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The map label for this gene is xdhA [H]

Identifier: 78065399

GI number: 78065399

Start: 841497

End: 843851

Strand: Direct

Name: xdhA [H]

Synonym: Bcep18194_A3925

Alternate gene names: 78065399

Gene position: 841497-843851 (Clockwise)

Preceding gene: 78065398

Following gene: 78065400

Centisome position: 22.78

GC content: 68.15

Gene sequence:

>2355_bases
ATGAACCAGCAAGCAGAACCGTTCCTGAGCACCCTCGACCCGCAAGCCGACGCGGCGCAGGTCCACGTATCGCGCGCGCA
CGAATCCGCGCACCTGCACGTCAGCGGGCGTGCCACCTACACCGACGACATCCCGGTCGTCGCGGGCACGCTGCACGCGG
CGCTCGGCCTGTCGGCGAAGCCGCACGCGAAGATCGTGTCGATGAACTTCGACGCGGTGCGCGCGACGCCGGGCGTGGTC
GCCGTGTTCACGGCCGACGACATCCCGGGCGTCAACGATTGCGGCCCGATCATCCACGACGACCCGGTGCTCGCGAAGGG
CATCGTGCAGTTCGTCGGCCAGCCGATGTTCATCGTCGTCGCGACGTCGCATGAAACCGCGCGGCTCGCCGCGCGCCGTG
CGCAGGTCGACTACGAGGAGCTGCCGGCGATCCTCACCGCGCAGGAAGCGCGCGCGGCCGAAACCTACGTGATCCCGCCG
CTGAAGCTCGCGCGCGGCGATGCGGCCGCGCGGCTCGCCGTCGCGCCGCACCGCGAGTCGGGCGAAATGCTGCTCGGCGG
CCAGGAGCAGTTCTACCTCGAAGGGCAGATCGCGTACGCCGTGCCGAAGGACGACGACGGGATGCACGTGTACTGCTCGA
CGCAGCACCCGAGCGAGATGCAGCACCTCGTCGCGCACGTGCTCGGCGTCGCGTCGCACAACGTGCTCGTCGAATGCCGC
CGGATGGGCGGCGGGTTCGGCGGCAAGGAATCGCAGTCGGGCCTGTTCGCCTGCTGCGCGGCGCTCGCGGCGTGGAAGCT
GCTGTGCCCGGTGAAGCTGCGTCCGGACCGCGACGACGACATGATGATCACCGGCAAGCGGCACGACTTCCATTACCGCT
TCGACGTCGGCTACGACGACGACGGCCGCATCGACGGCGTGGCGCTCGACATGACGTCGCGCTGCGGCTTCTCGGCCGAC
CTGTCGGGCCCGGTGATGACGCGCGCGGTGTGCCACTTCGACAACGCGTACTGGCTGGGCGACGTCGATATCGCCGGCTA
CTGCGGCAAGACCAACACGCAGTCGAACACCGCGTTCCGCGGCTTCGGCGGCCCGCAGGGTGCGTTCGCGATCGAGTACA
TCCTCGACGACGTCGCGCGTTCGCTCGATCGCGATCCGCTCGATGTCCGTTACGCGAACCTGTACGGCAAGACCGAACGC
AACGTCACGCCGTACGGGCAGACGGTCGAGGACAACGTGCTGCAGGAGCTGCTCGGCGAACTCGAAACGACGAGCGACTA
CCGCGCGCGGCGTGCGGGCGTGCGCGAATTCAACGCACGCAACACGGTGCTGAAGAAGGGCATCGCGATCACGCCGGTGA
AGTTCGGCATTGCGTTCAACGTCACGCACTTCAACCAGGCCGGCGCGCTGGTGCACATCTACACTGACGGCTCGGTGCTC
GTGAACCACGGCGGCACGGAGATGGGGCAGGGGCTCAACACGAAGGTCGCGCAGGTCGTCGCGCACGAGCTCGGCATCCG
CTTCGGCCGGATCCGCGTGACGGCGACCGACACCAGCAAGGTTGCGAACACGTCCGCGACGGCGGCGTCGACGGGCTCGG
ACCTGAACGGCAAGGCCGCGCAGGATGCGGCGCGCCAGTTGCGCGAGCGGCTCGCGGTGTTCGCGGCGAAGCAGTTCGGC
GACGGCAAGGTCGATGCGGCCGACGTGAAGTTCGGCAACGACTTCGTGTGGGTCGGCGGCGCGAGCGTGCCGTTCGGCGA
AGTGATCTCGAAGGCGTACCTCGCGCGCGTGCAGCTGTGGTCCGACGGCTTCTACGCGACGCCGAAGCTGTACTGGGATC
AGTCGAAGCTGCAAGGCCGGCCGTTCTACTACTACTCGTACGGCGCGGCCGTGTCGGAAGTCGTGATCGACACGCTGACG
GGCGAGATGCGCACGCTGCGTGTCGATGCGCTGCACGACGTGGGCGCATCACTGAACCCGGCGCTCGACGTCGGCCAGGT
CGAAGGCGCGTTCATCCAGGGGATGGGCTGGCTCACGACCGAGGAGCTGTGGTGGAACAAGGGCGGCAAGCTGATGACGC
ATGCGCCGTCCACGTACAAGATCCCGACGGTGAACGACACGCCGCCGGAATTCAACGTGCTGCTGTTCAAGAACCGCAAC
GTCGAGGACAGCATCCACCGTTCGAAGGCCGTCGGCGAGCCGCCGCTGCTGCTGCCGTTCTCGGTGTTCTTCGCGGTGCG
CGATGCCGTGGCTGCGGTCGGCGACTACAAGGTGAACCCGCCGCTCGACGCGCCGGCTACCGGCGAGTCGATCCTGCGTG
CGGTCAGCGCGGTGCGTGCGGCGAAGGCAGGCTGA

Upstream 100 bases:

>100_bases
CCCGCACGACCCGCTGCCGCCGCAAGCCCTGAATGTGCGTGAAGTGGCCGCCGAACTCGGCACCGACGCGGCGCGCGTCT
GAAGACGGAGAACACCGAAC

Downstream 100 bases:

>100_bases
GATGAAACGGCCCCCGCGCTCACTTCGTTCACTGTCTACGGGAGTTGGCGCTTCAGCGCTTGCTCCTGTCCCATGCACGG
CTCCCCCCGAGGGGGCGGTC

Product: xanthine dehydrogenase, molybdenum binding subunit apoprotein / xanthine oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MNQQAEPFLSTLDPQADAAQVHVSRAHESAHLHVSGRATYTDDIPVVAGTLHAALGLSAKPHAKIVSMNFDAVRATPGVV
AVFTADDIPGVNDCGPIIHDDPVLAKGIVQFVGQPMFIVVATSHETARLAARRAQVDYEELPAILTAQEARAAETYVIPP
LKLARGDAAARLAVAPHRESGEMLLGGQEQFYLEGQIAYAVPKDDDGMHVYCSTQHPSEMQHLVAHVLGVASHNVLVECR
RMGGGFGGKESQSGLFACCAALAAWKLLCPVKLRPDRDDDMMITGKRHDFHYRFDVGYDDDGRIDGVALDMTSRCGFSAD
LSGPVMTRAVCHFDNAYWLGDVDIAGYCGKTNTQSNTAFRGFGGPQGAFAIEYILDDVARSLDRDPLDVRYANLYGKTER
NVTPYGQTVEDNVLQELLGELETTSDYRARRAGVREFNARNTVLKKGIAITPVKFGIAFNVTHFNQAGALVHIYTDGSVL
VNHGGTEMGQGLNTKVAQVVAHELGIRFGRIRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQLRERLAVFAAKQFG
DGKVDAADVKFGNDFVWVGGASVPFGEVISKAYLARVQLWSDGFYATPKLYWDQSKLQGRPFYYYSYGAAVSEVVIDTLT
GEMRTLRVDALHDVGASLNPALDVGQVEGAFIQGMGWLTTEELWWNKGGKLMTHAPSTYKIPTVNDTPPEFNVLLFKNRN
VEDSIHRSKAVGEPPLLLPFSVFFAVRDAVAAVGDYKVNPPLDAPATGESILRAVSAVRAAKAG

Sequences:

>Translated_784_residues
MNQQAEPFLSTLDPQADAAQVHVSRAHESAHLHVSGRATYTDDIPVVAGTLHAALGLSAKPHAKIVSMNFDAVRATPGVV
AVFTADDIPGVNDCGPIIHDDPVLAKGIVQFVGQPMFIVVATSHETARLAARRAQVDYEELPAILTAQEARAAETYVIPP
LKLARGDAAARLAVAPHRESGEMLLGGQEQFYLEGQIAYAVPKDDDGMHVYCSTQHPSEMQHLVAHVLGVASHNVLVECR
RMGGGFGGKESQSGLFACCAALAAWKLLCPVKLRPDRDDDMMITGKRHDFHYRFDVGYDDDGRIDGVALDMTSRCGFSAD
LSGPVMTRAVCHFDNAYWLGDVDIAGYCGKTNTQSNTAFRGFGGPQGAFAIEYILDDVARSLDRDPLDVRYANLYGKTER
NVTPYGQTVEDNVLQELLGELETTSDYRARRAGVREFNARNTVLKKGIAITPVKFGIAFNVTHFNQAGALVHIYTDGSVL
VNHGGTEMGQGLNTKVAQVVAHELGIRFGRIRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQLRERLAVFAAKQFG
DGKVDAADVKFGNDFVWVGGASVPFGEVISKAYLARVQLWSDGFYATPKLYWDQSKLQGRPFYYYSYGAAVSEVVIDTLT
GEMRTLRVDALHDVGASLNPALDVGQVEGAFIQGMGWLTTEELWWNKGGKLMTHAPSTYKIPTVNDTPPEFNVLLFKNRN
VEDSIHRSKAVGEPPLLLPFSVFFAVRDAVAAVGDYKVNPPLDAPATGESILRAVSAVRAAKAG
>Mature_784_residues
MNQQAEPFLSTLDPQADAAQVHVSRAHESAHLHVSGRATYTDDIPVVAGTLHAALGLSAKPHAKIVSMNFDAVRATPGVV
AVFTADDIPGVNDCGPIIHDDPVLAKGIVQFVGQPMFIVVATSHETARLAARRAQVDYEELPAILTAQEARAAETYVIPP
LKLARGDAAARLAVAPHRESGEMLLGGQEQFYLEGQIAYAVPKDDDGMHVYCSTQHPSEMQHLVAHVLGVASHNVLVECR
RMGGGFGGKESQSGLFACCAALAAWKLLCPVKLRPDRDDDMMITGKRHDFHYRFDVGYDDDGRIDGVALDMTSRCGFSAD
LSGPVMTRAVCHFDNAYWLGDVDIAGYCGKTNTQSNTAFRGFGGPQGAFAIEYILDDVARSLDRDPLDVRYANLYGKTER
NVTPYGQTVEDNVLQELLGELETTSDYRARRAGVREFNARNTVLKKGIAITPVKFGIAFNVTHFNQAGALVHIYTDGSVL
VNHGGTEMGQGLNTKVAQVVAHELGIRFGRIRVTATDTSKVANTSATAASTGSDLNGKAAQDAARQLRERLAVFAAKQFG
DGKVDAADVKFGNDFVWVGGASVPFGEVISKAYLARVQLWSDGFYATPKLYWDQSKLQGRPFYYYSYGAAVSEVVIDTLT
GEMRTLRVDALHDVGASLNPALDVGQVEGAFIQGMGWLTTEELWWNKGGKLMTHAPSTYKIPTVNDTPPEFNVLLFKNRN
VEDSIHRSKAVGEPPLLLPFSVFFAVRDAVAAVGDYKVNPPLDAPATGESILRAVSAVRAAKAG

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=771, Percent_Identity=42.6718547341115, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI71773480, Length=754, Percent_Identity=37.9310344827586, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1789230, Length=751, Percent_Identity=27.5632490013316, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789246, Length=777, Percent_Identity=26.5122265122265, Blast_Score=189, Evalue=6e-49,
Organism=Escherichia coli, GI1786478, Length=698, Percent_Identity=24.2120343839542, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=763, Percent_Identity=40.7601572739187, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI32566215, Length=708, Percent_Identity=32.0621468926554, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17539860, Length=720, Percent_Identity=31.8055555555556, Blast_Score=316, Evalue=4e-86,
Organism=Drosophila melanogaster, GI17737937, Length=759, Percent_Identity=43.0830039525692, Blast_Score=574, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24647199, Length=735, Percent_Identity=31.0204081632653, Blast_Score=319, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24647193, Length=775, Percent_Identity=32.3870967741935, Blast_Score=319, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24647201, Length=762, Percent_Identity=30.9711286089239, Blast_Score=292, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24647197, Length=774, Percent_Identity=30.3617571059432, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24647195, Length=774, Percent_Identity=30.3617571059432, Blast_Score=287, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84657; Mature: 84657

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQAEPFLSTLDPQADAAQVHVSRAHESAHLHVSGRATYTDDIPVVAGTLHAALGLSAK
CCCCCCCHHHHCCCCCCHHHEEHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHCCCCC
PHAKIVSMNFDAVRATPGVVAVFTADDIPGVNDCGPIIHDDPVLAKGIVQFVGQPMFIVV
CCCEEEEECCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
ATSHETARLAARRAQVDYEELPAILTAQEARAAETYVIPPLKLARGDAAARLAVAPHRES
ECCCHHHHHHHHHHCCCHHHCCHHEEHHHHCCCCEEECCCHHCCCCCCCEEEEECCCCCC
GEMLLGGQEQFYLEGQIAYAVPKDDDGMHVYCSTQHPSEMQHLVAHVLGVASHNVLVECR
CCEEECCCCEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHH
RMGGGFGGKESQSGLFACCAALAAWKLLCPVKLRPDRDDDMMITGKRHDFHYRFDVGYDD
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCEEEEEECCCCC
DGRIDGVALDMTSRCGFSADLSGPVMTRAVCHFDNAYWLGDVDIAGYCGKTNTQSNTAFR
CCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHCCCCEEEEECCEEECCCCCCCCCCCCEEE
GFGGPQGAFAIEYILDDVARSLDRDPLDVRYANLYGKTERNVTPYGQTVEDNVLQELLGE
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
LETTSDYRARRAGVREFNARNTVLKKGIAITPVKFGIAFNVTHFNQAGALVHIYTDGSVL
HCCCHHHHHHHHCHHHCCCHHHHHHCCCEEEEEEEEEEEEEEEECCCCCEEEEEECCEEE
VNHGGTEMGQGLNTKVAQVVAHELGIRFGRIRVTATDTSKVANTSATAASTGSDLNGKAA
EECCCHHHCCCCCHHHHHHHHHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHHH
QDAARQLRERLAVFAAKQFGDGKVDAADVKFGNDFVWVGGASVPFGEVISKAYLARVQLW
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHHHEEEE
SDGFYATPKLYWDQSKLQGRPFYYYSYGAAVSEVVIDTLTGEMRTLRVDALHDVGASLNP
CCCCEECCEEEECHHHCCCCCEEEEECCHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCC
ALDVGQVEGAFIQGMGWLTTEELWWNKGGKLMTHAPSTYKIPTVNDTPPEFNVLLFKNRN
CCCCCCCCCCEEECCCCCEEHHHHHCCCCEEEEECCCCEECCCCCCCCCCEEEEEEECCC
VEDSIHRSKAVGEPPLLLPFSVFFAVRDAVAAVGDYKVNPPLDAPATGESILRAVSAVRA
CHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHH
AKAG
HCCC
>Mature Secondary Structure
MNQQAEPFLSTLDPQADAAQVHVSRAHESAHLHVSGRATYTDDIPVVAGTLHAALGLSAK
CCCCCCCHHHHCCCCCCHHHEEHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHCCCCC
PHAKIVSMNFDAVRATPGVVAVFTADDIPGVNDCGPIIHDDPVLAKGIVQFVGQPMFIVV
CCCEEEEECCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
ATSHETARLAARRAQVDYEELPAILTAQEARAAETYVIPPLKLARGDAAARLAVAPHRES
ECCCHHHHHHHHHHCCCHHHCCHHEEHHHHCCCCEEECCCHHCCCCCCCEEEEECCCCCC
GEMLLGGQEQFYLEGQIAYAVPKDDDGMHVYCSTQHPSEMQHLVAHVLGVASHNVLVECR
CCEEECCCCEEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHH
RMGGGFGGKESQSGLFACCAALAAWKLLCPVKLRPDRDDDMMITGKRHDFHYRFDVGYDD
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCEEEEEECCCCC
DGRIDGVALDMTSRCGFSADLSGPVMTRAVCHFDNAYWLGDVDIAGYCGKTNTQSNTAFR
CCCCCEEEEEEHHCCCCCCCCCCCHHHHHHHCCCCEEEEECCEEECCCCCCCCCCCCEEE
GFGGPQGAFAIEYILDDVARSLDRDPLDVRYANLYGKTERNVTPYGQTVEDNVLQELLGE
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
LETTSDYRARRAGVREFNARNTVLKKGIAITPVKFGIAFNVTHFNQAGALVHIYTDGSVL
HCCCHHHHHHHHCHHHCCCHHHHHHCCCEEEEEEEEEEEEEEEECCCCCEEEEEECCEEE
VNHGGTEMGQGLNTKVAQVVAHELGIRFGRIRVTATDTSKVANTSATAASTGSDLNGKAA
EECCCHHHCCCCCHHHHHHHHHHHCCEEEEEEEEECCCHHHCCCCCCCCCCCCCCCCHHH
QDAARQLRERLAVFAAKQFGDGKVDAADVKFGNDFVWVGGASVPFGEVISKAYLARVQLW
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHHHEEEE
SDGFYATPKLYWDQSKLQGRPFYYYSYGAAVSEVVIDTLTGEMRTLRVDALHDVGASLNP
CCCCEECCEEEECHHHCCCCCEEEEECCHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCC
ALDVGQVEGAFIQGMGWLTTEELWWNKGGKLMTHAPSTYKIPTVNDTPPEFNVLLFKNRN
CCCCCCCCCCEEECCCCCEEHHHHHCCCCEEEEECCCCEECCCCCCCCCCEEEEEEECCC
VEDSIHRSKAVGEPPLLLPFSVFFAVRDAVAAVGDYKVNPPLDAPATGESILRAVSAVRA
CHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHH
AKAG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]