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The map label for this gene is uvrB [H]

Identifier: 78048368

GI number: 78048368

Start: 3198857

End: 3200950

Strand: Reverse

Name: uvrB [H]

Synonym: XCV2812

Alternate gene names: 78048368

Gene position: 3200950-3198857 (Counterclockwise)

Preceding gene: 78048370

Following gene: 78048367

Centisome position: 61.81

GC content: 61.03

Gene sequence:

>2094_bases
TTGCGTAGCTGTCAGGGTTCTACCGATGCTGGCCTCCGTAAATTCGTGCAGCCTCCCCCCGAGATCCGCTCCATGACCGA
CCGTTTTCAGCTCGTATCCCCTTACTCGCCAGCGGGCGACCAGCCTGCGGCCATCGACAAGTTGGTGGCCAACTTCGAGG
CTGGGCTGGCCAAGCAGACCTTGTTGGGTGTAACGGGCTCGGGCAAAACCTACACCATTGCCAATGTGGTCCAGCAGGTG
CAGAAGCCGACGCTGGTGATGGCGCCGAACAAGACGTTGGCGGCGCAGCTGTACGGCGAGTTCAAGTCGTTCTTCCCGCA
TAACGCGGTCGAGTACTTCGTCAGCTACTACGACTACTACCAGCCGGAGGCCTATGTGCCGTCGTCGGACACCTTCATCG
AGAAGGACAGTTCGATCAATGAACACATCGAGCAGATGCGCTTGTCGGCGACCAAGACCTTGCTGTCTCGGCGCGATTCG
CTGGTGGTGGCGACGGTGTCGGCAATCTACGGCCTCGGCGCGCCGGAGGACTATCTATCGCTGCGCCTGATCCTGTCGGT
TGGGGAGCACATCGATCAGCGCCAGTTGATCCGCCATCTCACCGATCTGCAATACACCCGCAACGAGTTCGAACTGACGC
GCGGTGCCTTTCGCGTGCGCGGCGAGGTGTTGGATGTGTTCCCGGCCGAGTCGGATACCGAAGCCTTGCGCATCGAGTTG
TTCGATGGCGACATCGAGCAGCTGACCTTGTTCGATCCACTCACTGGCGAAACCTTGCGCAAGTTGCAGCGCTACACCGT
GTACCCGAAGACCCATTACGCCACGACGCGTGAGCGCACGTTGAGTGCGGTGGACACCATCAAGGAAGAGCTGAAAGAAC
GCCTGGAGCAGCTCTATGCGCAGAACAAGCTGGTCGAGGCGCAACGTCTGGCGCAGCGCACGCAATTCGACCTGGAAATG
ATGGCCGAGGTGGGTTTTTGCAACGGTATCGAAAACTACTCGCGTCATCTCACCGGCAAGGCGCCCGGCGAGCCGCCGCC
GACCCTGTTCGACTACCTGCCGCCGGACGCGCTGCTGGTCATCGATGAGTCGCATGTGACCATTCCGCAGATCGGCGCGA
TGTACAAGGGCGACCGTTCGCGCAAGGAAACGCTGGTGGAGTTCGGTTTTCGATTGCCGTCTGCCTTGGACAACCGCCCC
TTGCGTTTCGAAGAGTGGGAGGCGCGTTCGCCACGCAGCATCTATGTCTCGGCAACGCCGGGGCCTTATGAGGTGCGCGA
GTCTGCCGGCGAAGTCACGGAGCTGGTGGTGCGCCCAACCGGTCTGATCGACCCGGTGGTGGAGATCCGTCCGGTTGGTA
CGCAGGTCGACGACCTCATGTCCGAGGTTCACGAGCGCATCAAGCTCGGCGATCGCGTGTTGGTGACCACGTTGACCAAG
CGCATGGCCGAGAATCTCACCGAGTATCTGGGCGAGCACGGGATTCGGGTGCGCTACCTGCACTCGGATATCGACACCGT
CGAGCGCGTGGAGATCATCCGCGACCTGCGCCTGGGCAAGTTCGATGTGCTCGTGGGCATCAACCTGCTGCGCGAGGGTT
TGGACATGCCGGAAGTCTCGCTGGTGGCCATCCTGGATGCCGACAAGGAGGGCTTCCTGCGATCGACCGGATCGCTGATT
CAGACCATTGGCCGTGCAGCACGCAATCTGCGCGGCAAGGCCATTTTGTACGCCGACAAGATAACGCGCTCGATGCAGGC
GGCAATCGACGAGACCGATCGTCGCCGCGAGAAGCAGGTCGAGTACAACCTGGAGCATGGCATCACGCCGAAATCCGTTG
AGCGGCCGATCGCCGACATCATGGAAGGCGCGCGCGACGATGCGGCCGAGAAGAAGTCGGGCAAGGGCCGTTCGAAATCG
CGCCAGGTTGCAGAGGAGACGCCCGATTACCGTGCCATGAAGCCTGCGGAAATCGCTGGCAAGCTCAAGAGTCTGGAACA
GAAGATGTACCAGCACGCCAAGGATCTGGAGTTCGAGGCCGCAGCCCAGATTCGCGACCAGATCCAGAAGTTGAAGGCTG
CCAGCTTGGGATAG

Upstream 100 bases:

>100_bases
CCTCTCGCGCTCGAATAGCCTGCTGCGTCCATTGCGCGTCTCCTTGAAGTGGAGCAAGCAGTCTCAACATTGGTTGCTTG
CCAGGTAACCCTGCCTTTCC

Downstream 100 bases:

>100_bases
GGCGGGTGACTCGCCCTGCAGACACGATAGGACTTGTGGTCGGTAAAACCCTGCGCTAGAATGCGCGCCCTGCACAGCGC
AATGCTGACGCAGGATTCGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 697; Mature: 697

Protein sequence:

>697_residues
MRSCQGSTDAGLRKFVQPPPEIRSMTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQV
QKPTLVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDS
LVVATVSAIYGLGAPEDYLSLRLILSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIEL
FDGDIEQLTLFDPLTGETLRKLQRYTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYAQNKLVEAQRLAQRTQFDLEM
MAEVGFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRP
LRFEEWEARSPRSIYVSATPGPYEVRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTK
RMAENLTEYLGEHGIRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLI
QTIGRAARNLRGKAILYADKITRSMQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKS
RQVAEETPDYRAMKPAEIAGKLKSLEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG

Sequences:

>Translated_697_residues
MRSCQGSTDAGLRKFVQPPPEIRSMTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQV
QKPTLVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDS
LVVATVSAIYGLGAPEDYLSLRLILSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIEL
FDGDIEQLTLFDPLTGETLRKLQRYTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYAQNKLVEAQRLAQRTQFDLEM
MAEVGFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRP
LRFEEWEARSPRSIYVSATPGPYEVRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTK
RMAENLTEYLGEHGIRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLI
QTIGRAARNLRGKAILYADKITRSMQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKS
RQVAEETPDYRAMKPAEIAGKLKSLEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG
>Mature_697_residues
MRSCQGSTDAGLRKFVQPPPEIRSMTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQTLLGVTGSGKTYTIANVVQQV
QKPTLVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYYQPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDS
LVVATVSAIYGLGAPEDYLSLRLILSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIEL
FDGDIEQLTLFDPLTGETLRKLQRYTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYAQNKLVEAQRLAQRTQFDLEM
MAEVGFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLVIDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRP
LRFEEWEARSPRSIYVSATPGPYEVRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTK
RMAENLTEYLGEHGIRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSTGSLI
QTIGRAARNLRGKAILYADKITRSMQAAIDETDRRREKQVEYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKS
RQVAEETPDYRAMKPAEIAGKLKSLEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=68.562874251497, Blast_Score=928, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=309, Percent_Identity=21.3592233009709, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78578; Mature: 78578

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSCQGSTDAGLRKFVQPPPEIRSMTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQT
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LLGVTGSGKTYTIANVVQQVQKPTLVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYY
HEEECCCCCEEEHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
QPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHH
LRLILSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIEL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEE
FDGDIEQLTLFDPLTGETLRKLQRYTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYA
ECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEE
IDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATP
ECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEECCC
GPYEVRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTK
CCHHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHH
RMAENLTEYLGEHGIRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVS
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEE
LVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKITRSMQAAIDETDRRREKQV
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
EYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKSRQVAEETPDYRAMKPAEIAG
HHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHH
KLKSLEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSCQGSTDAGLRKFVQPPPEIRSMTDRFQLVSPYSPAGDQPAAIDKLVANFEAGLAKQT
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
LLGVTGSGKTYTIANVVQQVQKPTLVMAPNKTLAAQLYGEFKSFFPHNAVEYFVSYYDYY
HEEECCCCCEEEHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
QPEAYVPSSDTFIEKDSSINEHIEQMRLSATKTLLSRRDSLVVATVSAIYGLGAPEDYLS
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHH
LRLILSVGEHIDQRQLIRHLTDLQYTRNEFELTRGAFRVRGEVLDVFPAESDTEALRIEL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCEEEEEE
FDGDIEQLTLFDPLTGETLRKLQRYTVYPKTHYATTRERTLSAVDTIKEELKERLEQLYA
ECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QNKLVEAQRLAQRTQFDLEMMAEVGFCNGIENYSRHLTGKAPGEPPPTLFDYLPPDALLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEE
IDESHVTIPQIGAMYKGDRSRKETLVEFGFRLPSALDNRPLRFEEWEARSPRSIYVSATP
ECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCEEEEECCC
GPYEVRESAGEVTELVVRPTGLIDPVVEIRPVGTQVDDLMSEVHERIKLGDRVLVTTLTK
CCHHHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHH
RMAENLTEYLGEHGIRVRYLHSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVS
HHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEE
LVAILDADKEGFLRSTGSLIQTIGRAARNLRGKAILYADKITRSMQAAIDETDRRREKQV
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
EYNLEHGITPKSVERPIADIMEGARDDAAEKKSGKGRSKSRQVAEETPDYRAMKPAEIAG
HHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHH
KLKSLEQKMYQHAKDLEFEAAAQIRDQIQKLKAASLG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA