Click here to switch to the map view.

The map label for this gene is glyA

Identifier: 78065369

GI number: 78065369

Start: 811150

End: 812397

Strand: Direct

Name: glyA

Synonym: Bcep18194_A3895

Alternate gene names: 78065369

Gene position: 811150-812397 (Clockwise)

Preceding gene: 78065360

Following gene: 78065370

Centisome position: 21.96

GC content: 64.26

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATTGCGAACGTCGATCCCGAAATCTTTGCCGCGATCGAGCAGGAAAACCGCCGCCA
GGAAGATCACATCGAGCTGATCGCGTCGGAAAACTACACGAGCCCGGCCGTGATGGCTGCGCAGGGTTCGCAACTCACGA
ACAAGTACGCGGAAGGGTATCCGGGCAAGCGCTACTACGGCGGCTGCGAATACGTGGACGTCGTTGAGCAGCTGGCGATC
GACCGCGTGAAGCAGCTGTTCGGCGCGGAAGCGGCGAACGTGCAGCCGAACTCGGGTTCGCAGGCGAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGACACGATCATGGGCATGAGCCTCGCGCACGGCGGCCACCTGACGCACGGCTCGCCCG
TGAACATGTCGGGCAAGTGGTTCAACGTGGTGAGCTACGGCCTGAACGAAAACGAAGACATCGACTACGAAGCGGCCGAG
CAGCTCGCGCAGGAACACAAGCCGAAGCTGATCGTCGCGGGCGCGTCTGCGTTCTCGCTGAAGATCGATTTCGAGCGTCT
GGCGAAGATCGCGAAGTCGGTCGGCGCGTACCTGATGGTCGACATGGCCCACTACGCAGGCCTGATCGCAGCGGGCGTGT
ACCCGAACCCGGTGCCGCACGCGGACTTCGTGACGACGACGACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAGTACGAGAAGCCGATCAACTCGGCGATCTTCCCGGGGATCCAGGGCGGCCCGCTGATGCACGTGAT
CGCGGGCAAGGCCGTGGCGTTCAAGGAAGCGCTGTCGCCGGAATTCAAGGCGTACCAGGAGAAGGTGGTCGAGAACGCCC
GCGTGCTGGCTGAAACGCTGGTGAAGCGTGGCCTGCGGATCGTGTCGGGCCGTACGGAAAGCCACGTGATGCTGGTGGAC
CTGCGTGCGAAGCACATCACGGGCAAGGCGGCGGAAGCAGCGCTGGGCGCGGCGCACATCACGGTGAACAAGAACGCGAT
CCCGAACGATCCGGAAAAGCCGTTCGTGACGAGCGGTGTGCGCCTGGGTTCGCCGGCAATGACGACGCGCGGCTTCGGTC
CGGCGGAAGCGGAACAGGTGGGTAACCTGATCGCGGACGTGCTGGACAACCCGGAAGATGCAGCGACGATCGAGCGCGTG
CGCGCGCAGGTCGCCGAGCTGACCAAGCGTTTCCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
TCGCGTCATACGGATTCTTCCGCCACGTCGAGCTGGTCCCGCCAGCAGCGCACCGTACTCGGCCGCTCCGGTCAACCTGT
ACACACTTAACGGAAACCGT

Downstream 100 bases:

>100_bases
TCGACGATGCGCTGCCCGTTCTGCCGGCATGACGACACGCAGGTCGTGGACTCGCGCGTGTCCGAAGATGGCGCCGCGAT
CCGGCGGCGCCGTCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
QLAQEHKPKLIVAGASAFSLKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKPINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKHITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPAEAEQVGNLIADVLDNPEDAATIERV
RAQVAELTKRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
QLAQEHKPKLIVAGASAFSLKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKPINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKHITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPAEAEQVGNLIADVLDNPEDAATIERV
RAQVAELTKRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
QLAQEHKPKLIVAGASAFSLKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKPINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKHITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPAEAEQVGNLIADVLDNPEDAATIERV
RAQVAELTKRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.3083700440529, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.3083700440529, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.3083700440529, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.3083700440529, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=39.7350993377483, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=43.2242990654206, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=41.6464891041162, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.768115942029, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25144732, Length=441, Percent_Identity=43.9909297052154, Blast_Score=350, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=441, Percent_Identity=43.9909297052154, Blast_Score=350, Evalue=8e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=46.2287104622871, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=43.1870669745958, Blast_Score=334, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=42.4175824175824, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=42.4175824175824, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44843; Mature: 44843

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHCCCCHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAEQLAQEHKPKLIVAGASAFSL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKPINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEKVVENARVLAETL
EEEECCCCCCCHHHCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKHITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEECHHHCCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPAEAEQVGNLIADVLDNPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHCCCCHHHEEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAEQLAQEHKPKLIVAGASAFSL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKPINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEKVVENARVLAETL
EEEECCCCCCCHHHCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKHITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEECHHHCCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPAEAEQVGNLIADVLDNPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA