATCAGCCGCGTATGGCCGACCTTCCCTGC
CATCAAGATCGATGCGGCGCTGCTGTCGCGCGATCCGGCCATCGTCGCGGCCAATCGCGCCGATCCGCTCGTGCATCACG
GCGCGGTGCCCGCACGCACCGGTGCGGAGATTCTCGACGCGATGGCACGCATCGAAAGCGGCCGTGGTGGGTTGCGCGTT
CCGGTGCTCGTCTATCACGGCACCGAAGACAAGCTGACCGAGCCCGACGGCAGCCGGGCGTTCGGCGCGCGCGTCGGCTC
GCCCGATCGCACGCTGACGCTGTACGAAGGCGGCTTTCACGAAACGATGAACGATCTCGAACGCGACCGCGTGATCGACG
CGCTGATCGCGTGGATTCACGCACGCGCGCCGGCGCGCTGA

Upstream 100 bases:

>100_bases
TTCATAACCACACGAAATTAGAGGAGCGCCGCTGGCGCGTCACGACGGTGCCGCGACTATGATCCGGAACACACATGCCA
ACCGACAGGGGACACGCCAG

Downstream 100 bases:

>100_bases
GCGTGCCCGGCCCGGCCCCGGTCAATCGGTAATCAGATGCCGGCCAGCACGCGCAGGTGGGCCACGACGCTGCGCCCGAG
TGCGGACAGGTTGTAGCCGC

Product: Alpha/beta hydrolase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTATTTPAAAPATAGPAPSSSPAPTMGRLRTVDGLELASYRWPAGGGTAPPRATIALVHGLAEHAGRYAALAGRLNAAGI
DVLAIDLRGHGQSPGKRAWVERFDGYLNDADALVAEAARGNSPLFLMGHSMGGAVAALYAIERAPTRGHALTGLVLSSPA
LAPGRDVPRWMLAVSRVISRVWPTFPAIKIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMARIESGRGGLRV
PVLVYHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARAPAR

Sequences:

>Translated_306_residues
MTATTTPAAAPATAGPAPSSSPAPTMGRLRTVDGLELASYRWPAGGGTAPPRATIALVHGLAEHAGRYAALAGRLNAAGI
DVLAIDLRGHGQSPGKRAWVERFDGYLNDADALVAEAARGNSPLFLMGHSMGGAVAALYAIERAPTRGHALTGLVLSSPA
LAPGRDVPRWMLAVSRVISRVWPTFPAIKIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMARIESGRGGLRV
PVLVYHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARAPAR
>Mature_305_residues
TATTTPAAAPATAGPAPSSSPAPTMGRLRTVDGLELASYRWPAGGGTAPPRATIALVHGLAEHAGRYAALAGRLNAAGID
VLAIDLRGHGQSPGKRAWVERFDGYLNDADALVAEAARGNSPLFLMGHSMGGAVAALYAIERAPTRGHALTGLVLSSPAL
APGRDVPRWMLAVSRVISRVWPTFPAIKIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMARIESGRGGLRVP
VLVYHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARAPAR

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI6005786, Length=308, Percent_Identity=32.7922077922078, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI51242953, Length=299, Percent_Identity=33.1103678929766, Blast_Score=144, Evalue=8e-35,
Organism=Escherichia coli, GI1787678, Length=287, Percent_Identity=25.7839721254355, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322756, Length=304, Percent_Identity=26.9736842105263, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 32014; Mature: 31883

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATTTPAAAPATAGPAPSSSPAPTMGRLRTVDGLELASYRWPAGGGTAPPRATIALVHG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEECCEECCCCCCCCCCHHHHHHHHH
LAEHAGRYAALAGRLNAAGIDVLAIDLRGHGQSPGKRAWVERFDGYLNDADALVAEAARG
HHHHCCCHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
NSPLFLMGHSMGGAVAALYAIERAPTRGHALTGLVLSSPALAPGRDVPRWMLAVSRVISR
CCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEHEECCCCCCCCCCCHHHHHHHHHHHHH
VWPTFPAIKIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMARIESGRGGLRV
HCCCCCCCEEHHHHHCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEE
PVLVYHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIH
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ARAPAR
HCCCCC
>Mature Secondary Structure 
TATTTPAAAPATAGPAPSSSPAPTMGRLRTVDGLELASYRWPAGGGTAPPRATIALVHG
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEECCEECCCCCCCCCCHHHHHHHHH
LAEHAGRYAALAGRLNAAGIDVLAIDLRGHGQSPGKRAWVERFDGYLNDADALVAEAARG
HHHHCCCHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
NSPLFLMGHSMGGAVAALYAIERAPTRGHALTGLVLSSPALAPGRDVPRWMLAVSRVISR
CCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEHEECCCCCCCCCCCHHHHHHHHHHHHH
VWPTFPAIKIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMARIESGRGGLRV
HCCCCCCCEEHHHHHCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEE
PVLVYHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIH
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ARAPAR
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]