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The map label for this gene is wecB [H]

Identifier: 78065448

GI number: 78065448

Start: 895108

End: 896208

Strand: Reverse

Name: wecB [H]

Synonym: Bcep18194_A3974

Alternate gene names: 78065448

Gene position: 896208-895108 (Counterclockwise)

Preceding gene: 78065449

Following gene: 78065447

Centisome position: 24.26

GC content: 61.22

Gene sequence:

>1101_bases
ATGTCTAAAACCATACTGTGCGTCGTAGGTACGCGACCGGAGGCCATCAAGATGGCGCCGGTCATCCTGCGTTTGCGAGC
GGATCCGGGATTCAAGGTGCACGTGCTCGCGACCGCGCAACACCGCGATCTGCTCGACCAGATCCTGACCTGTTTCGATA
TCAAACCGGATGTCGATCTCGACATCATGCGTCCGAATCAGGGGCTTGCCAGCCTGACGTCGCGTCTGCTTGACGGTATC
GATGCCGTGCTCGTGGACAAGCGTCCCGATCTCGTACTGGGACAAGGCGACACCACGACGGTCATGGCCACGGCGCTTGC
ATGCTTCTATCGGCATATACCGTTCGGTCATATTGAAGCGGGCCTGCGTACCCGCGATCTCGGCAATCCGTTTCCTGAAG
AGATGAACCGCGTTTTCGCGGGGCGCCTCGCAAGGCTGCATTTCGCGCCGACAGCGAGTTCGCGCGACAACCTCTTGCAT
GAAAACATCCCCAGCGACCAGATCTGGGTGACCGGGAACACCGTCATCGACGCGCTTCACACTGTCTTGCGGACACATCC
GTCCTGCGGCGTCGATATCGACGACACGAAACGGCTGATTCTAGTCACCGCGCATCGCCGGGAGAATTTCGGCGCCCCGC
TCGAACGGATCTGCCATGCCATTCGCCAGATTGTCGACGCCAACGACGACATCGAGGTGCTGTTTCCCGTACATCCCAAT
CCGCACGTCCAGCGTACGACGCGCGAACTGCTGTCGCACCACGCCCGGATCCGGCTCTGCCCGCCGCTCGACTATGTGCC
GTTCGTCGCCGCCATGCAGCGCTCGTACCTCATCCTCAGCGACTCGGGCGGCGTGCAGGAAGAAGCGCCGGCTCTGGGCA
AACCGGTCCTGGTGTTGCGCGACGAGACCGAGCGCCCGGAAGCTGTCGAAGCCGGTGTCGTCAGGCTCGTCGGCACTCAA
ACCGATACGATCGTCAATGCGGTCCAACTGATGCTCGACAACGCCGACGAATACAGCAAGGTTGCACGCGGCGTCTCGCC
CTACGGTGACGGAAAGGCAGCCCAGCGGATTTTCGACGTCATCCGGGAACAATGCGTGTGA

Upstream 100 bases:

>100_bases
ATCGCAAGCTATTCCTTCGCAACGCGAACTACTTCAAGGAGAAGTGGCGCGATTACCCGCATTTCTATCTGGACTACATC
GATTGATTCGTAGCGACAGC

Downstream 100 bases:

>100_bases
TCGAACAACTCGTCTATCTGTCGCCGGTGCCATGGAGCAGCTTTGCACAGCGACCTCACAAGTTCGTCGAGTGGTTTCAT
CAAGAAACCCATGGCCGTGT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSKTILCVVGTRPEAIKMAPVILRLRADPGFKVHVLATAQHRDLLDQILTCFDIKPDVDLDIMRPNQGLASLTSRLLDGI
DAVLVDKRPDLVLGQGDTTTVMATALACFYRHIPFGHIEAGLRTRDLGNPFPEEMNRVFAGRLARLHFAPTASSRDNLLH
ENIPSDQIWVTGNTVIDALHTVLRTHPSCGVDIDDTKRLILVTAHRRENFGAPLERICHAIRQIVDANDDIEVLFPVHPN
PHVQRTTRELLSHHARIRLCPPLDYVPFVAAMQRSYLILSDSGGVQEEAPALGKPVLVLRDETERPEAVEAGVVRLVGTQ
TDTIVNAVQLMLDNADEYSKVARGVSPYGDGKAAQRIFDVIREQCV

Sequences:

>Translated_366_residues
MSKTILCVVGTRPEAIKMAPVILRLRADPGFKVHVLATAQHRDLLDQILTCFDIKPDVDLDIMRPNQGLASLTSRLLDGI
DAVLVDKRPDLVLGQGDTTTVMATALACFYRHIPFGHIEAGLRTRDLGNPFPEEMNRVFAGRLARLHFAPTASSRDNLLH
ENIPSDQIWVTGNTVIDALHTVLRTHPSCGVDIDDTKRLILVTAHRRENFGAPLERICHAIRQIVDANDDIEVLFPVHPN
PHVQRTTRELLSHHARIRLCPPLDYVPFVAAMQRSYLILSDSGGVQEEAPALGKPVLVLRDETERPEAVEAGVVRLVGTQ
TDTIVNAVQLMLDNADEYSKVARGVSPYGDGKAAQRIFDVIREQCV
>Mature_365_residues
SKTILCVVGTRPEAIKMAPVILRLRADPGFKVHVLATAQHRDLLDQILTCFDIKPDVDLDIMRPNQGLASLTSRLLDGID
AVLVDKRPDLVLGQGDTTTVMATALACFYRHIPFGHIEAGLRTRDLGNPFPEEMNRVFAGRLARLHFAPTASSRDNLLHE
NIPSDQIWVTGNTVIDALHTVLRTHPSCGVDIDDTKRLILVTAHRRENFGAPLERICHAIRQIVDANDDIEVLFPVHPNP
HVQRTTRELLSHHARIRLCPPLDYVPFVAAMQRSYLILSDSGGVQEEAPALGKPVLVLRDETERPEAVEAGVVRLVGTQT
DTIVNAVQLMLDNADEYSKVARGVSPYGDGKAAQRIFDVIREQCV

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=368, Percent_Identity=51.9021739130435, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 40526; Mature: 40395

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTILCVVGTRPEAIKMAPVILRLRADPGFKVHVLATAQHRDLLDQILTCFDIKPDVDL
CCCEEEEEECCCCCHHHHCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCE
DIMRPNQGLASLTSRLLDGIDAVLVDKRPDLVLGQGDTTTVMATALACFYRHIPFGHIEA
EEECCCCCHHHHHHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHC
GLRTRDLGNPFPEEMNRVFAGRLARLHFAPTASSRDNLLHENIPSDQIWVTGNTVIDALH
CCEECCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCHHHCCCCCCEEEEECHHHHHHHH
TVLRTHPSCGVDIDDTKRLILVTAHRRENFGAPLERICHAIRQIVDANDDIEVLFPVHPN
HHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCC
PHVQRTTRELLSHHARIRLCPPLDYVPFVAAMQRSYLILSDSGGVQEEAPALGKPVLVLR
CCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEE
DETERPEAVEAGVVRLVGTQTDTIVNAVQLMLDNADEYSKVARGVSPYGDGKAAQRIFDV
CCCCCCCHHHHCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHH
IREQCV
HHHHCC
>Mature Secondary Structure 
SKTILCVVGTRPEAIKMAPVILRLRADPGFKVHVLATAQHRDLLDQILTCFDIKPDVDL
CCEEEEEECCCCCHHHHCEEEEEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCE
DIMRPNQGLASLTSRLLDGIDAVLVDKRPDLVLGQGDTTTVMATALACFYRHIPFGHIEA
EEECCCCCHHHHHHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHC
GLRTRDLGNPFPEEMNRVFAGRLARLHFAPTASSRDNLLHENIPSDQIWVTGNTVIDALH
CCEECCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCHHHCCCCCCEEEEECHHHHHHHH
TVLRTHPSCGVDIDDTKRLILVTAHRRENFGAPLERICHAIRQIVDANDDIEVLFPVHPN
HHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCC
PHVQRTTRELLSHHARIRLCPPLDYVPFVAAMQRSYLILSDSGGVQEEAPALGKPVLVLR
CCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEE
DETERPEAVEAGVVRLVGTQTDTIVNAVQLMLDNADEYSKVARGVSPYGDGKAAQRIFDV
CCCCCCCHHHHCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHH
IREQCV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]