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The map label for this gene is pntAA [H]

Identifier: 78065262

GI number: 78065262

Start: 681950

End: 683107

Strand: Direct

Name: pntAA [H]

Synonym: Bcep18194_A3786

Alternate gene names: 78065262

Gene position: 681950-683107 (Clockwise)

Preceding gene: 78065258

Following gene: 78065263

Centisome position: 18.46

GC content: 69.69

Gene sequence:

>1158_bases
ATGACGGAGGGACCGACGATGCATATTGGCGTGCCTGCCGAAACGCGGGCGAACGAGACGCGCGTGGCCGCGACGCCGGA
AACCGTGAAGAAATACGCGGCGGCCGGGCATCGGGTCAGTATCGCGAAAGGGGCCGGCATCGCCGCGAGTTATCCGGACG
AAGCCTACGCGGCCGCCGGTGCCGAACTGACGGGCCAGTCAGCTGCTTTCGATGTCGACATCGTGCTGAAAGTGCAGGCG
CCCACCGACGCCGAACTGCCGTTGCTCAAGCGCGGCGCCGTGCTGGTCGGCATGCTCGACCCGTTCAACGGCGAACAGGC
GGCGCAGCTCGCCGCGGCCGGCGTGACGGCCTTCGCGCTCGAAGCCGCGCCGCGCACGACGCGTGCGCAGAGCCTCGACG
TGCTGTCGTCGCAGGCGAACATCGCGGGCTACAAGGCCGTGCTGGTGGCCGCGGCGCTGTATCCGCGCTTCTTTCCGATG
CTGATGACGGCCGCGGGCACCGTGAAGGCCGCGCGCGTGCTGATTCTCGGCGCGGGCGTCGCGGGCCTGCAGGCGATCGC
GACCGCGAAGCGCCTCGGCGCGGTGATCGAGGCGTCCGACGTGCGGCCGGCCGTGAAGGAGCAGATCGAGTCGCTCGGCG
CGAAATTCCTCGACGTCCCGTACGAAACCGACGAAGAGCGCGACGCTGCGCAGGGCGTGGGCGGCTATGCGCGCCCGATG
CCGCCGTCGTGGCTCGGCCGCCAGGCCGCGCTCGTGCACGAGCGCGCGAAGCAGGCCGACATCGTGATCACCACCGCGCT
GATTCCCGGGCGCCCGGCGCCGACCCTGATCTCGGTCGAGACTGTGCAGTCGATGAAGCCGGGCTCGGTGCTCGTCGATC
TCGCGGCCGGCCGCGGCCCGGAATTCGACGGCCGCAAGAGCGGCAACTGCCCGCTGACGGTCGCCGACCAGGTGATCGTG
CACGACGGCGTGACGATCGCCGGCTACACGAATCTCGCGTCGATGGTCGCAGCGGACGCGTCGGCGCTGTATGCACGCAA
CCTGCTCGACTTCATGAAGCTGATCGTCACGAAGGACGGCACGCTGAACATCGACCTGACCGACGACATCGTCGCCGCGA
CGCTCCTGTGCCGCGACGGCGAAGTCGCGCGCAAGTAG

Upstream 100 bases:

>100_bases
TTTCGCCTAAAGTGAAAGGTGAATGCCGTCGCTCGTGAGCCGGTCGTCAGCCTGCCCGGCTCGTTGCGCAGTAGAAATCG
CAGGAAACGAAAAACTGACG

Downstream 100 bases:

>100_bases
CCGGGAGAGGAGGCGACCATGGAAGTCATCAATCACACGGTGATCAACGTGATCATCTTCGTGCTGGCGGTGTACGTCGG
CTACCACGTGGTGTGGAACG

Product: NAD(P)(+) transhydrogenase (AB-specific)

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTEGPTMHIGVPAETRANETRVAATPETVKKYAAAGHRVSIAKGAGIAASYPDEAYAAAGAELTGQSAAFDVDIVLKVQA
PTDAELPLLKRGAVLVGMLDPFNGEQAAQLAAAGVTAFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPM
LMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPM
PPSWLGRQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIV
HDGVTIAGYTNLASMVAADASALYARNLLDFMKLIVTKDGTLNIDLTDDIVAATLLCRDGEVARK

Sequences:

>Translated_385_residues
MTEGPTMHIGVPAETRANETRVAATPETVKKYAAAGHRVSIAKGAGIAASYPDEAYAAAGAELTGQSAAFDVDIVLKVQA
PTDAELPLLKRGAVLVGMLDPFNGEQAAQLAAAGVTAFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPM
LMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPM
PPSWLGRQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIV
HDGVTIAGYTNLASMVAADASALYARNLLDFMKLIVTKDGTLNIDLTDDIVAATLLCRDGEVARK
>Mature_384_residues
TEGPTMHIGVPAETRANETRVAATPETVKKYAAAGHRVSIAKGAGIAASYPDEAYAAAGAELTGQSAAFDVDIVLKVQAP
TDAELPLLKRGAVLVGMLDPFNGEQAAQLAAAGVTAFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPML
MTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPMP
PSWLGRQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGPEFDGRKSGNCPLTVADQVIVH
DGVTIAGYTNLASMVAADASALYARNLLDFMKLIVTKDGTLNIDLTDDIVAATLLCRDGEVARK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=391, Percent_Identity=38.8746803069054, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI122939153, Length=391, Percent_Identity=38.8746803069054, Blast_Score=251, Evalue=8e-67,
Organism=Escherichia coli, GI1787887, Length=379, Percent_Identity=45.1187335092348, Blast_Score=305, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=383, Percent_Identity=41.77545691906, Blast_Score=275, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39908; Mature: 39777

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEGPTMHIGVPAETRANETRVAATPETVKKYAAAGHRVSIAKGAGIAASYPDEAYAAAG
CCCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCC
AELTGQSAAFDVDIVLKVQAPTDAELPLLKRGAVLVGMLDPFNGEQAAQLAAAGVTAFAL
CCCCCCCCEEEEEEEEEEECCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHCHHHEEE
EAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAGTVKAARVLILGAGV
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCH
AGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPM
HHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCHHEECCCCCCCCHHHHHHCCCCCCCCC
PPSWLGRQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGP
CHHHHCHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHCCCCCCEEEEECCCCCC
EFDGRKSGNCPLTVADQVIVHDGVTIAGYTNLASMVAADASALYARNLLDFMKLIVTKDG
CCCCCCCCCCCEEEECEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TLNIDLTDDIVAATLLCRDGEVARK
EEEEEECHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
TEGPTMHIGVPAETRANETRVAATPETVKKYAAAGHRVSIAKGAGIAASYPDEAYAAAG
CCCCEEEEECCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCC
AELTGQSAAFDVDIVLKVQAPTDAELPLLKRGAVLVGMLDPFNGEQAAQLAAAGVTAFAL
CCCCCCCCEEEEEEEEEEECCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHHCHHHEEE
EAAPRTTRAQSLDVLSSQANIAGYKAVLVAAALYPRFFPMLMTAAGTVKAARVLILGAGV
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEECCH
AGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPM
HHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCHHEECCCCCCCCHHHHHHCCCCCCCCC
PPSWLGRQAALVHERAKQADIVITTALIPGRPAPTLISVETVQSMKPGSVLVDLAAGRGP
CHHHHCHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHCCCCCCEEEEECCCCCC
EFDGRKSGNCPLTVADQVIVHDGVTIAGYTNLASMVAADASALYARNLLDFMKLIVTKDG
CCCCCCCCCCCEEEECEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TLNIDLTDDIVAATLLCRDGEVARK
EEEEEECHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]