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The map label for this gene is speA [H]

Identifier: 78049594

GI number: 78049594

Start: 4637944

End: 4639881

Strand: Reverse

Name: speA [H]

Synonym: XCV4038

Alternate gene names: 78049594

Gene position: 4639881-4637944 (Counterclockwise)

Preceding gene: 78049596

Following gene: 78049593

Centisome position: 89.6

GC content: 64.65

Gene sequence:

>1938_bases
ATGCCAGGCGTTACACTTCACGCCCTTTTTTATTCCAGCCGAGACAGCGAAATGAGCGATTGGTCCCTCGACCAAGCCCG
CAAGACCTATTCGATCCCGCATTGGGCCGACGGGTATTTCGATGTGAACGCTGCCGGACACGTGGTGGTCACCCCGACCG
CCGATGGCCCGGCGGTGTCGCTGCCCGAGGTGGTGGATGCCGCGCGCGCAGCCGGTGCCAAGCTGCCGCTACTGGTGCGC
TTCCCGGACATCCTGGGCCAGCGCCTGGGCAAGCTGCAGGCAGCGTTTGCGCAGGCGCAGTCGGAGTGGGACTACGCCGG
AGGCTATACGGCGGTGTATCCGATCAAGGTCAACCAGCATCGTGGCGTGGCCGGCACCCTGGCCGGTCACCACGGTGAGG
GCTTCGGGCTGGAAGCGGGCAGCAAGCCCGAGCTGATGGCGGTGCTGGCGCTGTCGCGTCCGGGCGGGCTGATCGTGTGC
AACGGCTACAAGGACCGCGAATACATCCGCCTGGCGCTGATCGGCCGCAAACTCGGCCTGCAGACCTTCATCGTCATCGA
AAAGCCCTCCGAACTGACCCTGGTGCTGGAAGAAGCACGCGCGCTGGACGTCAAGCCCGGCCTGGGCGTGCGCATGCGCC
TGGCCTCGCTGGGCGCGGGCAAGTGGCAGAACAGCGGTGGCGACAAGGCCAAGTTCGGTCTCTCGCCGCGCCAGGTGCTG
GACCTGTGGAAGACGCTGCGCGACACCGAGTACGCCGACAGCCTGAACCTGCTGCATTTCCATATGGGCTCGCAGATTTC
CAACGTGCGCGACATCGCCAACGGCATGCGCGAGGCCACGCGCTATTTCGTGGAGCTCTCGCGCCTGGGCGCAAAGATCA
GCCATGTGGACGTGGGCGGCGGCCTGGGCATCGATTACGAAGGCACTCGCTCGCGCAGCTATTGCTCGATCAACTACGGC
CTGCACTCGTATGCCAGCAACATCGTGCAGCCGTTGGCCAGCGCTTGCGAAGAGCATGGCCTGGCCCCGCCGCGCATCGT
CACCGAGTGCGGGCGCGCAATGACGGCGCACCATGCGGTGCTGATCGCCAACGTGTCGGAAGTGGAGCAGGCGCCGGAAG
GCCGCGTGCCGGTTGCGCACGACGATGAGCCGGCCGCGATCCGCCACCTGCGCGAGATCCATGACGAGCTCGATGTGCGC
CCGGCGGTGGAGCTGTTCCAGGAAGCCCAGCATTTCCATGCCGAAGGTTTGAGCGCGTATGCGCTGGGCCAGATCGACCT
GCCGCAGCGCGCGCGCATCGACGATCTGTTCTACGCCATCGCACATGGCGTGCGCGCACGCCTGAGCTTCGATGAGAAGA
GCCATCGCCCGGTGCTGGATGAGCTCAACGAGCGGCTGGTGGACAAGTACTTCGTCAACTTCAGCGTGTTCGAATCGATC
CCGGACGTGTGGGCGATCGATCAGGTGTTCCCGATCGTGCCGATCGAGCGCTTGAACGAAGCGCCGCAGCGGCGCGGCAT
CATCGCCGACATGACCTGCGATTCCGACGGCATGGTCAAGACCTATGTCGAGAACGAAAGCCTGGACAGCTCGCTGCCGC
TGCATGGTTTGAATGCCGGCGAGAGCTATCGCATCGGCTTCTTCCTGGTGGGCGCCTACCAGGAAATCCTGGGCGATATC
CATAACCTATTCGGCGATACCGATGCGGTGGAAGTCGTGGTGAATCGCGATGGCTATCGCATCGCACAGCAGCGCCGCGG
CGATACCACCGACGTGATGCTGGACTACGTGGGCTATCAGCTGGACACGCTGCGTGCCACCTATGCCGAGCGCATTGCTG
CCGCAAATCTGTCGCCCGAGCGGGCGCAGGAACTCGGCGCTGCGTTGGAAGCGGGGCTGACCGGCTACACCTATCTGTCC
GACGAGCCGCTGAGCTGA

Upstream 100 bases:

>100_bases
GATGAATGTCGGGTGCAGCCTCGCGCAGCCAACCTGCGCCAACCCCGCTCCAACCAGGAGCGGGGCGTGAAGTCGGCGCG
GATTGTAACGGACCCTGCGC

Downstream 100 bases:

>100_bases
TCCGCAGTGCGCTGCGGCTGGTCCGCAGCGCTGGCTGTGCGCGACATGGCCCATCTTGCACGCGCTCCTGCCGCGAGCGC
CGCTTGCAGCAGCAGGGACA

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MPGVTLHALFYSSRDSEMSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPLLVR
FPDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQHRGVAGTLAGHHGEGFGLEAGSKPELMAVLALSRPGGLIVC
NGYKDREYIRLALIGRKLGLQTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVL
DLWKTLRDTEYADSLNLLHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSINYG
LHSYASNIVQPLASACEEHGLAPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVPVAHDDEPAAIRHLREIHDELDVR
PAVELFQEAQHFHAEGLSAYALGQIDLPQRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESI
PDVWAIDQVFPIVPIERLNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHGLNAGESYRIGFFLVGAYQEILGDI
HNLFGDTDAVEVVVNRDGYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAANLSPERAQELGAALEAGLTGYTYLS
DEPLS

Sequences:

>Translated_645_residues
MPGVTLHALFYSSRDSEMSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPLLVR
FPDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQHRGVAGTLAGHHGEGFGLEAGSKPELMAVLALSRPGGLIVC
NGYKDREYIRLALIGRKLGLQTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVL
DLWKTLRDTEYADSLNLLHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSINYG
LHSYASNIVQPLASACEEHGLAPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVPVAHDDEPAAIRHLREIHDELDVR
PAVELFQEAQHFHAEGLSAYALGQIDLPQRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESI
PDVWAIDQVFPIVPIERLNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHGLNAGESYRIGFFLVGAYQEILGDI
HNLFGDTDAVEVVVNRDGYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAANLSPERAQELGAALEAGLTGYTYLS
DEPLS
>Mature_644_residues
PGVTLHALFYSSRDSEMSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVSLPEVVDAARAAGAKLPLLVRF
PDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQHRGVAGTLAGHHGEGFGLEAGSKPELMAVLALSRPGGLIVCN
GYKDREYIRLALIGRKLGLQTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVLD
LWKTLRDTEYADSLNLLHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGGGLGIDYEGTRSRSYCSINYGL
HSYASNIVQPLASACEEHGLAPPRIVTECGRAMTAHHAVLIANVSEVEQAPEGRVPVAHDDEPAAIRHLREIHDELDVRP
AVELFQEAQHFHAEGLSAYALGQIDLPQRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESIP
DVWAIDQVFPIVPIERLNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHGLNAGESYRIGFFLVGAYQEILGDIH
NLFGDTDAVEVVVNRDGYRIAQQRRGDTTDVMLDYVGYQLDTLRATYAERIAAANLSPERAQELGAALEAGLTGYTYLSD
EPLS

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=647, Percent_Identity=47.9134466769706, Blast_Score=600, Evalue=1e-172,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 70772; Mature: 70640

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVTLHALFYSSRDSEMSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVS
CCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCCC
LPEVVDAARAAGAKLPLLVRFPDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQH
CHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCC
RGVAGTLAGHHGEGFGLEAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRKLGL
CCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCHHEEEEEHHHHCCC
QTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVL
EEEEEEECCCCEEEEEEHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHHHH
DLWKTLRDTEYADSLNLLHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGG
HHHHHHHCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
GLGIDYEGTRSRSYCSINYGLHSYASNIVQPLASACEEHGLAPPRIVTECGRAMTAHHAV
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
LIANVSEVEQAPEGRVPVAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGLSAY
EEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
ALGQIDLPQRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESI
EECCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PDVWAIDQVFPIVPIERLNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHGLNAG
CCHHHHHHHCCCCCHHHHCCCHHHCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
ESYRIGFFLVGAYQEILGDIHNLFGDTDAVEVVVNRDGYRIAQQRRGDTTDVMLDYVGYQ
CCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHCCH
LDTLRATYAERIAAANLSPERAQELGAALEAGLTGYTYLSDEPLS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure 
PGVTLHALFYSSRDSEMSDWSLDQARKTYSIPHWADGYFDVNAAGHVVVTPTADGPAVS
CCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCCCCCC
LPEVVDAARAAGAKLPLLVRFPDILGQRLGKLQAAFAQAQSEWDYAGGYTAVYPIKVNQH
CHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCC
RGVAGTLAGHHGEGFGLEAGSKPELMAVLALSRPGGLIVCNGYKDREYIRLALIGRKLGL
CCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEECCCCCCHHEEEEEHHHHCCC
QTFIVIEKPSELTLVLEEARALDVKPGLGVRMRLASLGAGKWQNSGGDKAKFGLSPRQVL
EEEEEEECCCCEEEEEEHHHHCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCHHHHH
DLWKTLRDTEYADSLNLLHFHMGSQISNVRDIANGMREATRYFVELSRLGAKISHVDVGG
HHHHHHHCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
GLGIDYEGTRSRSYCSINYGLHSYASNIVQPLASACEEHGLAPPRIVTECGRAMTAHHAV
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
LIANVSEVEQAPEGRVPVAHDDEPAAIRHLREIHDELDVRPAVELFQEAQHFHAEGLSAY
EEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEE
ALGQIDLPQRARIDDLFYAIAHGVRARLSFDEKSHRPVLDELNERLVDKYFVNFSVFESI
EECCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PDVWAIDQVFPIVPIERLNEAPQRRGIIADMTCDSDGMVKTYVENESLDSSLPLHGLNAG
CCHHHHHHHCCCCCHHHHCCCHHHCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
ESYRIGFFLVGAYQEILGDIHNLFGDTDAVEVVVNRDGYRIAQQRRGDTTDVMLDYVGYQ
CCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHCCH
LDTLRATYAERIAAANLSPERAQELGAALEAGLTGYTYLSDEPLS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]