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The map label for this gene is cobB [H]

Identifier: 78065518

GI number: 78065518

Start: 970132

End: 971004

Strand: Direct

Name: cobB [H]

Synonym: Bcep18194_A4046

Alternate gene names: 78065518

Gene position: 970132-971004 (Clockwise)

Preceding gene: 78065517

Following gene: 78065519

Centisome position: 26.26

GC content: 70.22

Gene sequence:

>873_bases
ATGCCGCTTTCCGATTCCGTGGACTCCACCGCTGCGGCCGCCGCCGCGCAACTGCCGGCCGACCTCGTCGCTTCCGCCGT
TGCTGCGCTCGCGCGCGCCGACGCATTGCTCGTGACGGCCGGTGCCGGTATCGGCGTCGATTCCGGGTTGCCCGATTTTC
GCGGTACGGACGGCTTCTGGCGTGCGTATCCGGCGCTGCGCCACGAGCGTTTCGAATTCCACGAGATCGCCTCGCCGCAC
GCGTTCCGTGCGCGCGCGCAACTCGCGTGGGGCTTCTACGGACACCGCCTCGCGCTCTATCGTGCGACGGTGCCGCATGC
GGGCTTCGCGATCCTGCGCCGCTGGATCGACGCGATGCCGAACGGCGGCTTCGTGCTGACGAGCAATGTCGACGGCCAGT
TCCAGAAAGCCGGCTTCGATCCGGCGCGGATCGTCGAGATCCACGGCTCGATCCATGCGATGCAGTGCCTGCGTCCCTGT
TCGGACGATACATGGGAGGCGGCGCCGTTCGTACCGGACGTCGACGAAGCCACCTGCCGCCTCGTCGGTGACATGCCGCG
GTGCCCGCACTGCGGCGGCCTCGCGCGGCCGAACATCCTGATGTTCGGCGATACCGGCTGGCTTGGTGCGCGCTACGACG
CGCAGGAGCGTGCGCTGGAAGACTGGCTCGCGCAGGCCGGGCGCGTCGCCGTGGTGGAGATCGGCGCGGGCACCGCGATC
CCGACCGTGCGCCTGCTGAGCGAACGCCTCGGCGCCGACGTGATCCGCATCAACGCTCGCGAAGCGCATGCGCGTCGTGC
GGACGTGATCGGCTTGAAGGGCGGCGCGCTGGCGACGCTGAGCGCGCTCGACGCGGCCTGGCCAAGCGCGTGA

Upstream 100 bases:

>100_bases
ATCGCGTCATGCCGTTGCATCGCGCATGCCGCGCCGCGCGCGAACCGGCGTATGATCGCGACGCCACTCGCGCACCGCCC
GACGCTATCGCCGCCCCATC

Downstream 100 bases:

>100_bases
GCCTGCGGGCGGGCAAGACGATCCGAACGGGCCGGCATCCTGCAGACGGTCGCCGTTGCAGGGGCGCGGTGAATCCGCAT
ACAGTTCAGCGTGTGCCGCC

Product: Sir2 family NAD-dependent protein deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MPLSDSVDSTAAAAAAQLPADLVASAVAALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPH
AFRARAQLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPC
SDDTWEAAPFVPDVDEATCRLVGDMPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWLAQAGRVAVVEIGAGTAI
PTVRLLSERLGADVIRINAREAHARRADVIGLKGGALATLSALDAAWPSA

Sequences:

>Translated_290_residues
MPLSDSVDSTAAAAAAQLPADLVASAVAALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPH
AFRARAQLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPC
SDDTWEAAPFVPDVDEATCRLVGDMPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWLAQAGRVAVVEIGAGTAI
PTVRLLSERLGADVIRINAREAHARRADVIGLKGGALATLSALDAAWPSA
>Mature_289_residues
PLSDSVDSTAAAAAAQLPADLVASAVAALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPHA
FRARAQLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCS
DDTWEAAPFVPDVDEATCRLVGDMPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWLAQAGRVAVVEIGAGTAIP
TVRLLSERLGADVIRINAREAHARRADVIGLKGGALATLSALDAAWPSA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=190, Percent_Identity=28.4210526315789, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI13787215, Length=203, Percent_Identity=29.064039408867, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI6912664, Length=203, Percent_Identity=29.064039408867, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30898; Mature: 30767

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSDSVDSTAAAAAAQLPADLVASAVAALARADALLVTAGAGIGVDSGLPDFRGTDGFW
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHH
RAYPALRHERFEFHEIASPHAFRARAQLAWGFYGHRLALYRATVPHAGFAILRRWIDAMP
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHCC
NGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCSDDTWEAAPFVPDVDEATCR
CCCEEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
LVGDMPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWLAQAGRVAVVEIGAGTAI
HHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCH
PTVRLLSERLGADVIRINAREAHARRADVIGLKGGALATLSALDAAWPSA
HHHHHHHHHHCCCEEEEECHHHHHHHHCEEECCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLSDSVDSTAAAAAAQLPADLVASAVAALARADALLVTAGAGIGVDSGLPDFRGTDGFW
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHH
RAYPALRHERFEFHEIASPHAFRARAQLAWGFYGHRLALYRATVPHAGFAILRRWIDAMP
HHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHCC
NGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCSDDTWEAAPFVPDVDEATCR
CCCEEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
LVGDMPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWLAQAGRVAVVEIGAGTAI
HHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCH
PTVRLLSERLGADVIRINAREAHARRADVIGLKGGALATLSALDAAWPSA
HHHHHHHHHHCCCEEEEECHHHHHHHHCEEECCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]