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The map label for this gene is hmp [H]

Identifier: 78065299

GI number: 78065299

Start: 724376

End: 725584

Strand: Direct

Name: hmp [H]

Synonym: Bcep18194_A3823

Alternate gene names: 78065299

Gene position: 724376-725584 (Clockwise)

Preceding gene: 78065298

Following gene: 78065306

Centisome position: 19.61

GC content: 66.83

Gene sequence:

>1209_bases
ATGACCCACATCACCGCTGACCAGATGGCTCGCGTGAAGGCCACTGCCCCTGTCCTCGCCGTGCACGGCGCGACGATCAC
GAAGCACTTCTACCAGCGCATGTTCGCGCGCCATCCGGAACTGAAGAACCTGTTCAACCAGACGCACCAGAAGACGGGCA
GCCAGCCGGAAACGCTCGCGAAGGCCGTCTACGCGTATGCGGCGAACATCGACAATCTCGGCGCGCTGGGCGGCGCAGTG
ACCAAGATCGCGCACAAGCACGCGAGCCTGAACATCCGCCCCGAGCATTACCCGATCGTCGGCGAGAACCTGCTCGCGTC
GATCGTCGAAGTGCTGGGCGACGCGGTCGATGCAGAAACGCTCGAGGCCTGGCGCGTCGCGTACGGCCAGCTCGCGCAGA
TCCTGATCGGCGTCGAGGCCGACCTGTACGCGGGCGCCGCGTGGAGCGGGTTCCGCCCGTTCAAGGTCGAGCGCAAGGTG
CGCGAAAGCGACGAGATCACGTCGTTCTACCTGACGCCGGCCGACGGCGGCGCGGCGCCGACGTTCGAGCCCGGCCAGTA
CATCACGGTGAAGCGCTTCGTCGGTGATCTCGGCGTCGACCAGCCGCGCCAGTACAGCCTGTCCGACGCGCCGCACGGCA
AGTGGCTGCGCATCTCGGTGAAGCGCGAGGCCGGCAAGCCGGAAGTCATTCCGGCCGGCAAGGTGTCGACGCTGATGCAC
GACGGTGTGGAGGAGGGGGCGATCGTCGAGGTGACCGCGCCGATGGGCGAATTCTCGCTGAAGCGTGGCGTCGAGACGCC
GGTGGTGCTGATCTCCGGCGGTGTCGGCATCACGCCGATGATGTCGATGGCGTCGACGTTGATCGCCGAGGGCAGCCAGC
GCGAAGTGCGGTTCGTCCACGCGTGCCGCTCGGGCGCGGTGCATGCGTTCCGCGACTGGCTGAACGATACGGTGCGCGAC
CATGCGAACGTCAAGCGCACGGTGCTGTACGAACTGGTCGGCCCGAACGATCGCGCCGGCATCGACTACGACCTGGAAGG
GCGCCTCACGCCGGAACGCGTGCAGCAATACGCGCTGGTGCCGGATGCCGATTACTACATCTGCGGCCCGATCGGGTTCA
TGAAGGCGCAGCGTGACGCGCTCGTCGCACTCGGCGTCGCGCCGGAACGCGTGAACACCGAAATCTTTGGTTCGGGCGCG
CTCGAGTGA

Upstream 100 bases:

>100_bases
TCCGCTGACGTTTTGCCCCTTTTCCGCACTGCGACAATTTGCCCAAGGGGCATCCATTTTTAAAGATGTATCGTATGTGC
ATGTTTAACGGAGAACGAAC

Downstream 100 bases:

>100_bases
TGCACGGGAGGATTGCCTCCGGCCAATGAAAAAGCCCGGCGTGAGCCGGGCTTTTTTGTTGCGTGCATACGGCGTCAGGC
GCGCAGCATCAGCGTGGCAT

Product: hemoglobin-like flavoprotein

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTHITADQMARVKATAPVLAVHGATITKHFYQRMFARHPELKNLFNQTHQKTGSQPETLAKAVYAYAANIDNLGALGGAV
TKIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDAETLEAWRVAYGQLAQILIGVEADLYAGAAWSGFRPFKVERKV
RESDEITSFYLTPADGGAAPTFEPGQYITVKRFVGDLGVDQPRQYSLSDAPHGKWLRISVKREAGKPEVIPAGKVSTLMH
DGVEEGAIVEVTAPMGEFSLKRGVETPVVLISGGVGITPMMSMASTLIAEGSQREVRFVHACRSGAVHAFRDWLNDTVRD
HANVKRTVLYELVGPNDRAGIDYDLEGRLTPERVQQYALVPDADYYICGPIGFMKAQRDALVALGVAPERVNTEIFGSGA
LE

Sequences:

>Translated_402_residues
MTHITADQMARVKATAPVLAVHGATITKHFYQRMFARHPELKNLFNQTHQKTGSQPETLAKAVYAYAANIDNLGALGGAV
TKIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDAETLEAWRVAYGQLAQILIGVEADLYAGAAWSGFRPFKVERKV
RESDEITSFYLTPADGGAAPTFEPGQYITVKRFVGDLGVDQPRQYSLSDAPHGKWLRISVKREAGKPEVIPAGKVSTLMH
DGVEEGAIVEVTAPMGEFSLKRGVETPVVLISGGVGITPMMSMASTLIAEGSQREVRFVHACRSGAVHAFRDWLNDTVRD
HANVKRTVLYELVGPNDRAGIDYDLEGRLTPERVQQYALVPDADYYICGPIGFMKAQRDALVALGVAPERVNTEIFGSGA
LE
>Mature_401_residues
THITADQMARVKATAPVLAVHGATITKHFYQRMFARHPELKNLFNQTHQKTGSQPETLAKAVYAYAANIDNLGALGGAVT
KIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDAETLEAWRVAYGQLAQILIGVEADLYAGAAWSGFRPFKVERKVR
ESDEITSFYLTPADGGAAPTFEPGQYITVKRFVGDLGVDQPRQYSLSDAPHGKWLRISVKREAGKPEVIPAGKVSTLMHD
GVEEGAIVEVTAPMGEFSLKRGVETPVVLISGGVGITPMMSMASTLIAEGSQREVRFVHACRSGAVHAFRDWLNDTVRDH
ANVKRTVLYELVGPNDRAGIDYDLEGRLTPERVQQYALVPDADYYICGPIGFMKAQRDALVALGVAPERVNTEIFGSGAL
E

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=399, Percent_Identity=41.6040100250627, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1787658, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321673, Length=396, Percent_Identity=36.3636363636364, Blast_Score=234, Evalue=2e-62,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 43743; Mature: 43612

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHITADQMARVKATAPVLAVHGATITKHFYQRMFARHPELKNLFNQTHQKTGSQPETLA
CCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHH
KAVYAYAANIDNLGALGGAVTKIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDAET
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHH
LEAWRVAYGQLAQILIGVEADLYAGAAWSGFRPFKVERKVRESDEITSFYLTPADGGAAP
HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCC
TFEPGQYITVKRFVGDLGVDQPRQYSLSDAPHGKWLRISVKREAGKPEVIPAGKVSTLMH
CCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHH
DGVEEGAIVEVTAPMGEFSLKRGVETPVVLISGGVGITPMMSMASTLIAEGSQREVRFVH
CCCCCCCEEEEECCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHH
ACRSGAVHAFRDWLNDTVRDHANVKRTVLYELVGPNDRAGIDYDLEGRLTPERVQQYALV
HHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHEECC
PDADYYICGPIGFMKAQRDALVALGVAPERVNTEIFGSGALE
CCCCEEEECCHHHHHHCCCEEEEECCCCHHCCCEEECCCCCC
>Mature Secondary Structure 
THITADQMARVKATAPVLAVHGATITKHFYQRMFARHPELKNLFNQTHQKTGSQPETLA
CCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHH
KAVYAYAANIDNLGALGGAVTKIAHKHASLNIRPEHYPIVGENLLASIVEVLGDAVDAET
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHCCCCHHH
LEAWRVAYGQLAQILIGVEADLYAGAAWSGFRPFKVERKVRESDEITSFYLTPADGGAAP
HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCC
TFEPGQYITVKRFVGDLGVDQPRQYSLSDAPHGKWLRISVKREAGKPEVIPAGKVSTLMH
CCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHH
DGVEEGAIVEVTAPMGEFSLKRGVETPVVLISGGVGITPMMSMASTLIAEGSQREVRFVH
CCCCCCCEEEEECCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHH
ACRSGAVHAFRDWLNDTVRDHANVKRTVLYELVGPNDRAGIDYDLEGRLTPERVQQYALV
HHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHEECC
PDADYYICGPIGFMKAQRDALVALGVAPERVNTEIFGSGALE
CCCCEEEECCHHHHHHCCCEEEEECCCCHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]