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The map label for this gene is 78048304

Identifier: 78048304

GI number: 78048304

Start: 3128320

End: 3129258

Strand: Reverse

Name: 78048304

Synonym: XCV2748

Alternate gene names: NA

Gene position: 3129258-3128320 (Counterclockwise)

Preceding gene: 78048310

Following gene: 78048303

Centisome position: 60.43

GC content: 69.86

Gene sequence:

>939_bases
ATGCACACCATCGACGTCATCGACTCCCACACGGCTGGCGAGCCTACCCGCGTGGTCCTTTCCGGTTTTCCAGATCTGGG
CGATGGCGACCTGGCGCAGTGCCGCGAACGCTTTCGCAGCAAGTTCGACCACTGGCGCAGCGCCATCGCCTGCGAGCCGC
GTGGGTCGGACACCATGGTGGGCGCCTTGTTGCTGCCCCCGCGCGACCCAGGCGCCTGCACCGGGGTGATCTTCTTCAAC
AACGTGGGCTACCTGGGCATGTGCGGGCACGGCACCATCGGGGTGGTCCGCACGCTGGCCGAGCTGGGGCGCATCGGCCC
GGGCCAGCACCGGATCGAGACGCCGGTCGGCACGGTGGGCGTGGAGCTGGCCGACGACGGCACGGTGTGGGTGGACAATG
TCGAGAGCTATCGCGTTGCCAGCGGGGTGGAGGTGGAGGTGCCGGGGCATGGCCGGGTGCGCGGCGACGTGGCCTGGGGC
GGCAACTGGTTCTTCATCACCGAGCAGGCGCCGTGCGCGCTGGACCTGGCGCACCAGCGCGAGCTGACCGCCTATACCGA
GGCGGTTCGGCTGGCCCTGGAAGCGGCCGGAATCACGGGCGAGGCCGGTGGCGAGATCGACCATATCGAAGTCAACGGCG
CTGCGCCCGACGGTAGCGGCGTGGCGCGCAATTTCGTGCTGTGCCCGGGGTTGGCCTACGACCGCTCGCCGTGCGGCACC
GGCACCAGCGCCAAGCTGGCCTGCCTGGCGGCGGACGGCAAATTGGCCGAAGGCGAGCGCTGGGTGCAGCAAGGCATTCT
GGGCAGCGCCTTCGAAGGCAATTATCGGTTGAGCGGGCGTGGCATCGCACCGCGCATCAGTGGGCGGGCGTACATCACCG
CGCGCGCGCAACTGGTGATCGACCCGGCGGACCCGTTCGCCTGGGGCATCGTGGCCTGA

Upstream 100 bases:

>100_bases
ACGCGCGGTTGTGATTCGGGTTGATGATTGTGCGGATTTCCGCATTTTCACTTGGCATTGAACGCTAGTCGCCCGCAGGT
CGGCAGTGGGAGCATGGGGT

Downstream 100 bases:

>100_bases
TGGAACCCCAGCGGCCCGCACCGGTGCTTGCGTCGGTCACGCCGTCTGGCGCAGCACTGTCTGCTGCGCTGGCAGGAACT
GCTGCTGCAACGCCTGCGTC

Product: proline racemase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSKFDHWRSAIACEPRGSDTMVGALLLPPRDPGACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIGPGQHRIETPVGTVGVELADDGTVWVDNVESYRVASGVEVEVPGHGRVRGDVAWG
GNWFFITEQAPCALDLAHQRELTAYTEAVRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVIDPADPFAWGIVA

Sequences:

>Translated_312_residues
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSKFDHWRSAIACEPRGSDTMVGALLLPPRDPGACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIGPGQHRIETPVGTVGVELADDGTVWVDNVESYRVASGVEVEVPGHGRVRGDVAWG
GNWFFITEQAPCALDLAHQRELTAYTEAVRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVIDPADPFAWGIVA
>Mature_312_residues
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSKFDHWRSAIACEPRGSDTMVGALLLPPRDPGACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIGPGQHRIETPVGTVGVELADDGTVWVDNVESYRVASGVEVEVPGHGRVRGDVAWG
GNWFFITEQAPCALDLAHQRELTAYTEAVRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVIDPADPFAWGIVA

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases [H]

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=333, Percent_Identity=30.03003003003, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 32891; Mature: 32891

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSKFDHWRSAIACEPRGSDTMV
CCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
GALLLPPRDPGACTGVIFFNNVGYLGMCGHGTIGVVRTLAELGRIGPGQHRIETPVGTVG
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEE
VELADDGTVWVDNVESYRVASGVEVEVPGHGRVRGDVAWGGNWFFITEQAPCALDLAHQR
EEEECCCEEEEECCCCEEECCCCEEEECCCCCEEEEEEECCEEEEEECCCCCEEEHHHHH
ELTAYTEAVRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCC
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVI
CCCCEEEEEEECCCCCCCHHHHHHCCCCCCCCCCEEECCCCCCCEECCEEEEEEEEEEEE
DPADPFAWGIVA
ECCCCCEEECCC
>Mature Secondary Structure
MHTIDVIDSHTAGEPTRVVLSGFPDLGDGDLAQCRERFRSKFDHWRSAIACEPRGSDTMV
CCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
GALLLPPRDPGACTGVIFFNNVGYLGMCGHGTIGVVRTLAELGRIGPGQHRIETPVGTVG
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEE
VELADDGTVWVDNVESYRVASGVEVEVPGHGRVRGDVAWGGNWFFITEQAPCALDLAHQR
EEEECCCEEEEECCCCEEECCCCEEEECCCCCEEEEEEECCEEEEEECCCCCEEEHHHHH
ELTAYTEAVRLALEAAGITGEAGGEIDHIEVNGAAPDGSGVARNFVLCPGLAYDRSPCGT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCC
GTSAKLACLAADGKLAEGERWVQQGILGSAFEGNYRLSGRGIAPRISGRAYITARAQLVI
CCCCEEEEEEECCCCCCCHHHHHHCCCCCCCCCCEEECCCCCCCEECCEEEEEEEEEEEE
DPADPFAWGIVA
ECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA