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The map label for this gene is cysM

Identifier: 78065640

GI number: 78065640

Start: 1103677

End: 1104579

Strand: Direct

Name: cysM

Synonym: Bcep18194_A4168

Alternate gene names: 78065640

Gene position: 1103677-1104579 (Clockwise)

Preceding gene: 78065639

Following gene: 78065642

Centisome position: 29.88

GC content: 64.23

Gene sequence:

>903_bases
ATGGCTTACAAAACTATCGAAGACACGATCGGCAATACGCCGCTCGTCCAACTGGTCCGCTTGCCGGACGACGAAATCCG
CGCGCGCAACAACGTGGTGCTCGCGAAGCTCGAAGGCAACAATCCGGCCGGTTCGGTGAAGGATCGTCCGGCACTGTCGA
TGATCAGCAAGGCCGAGGCGCGCGGGCGCATCAAGCCGGGCGATACGCTGATCGAGGCGACCAGCGGCAACACGGGTATC
GCACTCGCGATGGCAGCGGCGATCCGCGGCTACAAGATGGTGCTGATCATGCCGGAGGACCTGTCGGTCGAGCGCCGCCA
GAGCATGGCCGCCTACGGTGCCGAGATCATCCTGACGCCGGTGAAGGGCGGGATGGAACTGGCACGCGATCTCGCGGACC
AGATGCAGCGCGAAGGCAAGGGCGTGATCCTCGACCAGTTCGCGAACCCCGACAATCCGATTGCGCACTACGAAGCGACG
GGCCCGGAAATCTGGCGCGATACCGAAGGGCGCATCACGCACTTCGTATCGGCCATGGGCACGACGGGCACGATCATGGG
CACGTCGCACTATCTGAAGGAACAGAATCCGGCGATCGAGATCGTCGGTGCGCAGCCGGAAGACGGTTCGCGCATTCCGG
GCATCCGCAAGTGGCCGGAAGCGTACATGCCGACCATCTTCGATCGCAGCCGCGTCGACCGCGTCGAGAACGTGAGCCAG
GCCGCGGCGGAAACGATGGCGCGCCGGCTCGCGTCGGTCGAAGGCATTTTCGCGGGCATTTCGTCGGGCGGCGCATGTGA
AGTCGCGATGCGCATCGCGCGTCAGGTCGAGAATGCGACGATCGTGTTCATCGTCTGCGATCGCGGCGACCGCTACCTGT
CCACGGGCGTGTTTCCTGCCTGA

Upstream 100 bases:

>100_bases
ATGCCACGCGTATTCCATCGTCGCAATGGGGTTGCCGGCGCGAGCAGCGGTGCTGGTTTACAATCGTTTGATTGATCGGC
CTCGTACTCACGGTATATCC

Downstream 100 bases:

>100_bases
GCGCGGGCAGGCGCGCGTCGTGCGCGTGAGATAAAAAAAGCGCCGCATCTGCGGCGCTTTTTCTTTGGGCGGTCGGTGCT
TACTGCGACTCGGTGTCGGC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVVLAKLEGNNPAGSVKDRPALSMISKAEARGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMELARDLADQMQREGKGVILDQFANPDNPIAHYEAT
GPEIWRDTEGRITHFVSAMGTTGTIMGTSHYLKEQNPAIEIVGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIVCDRGDRYLSTGVFPA

Sequences:

>Translated_300_residues
MAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVVLAKLEGNNPAGSVKDRPALSMISKAEARGRIKPGDTLIEATSGNTGI
ALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMELARDLADQMQREGKGVILDQFANPDNPIAHYEAT
GPEIWRDTEGRITHFVSAMGTTGTIMGTSHYLKEQNPAIEIVGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIVCDRGDRYLSTGVFPA
>Mature_299_residues
AYKTIEDTIGNTPLVQLVRLPDDEIRARNNVVLAKLEGNNPAGSVKDRPALSMISKAEARGRIKPGDTLIEATSGNTGIA
LAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTPVKGGMELARDLADQMQREGKGVILDQFANPDNPIAHYEATG
PEIWRDTEGRITHFVSAMGTTGTIMGTSHYLKEQNPAIEIVGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQA
AAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=37.785016286645, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=37.785016286645, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=37.785016286645, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=62.7118644067797, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1788754, Length=317, Percent_Identity=41.9558359621451, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=43.3774834437086, Blast_Score=217, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=41.9672131147541, Blast_Score=216, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI32566674, Length=297, Percent_Identity=44.1077441077441, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=40.3333333333333, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=41.0596026490066, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI25147552, Length=318, Percent_Identity=35.5345911949685, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=36.2776025236593, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=38.6792452830189, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=39.5569620253165, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=31.7220543806647, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=37.987012987013, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=37.987012987013, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32488; Mature: 32356

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKTIEDTIGNTPLVQLVRLPDDEIRARNNVVLAKLEGNNPAGSVKDRPALSMISKAEA
CCCCCHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMELARDLADQMQREGKGVILDQFANPDNPIAHYEATGPEIWRDTEGRITHFVSAMG
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHCC
TTGTIMGTSHYLKEQNPAIEIVGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
CCCEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHH
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
AYKTIEDTIGNTPLVQLVRLPDDEIRARNNVVLAKLEGNNPAGSVKDRPALSMISKAEA
CCCCHHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHH
RGRIKPGDTLIEATSGNTGIALAMAAAIRGYKMVLIMPEDLSVERRQSMAAYGAEIILTP
CCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEE
VKGGMELARDLADQMQREGKGVILDQFANPDNPIAHYEATGPEIWRDTEGRITHFVSAMG
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCHHHCCCCCHHHHHHHHCC
TTGTIMGTSHYLKEQNPAIEIVGAQPEDGSRIPGIRKWPEAYMPTIFDRSRVDRVENVSQ
CCCEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHH
AAAETMARRLASVEGIFAGISSGGACEVAMRIARQVENATIVFIVCDRGDRYLSTGVFPA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]